Ras
Les protéines Ras sont de petites GTPases qui agissent comme des commutateurs moléculaires dans la voie de signalisation MAPK, contrôlant la croissance, la différenciation et la survie cellulaires. Ras activé initie une cascade de signalisation qui inclut Raf, MEK et ERK, conduisant à diverses réponses cellulaires. Les mutations des gènes Ras sont courantes dans les cancers, faisant de Ras un point focal important de la recherche sur le cancer. Chez CymitQuimica, nous offrons une gamme de modulateurs de Ras pour soutenir vos recherches en biologie du cancer, transduction de signaux et développement thérapeutique.
155 produits trouvés pour "Ras"
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MRTX-1257
CAS :<p>MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.</p>Formule :C33H39N7O2Degré de pureté :97.3% - 99.07%Couleur et forme :SolidMasse moléculaire :565.71HJC0197
CAS :<p>HJC0197 is a selective Epac antagonist; blocks cAMP-induced activation with IC50=5.9 μM for Epac2.</p>Formule :C19H21N3OSDegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :339.45Ketoconazole
CAS :<p>Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.</p>Formule :C26H28Cl2N4O4Degré de pureté :99.53% - 99.62%Couleur et forme :Crystals From 4-Methylpentanone SolidMasse moléculaire :531.43ARS-1630
CAS :<p>ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.</p>Formule :C21H17ClF2N4O2Degré de pureté :97.78%Couleur et forme :SolidMasse moléculaire :430.84BI-3406
CAS :<p>BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.</p>Formule :C23H25F3N4O3Degré de pureté :99.2% - 99.66%Couleur et forme :SolidMasse moléculaire :462.46RMC-6236
CAS :<p>RMC-6236 is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.</p>Formule :C44H58N8O5SDegré de pureté :98.24% - 99.92%Couleur et forme :SolidMasse moléculaire :811.05K-Ras G12C-IN-4
CAS :<p>K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。</p>Formule :C31H33ClN4O4Degré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :561.07MBQ-167
CAS :<p>MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).</p>Formule :C22H18N4Degré de pureté :98.07% - 99.52%Couleur et forme :SolidMasse moléculaire :338.41KRAS inhibitor-38
CAS :<p>KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.</p>Formule :C53H68ClF2N9O8SCouleur et forme :SolidMasse moléculaire :1064.68GGTI298 Trifluoroacetate
CAS :<p>GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.</p>Formule :C27H33N3O3S·C2HF3O2Degré de pureté :98.07% - >99.99%Couleur et forme :SolidMasse moléculaire :593.66KRAS G12D inhibitor 20
<p>KRAS G12D inhibitor 20 (Compound 14) is a selective G12D KRAS inhibitor with antitumor activity.</p>Formule :C18H26N6OMasse moléculaire :342.21681Rapaprutug
CAS :<p>Rapaprutug is a monoclonal antibody that targets human KARS1 (lysyl-tRNA synthetase 1). It can block inflammation-related signaling pathways involving KARS1, thereby reducing the production and release of inflammatory factors. Rapaprutug shows potential for research into inflammatory diseases.</p>Couleur et forme :LiquidG12 TFA
<p>G12 (Ras5-17) TFA is a wild-type Ras peptide comprising amino acids 5-17 (KLVVVGAGGVGKS). It serves as a control in studies involving mutant Ras peptides, such as V12.</p>Formule :C54H96F3N15O17Masse moléculaire :1283.70607pan-KRAS-IN-10
<p>Pan-KRAS-IN-10 (Compound 58) acts as an inhibitor of the human tumor mutant gene KRAS. It suppresses the proliferation of KRAS mutant cells, specifically AsPC-1 (G12D mutant) and SW480 (G12V mutant), with IC50 values of 0.7 and 0.24 nM, respectively.</p>Formule :C45H57N7O5SMasse moléculaire :807.41419KRpep-2d TFA
<p>KRpep-2d (TFA) is a potent inhibitor of K-Ras, effectively hindering the proliferation of K-Ras-driven cancer cells, thereby serving as a valuable asset for</p>Formule :C110H183F3N44O27S2Couleur et forme :SolidMasse moléculaire :2675.03SOS1-IN-11
CAS :<p>SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).</p>Formule :C22H24F3N5ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :431.45KRpep-2d
