MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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B-Raf IN 1
CAS :<p>B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.</p>Formule :C29H24F3N5ODegré de pureté :97.22% - 99.27%Couleur et forme :SolidMasse moléculaire :515.53CAY10404
CAS :<p>CAY10404: potent COX-1/2 inhibitor; blocks PKB/Akt, MAPK pathways; triggers NSC-LC apoptosis; analgesic, anti-inflammatory, anti-cancer.</p>Formule :C17H12F3NO3SDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :367.34N-tert-butyl-α-Phenylnitrone
CAS :<p>N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.</p>Formule :C11H15NODegré de pureté :99.46% - 99.84%Couleur et forme :SolidMasse moléculaire :177.24Refametinib
CAS :<p>Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).</p>Formule :C19H20F3IN2O5SDegré de pureté :99.53% - >99.99%Couleur et forme :SolidMasse moléculaire :572.34JNK Inhibitor VIII
CAS :<p>JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,</p>Formule :C18H20N4O4Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :356.38UM-164
CAS :<p>UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.</p>Formule :C30H31F3N8O3SDegré de pureté :98.72% - 99.52%Couleur et forme :SolidMasse moléculaire :640.68NG25 trihydrochloride
CAS :<p>NG25 trihydrochloride: kinase inhibitor for MAP4K2, TAK1, Src, LYN, Abl, CSK, FER, p38α; blocks TNF-α signals; impedes IFN secretion; anti-cancer properties.</p>Formule :C29H33Cl3F3N5O2Couleur et forme :SolidMasse moléculaire :646.96I-49 free base
<p>I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novel</p>Formule :C23H26ClF3N4O2Degré de pureté :99.64% - 99.88%Couleur et forme :SolidMasse moléculaire :482.92Ulixertinib
CAS :<p>Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.</p>Formule :C21H22Cl2N4O2Degré de pureté :99.31% - 99.95%Couleur et forme :SolidMasse moléculaire :433.33VX-11e
CAS :<p>VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.</p>Formule :C24H20Cl2FN5O2Degré de pureté :98.92% - ≥98%Couleur et forme :SolidMasse moléculaire :500.35AD80
CAS :<p>AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.</p>Formule :C22H19F4N7ODegré de pureté :99.49% - 99.75%Couleur et forme :SolidMasse moléculaire :473.43SB 239063
CAS :<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Formule :C20H21FN4O2Degré de pureté :99.42% - 99.81%Couleur et forme :SolidMasse moléculaire :368.4K-Ras(G12C) inhibitor 6
CAS :<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Formule :C17H22Cl2N2O3SDegré de pureté :89.07% - 97.09%Couleur et forme :SolidMasse moléculaire :405.34AS601245
CAS :<p>AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.</p>Formule :C20H16N6SDegré de pureté :98% - 99.02%Couleur et forme :SolidMasse moléculaire :372.45Talmapimod
CAS :<p>Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.</p>Formule :C27H30ClFN4O3Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :513Butein
CAS :<p>Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.</p>Formule :C15H12O5Degré de pureté :98.76% - >99.99%Couleur et forme :SolidMasse moléculaire :272.25D-JNKI-1 acetate
<p>D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.</p>Formule :C166H290N66O42Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :3882.5Encorafenib
CAS :<p>Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.</p>Formule :C22H27ClFN7O4SDegré de pureté :99.51% - 99.83%Couleur et forme :SolidMasse moléculaire :540.01CCT196969
CAS :<p>CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.</p>Formule :C27H24FN7O3Degré de pureté :98.93% - 99.65%Couleur et forme :SolidMasse moléculaire :513.52SD 0006
CAS :<p>SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.</p>Formule :C20H20ClN5O2Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :397.86Cefotetan
CAS :<p>Cefotetan, a cephamycin antibiotic, fights various bacteria by disrupting cell wall synthesis.</p>Formule :C17H17N7O8S4Degré de pureté :95.72% - 99.38%Couleur et forme :SolidMasse moléculaire :575.62ML-098
CAS :<p>ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).</p>Formule :C19H19NO3Degré de pureté :99.06% - 99.23%Couleur et forme :SolidMasse moléculaire :309.36AZ7550
CAS :<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formule :C27H31N7O2Degré de pureté :97.07% - 99.75%Couleur et forme :SolidMasse moléculaire :485.58Deltarasin HCl
CAS :<p>Deltarasin hinders KRAS-PDEδ, impairs cancer cell growth via a PDEδ pocket, disrupting RAS/RAF signaling and autophagy.</p>Formule :C40H37N5O·xHClCouleur et forme :SolidMasse moléculaire :713.144GSK-114
