TLR
Les récepteurs de type Toll (TLR) sont une classe de protéines qui jouent un rôle crucial dans le système immunitaire inné en reconnaissant les motifs moléculaires associés aux pathogènes (PAMP) et en initiant des réponses immunitaires. Les TLR sont impliqués dans la détection d'une large gamme de pathogènes, y compris les bactéries, les virus et les champignons, et sont essentiels pour l'activation des voies de signalisation inflammatoires. La dérégulation de la signalisation des TLR est associée à des maladies inflammatoires chroniques, des troubles auto-immuns et le cancer. Chez CymitQuimica, nous offrons une variété de modulateurs TLR de haute qualité pour soutenir vos recherches sur l'immunité innée, l'inflammation et les maladies infectieuses.
87 produits trouvés pour "TLR".
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BMS-905
CAS :BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.Formule :C23H29N3Degré de pureté :99.94%Couleur et forme :White SolidMasse moléculaire :347.5CU-T12-9
CAS :CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).Formule :C17H13F3N4O2Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :362.31Ref: TM-T15017
1mg50,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg160,00€25mg268,00€50mg409,00€100mg583,00€IAXO-102
CAS :IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.Formule :C35H71NO5Degré de pureté :98.17%Couleur et forme :White SolidMasse moléculaire :585.94TLR7/8 agonist 3
CAS :TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.Formule :C17H23N5ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :313.4Ref: TM-T13167
1mg60,00€5mg133,00€1mL*10mM (DMSO)147,00€10mg215,00€25mg349,00€50mg482,00€100mg665,00€200mg893,00€CU-CPT17e
CAS :CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).Formule :C27H24N2O8Degré de pureté :98.49%Couleur et forme :White SolidMasse moléculaire :504.49CU-CPT22
CAS :CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).Formule :C19H22O7Degré de pureté :98.66% - 99.80%Couleur et forme :Red SolidMasse moléculaire :362.37Ref: TM-T15020
1mg49,00€2mg66,00€5mg94,00€1mL*10mM (DMSO)108,00€10mg159,00€25mg296,00€50mg444,00€100mg647,00€200mg888,00€TLR7 agonist 17
CAS :TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].Formule :C25H37N7O3Couleur et forme :SolidMasse moléculaire :483.61TLR7/8 agonist 12
TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.Formule :C29H38N6O3Couleur et forme :SolidMasse moléculaire :518.65TLR2 antagonist-1
TLR2antagonist-1 is a selective antagonist of Toll-like receptor 2 (TLR2). It effectively inhibits excessive activation of TLR2, with an IC50 value of 11.41 μM, and reduces the production of inflammatory factors. TLR2antagonist-1 exhibits metabolic stability, with a half-life (T1/2) of 16.67 minutes in mouse liver microsomes. This compound is useful for research in inflammation, immunology, and neurological disorders.TLR7 agonist 21
TLR7 agonist21 (Compound 27B) is a selective activator of Toll-like receptor 7 (TLR7), with an EC50 of 17.53 nM for human TLR7 and 41.7 nM for mouse TLR7. It induces the secretion of pro-inflammatory cytokines, including IL-6, TNF-α, IFN-α1, and IL-4. Acting as a vaccine adjuvant, TLR7 agonist21 enhances IgG and IgA levels, offering protection for mice against influenza virus infection.Formule :C22H33N7OMasse moléculaire :411.27466CRX 527
CAS :CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.Formule :C81H151N2O19PCouleur et forme :SolidMasse moléculaire :1488.04MTT5
MTT5, a toll-like receptor 7 (TLR7) agonist, can be conjugated with Deruxtecan to exert antitumor activity in HER2-positive solid tumors through tumor cell killing and immune activation.Formule :C22H27N7O4Couleur et forme :SolidMasse moléculaire :453.49PTD-N5-1
CAS :PTD-N5-1 (N5-1) is an IRF5 inhibitory peptide. It can block the production of IL-12 induced by β-glucan in both wild-type and Clec2d-deficient bone marrow-derived dendritic cells (BMDC) that are activated by IFN-γ. PTD-N5-1 modulates antifungal immunity by inhibiting IRF5-mediated IL-12 production.Formule :C148H248N52O30SCouleur et forme :SolidMasse moléculaire :3267.95MTvkPABC-P5 TFA
MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).Couleur et forme :Odour SolidEzeprogind
CAS :Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can TrustFormule :C25H44N6Degré de pureté :99.28%Couleur et forme :White SolidMasse moléculaire :428.66Lipopolysaccharides, from Klebsiella pneumoniae
Lipopolysaccharides from Klebsiella pneumoniae (LPS, from bacterial [Klebsiella pneumoniae]) are lipid-polysaccharide endotoxins and TLR4 activators originating from Klebsiella pneumoniae, classified as S-type LPS. They exhibit a characteristic tripartite structure comprising an O-antigen, a core oligosaccharide, and lipid A. These lipopolysaccharides may contribute to bacterial immune evasion by inhibiting complement-mediated killing and suppressing host antimicrobial peptide secretion, thus helping bacteria evade immune defenses. Possessing high viscosity and serum resistance, they can potentially induce sepsis. Additionally, these lipopolysaccharides are utilized in the development of animal models for sepsis/septicemia.Pam3CSK4
CAS :Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.Formule :C81H156N10O13SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1510.23Pam3CSK4-Biotin
CAS :Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.Formule :C103H192N14O17S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1962.85Pam2CSK4
CAS :TLR2/6 agonist; boosts TNF-α in human cells & mouse B cell growth/activation.Formule :C65H126N10O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1271.83TLR8 agonist 8
CAS :TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.Formule :C53H63N11O10Couleur et forme :SolidMasse moléculaire :1014.14