CAS :<p>KRpep-2d, a potent inhibitor of K-Ras, effectively suppresses the proliferation of cancer cells driven by K-Ras.</p>Formule :C109H183N43O25S2Couleur et forme :SolidMasse moléculaire :2560.02Rac1 Inhibitor W56
CAS :<p>Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.</p>Formule :C74H117N19O23SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1671.93KRAS inhibitor-42
<p>KRAS inhibitor-42 (compound 8) is an effective USP7 inhibitor that exhibits high affinity for GDP-bound KRASG12D, with a Ki value of 2.7 μM.</p>Formule :C34H47ClN8O4S2Couleur et forme :SolidMasse moléculaire :730.285026-Thio-GTP tetrasodium
<p>6-Thio-GTP (tetrasodium) is an inhibitor of Vav1-Rac. It can suppress TCR-induced T cell proliferation and CD28-mediated T cell survival. In a murine model of allogeneic heart transplantation, 6-Thio-GTP (tetrasodium) demonstrates immunosuppressive effects, which can prolong the survival time of heart transplants.</p>Formule :C10H12N5Na4O13P3SCouleur et forme :SolidMasse moléculaire :626.89559SEPT9-IN-1
<p>SEPT9-IN-1 (compound 8b) is a SEPT9 inhibitor with an IC50 value of 94.83 μM. It exhibits cytotoxicity against human oral squamous carcinoma cells, with an IC50 of 21 µM.</p>Formule :C26H30ClN3O3Couleur et forme :SolidMasse moléculaire :467.988(E/Z)-ZINC09659342
CAS :<p>(E/Z)-ZINC09659342 is an inhibitor of Lbc-Rho A interaction.</p>Formule :C23H15F3N2O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :440.37Ibetazol
<p>Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.</p>Formule :C13H11F3N2OSCouleur et forme :SolidMasse moléculaire :300.3ADT-007
CAS :<p>ADT-007 is a pan-RAS inhibitor with potent anticancer activity.</p>Formule :C26H24FNO5Degré de pureté :97.75%Couleur et forme :SoildMasse moléculaire :449.47MAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Couleur et forme :Odour SolidMC 976
CAS :<p>MC 976 is a derivative of Vitamin D3.</p>Formule :C27H42O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.63KRAS G12C inhibitor 60
<p>KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and</p>Formule :C31H30F5N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :627.61KS-58
CAS :<p>KS-58 is a derivative of KRpep-2d. It acts as an inhibitory peptide for K-Ras(G12D), selectively binding to K-Ras. KS-58 is capable of penetrating cells and interrupts the interaction between intracellular Ras and effector proteins. It inhibits the proliferation of tumor cells and exhibits antitumor activity.</p>Formule :C64H89FN12O14S2Couleur et forme :SolidMasse moléculaire :1333.59Ras Inhibitory Peptide acetate
<p>Ras Inhibitory Peptide acetate, involved in cancer-related Ras signaling.</p>Formule :C55H95N19O13Degré de pureté :96.63%Couleur et forme :SolidMasse moléculaire :1230.46KRAS inhibitor-33
<p>KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.</p>Formule :C33H39ClF2N6O3Couleur et forme :SolidMasse moléculaire :641.15MRTF-A-IN-2
<p>MRTF-A-IN-2 (compound 16) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.</p>Couleur et forme :Odour SolidMRTF-A-IN-1
<p>MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.</p>Formule :C22H21N3Couleur et forme :SolidMasse moléculaire :327.42BI1701963
<p>BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.</p>Formule :C47H62N8O4SCouleur et forme :SolidMasse moléculaire :835.11Pan-RAS-IN-7
CAS :<p>Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.</p>Formule :C59H76N8O8Couleur et forme :SolidMasse moléculaire :1025.28KRASG12C IN-14
<p>KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.</p>Formule :C51H65F4N9O9S2Couleur et forme :SolidMasse moléculaire :1088.24FAM49B (190-198) mouse
CAS :<p>FAM49B (190-198) mouse represents a peptide fragment of the mitochondria-localized protein FAM49B, which is instrumental in regulating mitochondrial fission, function, and integrity, in addition to influencing tumor progression. Beyond its role in mitochondrial dynamics, FAM49B serves as a negative regulator of T cell activation by inhibiting GTPase Rac activity and affecting cytoskeleton reorganization.</p>Formule :C49H71N9O14SCouleur et forme :SolidMasse moléculaire :1042.2Sevelamer Carbonate
