Canal sodique
Les canaux sodiques sont des protéines membranaires essentielles qui permettent le passage des ions sodium (Na+) à travers la membrane cellulaire, générant et propageant des signaux électriques dans les neurones, les cellules musculaires et d'autres tissus excitables. Ces canaux sont vitaux pour l'initiation et la conduction des potentiels d'action, ce qui les rend cruciaux dans des processus tels que la transmission de l'influx nerveux, la contraction musculaire et la fonction cardiaque. La dysrégulation des canaux sodiques peut entraîner des troubles neurologiques, des arythmies et des conditions de douleur chronique. Chez CymitQuimica, nous proposons une variété de modulateurs de canaux sodiques pour soutenir vos recherches en neurobiologie, cardiologie et gestion de la douleur.
202 produits trouvés pour "Canal sodique"
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Mexiletine hydrochloride
CAS :<p>Mexiletine hydrochloride is a lidocaine-like antiarrhythmic (Class IB) and anesthetic, stabilizing heartbeats by inhibiting sodium in cardiac cells.</p>Formule :C11H18ClNODegré de pureté :99.88%Couleur et forme :White To Off-White SolidMasse moléculaire :215.72DSP-2230
CAS :<p>DSP-2230 is a selective blocker of Nav1.7/Nav1.8.</p>Formule :C20H20F3N5O2Degré de pureté :97.14%Couleur et forme :SolidMasse moléculaire :419.4Propafenone
CAS :<p>Propafenone: a drug for ventricular arrhythmias with mild beta-blocker activity, prolongs refractory period, and reduces heart automaticity.</p>Formule :C21H27NO3Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :341.44Eleclazine hydrochloride
CAS :<p>Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).</p>Formule :C21H17ClF3N3O3Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :451.83Ropivacaine
CAS :<p>Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group.</p>Formule :C17H26N2ODegré de pureté :97.75% - >99.99%Couleur et forme :SolidMasse moléculaire :274.40Nav1.8-IN-4
CAS :<p>Nav1.8-IN-4 is a potent Nav1.8 channel inhibitor with potential analgesic activity.Nav1.8-IN-4 can be used for pain and neurological related disorders.</p>Formule :C20H14F4N2O3Degré de pureté :99.83%Couleur et forme :SoildMasse moléculaire :406.33Oxcarbazepine
CAS :<p>Oxcarbazepine (GP 47680), an anti-epileptic, reduces CNS disorganized electrical activity.</p>Formule :C15H12N2O2Degré de pureté :98.46%Couleur et forme :Crystals From Ethanol SolidMasse moléculaire :252.27Tocainide hydrochloride
CAS :<p>Tocainide hydrochloride (2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride) is a sodium channel blocker.</p>Formule :C11H17ClN2ODegré de pureté :97%Couleur et forme :SolidMasse moléculaire :228.72Dibucaine
CAS :<p>Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.</p>Formule :C20H29N3O2Degré de pureté :99.698% - 99.88%Couleur et forme :Colorless Or Almost Colorless Powder SolidMasse moléculaire :343.46Phenytoin sodium
CAS :<p>Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .</p>Formule :C15H11N2NaO2Degré de pureté :99.88% - 99.92%Couleur et forme :SolidMasse moléculaire :274.25Ranolazine dihydrochloride
CAS :<p>Ranolazine 2HCl, an antianginal, treats arrhythmia by inhibiting sodium current without changing blood pressure or heart rate.</p>Formule :C24H35Cl2N3O4Degré de pureté :99.30% - >99.99%Couleur et forme :White Crystalline PowderMasse moléculaire :500.46Bupivacaine hydrochloride
CAS :<p>Bupivacaine hydrochloride (Vivacaine) is a long-lasting, amide local anesthetic that blocks sodium channels, inhibiting nerve impulses and sensation.</p>Formule :C18H28N2O·HClDegré de pureté :99.9% - >99.99%Couleur et forme :SolidMasse moléculaire :324.89PF-04885614
CAS :<p>PF-04885614 is a potent inhibitor of NaV1.8, has potential for neurological and neurodevelopmental diseases treatment.</p>Formule :C13H14F3N3ODegré de pureté :98.02%Couleur et forme :SolidMasse moléculaire :285.27Butamben
CAS :<p>Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.</p>Formule :C11H15NO2Degré de pureté :99.43%Couleur et forme :Crystals From Alc Physical Description Yellow Powder Insoluble In Water (Ntp 1992)Masse moléculaire :193.24Amitriptyline hydrochloride
