Ras
Les protéines Ras sont de petites GTPases qui agissent comme des commutateurs moléculaires dans la voie de signalisation MAPK, contrôlant la croissance, la différenciation et la survie cellulaires. Ras activé initie une cascade de signalisation qui inclut Raf, MEK et ERK, conduisant à diverses réponses cellulaires. Les mutations des gènes Ras sont courantes dans les cancers, faisant de Ras un point focal important de la recherche sur le cancer. Chez CymitQuimica, nous offrons une gamme de modulateurs de Ras pour soutenir vos recherches en biologie du cancer, transduction de signaux et développement thérapeutique.
154 produits trouvés pour "Ras"
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MRTX-1257
CAS :MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Formule :C33H39N7O2Degré de pureté :97.3% - 99.07%Couleur et forme :SolidMasse moléculaire :565.71Ref: TM-T16143
1mg60,00€2mg85,00€5mg124,00€10mg195,00€25mg351,00€50mg512,00€100mg743,00€200mg982,00€1mL*10mM (DMSO)166,00€BI-3406
CAS :BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Formule :C23H25F3N4O3Degré de pureté :99.2% - 99.66%Couleur et forme :SolidMasse moléculaire :462.46Ref: TM-T12979
1mg73,00€5mg160,00€10mg250,00€25mg464,00€50mg663,00€100mg919,00€500mg1.833,00€1mL*10mM (DMSO)170,00€ARS-1630
CAS :ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Formule :C21H17ClF2N4O2Degré de pureté :97.78%Couleur et forme :SolidMasse moléculaire :430.84Ref: TM-T10376
1mg38,00€5mg86,00€10mg112,00€25mg216,00€50mg310,00€100mg408,00€200mg580,00€1mL*10mM (DMSO)88,00€Ketoconazole
CAS :Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.Formule :C26H28Cl2N4O4Degré de pureté :99.53% - 99.95%Couleur et forme :Crystals From 4-Methylpentanone SolidMasse moléculaire :531.43K-Ras G12C-IN-4
CAS :K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。Formule :C31H33ClN4O4Degré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :561.07Ref: TM-T11738
1mg71,00€5mg161,00€10mg236,00€25mg403,00€50mg532,00€100mg783,00€200mg1.054,00€1mL*10mM (DMSO)192,00€MBQ-167
CAS :MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Formule :C22H18N4Degré de pureté :98.07% - 99.52%Couleur et forme :SolidMasse moléculaire :338.41Ref: TM-T16021
1mg34,00€2mg49,00€5mg74,00€10mg105,00€25mg197,00€50mg356,00€100mg537,00€1mL*10mM (DMSO)82,00€HJC0197
CAS :HJC0197 is a selective Epac antagonist; blocks cAMP-induced activation with IC50=5.9 μM for Epac2.Formule :C19H21N3OSDegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :339.45Ref: TM-T15485
2mg38,00€5mg54,00€10mg86,00€25mg135,00€50mg188,00€100mg283,00€200mg426,00€1mL*10mM (DMSO)64,00€(E/Z)-ZINC09659342
CAS :(E/Z)-ZINC09659342 is an inhibitor of Lbc-Rho A interaction.