CAS :<p>Sevelamer carbonate, a non-absorbed polymer, binds phosphate with carbonate instead of chloride.</p>Formule :(C3H7N·C3H5ClO)x·xCH2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :211.64Y16
CAS :<p>Y16 is a G protein-coupled Rho GEFs inhibitor and also a specific inhibitor of LARG with a Kd of 76 nM.Cost-effective and quality-assured.</p>Formule :C24H20N2O3Degré de pureté :98.26% - 99.32%Couleur et forme :SolidMasse moléculaire :384.43APS6-45
CAS :<p>APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.</p>Formule :C23H16F8N4O3Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :548.39CCG-100602
CAS :<p>CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).</p>Formule :C21H17ClF6N2O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :478.82K-Ras(G12C) inhibitor 6
CAS :<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Formule :C17H22Cl2N2O3SDegré de pureté :89.07% - 97.09%Couleur et forme :SolidMasse moléculaire :405.34Rhosin hydrochloride
CAS :<p>Rhosin hydrochloride is a specific inhibitor of the RhoA subfamily Rho GTPases.Cost-effective and quality-assured.</p>Formule :C20H20Cl2N6ODegré de pureté :97.33% - 98.92%Couleur et forme :SolidMasse moléculaire :431.318CCG-203971
CAS :<p>CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.</p>Formule :C23H21ClN2O3Degré de pureté :98.82% - 99.50%Couleur et forme :SolidMasse moléculaire :408.88ML141
CAS :<p>ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).</p>Formule :C22H21N3O3SDegré de pureté :99.36% - 99.56%Couleur et forme :SolidMasse moléculaire :407.49ARS-1620
CAS :<p>ARS-1620 is a covalent inhibitor of K-RASG12C.</p>Formule :C21H17ClF2N4O2Degré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :430.84Rasarfin
CAS :<p>Rasarfin inhibits Ras and ARF6.</p>Formule :C23H24ClN3O3Degré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :425.91Atranorin
CAS :<p>Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.</p>Formule :C19H18O8Degré de pureté :98.76% - 99.57%Couleur et forme :SolidMasse moléculaire :374.34CASIN
CAS :<p>CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).</p>Formule :C20H22N2ODegré de pureté :98.18% - >99.99%Couleur et forme :SolidMasse moléculaire :306.4EHT 1864 2HCl
CAS :<p>EHT 1864 (EHT 1864 2HCl) is a Rac family GTPase inhibitor that blocks activation by direct binding to Rac1, Rac1b, Rac2, and Rac3. Cost effective and quality assured.</p>Formule :C25H29Cl2F3N2O4SDegré de pureté :98.39% - 99.42%Couleur et forme :SolidMasse moléculaire :581.47Kobe0065
CAS :<p>Kobe0065: novel small-molecule, inhibits Ras–Raf, Ki=46±13 μM, blocks H-Ras·GTP/c-Raf-1 RBD binding.</p>Formule :C15H11ClF3N5O4SDegré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :449.79FTI-277 hydrochloride
CAS :<p>FTI-277 HCl: potent FTase inhibitor, IC50 500 pM, 100x more selective than GGTase I.</p>Formule :C22H30ClN3O3S2Degré de pureté :97.57% - 97.61%Couleur et forme :SolidMasse moléculaire :484.07(S)-AMG-510
CAS :<p>(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.</p>Formule :C30H30F2N6O3Degré de pureté :99.05% - 99.76%Couleur et forme :SolidMasse moléculaire :560.594K-Ras(G12C) inhibitor 12
CAS :<p>K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Formule :C15H17ClIN3O3Degré de pureté :97.16%Couleur et forme :SolidMasse moléculaire :449.67ERK-IN-3
CAS :<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Formule :C22H25ClFN7O2Degré de pureté :99.55% - 99.76%Couleur et forme :SolidMasse moléculaire :473.93ASP2453
CAS :<p>ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.</p>Formule :C40H48F3N7O4Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :747.85CCG-1423
CAS :<p>CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.</p>Formule :C18H13ClF6N2O3Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :454.756H05 (TFA)