CAS :<p>GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.</p>Formule :C19H23N5O4SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :417.48JNK-IN-7
CAS :<p>JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).</p>Formule :C28H27N7O2Degré de pureté :98.02% - 99.53%Couleur et forme :SolidMasse moléculaire :493.56K-Ras(G12C) inhibitor 9
CAS :<p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Formule :C16H21ClIN3O4SDegré de pureté :97.33% - 97.45%Couleur et forme :SolidMasse moléculaire :513.78Pyridoxal 5'-phosphate hydrate
CAS :<p>Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,</p>Formule :C8H10NO6PDegré de pureté :97.52%Couleur et forme :SolidMasse moléculaire :247.14PF-06260933
CAS :<p>PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.</p>Formule :C16H13ClN4Degré de pureté :99.63% - 99.97%Couleur et forme :SolidMasse moléculaire :296.75GW284543
CAS :<p>GW284543 (UNC10225170) is a selective inhibitor of MEK5 .</p>Formule :C23H20N2O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :372.42ERK-IN-4
CAS :<p>ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.</p>Formule :C14H17ClN2O3SDegré de pureté :98.92% - 99.84%Couleur et forme :SolidMasse moléculaire :328.814Raf inhibitor 1
CAS :<p>B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.</p>Formule :C26H19ClN8Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :478.94Cerdulatinib hydrochloride
CAS :<p>Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.</p>Formule :C20H28ClN7O3SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :482Ulixertinib hydrochloride
CAS :<p>Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosis</p>Formule :C21H23Cl3N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :469.79NCB-0846
CAS :<p>NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).</p>Formule :C21H21N5O2Degré de pureté :97.04% - 99.89%Couleur et forme :SolidMasse moléculaire :375.42TBAP-001
CAS :TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Formule :C27H23F2N7O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :531.51VX-702
CAS :<p>VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.</p>Formule :C19H12F4N4O2Degré de pureté :99% - >99.99%Couleur et forme :SolidMasse moléculaire :404.32Trametiglue
CAS :<p>Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.</p>Formule :C25H24FIN6O5SCouleur et forme :SolidMasse moléculaire :666.46AZD0022
CAS :<p>AZD0022 is a selective, reversible, and orally active KRAS G12D inhibitor, exhibits tumour marker inhibition in PDAC and NSCLC models.</p>Formule :C34H30F4N6ODegré de pureté :98.73%Couleur et forme :SoildMasse moléculaire :614.64AMG410
CAS :<p>AMG410 is a non-covalent, dual-modality KRAS inhibitor effective against both GDP (OFF) and GTP (ON) binding independently of the cell cycle and other mutants,</p>Formule :C31H32ClF2N7O5Degré de pureté :98.01% - 99.84%Couleur et forme :SoildMasse moléculaire :656.08SC-68376
CAS :<p>SC-68376 is a potent, reversible, cell-permeable, ATP-competitive, and selective inhibitor of p38 MAP kinase.</p>Formule :C15H12N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :236.27Deltarasin
CAS :<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Formule :C40H37N5ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :603.75Cephradine monohydrate
CAS :<p>Cephradine monohydrate is a β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens.</p>Formule :C16H21N3O5SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :367.42ETC-168
CAS :<p>ETC-168 is a selective, orally active MNK inhibitor with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. It demonstrates antiproliferative efficacy both in vivo and in vitro [1].</p>Formule :C24H19N5O2Couleur et forme :SolidMasse moléculaire :409.44FMK
CAS :<p>FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。</p>Formule :C18H19FN4O2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :342.376H05
CAS :<p>6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).</p>Formule :C20H30ClN3O2S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.12Sulindac sulfide
CAS :<p>Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.</p>Formule :C20H17FO2SDegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :340.41PLX7904
CAS :<p>PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.</p>Formule :C24H22F2N6O3SDegré de pureté :99.51% - 99.66%Couleur et forme :SolidMasse moléculaire :512.53CP-281384
CAS :<p>CP-281384 is a potent, p38alpha-selective inhibitor.</p>Formule :C18H14F2N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :340.33BRAF inhibitor