CAS :<p>Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive</p>Formule :C20H24ClNDegré de pureté :97% - 99.94%Couleur et forme :Crystals White To Off-White PowderMasse moléculaire :313.86Oxybuprocaine hydrochloride
CAS :<p>Oxybuprocaine hydrochloride (Oxybuprocaine HCl), a local anesthetic, is used especially in otolaryngology and ophthalmology.</p>Formule :C17H29ClN2O3Degré de pureté :>99.99%Couleur et forme :White Crystalline PowderMasse moléculaire :344.88Diphenidol hydrochloride
CAS :<p>Diphenidol hydrochloride (Difenidol hydrochloride), a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.</p>Formule :C21H28ClNODegré de pureté :99.15% - 99.33%Couleur et forme :Crystals Soluble In Methanol WaterMasse moléculaire :345.91E 0747 FA
<p>E 0747 FA is an antiarrhythmic compound that inhibits the voltage of action potential Vmax in Purkinje fibers of porcine heart.E 0747 FA inhibits Na channels in cardiac cells.</p>Formule :C22H30ClN3O6Degré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :467.94NaV1.7 inhibitor-1
CAS :<p>NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).</p>Formule :C23H30FNO4SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :435.55Articaine hydrochloride
CAS :<p>Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.</p>Formule :C13H21ClN2O3SDegré de pureté :99.76%Couleur et forme :White Crystalline PowderMasse moléculaire :320.84Ropivacaine hydrochloride
CAS :<p>Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity</p>Formule :C17H26N2O·HClDegré de pureté :99.85% - 99.95%Couleur et forme :SolidMasse moléculaire :310.86Primidone
CAS :<p>Primidone (NCI-C56360) is a potent anticonvulsant agent.</p>Formule :C12H14N2O2Degré de pureté :99.91%Couleur et forme :Crystals (Ntp 1992)Masse moléculaire :218.25Amiloride hydrochloride
CAS :<p>Amiloride hydrochloride (Amiloride HCl) 是上皮钠通道和尿激酶型纤溶酶原激活物受体的抑制剂，也是 polycystin-2通道阻断剂。</p>Formule :C6H9Cl2N7ODegré de pureté :99.72% - 99.95%Couleur et forme :Physical Description Crystalline Solid Or Very Light Yellow Powder (Ntp 1992)Masse moléculaire :266.09Tocainide
CAS :<p>Tocainide is a blocker of the sodium channel and used for the treatment of tinnitus.</p>Formule :C11H16N2ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :192.26Lidocaine
CAS :<p>Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.</p>Formule :C14H22N2ODegré de pureté :99.95% - >99.99%Couleur et forme :Needles From Benzene Or Alcohol SolidMasse moléculaire :234.34BIIB 722 Mesylate
CAS :<p>BIIB 722 Mesylate is a sodium-hydrogen exchange inhibitor with cardioprotective properties and can be used to study myocardial ischemia.</p>Formule :C19H23F3N6O5SDegré de pureté :99.57%Couleur et forme :SoildMasse moléculaire :504.483Vinpocetine
CAS :<p>Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).</p>Formule :C22H26N2O2Degré de pureté :99.85% - 99.98%Couleur et forme :White Crystalline SolidMasse moléculaire :350.45Topiramate
CAS :<p>Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.</p>Formule :C12H21NO8SDegré de pureté :99.79% - 99.92%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :339.36Flunarizine dihydrochloride
CAS :<p>Flunarizine dihydrochloride: a calcium blocker also targeting calmodulin and histamine H1, used for migraine, vertigo, vascular disease, and epilepsy aid.</p>Formule :C26H28Cl2F2N2Degré de pureté :99.53% - 99.89%Couleur et forme :White Crystalline Powder Odorless And TastelessMasse moléculaire :477.42Meticrane
CAS :<p>Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.</p>Formule :C10H13NO4S2Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :275.34Benzocaine
CAS :<p>Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.</p>Formule :C9H11NO2Degré de pureté :99.16% - 99.88%Couleur et forme :Rhombohedra From Ether DrypowderMasse moléculaire :165.19Brompheniramine maleate
CAS :<p>Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.</p>Formule :C16H19BrN2·C4H4O4Degré de pureté :99.80%Couleur et forme :Crystal PowderMasse moléculaire :435.31QX-314 chloride
CAS :<p>QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.</p>Formule :C16H27ClN2ODegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :298.85Disopyramide