CAS :<p>6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.</p>Formule :C22H31ClF3N3O4S3Degré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :590.14SCH54292
CAS :<p>SCH-54292 is a GDP exchange inhibitor.</p>Formule :C24H28N2O9SDegré de pureté :95.65%Couleur et forme :SolidMasse moléculaire :520.55ZT-12-037-01
CAS :<p>Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).</p>Formule :C21H31N5O2Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :385.5BAY-293
CAS :<p>BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).</p>Formule :C25H28N4O2SDegré de pureté :97.16%Couleur et forme :SolidMasse moléculaire :448.58(Rac)-Antineoplaston A10
CAS :<p>Antineoplaston A10 is the first identified human antineoplaston, naturally occurring with anti-proliferative properties.</p>Formule :C13H14N2O3Degré de pureté :98.41%Couleur et forme :SolidMasse moléculaire :246.261A-116
CAS :<p>1A-116 is a specific Rac1 inhibitor.</p>Formule :C16H16F3N3Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :307.31K-Ras(G12C) inhibitor 9
CAS :<p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Formule :C16H21ClIN3O4SDegré de pureté :97.33% - 97.45%Couleur et forme :SolidMasse moléculaire :513.78RBC8
CAS :<p>RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.</p>Formule :C25H20N4O3Degré de pureté :98.44% - 99.81%Couleur et forme :SolidMasse moléculaire :424.45Adagrasib
CAS :<p>View and buy Adagrasib (MRTX849) from TargetMol.MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. Cited in 2 publications.</p>Formule :C32H35ClFN7O2Degré de pureté :99.10% - 99.9%Couleur et forme :SolidMasse moléculaire :604.12MLS000532223
CAS :<p>MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).</p>Formule :C15H9NO3Degré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :251.24ML-097
CAS :<p>ML-097 (CID-2160985) is a pan activator of Ras-related GTPases</p>Formule :C14H11BrO3Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :307.139ZCL278
CAS :<p>ZCL278 is a selective Cdc42 GTPase inhibitor.</p>Formule :C21H19BrClN5O4S2Degré de pureté :96.29% - 99.72%Couleur et forme :SolidMasse moléculaire :584.89EHop-016
CAS :<p>EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.</p>Formule :C25H30N6ODegré de pureté :98.99% - >99.99%Couleur et forme :SolidMasse moléculaire :430.551-(4-methansulfinylphenyl)ethanone
CAS :<p>The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.</p>Formule :C9H10O2SDegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :182.24ARS-853
CAS :<p>ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells</p>Formule :C22H29ClN4O3Degré de pureté :97.43% - 98.4%Couleur et forme :SolidMasse moléculaire :432.94Antineoplaston A10
CAS :<p>Antineoplaston A10 (NSC-648539) is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.</p>Formule :C13H14N2O3Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :246.26Phellodendrine chloride
CAS :<p>Phellodendrine chloride combats kidney inflammation by blocking macrophage and T cell activity in glomeruli.</p>Formule :C20H24ClNO4Degré de pureté :98.85% - 99.05%Couleur et forme :SolidMasse moléculaire :377.86NSC 23766 trihydrochloride
CAS :<p>NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs; no inhibitory for RhoA or Cdc42.</p>Formule :C24H35N7·3HClDegré de pureté :96.48% - 99.54%Couleur et forme :SolidMasse moléculaire :530.96CID-1067700
CAS :<p>CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases（Rab7 with a Ki of 13 nM).</p>Formule :C18H18N2O4S2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :390.48MLS-573151
CAS :<p>MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).</p>Formule :C21H19N3O2SDegré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :377.46CCG-222740
CAS :<p>CCG-222740 is an inhibitor of Rho/MRTF pathway</p>Formule :C23H19ClF2N2O3Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :444.86Salirasib
CAS :<p>Salirasib: Competitive PPMTase inhibitor, blocks Ras methylation, potential cancer treatment, Ki=2.6 μM.</p>Formule :C22H30O2SDegré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :358.54Kobe2602