CAS :<p>BRAF inhibitor is an inhibitor of B-Raf.</p>Formule :C22H18F2N4O3SDegré de pureté :98.2% - 98.41%Couleur et forme :SolidMasse moléculaire :456.47ERK1/2 inhibitor 1
CAS :<p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>Formule :C29H32ClN5O4Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :550.05PF-05381941
CAS :<p>PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α that inhibits the kinase activity of TAK1 by binding to its active site.</p>Formule :C27H26N6O2Degré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :466.53MEK-IN-1
CAS :<p>MEK-IN-1 is a MEK inhibitor.</p>Formule :C24H20N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.44PAF (C16)
CAS :<p>PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability.</p>Formule :C26H54NO7PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.68B-Raf IN 13
CAS :<p>B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.</p>Formule :C19H19ClFN3O4SDegré de pureté :99.41% - >99.99%Couleur et forme :SoildMasse moléculaire :439.89KRAS G12D inhibitor 10
CAS :<p>KRAS G12D inhibitor 10 targets KRAS G12D in cancer research (WO2021108683A1, compound 34).</p>Formule :C33H41ClN8O2Couleur et forme :SolidMasse moléculaire :617.18GGTI-286
CAS :<p>GGTI-286: GGTase I inhibitor, cell-permeable, IC50=2μM. Strongly blocks Rap1A geranylation; less effective on H-Ras, Ras4B IC50=1μM.</p>Formule :C23H31N3O3SCouleur et forme :SolidMasse moléculaire :429.58MCP110
CAS :<p>MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.</p>Formule :C33H36N2O3Degré de pureté :97.23%Couleur et forme :OilMasse moléculaire :508.65KYA1797
CAS :<p>KYA1797 inhibits Wnt/ß-catenin, targeting axin, and promotes ß-catenin/Ras decay, halting APC/KRAS mutant CRC growth.</p>Formule :C17H12N2O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.42RSK2-IN-2
CAS :<p>RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 ( RSK2 ) kinase which also inhibits MSK1, MSK2, and RSK3 [1].</p>Formule :C16H11N5OCouleur et forme :SolidMasse moléculaire :289.29GABAB receptor antagonist 1
CAS :<p>(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selective</p>Formule :C18H24O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :304.38B-Raf IN 8
CAS :<p>B-Raf IN 8: strong B-Raf inhibitor (70.65 nM IC50); combats liver, colon, breast & prostate cancer with IC50s from 9.78 to 29.85 μM.</p>Formule :C18H17N3O2Couleur et forme :SolidMasse moléculaire :307.35HPK1-IN-24
CAS :<p>HPK1-IN-24 (example 51) has potential to be used in the cancer research which is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 100 nM) [1].</p>Formule :C19H14FN5Couleur et forme :SolidMasse moléculaire :331.35UC-857993
CAS :<p>UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.</p>Formule :C25H22ClNO2Couleur et forme :SolidMasse moléculaire :403.9JNK3 inhibitor-2
CAS :<p>JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (>100 μM); targets DDR1 and EGFR mutations.</p>Formule :C20H14N2O2Couleur et forme :SolidMasse moléculaire :314.34Tpl2 Kinase Inhibitor 1
CAS :<p>Tpl2 Kinase Inhibitor 1 is an effective and selective Tpl2 inhibitor.</p>Formule :C21H14ClFN6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.83SX 011
CAS :<p>SX 011 is a p38α inhibitor.</p>Formule :C26H27ClFN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :483.96KRAS inhibitor-7
CAS :<p>KRAS inhibitor-7 is a potent KRAS G12C inhibitor.</p>Formule :C26H27ClF2N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.98HPK1-IN-25
CAS :<p>HPK1-IN-25, an HPK1 inhibitor, IC50 129 nM, may aid cancer research.</p>Formule :C23H25N5OCouleur et forme :SolidMasse moléculaire :387.48KRAS G12C inhibitor 43
CAS :<p>KRAS G12C inhibitor 43 strongly blocks KRAS G12C, H358 cell growth (IC50: 0.001-1μM), less effective on A549, HCC cells (IC50>1μM).</p>Formule :C33H35N7O3Couleur et forme :SolidMasse moléculaire :577.68GGTI-286 hydrochloride
CAS :<p>GGTI-286 HCl strongly inhibits GGTase I (IC50: 2 μM) and K-Ras4B farnesylation (IC50: 1 μM).</p>Formule :C23H32ClN3O3SCouleur et forme :SolidMasse moléculaire :466.04SMAP-2
CAS :<p>SMAP-2: oral PP2A activator, targets Aα subunit, halts KRAS-mutant lung cancer growth.</p>Formule :C27H27F3N2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.57HPK1-IN-26
CAS :<p>HPK1-IN-26, from WO2021254118A1, is a potent dual HPK1/GLK inhibitor for studying animal infections.</p>Formule :C19H21N5OSCouleur et forme :SolidMasse moléculaire :367.47ZINC09659342
CAS :<p>ZINC09659342 (compound 13) is an inhibitor of Lbc-RhoA interaction (IC50: 3.6 μM).</p>Formule :C23H15F3N2O4Couleur et forme :SolidMasse moléculaire :440.37NSC-658497
