MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
902 produits trouvés pour "MAPK".
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IQ-3
CAS :IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.Formule :C20H11N3O3Degré de pureté :≥98%Couleur et forme :White SolidMasse moléculaire :341.32B-Raf IN 1
CAS :B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.Formule :C29H24F3N5ODegré de pureté :97.22% - 99.27%Couleur et forme :SolidMasse moléculaire :515.53APS-2-79
CAS :APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.Formule :C23H21N3O3Couleur et forme :SolidMasse moléculaire :387.43CC-401 Hydrochloride
CAS :CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.Formule :C22H25ClN6ODegré de pureté :99.71% - ≥95%Couleur et forme :White SolidMasse moléculaire :424.93Raf inhibitor 1
CAS :B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Formule :C26H19ClN8Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :478.94ERK-IN-4
CAS :ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.Formule :C14H17ClN2O3SDegré de pureté :98.92% - 99.95%Couleur et forme :SolidMasse moléculaire :328.814Ref: TM-T36675
1mg46,00€2mg57,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg137,00€25mg219,00€50mg324,00€100mg484,00€GW284543
CAS :GW284543 (UNC10225170) is a selective inhibitor of MEK5 .Formule :C23H20N2O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :372.42CHIR 98024
CAS :CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.Formule :C20H17Cl2N9O2Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :486.31Ref: TM-T3074
1mg42,00€2mg52,00€5mg90,00€1mL*10mM (DMSO)92,00€10mg144,00€25mg281,00€50mg462,00€100mg668,00€SHP389
CAS :SHP389 is a highly effective allosteric inhibitor of SHP2, inhibiting SHP2 and p-ERK, used in cancer research.Formule :C23H29ClN8O2Degré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :484.98Ulixertinib hydrochloride
CAS :Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosisFormule :C21H23Cl3N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :469.79TBAP-001
CAS :TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Formule :C27H23F2N7O3Degré de pureté :99.28% - 99.58%Couleur et forme :Yellow SolidMasse moléculaire :531.51Ref: TM-T9693
1mg46,00€5mg92,00€1mL*10mM (DMSO)107,00€10mg147,00€25mg258,00€50mg386,00€100mg537,00€200mg710,00€NCB-0846
CAS :NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).Formule :C21H21N5O2Degré de pureté :97.04% - 99.89%Couleur et forme :SolidMasse moléculaire :375.42Trametiglue
CAS :Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.Formule :C25H24FIN6O5SCouleur et forme :SolidMasse moléculaire :666.46AZD0022
CAS :AZD0022 is a selective, reversible, and orally active KRAS G12D inhibitor, exhibits tumour marker inhibition in PDAC and NSCLC models.Formule :C34H30F4N6ODegré de pureté :98.73%Couleur et forme :Yellow SolidMasse moléculaire :614.64ASK1-IN-6
CAS :ASK1-IN-6 (Compound 32), a selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor, exhibits an IC50 of 25 nM. This compound readily crosses the blood-brain barrier, as evidenced by rat pharmacokinetics showing a clearance/unchanged clearance rate of 1.6/56 L/h/kg and an unbound partition coefficient (Kp,uu) of 0.46. Additionally, ASK1-IN-6 demonstrates anti-inflammatory activity and effectively improves symptoms in the Alzheimer's Disease Tg4510 mouse model.Formule :C17H14F4N6O2Couleur et forme :SolidMasse moléculaire :410.33AMG410
CAS :AMG410 is a non-covalent, dual-modality KRAS inhibitor effective against both GDP (OFF) and GTP (ON) binding independently of the cell cycle and other mutants,Formule :C31H32ClF2N7O5Degré de pureté :98.01% - 99.84%Couleur et forme :White SolidMasse moléculaire :656.08IQ-1S
CAS :IQ-1S is an inhibitor of NF-κB/activating protein 1 (AP-1) with an IC50 of 1.8 μM. It exhibits high binding affinity to all three JNKs, with Kd values for JNK3, JNK2, and JNK1 being 87 nM, 360 nM, and 390 nM, respectively.Formule :C15H8N3NaOCouleur et forme :SolidMasse moléculaire :269.236H05
CAS :6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).Formule :C20H30ClN3O2S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.12FMK
CAS :FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。Formule :C18H19FN4O2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :342.37Ref: TM-TQ0310
1mg71,00€2mg90,00€5mg165,00€1mL*10mM (DMSO)177,00€10mg285,00€25mg485,00€50mg700,00€100mg982,00€500mg1.953,00€Cephradine monohydrate
CAS :Cephradine monohydrate is a β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens.Formule :C16H21N3O5SDegré de pureté :99.91%Couleur et forme :Yellow SolidMasse moléculaire :367.42