CAS :<p>Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.</p>Formule :C14H9F4N5O4SDegré de pureté :98.36% - 99.39%Couleur et forme :SolidMasse moléculaire :419.31Arglabin
CAS :<p>Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.</p>Formule :C15H18O3Degré de pureté :98.97% - 99.62%Couleur et forme :SolidMasse moléculaire :246.3BQU57
CAS :<p>BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.</p>Formule :C16H13F3N4ODegré de pureté :97.45% - 98.72%Couleur et forme :SolidMasse moléculaire :334.3Sotorasib
CAS :<p>Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.</p>Formule :C30H30F2N6O3Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :560.594KRAS inhibitor-9
CAS :<p>KRAS inhibitor-9 (DUN09716) hinders GTP-KRAS formation, with a Kd of 92 μM, causes G2/M arrest, and induces apoptosis in mutated NSC-LC cells.</p>Formule :C13H9ClN2S2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :292.81CID44216842
CAS :<p>CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.</p>Formule :C22H20BrN3O3SDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :486.38Eicosapentaenoic Acid
CAS :<p>Eicosapentaenoic Acid is an ω-3 fatty acid and an inhibitor of fatty acid synthase (FASN). High-Quality, Low-Cost!</p>Formule :C20H30O2Degré de pureté :97.03% - 99.83%Couleur et forme :LiquidMasse moléculaire :302.45K-Ras-IN-1
CAS :<p>K-Ras-IN-1 is a K-Ras inhibitor.</p>Formule :C11H13NOSDegré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :207.29MRTX1133
CAS :<p>View and buy MRTX1133 from TargetMol.MRTX1133 is a potent, selective, and noncovalent inhibitor of KRAS G12D.</p>Formule :C33H31F3N6O2Degré de pureté :97.39% - 99.6%Couleur et forme :SolidMasse moléculaire :600.63ML-098
CAS :<p>ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).</p>Formule :C19H19NO3Degré de pureté :99.06% - 99.23%Couleur et forme :SolidMasse moléculaire :309.36Lonafarnib
CAS :<p>Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).</p>Formule :C27H31Br2ClN4O2Degré de pureté :98% - 99.94%Couleur et forme :SolidMasse moléculaire :638.82Oncrasin-1
CAS :<p>Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations</p>Formule :C16H12ClNODegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :269.73Z62954982
CAS :<p>Z62954982 (ZINC08010136) is a Rac1 inhibitor that inhibits Rac1 activation and reduces proliferation, p38 phosphorylation, and IL-6 levels in pulmonary arteries</p>Formule :C20H21N3O5SDegré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :415.46AZD0022
CAS :<p>AZD0022 is a selective, reversible, and orally active KRAS G12D inhibitor, exhibits tumour marker inhibition in PDAC and NSCLC models.</p>Formule :C34H30F4N6ODegré de pureté :98.73%Couleur et forme :SoildMasse moléculaire :614.64Deltarasin
CAS :<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Formule :C40H37N5ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :603.756H05
CAS :<p>6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).</p>Formule :C20H30ClN3O2S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.12KRas G12C inhibitor 3
CAS :<p>KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.</p>Formule :C32H36ClN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.13KRas G12C inhibitor 4
CAS :<p>KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.</p>Formule :C33H38ClN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :600.15CCG-257081
CAS :<p>CCG-257081 blocks Rho/MRTF/SRF pathway; prevents fibrosis in mice; useful in cancer and fibrosis research.</p>Formule :C24H19ClF3N3O2Degré de pureté :99.76% - 99.94%Couleur et forme :SolidMasse moléculaire :473.87Digeranyl bisphosphonate
CAS :<p>Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.Digeranyl</p>Formule :C21H34Na4O6P2Degré de pureté :98.5%Couleur et forme :SolidMasse moléculaire :536.4Nexinhib20
CAS :<p>Nexinhib20 is an inhibitor of exosome synthesis and transport with anti-inflammatory activity, inhibits RAB27A and neutral sphingomyelinase 2 (nSMase2) nsMase2.</p>Formule :C15H16N4O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :300.31KRAS inhibitor-7