Formule :C23H15F3N2O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :440.37ADT-007
CAS :ADT-007 is a pan-RAS inhibitor with potent anticancer activity.Formule :C26H24FNO5Degré de pureté :97.75%Couleur et forme :SoildMasse moléculaire :449.47Ref: TM-T85316
1mg47,00€5mg96,00€10mg124,00€25mg200,00€50mg353,00€100mg602,00€200mg982,00€1mL*10mM (DMSO)104,00€MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Couleur et forme :Odour SolidRef: TM-L1400
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderMC 976
CAS :MC 976 is a derivative of Vitamin D3.Formule :C27H42O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.63KRAS G12D inhibitor 20
KRAS G12D inhibitor 20 (Compound 14) is a selective G12D KRAS inhibitor with antitumor activity.Formule :C18H26N6OMasse moléculaire :342.21681SEPT9-IN-1
SEPT9-IN-1 (compound 8b) is a SEPT9 inhibitor with an IC50 value of 94.83 μM. It exhibits cytotoxicity against human oral squamous carcinoma cells, with an IC50 of 21 µM.Formule :C26H30ClN3O3Couleur et forme :SolidMasse moléculaire :467.9886-Thio-GTP tetrasodium
6-Thio-GTP (tetrasodium) is an inhibitor of Vav1-Rac. It can suppress TCR-induced T cell proliferation and CD28-mediated T cell survival. In a murine model of allogeneic heart transplantation, 6-Thio-GTP (tetrasodium) demonstrates immunosuppressive effects, which can prolong the survival time of heart transplants.Formule :C10H12N5Na4O13P3SCouleur et forme :SolidMasse moléculaire :626.89559KRAS inhibitor-42
KRAS inhibitor-42 (compound 8) is an effective USP7 inhibitor that exhibits high affinity for GDP-bound KRASG12D, with a Ki value of 2.7 μM.Formule :C34H47ClN8O4S2Couleur et forme :SolidMasse moléculaire :730.28502Rac1 Inhibitor W56
CAS :Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.Formule :C74H117N19O23SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1671.93MRTF-A-IN-1
MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.Formule :C22H21N3Couleur et forme :SolidMasse moléculaire :327.42KRAS inhibitor-33
KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.Formule :C33H39ClF2N6O3Couleur et forme :SolidMasse moléculaire :641.15KRpep-2d
CAS :KRpep-2d, a potent inhibitor of K-Ras, effectively suppresses the proliferation of cancer cells driven by K-Ras.Formule :C109H183N43O25S2Couleur et forme :SolidMasse moléculaire :2560.02G12 TFA
G12 (Ras5-17) TFA is a wild-type Ras peptide comprising amino acids 5-17 (KLVVVGAGGVGKS). It serves as a control in studies involving mutant Ras peptides, such as V12.Formule :C54H96F3N15O17Masse moléculaire :1283.70607KRpep-2d TFA
KRpep-2d (TFA) is a potent inhibitor of K-Ras, effectively hindering the proliferation of K-Ras-driven cancer cells, thereby serving as a valuable asset forFormule :C110H183F3N44O27S2Couleur et forme :SolidMasse moléculaire :2675.03Pan-RAS-IN-7
CAS :Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.Formule :C59H76N8O8Couleur et forme :SolidMasse moléculaire :1025.28KRAS G12C inhibitor 60
KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, andFormule :C31H30F5N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :627.61Goralatide
CAS :Goralatide, isolated from fetal calf bone marrow, exerts a high inhibitory activity on the proliferation of hematopoietic pluripotent stem cells.Formule :C20H33N5O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :487.5KRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Formule :C51H65F4N9O9S2Couleur et forme :SolidMasse moléculaire :1088.24pan-KRAS-IN-10
Pan-KRAS-IN-10 (Compound 58) acts as an inhibitor of the human tumor mutant gene KRAS. It suppresses the proliferation of KRAS mutant cells, specifically AsPC-1 (G12D mutant) and SW480 (G12V mutant), with IC50 values of 0.7 and 0.24 nM, respectively.Formule :C45H57N7O5SMasse moléculaire :807.41419KRAS inhibitor-38
CAS :KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.Formule :C53H68ClF2N9O8SCouleur et forme :SolidMasse moléculaire :1064.68GGTI298 Trifluoroacetate
CAS :GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.Formule :C27H33N3O3S·C2HF3O2Degré de pureté :98.07% - >99.99%Couleur et forme :SolidMasse moléculaire :593.66SOS1-IN-11
CAS :SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).Formule :C22H24F3N5ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :431.45Ref: TM-T60029
1mg75,00€5mg169,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€1mL*10mM (DMSO)180,00€FAM49B (190-198) mouse
CAS :FAM49B (190-198) mouse represents a peptide fragment of the mitochondria-localized protein FAM49B, which is instrumental in regulating mitochondrial fission, function, and integrity, in addition to influencing tumor progression. Beyond its role in mitochondrial dynamics, FAM49B serves as a negative regulator of T cell activation by inhibiting GTPase Rac activity and affecting cytoskeleton reorganization.Formule :C49H71N9O14SCouleur et forme :SolidMasse moléculaire :1042.2KS-58
CAS :KS-58 is a derivative of KRpep-2d. It acts as an inhibitory peptide for K-Ras(G12D), selectively binding to K-Ras. KS-58 is capable of penetrating cells and interrupts the interaction between intracellular Ras and effector proteins. It inhibits the proliferation of tumor cells and exhibits antitumor activity.Formule :C64H89FN12O14S2Couleur et forme :SolidMasse moléculaire :1333.59BI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Formule :C47H62N8O4SCouleur et forme :SolidMasse moléculaire :835.11Ras Inhibitory Peptide acetate
Ras Inhibitory Peptide acetate, involved in cancer-related Ras signaling.