CAS :<p>NSC-658497 is a SOS1-Ras interaction inhibitor that acts by dose-dependently inhibiting SOS1 GEF activity.</p>Formule :C20H10N2O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.43SR 3576
CAS :<p>JNK3 inhibitor, potent and selective</p>Formule :C27H27N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.53CAY10561
CAS :<p>CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.</p>Formule :C22H17Cl2FN4O2Couleur et forme :SolidMasse moléculaire :459.3KRAS G12C inhibitor 22
CAS :<p>KRAS G12C inhibitor 22 is a KRAS G12C inhibitor.</p>Formule :C32H41N7O2Couleur et forme :SolidMasse moléculaire :555.71Quazinone
CAS :<p>Quazinone: PDE3 inhibitor, enhances heart muscle contractility, lowers blood pressure, and inhibits DNA synthesis in muscle cells. IC50 = 4.2 μM.</p>Formule :C11H10ClN3OCouleur et forme :SolidMasse moléculaire :235.67SB-747651A
CAS :<p>SB-747651A: ATP-competitive MSK1 inhibitor (IC50=11nM), affects N-terminal domain, also hinders MSK2, PKA, PKB, RSK, p70S6K.</p>Formule :C16H22N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.4EO 1428
CAS :<p>p38α and p38β2 inhibitor</p>Formule :C20H16BrClN2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.71PD 334581
CAS :<p>MEK1 inhibitor</p>Formule :C20H19F3IN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :545.3p38α inhibitor 2
CAS :<p>P38α Inhibitor 2, a potent and selective inhibitor of p38α MAPK, exhibits a pIC50 value of 9.6.</p>Formule :C27H33N5O3Couleur et forme :SolidMasse moléculaire :475.58pan-KRAS-IN-16
CAS :<p>3344 is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.</p>Formule :C24H26N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.47B-Raf IN 6
CAS :<p>B-Raf IN 6: potent B-Raf kinase inhibitor, IC50 of 1.7 nM, doesn't target PXR, metabolically stable, potential in cancer research.</p>Formule :C24H21F3N6O2S2Couleur et forme :SolidMasse moléculaire :546.59(R)-CE3F4
CAS :<p>(R)-CE3F4 is a selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1)(IC50 of 4.2 μM),</p>Formule :C11H10Br2FNOCouleur et forme :SolidMasse moléculaire :351.01SR-3737
CAS :<p>SR-3737 is potent both JNK3 and p38 inhibitor.</p>Formule :C29H25FN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.53TOPK-p38/JNK-IN-1
CAS :<p>TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NO</p>Formule :C17H15F3N2O4Couleur et forme :SolidMasse moléculaire :368.31B-Raf IN 7
CAS :<p>"B-Raf IN 7 inhibits B-Raf (IC50: 110.23 nM); fights colon, breast, liver, cervical, prostate cancers (IC50: 7.50-12.83 μM)."</p>Formule :C15H16N6O3Couleur et forme :SolidMasse moléculaire :328.33KB-5246
CAS :<p>KB-5246, displays antibacterial activities.is a tetracyclic quinolone.</p>Formule :C18H17ClFN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.86KRas G12C inhibitor 4
CAS :KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.Formule :C33H38ClN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :600.15Avutometinib potassium
CAS :<p>Avutometinib potassium, a MEKi, blocks Delta and Omicron infection in airway cells, potentially lessening disease severity.</p>Formule :C21H17FKN5O5SCouleur et forme :SolidMasse moléculaire :509.553,4-Dephostatin
CAS :<p>3,4-Dephostatin is an inhibitor of the interactions of CFTR-associated ligand (CAL) and PSD-95/Dlg1/ZO-1 (PDZ) domain.</p>Formule :C7H8N2O3Couleur et forme :SolidMasse moléculaire :168.15ERK5-IN-3
CAS :<p>ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).</p>Formule :C24H23Cl2FN4O2Couleur et forme :SolidMasse moléculaire :489.37Ras modulator-1
CAS :<p>Ras modulator-1 is a modulator of Ras.</p>Formule :C29H21N5O4SCouleur et forme :SolidMasse moléculaire :535.57KRas G12C inhibitor 3
CAS :<p>KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.</p>Formule :C32H36ClN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.13MW108
CAS :<p>MW108 is an active site targeted, CNS-active, p38αMAPK inhibitor.</p>Formule :C21H19ClN4Couleur et forme :SolidMasse moléculaire :362.86(S)-CCG-1423
<p>(S)-CCG-1423, a stereoisomer, inhibits Rho to block myocardin-related transcription factor A & serum response signaling.</p>Formule :C18H13ClF6N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.8K-Ras G12C-IN-3
CAS :<p>K-Ras G12C-IN-3: novel, irreversible inhibitor of K-Ras G12C mutant protein for cancer treatment.</p>Formule :C21H19Cl3N2O3Couleur et forme :SolidMasse moléculaire :453.75ML 3403
CAS :<p>p38 MAPK inhibitor; IC50: 0.38μM. Reduces IL-1β & TNF-α release in PBMC assay; IC50: 0.039μM & 0.16μM.</p>Formule :C23H21FN4SCouleur et forme :SolidMasse moléculaire :404.5CCG-232601