CAS :<p>KRAS inhibitor-7 is a potent KRAS G12C inhibitor.</p>Formule :C26H27ClF2N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.98ESI-08
CAS :<p>ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.</p>Formule :C20H23N3OSDegré de pureté :97.17%Couleur et forme :SolidMasse moléculaire :353.48KRAS inhibitor-6
CAS :<p>KRAS inhibitor-6 is a potent KRAS G12C inhibitor.</p>Formule :C27H30ClF2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :546.01Methylophiopogonanone B
CAS :<p>1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.</p>Formule :C19H20O5Degré de pureté :99.24% - 99.83%Couleur et forme :SolidMasse moléculaire :328.36MCP110
CAS :<p>MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.</p>Formule :C33H36N2O3Degré de pureté :97.23%Couleur et forme :OilMasse moléculaire :508.65BI-2852
CAS :<p>BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.</p>Formule :C31H28N6O2Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :516.59PROTAC KRAS G12C degrader-3
CAS :<p>PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].</p>Formule :C63H75ClN14O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1159.81KRAS G12C inhibitor 58
CAS :<p>KRAS G12C inhibitor 58 is utilized in cancer research as an inhibitor of the KRAS G12C mutation [1].</p>Formule :C51H64ClF4N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1074.62KRAS G12C inhibitor 5
CAS :<p>KRAS G12C inhibitor 5 is a KRas G12C inhibitor.</p>Formule :C32H37N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :551.68KRAS G12D modulator-1
CAS :<p>KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and is</p>Formule :C30H36FN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :549.64Rac1-IN-3
CAS :<p>Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].</p>Formule :C21H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.45TH-Z827
CAS :<p>TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C).</p>Formule :C30H38N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.66KRAS G12C inhibitor 32
CAS :<p>KRAS G12C Inhibitor 32, an eight-membered heterocyclic compound with nitrogen, acts as a potent inhibitor of KRAS G12C [1].</p>Formule :C29H30Cl3FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :635.94SOS1/KRAS-IN-1
CAS :<p>SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].</p>Formule :C24H26F3N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :457.49pan-KRAS-IN-2
CAS :<p>Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D</p>Formule :C34H34F2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :584.66pan-KRAS-IN-3
CAS :<p>Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].</p>Formule :C33H32F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :587.63KRas G12C inhibitor 1
CAS :<p>KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.</p>Formule :C31H38N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :542.67XRP44X
CAS :<p>XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.</p>Formule :C21H21ClN4ODegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :380.87KRAS G12C inhibitor 59
CAS :<p>KRAS G12C Inhibitor 59 is a compound with anticancer properties.</p>Formule :C32H39F6N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :715.69RBC10
CAS :<p>RBC10 inhibits the binding of Ral to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-</p>Formule :C24H25ClN2O2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :408.92KRAS G12C inhibitor 14
CAS :<p>KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of 18 nM [1].</p>Formule :C24H19ClF2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.88KRAS G12C inhibitor 17
CAS :<p>KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.</p>Formule :C24H20ClF2N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.88CCG-232964
CAS :<p>CCG-232964 is an orally active Rho/MRTF/SRF inhibitor that suppresses LPA-induced CTGF gene expression [1].</p>Formule :C15H15ClN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :338.81ML-099