Formule :C55H95N19O13Degré de pureté :96.63%Couleur et forme :SolidMasse moléculaire :1230.46MRTF-A-IN-2
MRTF-A-IN-2 (compound 16) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.Couleur et forme :Odour SolidIbetazol
Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.Formule :C13H11F3N2OSCouleur et forme :SolidMasse moléculaire :300.3Sevelamer Carbonate
CAS :Sevelamer carbonate, a non-absorbed polymer, binds phosphate with carbonate instead of chloride.Formule :(C3H7N·C3H5ClO)x·xCH2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :211.64CCG-222740
CAS :CCG-222740 is an inhibitor of Rho/MRTF pathwayFormule :C23H19ClF2N2O3Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :444.86Ref: TM-T7764
2mg39,00€5mg62,00€10mg94,00€25mg172,00€50mg260,00€100mg371,00€200mg530,00€1mL*10mM (DMSO)66,00€1A-116
CAS :1A-116 is a specific Rac1 inhibitor.
Formule :C16H16F3N3Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :307.31K-Ras(G12C) inhibitor 9
CAS :K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formule :C16H21ClIN3O4SDegré de pureté :97.33% - 97.45%Couleur et forme :SolidMasse moléculaire :513.78Ref: TM-T6556
1mg34,00€5mg78,00€10mg108,00€25mg215,00€50mg311,00€100mg425,00€200mg597,00€1mL*10mM (DMSO)108,00€K-Ras(G12C) inhibitor 6
CAS :Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.
Formule :C17H22Cl2N2O3SDegré de pureté :89.07% - 97.09%Couleur et forme :SolidMasse moléculaire :405.34RBC8
CAS :RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.Formule :C25H20N4O3Degré de pureté :98.44% - 99.81%Couleur et forme :SolidMasse moléculaire :424.45Ref: TM-T6634
1mg48,00€5mg92,00€10mg156,00€25mg298,00€50mg472,00€100mg687,00€200mg938,00€1mL*10mM (DMSO)97,00€Adagrasib
CAS :View and buy Adagrasib (MRTX849) from TargetMol.MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. Cited in 2 publications.Formule :C32H35ClFN7O2Degré de pureté :99.10% - 99.9%Couleur et forme :SolidMasse moléculaire :604.12MLS000532223
CAS :MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).Formule :C15H9NO3Degré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :251.24Ref: TM-T8473
1mg105,00€5mg250,00€10mg401,00€25mg685,00€50mg982,00€100mg1.341,00€1mL*10mM (DMSO)301,00€MLS-573151
CAS :MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Formule :C21H19N3O2SDegré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :377.46Ref: TM-T22106
2mg34,00€5mg50,00€10mg86,00€25mg161,00€50mg245,00€100mg363,00€200mg515,00€1mL*10mM (DMSO)55,00€CCG-203971
CAS :CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Formule :C23H21ClN2O3Degré de pureté :98.82% - 99.50%Couleur et forme :SolidMasse moléculaire :408.88ML141
CAS :ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).Formule :C22H21N3O3SDegré de pureté :99.36% - 99.56%Couleur et forme :SolidMasse moléculaire :407.49Ref: TM-T2463
1mg37,00€2mg52,00€5mg69,00€10mg101,00€25mg200,00€50mg321,00€100mg515,00€1mL*10mM (DMSO)71,00€ARS-1620
CAS :ARS-1620 is a covalent inhibitor of K-RASG12C.Formule :C21H17ClF2N4O2Degré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :430.84Rasarfin
CAS :Rasarfin inhibits Ras and ARF6.Formule :C23H24ClN3O3Degré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :425.91Ref: TM-T9407