CAS :<p>CCG-232601 is a inhibitor of the Rho/MRTF/SRF transcriptional pathway.</p>Formule :C24H20ClF2N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :455.88Tinlorafenib
CAS :<p>Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.</p>Formule :C19H19ClF2N4O3SCouleur et forme :SolidMasse moléculaire :456.89PHT-7.3
CAS :<p>PHT-7.3 is a selective connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain inhibitor</p>Formule :C24H23N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.52BRAF V600E/CRAF-IN-1
CAS :<p>BRAF V600E/CRAF-IN-1: potent BRAF/CRAF inhibitor, induces cell cycle arrest and apoptosis in HCT-116 cells, promising for cancer research.</p>Formule :C25H17F6N3O2Couleur et forme :SolidMasse moléculaire :505.41KRAS inhibitor-6
CAS :<p>KRAS inhibitor-6 is a potent KRAS G12C inhibitor.</p>Formule :C27H30ClF2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :546.01(R)-STU104
CAS :<p>(R)-STU104 is a TAK1-MKK3 protein-protein interaction (PPI) inhibitor. (R)-STU104 is a candidate compound for the treatment of ulcerative colitis.</p>Formule :C18H18O4Degré de pureté :98.91% - 99.42%Couleur et forme :SolidMasse moléculaire :298.33REDX05358
CAS :<p>REDX05358: Selective pan RAF inhibitor for BRAF/RAS mutant tumors with high affinity, safety, and low paradoxical activation.</p>Formule :C26H21ClN4O3Couleur et forme :SolidMasse moléculaire :472.92KRAS inhibitor-3
CAS :<p>KRAS inhibitor-3 targets WT/oncogenic KRAS; high affinity (KD: 0.28-0.74 μM); disrupts KRAS-Raf interaction.</p>Formule :C25H27N5OCouleur et forme :SolidMasse moléculaire :413.51Spiclomazine HCl
CAS :<p>Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.</p>Formule :C22H25Cl2N3OS2Couleur et forme :SolidMasse moléculaire :482.49PF-04880594
CAS :<p>PF-04880594 is a potent and selective RAF inhibitor which inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 exhibits antitumor activity [1].</p>Formule :C19H16F2N8Couleur et forme :SolidMasse moléculaire :394.38KRAS G12C inhibitor 48
<p>KRAS G12C inhibitor 48: potent with IC50 639.91 nM; hampers H358, H23, A549 cell growth with IC50s of 0.796, 6.33, 16.14 µM, respectively.</p>Formule :C36H39ClN8O2Couleur et forme :SolidMasse moléculaire :651.2KRAS G12C inhibitor 31
CAS :<p>KRAS G12C inhibitor 31 is an inhibitor of KRAS G12C that can be used to study cancer.</p>Formule :C25H22ClFN6O3Couleur et forme :SolidMasse moléculaire :508.93Nek2-IN-6
CAS :<p>Nek2-IN-6 inhibitor .</p>Formule :C33H33F3N6O4SCouleur et forme :SolidMasse moléculaire :666.71L-167307
CAS :<p>L-167307 is a p38 kinase inhibitor.</p>Formule :C22H17FN2OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.45KRAS4b-IN-D14
CAS :<p>KRAS4b-IN-D14 inhibits oncogenic KRAS4b, shrinks tumors, and induces cancer cell apoptosis.</p>Formule :C24H24ClN5O4Couleur et forme :SolidMasse moléculaire :481.93HPK1-IN-15
CAS :<p>HPK1-IN-15 selectively inhibits HPK1, a MAP4K family kinase, potentially aiding in cancer treatment.</p>Formule :C24H21ClF3N5Couleur et forme :SolidMasse moléculaire :471.91KRAS G12D inhibitor 13
CAS :<p>KRAS G12D inhibitor 13 targets KRAS G12D-mediated cancers with potency (WO2021108683A1, cmpd 142).</p>Formule :C31H33F2N7O3Couleur et forme :SolidMasse moléculaire :589.64KRAS G12C inhibitor 42
CAS :<p>KRAS G12C inhibitor 42 targets KRAS G12C for potential cancer therapy. (Patent WO2020146613A1, compound 10)</p>Formule :C33H34FN7O2Couleur et forme :SolidMasse moléculaire :579.67p38-α MAPK-IN-4
CAS :<p>p38-α MAPK-IN-4 (Compound 69) is a selective inhibitor of p38α MAPK, demonstrating potent inhibition with an IC50 of 1.5 μM.</p>Formule :C17H13BrN2OCouleur et forme :SolidMasse moléculaire :341.2LCRF-0004
CAS :<p>LCRF-0004 inhibits RON kinase, key in KRAS-driven pancreatic cancer, reducing cell migration and enhancing chemo sensitivity.</p>Formule :C28H18F4N6O2SCouleur et forme :SolidMasse moléculaire :578.54KRAS G12C inhibitor 39
CAS :<p>KRAS G12C inhibitor 39 effectively targets KRAS G12C, a key protein in cancer research.</p>Formule :C37H43N9O2Couleur et forme :SolidMasse moléculaire :645.8CBS-3595
CAS :<p>CBS-3595: potent p38α MAPK/PDE-4 dual inhibitor, strong anti-inflammatory, low toxicity.</p>Formule :C18H17FN4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.42GP17
CAS :<p>GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.</p>Formule :C26H21F3N4OCouleur et forme :SolidMasse moléculaire :462.47JNK-1-IN-1
CAS :<p>JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.</p>Formule :C24H22N6SCouleur et forme :SolidMasse moléculaire :426.54ADTL-EI1712
CAS :<p>ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.</p>Formule :C22H18Cl2N4O2S2Couleur et forme :SolidMasse moléculaire :505.44JX 401