CAS :<p>ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.</p>Formule :C14H13NO2SDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :259.32KRAS G12C inhibitor 13
CAS :<p>KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .</p>Formule :C40H46F3N7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :745.83ARS-1323
CAS :<p>ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.</p>Formule :C21H17ClF2N4O2Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :430.84pan-KRAS-IN-4
CAS :<p>Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].</p>Formule :C36H34F2N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :636.69BDP9066
CAS :<p>BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.</p>Formule :C20H24N6Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :348.44Pan-RAS-IN-1
CAS :<p>Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.</p>Formule :C36H41Cl2F3N6O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :717.65Rho GTPase inhibitor 1
CAS :<p>Rho GTPase inhibitor 1 (compound 7) is a potent inhibitor of Rho GTPase. It exhibits high affinity for Cdc42, Rac1, and RhoA, with dissociation constants (KDs) of 151 μM, 352 μM, and 232 μM, respectively. Additionally, Rho GTPase inhibitor 1 reduces cell migration in glioblastoma cell lines.</p>Formule :C18H16N2OCouleur et forme :SolidMasse moléculaire :276.33SOS2 ligand 1
CAS :<p>SOS2 ligand 1 (compound 2) is a selective ligand for son of sevenless 2 (SOS2), exhibiting a KD value of 4.6 µM.</p>Formule :C19H21N5OCouleur et forme :SolidMasse moléculaire :335.403(+)-Perillyl alcohol
CAS :<p>(+)-Perillyl alcohol (0.25-1 mM) inhibits cell growth in SW480 cells. At a concentration of 1 mM and a duration of 24 hours, (+)-Perillyl alcohol increases the number of cells in the G0/G1 phase and reduces the number in the S phase in SW480 cells.</p>Formule :C10H16OCouleur et forme :SolidMasse moléculaire :152.23PAT-IN-1
CAS :<p>PAT-IN-1, a protein acyl transferases (PAT) inhibitor, competitively inhibits Erf2 autopalmitoylation (WO2017011518A1; compound 13) [1].</p>Formule :C45H68N4OCouleur et forme :SolidMasse moléculaire :681.05KRAS G12C inhibitor 15
CAS :<p>KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .</p>Formule :C25H21ClF2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.91KRAS inhibitor-8
CAS :<p>KRAS inhibitor-8 is a potent KRAS G12C inhibitor.</p>Formule :C26H24ClF4N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.95KRAS G12D inhibitor 26
CAS :<p>KRAS G12D inhibitor 26 (Compound 64B) is an inhibitor of KRAS G12D with an IC50 ≤ 100 nM.</p>Formule :C35H44ClFN8O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :663.23INCB159020
CAS :<p>INCB159020 is an orally active inhibitor of KRAS G12D, exhibiting a KRAS G12D SPR value of 2.2 nM. It demonstrates anti-tumor activity.</p>Formule :C37H35ClFN7O2Couleur et forme :SolidMasse moléculaire :664.171pan-KRAS-IN-17
CAS :<p>pan-KRAS-IN-17 (Example 34) is an inhibitor that targets multiple forms of the KRAS protein.</p>Formule :C34H33F3N5O8PCouleur et forme :SolidMasse moléculaire :727.623KRAS inhibitor-34
CAS :<p>KRAS inhibitor-34 (compound 27) is a KRAS inhibitor with an IC50 of 6.4 nM and is utilized in oncological research.</p>Formule :C43H41F3N6O3Couleur et forme :SolidMasse moléculaire :746.82SOF-436
CAS :<p>SOF-436 is a KRAS inhibitor that can suppress SOS1-mediated KRAS nucleotide exchange (IC50 = 60 μM) and inhibit the interaction between KRAS and the effector protein RAF. SOF-436 is applicable to cancer research.</p>Formule :C15H13F2NO4S2Couleur et forme :SolidMasse moléculaire :373.395J-104871
CAS :<p>J-104871 (UNII-6137X5QNJF) is an FTase inhibitor that inhibits tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.</p>Formule :C38H32N2O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :708.67RGT-018
CAS :<p>RGT-018 is a potent oral SOS1 inhibitor with antitumor properties. It exerts its anticancer activity by inhibiting KRAS activation, thereby hindering cancer cell proliferation.</p>Formule :C27H24F3N7O2Couleur et forme :SolidMasse moléculaire :535.52KRAS inhibitor-32