1mg38,00€5mg75,00€10mg110,00€25mg193,00€50mg323,00€100mg460,00€200mg620,00€1mL*10mM (DMSO)84,00€Atranorin
CAS :Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.Formule :C19H18O8Degré de pureté :98.76% - 99.57%Couleur et forme :SolidMasse moléculaire :374.34CASIN
CAS :CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).Formule :C20H22N2ODegré de pureté :98.18% - >99.99%Couleur et forme :SolidMasse moléculaire :306.4Ref: TM-T3971
1mg35,00€2mg50,00€5mg71,00€10mg114,00€25mg178,00€50mg268,00€100mg413,00€500mg888,00€1mL*10mM (DMSO)71,00€EHT 1864 2HCl
CAS :EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3. Cost effective and quality assured.Formule :C25H29Cl2F3N2O4SDegré de pureté :98.39% - 99.42%Couleur et forme :SolidMasse moléculaire :581.47Kobe0065
CAS :Kobe0065: novel small-molecule, inhibits Ras–Raf, Ki=46±13 μM, blocks H-Ras·GTP/c-Raf-1 RBD binding.Formule :C15H11ClF3N5O4SDegré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :449.79Oncrasin-1
CAS :Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrationsFormule :C16H12ClNODegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :269.73FTI-277 hydrochloride
CAS :FTI-277 HCl: potent FTase inhibitor, IC50 500 pM, 100x more selective than GGTase I.Formule :C22H30ClN3O3S2Degré de pureté :97.57% - 97.61%Couleur et forme :SolidMasse moléculaire :484.07Ref: TM-T2700
1mg50,00€2mg70,00€5mg90,00€10mg158,00€25mg304,00€50mg497,00€100mg708,00€200mg964,00€1mL*10mM (DMSO)102,00€(S)-AMG-510
CAS :(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.Formule :C30H30F2N6O3Degré de pureté :99.05% - 99.76%Couleur et forme :SolidMasse moléculaire :560.594Ref: TM-T22258
2mg34,00€5mg50,00€10mg80,00€25mg147,00€50mg259,00€100mg404,00€500mg888,00€1mL*10mM (DMSO)73,00€K-Ras(G12C) inhibitor 12
CAS :K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formule :C15H17ClIN3O3Degré de pureté :97.16%Couleur et forme :SolidMasse moléculaire :449.67ERK-IN-3
CAS :ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.Formule :C22H25ClFN7O2Degré de pureté :99.55% - 99.76%Couleur et forme :SolidMasse moléculaire :473.93ASP2453
CAS :ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Formule :C40H48F3N7O4Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :747.85CCG-1423
CAS :CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.Formule :C18H13ClF6N2O3Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :454.75Ref: TM-T2014
5mg35,00€10mg54,00€25mg90,00€50mg154,00€100mg248,00€200mg385,00€500mg625,00€1mL*10mM (DMSO)52,00€6H05 (TFA)
CAS :6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.Formule :C22H31ClF3N3O4S3Degré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :590.14Ref: TM-T7326
1mg65,00€2mg90,00€5mg127,00€10mg217,00€25mg358,00€50mg538,00€100mg765,00€1mL*10mM (DMSO)166,00€Lonafarnib
CAS :Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).Formule :C27H31Br2ClN4O2Degré de pureté :98% - 99.94%Couleur et forme :SolidMasse moléculaire :638.82ML-098
CAS :ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).Formule :C19H19NO3Degré de pureté :99.06% - 99.23%Couleur et forme :SolidMasse moléculaire :309.36Ref: TM-T4619
