ERK
ERK est une protéine clé de la voie de signalisation MAPK (Mitogen-Activated Protein Kinase), qui est impliquée dans la transmission des signaux des récepteurs de surface cellulaire à l'ADN dans le noyau de la cellule. ERK joue un rôle crucial dans la régulation de divers processus cellulaires, y compris la prolifération, la différenciation et la survie. La dérégulation de la signalisation ERK est associée au développement du cancer et d'autres maladies, ce qui en fait une cible importante pour les interventions thérapeutiques. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs et de modulateurs d'ERK de haute qualité pour soutenir vos recherches en signalisation cellulaire, oncologie et développement thérapeutique.
205 produits trouvés pour "ERK"
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Firazorexton
CAS :Firazorexton is a potent orexin type 2 receptor (OX2R) agonist.Formule :C22H25F3N2O4SCouleur et forme :SolidMasse moléculaire :470.51PROTAC MEK1 Degrader-1
CAS :PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2Formule :C53H66FIN8O11S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1201.17BTX6654
BTX-6654 is a cereblon-based bifunctional SOS1 PROTAC degrader. This compound exhibits antiproliferative activity against cells with various KRAS mutations by reducing the expression of downstream signaling markers pERK and pS6.Formule :C50H57F4N9O5Couleur et forme :SolidMasse moléculaire :940.04PROTAC HPK1 Degrader-5
PROTACHPK1 Degrader-5 is a potent, orally active HPK1 PROTAC degrader with a DC50 of 5.0 nM and a Dmax of at least 99%. It significantly inhibits HPK1 by degrading it, reducing SLP76 phosphorylation, and enhancing ERK pathway activation, which in turn stimulates the release of IL-2 and IFN-γ. This compound effectively counteracts immune suppression induced by PGE2, NECA, or TGF-β. Alone, PROTACHPK1 Degrader-5 is capable of suppressing tumor growth in MC38 syngeneic mouse models. It is used in research for immunotherapy applications in cancers such as colorectal cancer.Couleur et forme :Odour SolidROCK-IN-5
CAS :ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.Formule :C16H11ClFN3OSDegré de pureté :99.72% - 99.86%Couleur et forme :SolidMasse moléculaire :347.79Olomoucine
CAS :Olomoucine hinders Cdk2, Cdc2, CDK5, ERK1, regulates the cell cycle, and fights melanoma; IC50s: 3-25 µM.
Formule :C15H18N6ODegré de pureté :99.77%Couleur et forme :White Crystalline PowderMasse moléculaire :298.34PD 198306
CAS :PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Formule :C18H16F3IN2O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :476.23Ref: TM-T21980
1mg64,00€5mg138,00€10mg188,00€25mg330,00€50mg472,00€100mg655,00€500mg1.293,00€1mL*10mM (DMSO)160,00€Fulipiftide
CAS :Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.
Formule :C144H227N41O47Couleur et forme :SolidMasse moléculaire :3284.59Anti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Formule :C19H30O3Couleur et forme :SolidMasse moléculaire :306.44Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Couleur et forme :Odour SolidRef: TM-L1600
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderPPM-3
PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.
Formule :C54H69N11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1000.26ERK1/2 inhibitor 3
CAS :ERK1/2 inhibitor 3, a strong ERK1/2 blocker, may aid in cancer and inflammation research.Formule :C28H31ClFN5O6SCouleur et forme :SolidMasse moléculaire :620.09ERα degrader-2
CAS :ERα degrader-2 is an estrogen receptor (SERD) degrader with anticancer activity that inhibits ERα for the prevention and treatment of HER-positive breast cancFormule :C29H27F3N2O2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :492.53TRPM4 inhibitor 8
CAS :TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.Formule :C11H17BrN2Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :257.17Ref: TM-T9776
5mg44,00€10mg62,00€25mg90,00€50mg170,00€100mg268,00€200mg403,00€500mg660,00€1mL*10mM (DMSO)48,00€PERK-IN-2
CAS :PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).Formule :C23H18F3N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.42GPR34 receptor antagonist 3
Compound 5e, a GPR34 receptor antagonist, exhibits selective inhibition of lysophosphatidylserine-induced ERK1/2 phosphorylation in a dose-dependent manner,Couleur et forme :Odour SolidSBI-810 hydrochloride
CAS :SBI-810 hydrochloride is a β-arrestin-2 (βarr2)-biased allosteric modulator of NTSR1 (neurotensin receptor 1), exerting analgesic effects.Formule :C27H35ClN4O2Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :483.05Pamoic acid disodium
CAS :Pamoic acid disodium is a GPR35 agonist.Formule :C23H16NaO6Degré de pureté :99.73%Couleur et forme :Yellow PowderMasse moléculaire :411.36EM127
CAS :EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.Formule :C14H18ClN3O3Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :311.76EphB2 Protein, Human, Recombinant (His)
EphB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :59.2 kDa (predicted); 65-75 kDa (reducing condition, due to glycosylation)
