P-gp
La P-glycoprotéine est une pompe d'efflux dépendante de l'ATP qui transporte une grande variété de substrats, y compris des médicaments, des toxines et des lipides, hors des cellules. Elle joue un rôle crucial dans la résistance aux médicaments, en particulier dans le cancer, en réduisant la concentration intracellulaire des agents chimiothérapeutiques. La P-gp est également impliquée dans la barrière hémato-encéphalique, influençant l'exposition du système nerveux central à divers composés. Chez CymitQuimica, nous proposons une gamme de modulateurs de la P-gp pour soutenir vos recherches en résistance aux médicaments, pharmacocinétique et développement thérapeutique.
56 produits trouvés pour "P-gp".
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Piperine
CAS :Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.Formule :C17H19NO3Degré de pureté :98.41% - 98.51%Couleur et forme :SolidMasse moléculaire :285.34Trifluoperazine dihydrochloride
CAS :Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Formule :C21H26Cl2F3N3SDegré de pureté :99.57% - 99.96%Couleur et forme :Cream Fine PowderMasse moléculaire :480.43Encequidar mesylate
CAS :Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
Formule :C39H40N6O10SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :784.83Atazanavir
CAS :Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.Formule :C38H52N6O7Degré de pureté :98% - 99.95%Couleur et forme :Crystalline SolidMasse moléculaire :704.86Atazanavir sulfate
CAS :Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.Formule :C38H52N6O7·H2SO4Degré de pureté :99.31% - 99.40%Couleur et forme :SolidMasse moléculaire :802.93Ref: TM-T0100
5mg44,00€1mL*10mM (DMSO)50,00€10mg58,00€25mg90,00€50mg114,00€100mg170,00€200mg250,00€500mg425,00€(20S)-Protopanaxadiol
CAS :(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-typeFormule :C30H52O3Degré de pureté :97.07% - 98.91%Couleur et forme :SolidMasse moléculaire :460.73Zamicastat
CAS :Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).Formule :C21H21F2N3OSDegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :401.47Ref: TM-T13383
1mg92,00€5mg193,00€1mL*10mM (DMSO)210,00€10mg293,00€25mg528,00€50mg795,00€100mg1.153,00€Norverapamil hydrochloride
CAS :Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.Formule :C26H37ClN2O4Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :477.04Ref: TM-T16339
1mg34,00€5mg105,00€1mL*10mM (DMSO)110,00€10mg177,00€25mg299,00€50mg447,00€100mg602,00€200mg842,00€Dofequidar fumarate
CAS :Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through theFormule :C34H35N3O7Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :597.66Ref: TM-T11071
1mg37,00€2mg52,00€5mg80,00€1mL*10mM (DMSO)90,00€10mg118,00€25mg233,00€50mg447,00€100mg650,00€500mg1.369,00€Verapamil hydrochloride
CAS :Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.Formule :C27H39ClN2O4Degré de pureté :98.7% - 99.98%Couleur et forme :White To Off-White PowderMasse moléculaire :491.06Glibenclamide
CAS :Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formule :C23H28ClN3O5SDegré de pureté :99.05% - 99.75%Couleur et forme :SolidMasse moléculaire :494Risperidone
CAS :Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Formule :C23H27FN4O2Degré de pureté :99.73%Couleur et forme :Crystalline SolidMasse moléculaire :410.48Ref: TM-T0351
10mg48,00€1mL*10mM (DMSO)50,00€25mg56,00€50mg88,00€100mg122,00€200mg192,00€500mg323,00€Valspodar
CAS :Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Formule :C63H111N11O12Degré de pureté :95% - >99.99%Couleur et forme :SolidMasse moléculaire :1214.62Ref: TM-T17216
1mg411,00€5mg1.350,00€1mL*10mM (DMSO)1.900,00€10mg2.250,00€25mg4.950,00€100mg9.630,00€P-gp modulator-5
P-gp Modulator-5 (compound 25) serves as a modulator of P-gp, effectively inhibiting the proliferation of multidrug-resistant (MDR) tumors. This compound suppresses the function of drug efflux pumps in MDR cells, which results in significant accumulation of ROS and modifications in cell cycle profiles.Formule :C19H16N2O5Couleur et forme :SolidMasse moléculaire :352.34YS-370
CAS :YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.Formule :C37H35BrN4O3Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :663.6WS-917
WS-917 is an efficacious and orally active regulator of ABCB1. It enhances the ABCB1 ATPase activity and significantly boosts the antitumor efficacy of combined paclitaxel and anti-PD-1 antibody therapy. WS-917 also promotes the activation of CD8+ T cells.Formule :C16H13N5OS2Couleur et forme :SolidMasse moléculaire :355.44CPI1
CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.Formule :C111H131N23O30SCouleur et forme :SolidMasse moléculaire :2299.43P-gb-IN-1
CAS :P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.Formule :C30H28N2O6Degré de pureté :99.85%Couleur et forme :SoildMasse moléculaire :512.55P-gp inhibitor 14
CAS :Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].Formule :C37H38N2O8Couleur et forme :SolidMasse moléculaire :638.71Tariquidar methanesulfonate hydrate
CAS :m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Formule :C40H58N4O18S2Degré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :947.04