CAS :<p>JX 401 is a p38α inhibitor.</p>Formule :C21H25NO2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.49SB 204900
CAS :<p>SB 204900 inhibit the release of histamine and TNF-α from RBL-2H3 cells.</p>Formule :C18H17NO2Couleur et forme :SolidMasse moléculaire :279.33HPK1-IN-29
CAS :<p>"HPK1-IN-29 suppresses HPK1, boosting anti-tumor immunity; potential for immune disease research."</p>Formule :C26H18F3N5O2Couleur et forme :SolidMasse moléculaire :489.45DDO3711
CAS :<p>"DDO3711, a PHORC, links an ASK1 inhibitor to a PP5 activator, inhibiting ASK1 (IC50=164.1 nM), dephosphorylating p-ASK1, and showing anti-cancer potential."</p>Formule :C42H41N9O6Couleur et forme :SolidMasse moléculaire :767.83KRAS G12C inhibitor 29
CAS :<p>KRAS G12C inhibitor 29 is an inhibitor of KRAS G12C and can be used to study cancer.</p>Formule :C23H21ClFN5O2Couleur et forme :SolidMasse moléculaire :453.98-CPT-2Me-cAMP, sodium salt
CAS :<p>8-CPT-2Me-cAMP sodium activates Epac GEFS, targets Rap1/2, has 2.2 μM EC50 for Epac1, doesn't activate PKA, and prompts Ca2+ release in β-cells.</p>Formule :C17H16ClN5NaO6PSCouleur et forme :SolidMasse moléculaire :507.82SCH-53870
CAS :<p>SCH-53870 inhibits p21-hRas nucleotide exchange in vitro.</p>Formule :C18H18N2O4SCouleur et forme :SolidMasse moléculaire :358.41KRAS inhibitor-16
CAS :<p>KRAS inhibitor-16 blocks KRAS G12C and p-ERK in cancer cells; potential for pancreatic, colorectal, lung cancer treatment. IC50: 0.457 μM.</p>Formule :C20H16Cl2FN3O2SCouleur et forme :SolidMasse moléculaire :452.33SOS1-IN-12
CAS :<p>SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM).</p>Formule :C23H26F3N5Couleur et forme :SolidMasse moléculaire :429.48MTBT
CAS :<p>MTBT is the proliferation of cancer cells inhibitor. It induces cell cycle arrest and activates p38 MAPK.</p>Formule :C14H11NO2S2Couleur et forme :SolidMasse moléculaire :289.37ARS-2102
CAS :<p>ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research .</p>Formule :C28H31ClF2N6O2Couleur et forme :SolidMasse moléculaire :557.03ERK5-IN-4
CAS :<p>ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.</p>Formule :C16H11Cl2FN4O2Couleur et forme :SolidMasse moléculaire :381.19KRAS inhibitor-15
CAS :<p>KRAS inhibitor-15 blocks KRAS G12C and p-ERK in cancer cells; potent against pancreatic and lung cancers. IC50: 0.954 μM (KRAS), 2.03/>33.3 μM (p-ERK).</p>Formule :C20H17Cl2FN4OSCouleur et forme :SolidMasse moléculaire :451.34(S)-p38 MAPK Inhibitor III
CAS :<p>(S)-p38 MAPK inhibitor III: a cell-permeable, methylsulfanylimidazole; IC50s: 0.90 µM for p38 MAPK, 0.37 µM TNF-α, 0.044 µM IL-1β.</p>Formule :C23H21FN4SCouleur et forme :SolidMasse moléculaire :404.5(R)-PD 0325901CL
CAS :<p>(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.</p>Formule :C16H14ClF2IN2O4Couleur et forme :SolidMasse moléculaire :498.65RAS inhibitor Abd-7
CAS :<p>Abd-7: potent RAS inhibitor (Kd=51 nM) that blocks RAS-effector PPI, disrupting KRAS, NRAS Q61H, HRAS G12V signaling.</p>Formule :C23H25N3O3Couleur et forme :SolidMasse moléculaire :391.46RAF-IN-1
CAS :<p>RAF-IN-1: strong b/cRAF inhibitor; cRAF IC50=3.8 nM; bRAFwt IC50=36 nM; bRAFV600E IC50=29.4 nM; A375/H358 bRAFV600E GI50=3.4/2.9 nM.</p>Formule :C26H22F3N3O4Couleur et forme :SolidMasse moléculaire :497.47KRAS inhibitor-4
CAS :<p>KRAS inhibitor-4 developed as anticancer agents, is a potent KRAS inhibitor.</p>Formule :C30H39ClN8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :563.14Anti-inflammatory agent 33
CAS :<p>Agent 33: potent p38α inhibitor, reduces NO, iNOS, COX-2, p-p38α, p-MK2; shows anti-inflammatory effects.</p>Formule :C22H15N3O5SCouleur et forme :SolidMasse moléculaire :433.44RSK2-IN-3
CAS :<p>RSK2-IN-3 (Compound 26) is a covalent, reversible inhibitor of RPS6KA3 (RSK2) kinase.</p>Formule :C24H26N4O5Couleur et forme :SolidMasse moléculaire :450.49MLKL-IN-5
CAS :<p>MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis .</p>Formule :C18H20N6O4SCouleur et forme :SolidMasse moléculaire :416.45HPK1-IN-28
CAS :<p>HPK1-IN-28 inhibits HPK1, boosts anti-tumor immunity, and shows promise in immune disease research per patent WO2021175270A1.</p>Formule :C25H22F3N5O4Couleur et forme :SolidMasse moléculaire :513.47JTP-70902
CAS :<p>JTP-70902 is a protein kinase inhibitor with antineoplastic activity.</p>Formule :C24H21BrFN5O5SCouleur et forme :SolidMasse moléculaire :590.42Antifungal agent 46
CAS :<p>Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].</p>Formule :C26H28BrF3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.43p38 MAP Kinase Inhibitor IV