1mg37,00€2mg50,00€5mg66,00€10mg94,00€25mg190,00€50mg268,00€100mg374,00€500mg884,00€1mL*10mM (DMSO)84,00€MRTX1133
CAS :View and buy MRTX1133 from TargetMol.MRTX1133 is a potent, selective, and noncovalent inhibitor of KRAS G12D.Formule :C33H31F3N6O2Degré de pureté :97.39% - 99.6%Couleur et forme :SolidMasse moléculaire :600.63Ref: TM-T9303
1mg177,00€5mg379,00€10mg580,00€25mg893,00€50mg1.251,00€100mg1.639,00€200mg2.215,00€1mL*10mM (DMSO)502,00€K-Ras-IN-1
CAS :K-Ras-IN-1 is a K-Ras inhibitor.Formule :C11H13NOSDegré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :207.29APS6-45
CAS :APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.Formule :C23H16F8N4O3Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :548.39Ref: TM-T8843
2mg37,00€5mg84,00€10mg120,00€25mg236,00€50mg380,00€100mg583,00€200mg785,00€1mL*10mM (DMSO)92,00€Eicosapentaenoic Acid
CAS :Eicosapentaenoic Acid is an ω-3 fatty acid and an inhibitor of fatty acid synthase (FASN). High-Quality, Low-Cost!Formule :C20H30O2Degré de pureté :97.03% - 99.83%Couleur et forme :LiquidMasse moléculaire :302.45SCH54292
CAS :SCH-54292 is a GDP exchange inhibitor.Formule :C24H28N2O9SDegré de pureté :95.65%Couleur et forme :SolidMasse moléculaire :520.55ZT-12-037-01
CAS :Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).Formule :C21H31N5O2Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :385.5CID44216842
CAS :CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.Formule :C22H20BrN3O3SDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :486.38Ref: TM-T8930
2mg34,00€5mg50,00€10mg85,00€25mg159,00€50mg244,00€100mg359,00€200mg512,00€1mL*10mM (DMSO)55,00€KRAS inhibitor-9
CAS :KRAS inhibitor-9 (DUN09716) hinders GTP-KRAS formation, with a Kd of 92 μM, causes G2/M arrest, and induces apoptosis in mutated NSC-LC cells.Formule :C13H9ClN2S2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :292.81Ref: TM-T8756
1mg57,00€2mg81,00€5mg113,00€10mg178,00€25mg334,00€50mg485,00€100mg622,00€1mL*10mM (DMSO)136,00€CCG-100602
CAS :CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Formule :C21H17ClF6N2O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :478.82Ref: TM-T22062
5mg35,00€10mg54,00€25mg108,00€50mg178,00€100mg286,00€200mg425,00€1mL*10mM (DMSO)40,00€Sotorasib
CAS :Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.Formule :C30H30F2N6O3Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :560.594Ref: TM-T8684
1g1.359,00€1mg37,00€2mg52,00€5mg79,00€10mg126,00€25mg225,00€50mg374,00€100mg459,00€500mg1.026,00€1mL*10mM (DMSO)87,00€BAY-293
CAS :BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Formule :C25H28N4O2SDegré de pureté :97.16%Couleur et forme :SolidMasse moléculaire :448.58Ref: TM-T5418
1mg50,00€5mg105,00€10mg177,00€25mg321,00€50mg482,00€100mg710,00€200mg982,00€1mL*10mM (DMSO)116,00€BQU57
CAS :BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.Formule :C16H13F3N4ODegré de pureté :97.45% - 98.72%Couleur et forme :SolidMasse moléculaire :334.3Arglabin
CAS :Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.Formule :C15H18O3Degré de pureté :98.97% - 99.62%Couleur et forme :SolidMasse moléculaire :246.3Ref: TM-TQ0165
1mg88,00€2mgÀ demander5mg240,00€10mg360,00€25mg518,00€50mg692,00€100mg1.035,00€200mg1.388,00€1mL*10mM (DMSO)310,00€Kobe2602
