ERK
ERK est une protéine clé de la voie de signalisation MAPK (Mitogen-Activated Protein Kinase), qui est impliquée dans la transmission des signaux des récepteurs de surface cellulaire à l'ADN dans le noyau de la cellule. ERK joue un rôle crucial dans la régulation de divers processus cellulaires, y compris la prolifération, la différenciation et la survie. La dérégulation de la signalisation ERK est associée au développement du cancer et d'autres maladies, ce qui en fait une cible importante pour les interventions thérapeutiques. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs et de modulateurs d'ERK de haute qualité pour soutenir vos recherches en signalisation cellulaire, oncologie et développement thérapeutique.
238 produits trouvés pour "ERK".
Filtrer par
Pourcentage de pureté
0
100
|
0
|
50
|
90
|
95
|
100
- Tri par prix ascendant
- Tri par prix descendant
- Puretés inférieures
- Puretés supérieures
- Livraison estimée la plus rapide
KRAS G12D-IN-35
KRAS G12D-IN-35 (example 7) is a potent, orally active inhibitor of KRAS G12D. It effectively suppresses p-ERK in AGS cells and significantly inhibits the proliferation of various KRAS G12D mutant cancer cell lines. Additionally, KRAS G12D-IN-35 reduces tumor growth in HPAC and GP2D mouse models. This compound is applicable for cancer research, including studies on pancreatic and colorectal cancer.PROTAC ERK5 degrader-1
CAS :PROTACERK5 degrader-1 (compound 2) is a bifunctional ERK5 PROTAC degrader. It induces the degradation of ERK5 in MOLT-4 cells via a VHL-mediated proteasome pathway. PROTACERK5 degrader-1 is useful for studying diseases or disorders characterized by abnormal ERK5 activity.Formule :C54H67F3N10O6SCouleur et forme :SolidMasse moléculaire :1041.23MAPK Inhibitor Library
A unique collection of xnum cancer cell differentiation inducing compounds for high throughput and high content screening;Couleur et forme :Odour SolidTRV055
CAS :TRV055: Gq-biased AT1R ligand, stimulates Gq signaling, aids Gq-biased agonist development.Formule :C42H57N9O9Couleur et forme :SolidMasse moléculaire :831.972Edaxeterkib
CAS :Edaxeterkib is a potent extracellular signal- regulated kinase (ERK) inhibitor for the research of cancer.Formule :C26H27N7O2Couleur et forme :SolidMasse moléculaire :469.549ROCK-IN-5
CAS :ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.Formule :C16H11ClFN3OSDegré de pureté :99.72% - 99.86%Couleur et forme :SolidMasse moléculaire :347.794Endothelin-1 (1-31) (Human)
CAS :Endothelin-1 (1-31) is a human-derived vasoconstrictor and hypertensive formed by chymase hydrolysis of big ET-1.Formule :C162H236N38O47S5Masse moléculaire :3628.16BTX6654
BTX-6654 is a cereblon-based bifunctional SOS1 PROTAC degrader. This compound exhibits antiproliferative activity against cells with various KRAS mutations by reducing the expression of downstream signaling markers pERK and pS6.Formule :C50H57F4N9O5Couleur et forme :SolidMasse moléculaire :940.04Anti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Formule :C19H30O3Couleur et forme :SolidMasse moléculaire :306.44GSK143
CAS :GSK143: Oral SYK inhibitor, pIC50=7.5, curbs pErk, anti-inflammatory, hinders immune cells in mice.Formule :C17H22N6O2Couleur et forme :SolidMasse moléculaire :342.4034′-Demethylnobiletin
CAS :4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, andFormule :C20H20O8Couleur et forme :SolidMasse moléculaire :388.37LC-SF-14
LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR, with IC50 values of 71.6 nM and 8.9 nM, respectively. It blocks FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation, and also inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM). Furthermore, LC-SF-14 exhibits antitumor activity in SNU-16 xenograft mouse models, making it suitable for research on FGFR2-driven gastric cancer.Formule :C44H50Cl3N13O5SCouleur et forme :SolidMasse moléculaire :977.28442Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Couleur et forme :Odour SolidERK1/2 inhibitor 10
ERK1/2 inhibitor 10 (Compound 36c) is a potent inhibitor of ERK1 and ERK2, with IC50 values of 0.11 nM and 0.08 nM, respectively. It effectively hinders the phosphorylation of downstream substrates p90RSK and c-Myc. Additionally, ERK1/2 inhibitor 10 induces apoptosis and incomplete autophagy-related cell death. This compound demonstrates significant antitumor efficacy in models of triple-negative breast cancer and colorectal cancer harboring BRAF and RAS mutations.Formule :C23H20ClN5O2SMasse moléculaire :465.10262Rineterkib hydrochloride
CAS :Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.Formule :C26H28BrClF3N5O2Couleur et forme :SolidMasse moléculaire :614.89TCB-32 hydrochloride
CAS :TCB-32 (Compound I-1) hydrochloride is an FGFR1 agonist with an EC50 of 0.88 μM. It stimulates cell proliferation by activating FGFR1 and its downstream ERK1/2 pathway, exhibiting excellent thermal stability. TCB-32 hydrochloride can substitute bFGF in serum-free cell culture media and is applicable in research related to tissue repair and wound healing diseases such as psoriasis and eczema.Formule :C32H44Cl4N18O2Masse moléculaire :854.62PPM-3
PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.Formule :C54H69N11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1000.26VSLRGDTRG
CAS :VSLRGDTRG is a synthetic peptide derived from the RGD motif in cadherin17 (CDH17) that binds to the α2β1 integrin, activating its signaling pathways. By promoting high-affinity conformational changes in β1 integrins through the RGD motif, VSLRGDTRG enhances cell adhesion and the phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. This peptide is useful for research on cancers expressing CDH17, such as colorectal and pancreatic cancer.Formule :C38H69N15O14Couleur et forme :SolidMasse moléculaire :960.047HRS 4642
CAS :HRS 4642 is a selective KRAS G12D inhibitor with a Kd value of 0.083 nM, antitumour, inhibits phosphorylation of downstream MEK and ERK proteins.Formule :C34H35F3N6O3Degré de pureté :99.17%Masse moléculaire :632.68Anti-inflammatory agent 35
CAS :Anti-inflammatory agent 35 is a potent anti-inflammatory agent.Formule :C27H29NO8Degré de pureté :99.98%Couleur et forme :White SolidMasse moléculaire :495.5211