CAS :<p>p38 MAPK inhibitor IV blocks p38α/β/γ/δ with IC50s 0.13-8.63 μM and stops TNF-α/IL-1β at 22/44 nM in human cells.</p>Formule :C12H4Cl6O4SCouleur et forme :SolidMasse moléculaire :456.94KRAS inhibitor-10
CAS :<p>KRAS inhibitor-10: potent, selective KRAS protein blocker; effective in various cancers; oral; tetrahydroisoquinoline class.</p>Formule :C30H37N3O5Couleur et forme :SolidMasse moléculaire :519.63KRAS G12C inhibitor 45
CAS :<p>KRAS G12C inhibitor 45 is a potent KRAS G12C inhibitor .</p>Formule :C32H33F2N5O5SCouleur et forme :SolidMasse moléculaire :637.7JNK3 inhibitor-4
CAS :<p>JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.</p>Formule :C28H27N7OCouleur et forme :SolidMasse moléculaire :477.56HPK1-IN-17
CAS :<p>HPK1-IN-17 selectively inhibits HPK1, a MAP4Ks family kinase from blood progenitor cells; useful against HPK1-related diseases like cancer.</p>Formule :C26H28N6OCouleur et forme :SolidMasse moléculaire :440.54KRAS inhibitor-17
CAS :<p>KRAS inhibitor-17 blocks G12C mutation (IC50: 3.37μM) and p-ERK in MIA PaCA-2 (IC50: 9.25μM). Could target pancreatic, colorectal, lung cancers.</p>Formule :C21H18Cl2FN3O2SCouleur et forme :SolidMasse moléculaire :466.36BRAF V600E/CRAF-IN-2
CAS :<p>Potent BRAFV600E/CRAF inhibitor, IC50: 0.888/0.229 μM, induces G0/G1 arrest and apoptosis in HCT-116 cells, potential for cancer research.</p>Formule :C30H30F3N5O2Couleur et forme :SolidMasse moléculaire :549.59KRAS4b-PDEδ stabilizer C19
CAS :<p>KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis via</p>Formule :C18H20Cl2N2O3Couleur et forme :SolidMasse moléculaire :383.27SCH 51344
CAS :<p>SCH 51344 inhibits Ras induced malignant transformation. SCH 51344 prevents anchorage-independent growth of oncogene transformed fibroblasts [1].</p>Formule :C16H20N4O3Couleur et forme :SolidMasse moléculaire :316.36LX-3
CAS :<p>LX-3 activates p38 MAPK, enabling expression of genes normally silenced by DNA methylation.</p>Formule :C20H13BrN4OSCouleur et forme :SolidMasse moléculaire :437.31KRAS G12C inhibitor 47
CAS :<p>KRAS G12C inhibitor 47 strongly blocks KRAS G12C (IC50: 0.172 μM) and p-ERK in cells; promising for pancreatic, colorectal, lung cancers.</p>Formule :C30H28ClFN4O3Couleur et forme :SolidMasse moléculaire :547.02SOS1-IN-3
CAS :<p>SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity.</p>Formule :C21H21F3N4OCouleur et forme :SolidMasse moléculaire :402.41SOS1 activator 1
CAS :<p>SOS1 activator 1 enhances SOS1's GDP-GTP exchange on Ras (Kd: 44 nM).</p>Formule :C26H32ClFN6Couleur et forme :SolidMasse moléculaire :483.026-T-GDP
CAS :<p>6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.</p>Formule :C10H15N5O10P2SCouleur et forme :SolidMasse moléculaire :459.27GDC-0879
CAS :<p>GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.</p>Formule :C19H18N4O2Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :334.37Tpl2-IN-I
CAS :<p>Tpl2-IN-I is an inhibitor of tumour progression locus 2 (Tpl2) kinase.</p>Formule :C21H14ClFN6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.83NSC1011
CAS :<p>NSC1011 is an inhibitor of ras converting enzyme 1 (Rce1).</p>Formule :C23H18N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :370.4AZD6703 free base
CAS :<p>AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).</p>Formule :C24H27N5O2Couleur et forme :SolidMasse moléculaire :417.5Kobe2601
CAS :<p>Kobe2601 is a Kobe0065 and Kobe02602 water-soluble analog. It displays inhibitory activity towards Ras-Raf binding.</p>Formule :C13H10FN5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.31GSK329
CAS :<p>GSK329 selectively inhibits TNNI3K, showing cardioprotection in ischemic heart models.</p>Formule :C19H14Cl2F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :472.25HCI-2184
CAS :<p>HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.</p>Formule :C23H28ClN7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :502.03GSK649A
CAS :<p>GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.</p>Formule :C15H12ClFN6OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.81RBC6
CAS :<p>RBC6 is an inhibitor of the binding of Ral to its effector RALBP1.</p>Formule :C16H14Cl2N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.21CP-944629
CAS :<p>CP-944629 is a novel, potent, and selective inhibitor of p38alpha.</p>Formule :C19H15F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.34BNC-1
CAS :<p>BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.</p>Formule :C16H14N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.29BSJ-04-122