CAS :Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.Formule :C14H9F4N5O4SDegré de pureté :98.36% - 99.39%Couleur et forme :SolidMasse moléculaire :419.31(Rac)-Antineoplaston A10
CAS :Antineoplaston A10 is the first identified human antineoplaston, naturally occurring with anti-proliferative properties.Formule :C13H14N2O3Degré de pureté :98.41%Couleur et forme :SolidMasse moléculaire :246.26Ref: TM-T5379
1mg40,00€5mg88,00€10mg129,00€25mg210,00€50mg311,00€100mg449,00€200mg627,00€1mL*10mM (DMSO)95,00€Salirasib
CAS :Salirasib: Competitive PPMTase inhibitor, blocks Ras methylation, potential cancer treatment, Ki=2.6 μM.Formule :C22H30O2SDegré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :358.54Ref: TM-T6163
5mg34,00€10mg50,00€25mg90,00€50mg150,00€100mg210,00€200mg344,00€500mg567,00€1mL*10mM (DMSO)56,00€ML-097
CAS :ML-097 (CID-2160985) is a pan activator of Ras-related GTPasesFormule :C14H11BrO3Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :307.139Ref: TM-T21970
5mg62,00€10mg90,00€25mg133,00€50mg192,00€100mg286,00€500mg687,00€1mL*10mM (DMSO)67,00€ZCL278
CAS :ZCL278 is a selective Cdc42 GTPase inhibitor.Formule :C21H19BrClN5O4S2Degré de pureté :96.29% - 99.72%Couleur et forme :SolidMasse moléculaire :584.89Ref: TM-T1855
5mg52,00€10mg74,00€25mg129,00€50mg210,00€100mg294,00€200mg470,00€500mg763,00€1mL*10mM (DMSO)74,00€EHop-016
CAS :EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.Formule :C25H30N6ODegré de pureté :98.99% - >99.99%Couleur et forme :SolidMasse moléculaire :430.55Ref: TM-T2427
5mg46,00€10mg70,00€25mg120,00€50mg202,00€100mg316,00€200mg467,00€500mg747,00€1mL*10mM (DMSO)49,00€1-(4-methansulfinylphenyl)ethanone
CAS :The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.Formule :C9H10O2SDegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :182.24Ref: TM-T8870
1mg49,00€5mg144,00€10mg195,00€25mg273,00€50mg383,00€100mg532,00€200mg718,00€1mL*10mM (DMSO)96,00€Rhosin hydrochloride
CAS :Rhosin hydrochloride is a specific inhibitor of the RhoA subfamily Rho GTPases.Cost-effective and quality-assured.Formule :C20H20Cl2N6ODegré de pureté :97.33% - 98.92%Couleur et forme :SolidMasse moléculaire :431.318Ref: TM-T16745
1mg159,00€2mg40,00€5mg58,00€10mg97,00€25mg216,00€50mg406,00€100mg735,00€1mL*10mM (DMSO)64,00€ARS-853
CAS :ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cellsFormule :C22H29ClN4O3Degré de pureté :97.43% - 98.4%Couleur et forme :SolidMasse moléculaire :432.94Ref: TM-T7414
1mg142,00€5mg353,00€10mg525,00€25mg843,00€50mg1.144,00€100mg1.549,00€500mg3.087,00€1mL*10mM (DMSO)338,00€Antineoplaston A10
CAS :Antineoplaston A10 (NSC-648539) is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.Formule :C13H14N2O3Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :246.26Ref: TM-T7131
2mg44,00€5mg67,00€10mg103,00€25mg193,00€50mg295,00€100mg425,00€200mg595,00€1mL*10mM (DMSO)73,00€Phellodendrine chloride
CAS :Phellodendrine chloride combats kidney inflammation by blocking macrophage and T cell activity in glomeruli.Formule :C20H24ClNO4Degré de pureté :98.85% - 99.05%Couleur et forme :SolidMasse moléculaire :377.86Ref: TM-T5S0777