CAS :<p>KRAS inhibitor-32 (compound 139A) is a KRAS inhibitor utilized in cancer research.</p>Formule :C29H35FN10OS2Couleur et forme :SolidMasse moléculaire :622.78BMS-214662
CAS :<p>BMS-214662 is a selective farnesyl transferase inhibitor with anti-tumor activity, used in research on pancreatic cancer, head and neck cancer, and lung cancer.</p>Formule :C25H23N5O2S2Degré de pureté :99.58% - 99.58%Couleur et forme :SolidMasse moléculaire :489.61pan-KRAS degrader 1
CAS :<p>Pan-KRAS degrader 1 (Compound 1) is a broad-spectrum KRAS degrader, exhibiting an inhibitory constant Ki value of 25 nM against KRASG12V as determined by surface plasmon resonance (SPR). Additionally, this compound demonstrates antitumor activity.</p>Formule :C22H26N8OSCouleur et forme :SolidMasse moléculaire :450.56KRAS inhibitor-37
CAS :<p>KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM). This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from <2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.</p>Formule :C32H33ClFN7O3Couleur et forme :SolidMasse moléculaire :618.10KRas G12C inhibitor 2
CAS :<p>KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.</p>Formule :C32H37N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :567.68Dorrigocin A
CAS :<p>Dorrigocin A, an analog of Migrastatin, inhibits the carboxymethyltransferase involved in Ras processing, reversing the morphology of Ras-transformed NIH/3T3 cells. Dorrigocin A holds potential for research as an anticancer and anti-arthritis agent.</p>Formule :C27H41NO8Couleur et forme :SolidMasse moléculaire :507.616ZCL279
CAS :<p>ZCL279 is a small molecule modulator (SMM) that inhibits the interaction between CDC42 and intersectin (ITSN). At lower concentrations (<10 μM), ZCL279 activates Cdc42, a cytoplasmic small GTPase in the Ras superfamily, while at higher concentrations (<10 μM) it significantly inhibits it.</p>Formule :C24H18N2O7S2Couleur et forme :SolidMasse moléculaire :510.539KRAS inhibitor-31
CAS :<p>KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of 0.019 nM for KRas G12D, 0.019 nM for KRas G12C, and 0.096 nM for KRas G12V, illustrating its efficacy across these variants.</p>Formule :C33H30F3N5O4Couleur et forme :SolidMasse moléculaire :617.62XMU-MP-9
CAS :<p>XMU-MP-9, a bifunctional compound, targets the C2 domain of Nedd4-1 and the allosteric site of K-Ras. It enhances the interaction and induces conformational changes within the Nedd4-1/K-Ras complex. Furthermore, XMU-MP-9 facilitates the ubiquitination and degradation of various K-Ras mutants and inhibits the proliferation of cells with these mutants. This compound is useful in cancer research.</p>Formule :C19H13ClFN3OSCouleur et forme :SolidMasse moléculaire :385.84AM-001
CAS :<p>AM-001 is a non-competitive inhibitor of Epac1, preventing the activation of its downstream effector Rap1 in cultured cells. This compound is utilized in research related to cardiac diseases.</p>Formule :C24H16FN3OS2Couleur et forme :SolidMasse moléculaire :445.53KRAS inhibitor-35
CAS :<p>KRAS inhibitor-35 (compound 72) is a KRAS inhibitor with an IC50 of 2 nM, utilized in tumor research.</p>Formule :C38H32F4N6O3SCouleur et forme :SolidMasse moléculaire :728.76KRAS inhibitor-41
CAS :<p>KRAS inhibitor-41 is a KRAS inhibitor with an IC50 value of less than 0.01 μM for both KRAS G12D and KRAS G12V mutations. It effectively inhibits RAS mutant cell lines GP2D (KRAS-G12D) and SW620 (KRAS-G12V). KRAS inhibitor-41 is applicable for cancer research.</p>Formule :C30H37FN10OSCouleur et forme :SolidMasse moléculaire :604.745Sosimerasib
CAS :<p>Sosimerasib is an inhibitor of the kirsten rat sarcoma viral oncogene homolog (KRAS) and exhibits antitumor activity.</p>Formule :C36H39ClFN7O4Couleur et forme :SolidMasse moléculaire :688.191KRAS G12D inhibitor 28
CAS :<p>KRAS G12D inhibitor 28 (Compound 1) is an inhibitor of KRAS G12D and can be utilized in cancer research.</p>Formule :C35H32Cl2FN5OCouleur et forme :SolidMasse moléculaire :628.57