CAS :<p>BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.</p>Formule :C15H12ClN5ODegré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :313.74CK1-IN-2
CAS :<p>CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.</p>Formule :C17H12FN3O2Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :309.29SR-3306
CAS :<p>SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.</p>Formule :C28H26N8ODegré de pureté :99.38% - 99.71%Couleur et forme :SolidMasse moléculaire :490.56GNE-1858
CAS :<p>GNE-1858 inhibits HPK1; IC50: 1.9 nM for wild-type, 1.9 nM (HPK1-TSEE), 4.5 nM (HPK1-SA).</p>Formule :C21H26F2N8Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :428.48J30-8
CAS :<p>J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.</p>Formule :C17H9ClFN3O2SDegré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :373.79TAK1/MAP4K2 inhibitor 1
CAS :<p>TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.</p>Formule :C29H31F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :552.59RMM-46
CAS :<p>RMM-46 is a reversible covalent inhibitor with high ligand efficiency and selectivity for MSK/RSK family kinases.</p>Formule :C24H26N4O5Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :450.49LY-2584702 hydrochloride
CAS :<p>Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.</p>Formule :C21H20ClF4N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.88MEK inhibitor
CAS :<p>MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.</p>Formule :C26H26N4O2Degré de pureté :97.48%Couleur et forme :SolidMasse moléculaire :426.51NSC-70220
CAS :<p>SOS1-IN-1 is an inhibitor of SOS1.</p>Formule :C22H15NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :325.36MNK1/2-IN-5
CAS :<p>MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.</p>Formule :C17H16N4O2Degré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :308.33MEK-IN-4
CAS :<p>MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.</p>Formule :C21H18N4OSDegré de pureté :98.35% - 99.16%Couleur et forme :SolidMasse moléculaire :374.46Nek2-IN-5
CAS :<p>Nek2-IN-5 (NCL00017509) is a potent and selective inhibitor of NIMA-related kinase 2 (Nek2).</p>Formule :C15H12N6ODegré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :292.3mSIRK
CAS :<p>mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.</p>Formule :C93H150N20O25Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :1948.31p38α inhibitor 4
CAS :<p>p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.</p>Formule :C14H7F6N3ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :347.215UR13870
CAS :<p>UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.</p>Formule :C24H16F2N4Degré de pureté :99.18% - >99.99%Couleur et forme :SolidMasse moléculaire :398.41(E)-GABAB receptor antagonist 1
CAS :<p>(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.</p>Formule :C18H24O4Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :304.38GSK2008607
CAS :<p>GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.</p>Formule :C31H28F3N7O3S2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :667.72EO-1606
CAS :<p>EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis.</p>Formule :C21H17ClFNODegré de pureté :98.28% - 98.84%Couleur et forme :SolidMasse moléculaire :353.82DS12881479
CAS :<p>DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].</p>Formule :C16H19N3OSDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :301.41RMC-0331
CAS :<p>RMC-0331 (RM-023) is an oral SOS1 inhibitor with potential to block RAS activation and anticancer properties.</p>Formule :C22H25ClF3N5O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :499.91MKK7-COV-9
CAS :<p>MKK7-COV-9 is an MKK7 inhibitor that inhibits MKK7-induced protein-protein interactions and interrupts the activation of primary B cells in response to LPS.</p>Formule :C18H16N4O2Degré de pureté :99.07% - 99.73%Couleur et forme :SolidMasse moléculaire :320.35p38 MAPK Inhibitor
CAS :<p>p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.</p>Formule :C20H13ClFN3ODegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :365.79ZINC12409120
CAS :<p>ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23</p>Formule :C20H16N4O2Degré de pureté :99.71% - 99.95%Couleur et forme :SolidMasse moléculaire :344.37BI-2852
CAS :<p>BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.</p>Formule :C31H28N6O2Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :516.59JNK-IN-11
CAS :<p>JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.</p>Formule :C12H11NO3S2Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :281.35