5mg50,00€10mg71,00€25mg101,00€50mg150,00€100mg215,00€200mg318,00€1mL*10mM (DMSO)58,00€Y16
CAS :Y16 is a G protein-coupled Rho GEFs inhibitor and also a specific inhibitor of LARG with a Kd of 76 nM.Cost-effective and quality-assured.Formule :C24H20N2O3Degré de pureté :98.26% - 99.85%Couleur et forme :SolidMasse moléculaire :384.43Ref: TM-T3553
1mg34,00€2mg48,00€5mg70,00€10mg109,00€25mg177,00€50mg263,00€100mg389,00€1mL*10mM (DMSO)77,00€NSC 23766 trihydrochloride
CAS :NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs; no inhibitory for RhoA or Cdc42.Formule :C24H35N7·3HClDegré de pureté :96.48% - 99.54%Couleur et forme :SolidMasse moléculaire :530.96CID-1067700
CAS :CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases（Rab7 with a Ki of 13 nM).Formule :C18H18N2O4S2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :390.48Ref: TM-T7558
1mg34,00€2mg49,00€5mg71,00€10mg105,00€25mg178,00€50mg234,00€100mg303,00€1mL*10mM (DMSO)78,00€Z62954982
CAS :Z62954982 (ZINC08010136) is a Rac1 inhibitor that inhibits Rac1 activation and reduces proliferation, p38 phosphorylation, and IL-6 levels in pulmonary arteriesFormule :C20H21N3O5SDegré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :415.46Ref: TM-T37113
1mg38,00€5mg80,00€10mg111,00€25mg183,00€50mg269,00€100mg393,00€200mg560,00€1mL*10mM (DMSO)92,00€AZD0022
CAS :AZD0022 is a selective, reversible, and orally active KRAS G12D inhibitor, exhibits tumour marker inhibition in PDAC and NSCLC models.Formule :C34H30F4N6ODegré de pureté :98.73%Couleur et forme :SoildMasse moléculaire :614.64Deltarasin
CAS :Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.Formule :C40H37N5ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :603.756H05
CAS :6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).Formule :C20H30ClN3O2S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.12MCP110
CAS :MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.Formule :C33H36N2O3Degré de pureté :97.23%Couleur et forme :OilMasse moléculaire :508.65Ref: TM-T24437
1mg34,00€5mg92,00€10mg160,00€25mg276,00€50mg400,00€100mg532,00€500mg1.063,00€1mL*10mM (DMSO)103,00€Digeranyl bisphosphonate
CAS :Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.DigeranylFormule :C21H34Na4O6P2Degré de pureté :98.5%Couleur et forme :SolidMasse moléculaire :536.4Methylophiopogonanone B
CAS :1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.Formule :C19H20O5Degré de pureté :99.24% - 99.83%Couleur et forme :SolidMasse moléculaire :328.36Ref: TM-T5S1261
1mg84,00€5mg178,00€10mg295,00€25mg497,00€50mg708,00€100mg964,00€200mg1.288,00€1mL*10mM (DMSO)192,00€KRAS inhibitor-7
CAS :KRAS inhibitor-7 is a potent KRAS G12C inhibitor.Formule :C26H27ClF2N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.98KRas G12C inhibitor 3
CAS :KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.Formule :C32H36ClN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.13ESI-08
CAS :ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.Formule :C20H23N3OSDegré de pureté :97.17%Couleur et forme :SolidMasse moléculaire :353.48KRAS inhibitor-6
CAS :KRAS inhibitor-6 is a potent KRAS G12C inhibitor.Formule :C27H30ClF2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :546.01