CAS :<p>Disopyramide, or Triombrin, a class I anti-arrhythmic with membrane-stabilizing effects, has heart depressant, anticholinergic, and anesthetic properties.</p>Formule :C21H29N3ODegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :339.47Phenytoin
CAS :<p>Phenytoin: a non-sedative hydantoin, antiepileptic with anticonvulsant effects, stabilizes neurons, prevents seizure spread, and relaxes muscles.</p>Formule :C15H12N2O2Degré de pureté :99.95%Couleur et forme :Needles (Alcohol) Tasteless (Ntp 1992)Masse moléculaire :252.27Phenazopyridine hydrochloride
CAS :<p>Phenazopyridine HCl, an oral urinary analgesic, may cause nausea, anemia, and liver/kidney toxicity. Possibly carcinogenic.</p>Formule :C11H12ClN5Degré de pureté :99.27%Couleur et forme :Brownish-Yellow Crystals Aqueous Solutions Are Yellow To Brick-Red And Slightly Acidic; They May Be Stabilized By The AdditionMasse moléculaire :249.7Lidocaine hydrochloride
CAS :<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Formule :C14H23ClN2ODegré de pureté :99.81% - 99.92%Couleur et forme :White Crystal PowderMasse moléculaire :270.798Lamotrigine
CAS :<p>Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer.</p>Formule :C9H7Cl2N5Degré de pureté :99.76% - 99.95%Couleur et forme :White To Pale Cream-Colored Powder Crystals From Isopropanol SolidMasse moléculaire :256.09Methocarbamol
CAS :<p>Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established.</p>Formule :C11H15NO5Degré de pureté :99.96%Couleur et forme :Crystals From Benzene SolidMasse moléculaire :241.24Mebeverine hydrochloride
CAS :<p>Mebeverine hydrochloride (Colofac Hydrochloride), a β-phenylethylamine derivative, is a potent α1 repector inhibitor, relaxing the muscles in and around the gut</p>Formule :C25H35NO5Degré de pureté :99.81% - 99.81%Couleur et forme :SolidMasse moléculaire :429.55Lidocaine Hydrochloride hydrate
CAS :<p>Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.</p>Formule :C14H22N2O·HCl·H2ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :288.825-Tridecanol
CAS :<p>5-Tridecanol blocks ion flux in sodium channels.</p>Formule :C13H28ODegré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :200.36Nav1.7-IN-18
<p>Nav1.7-IN-18 (Compound 31) is a Nav1.7 inhibitor with a Ki value of 4.9 nM and an IC50 of 13 nM, demonstrating analgesic effects in transgenic mice with inherited erythromelalgia (IEM).</p>Formule :C30H33Cl2F2NO4Couleur et forme :SolidMasse moléculaire :580.49Indenebart
<p>Indenebart is a humanized IgG1λ2 monoclonal antibody targeting SNCA, with HumanIgG1lambda2, Isotype Control serving as the corresponding isotype control.</p>Couleur et forme :Odour LiquidCL-424032
CAS :<p>CL-424032 is an inhibitor of sodium channels (sodium channel).</p>Formule :C12H7F3N4O2Couleur et forme :SolidMasse moléculaire :296.21LTGO-33
CAS :<p>LTGO-33 is a voltage-gated sodium channel NaV1.8 inhibitor that inhibits NaV1.8, NaV1.1-NaV1.7, and NaV1.9.</p>Formule :C21H17F4N3O3SDegré de pureté :97.6%Couleur et forme :SoildMasse moléculaire :467.44ASG-5ME
<p>ASG-5ME is a drug-antibody coupling targeting SLC44A4 that shows anti-tumor activity in xenograft models and may be used to study pancreatic and gastric cancer.</p>Degré de pureté :98.1% (SDS-PAGE); 98.5% (SEC-HPLC) - 98.1% (SDS-PAGE); 98.5% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.5 kDaSodium Channel Targeted Library
<p>A unique collection of xnum sodium channel blockers and agonists for high throughput and high content screening;</p>Couleur et forme :Odour SolidTrapencaine
CAS :<p>Trapencaine is a newly synthesized carbamate type local anesthetic that induces conformational changes in sodium channels on hypertrophic cell membranes.</p>Formule :C22H34N2O3Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :374.52Zoniporide
CAS :<p>Zoniporide (CP-597396) is an NHE-1 inhibitor that inhibits platelet swelling and can be used in the study of cardiovascular diseases.</p>Formule :C17H16N6ODegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :320.35Amlenetug
<p>Amlenetug is a humanized IgG1κ antibody targeting SNCA, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidETD001
CAS :<p>ETD001 is a long-acting ENaC inhibitor with an IC50 value of 57.5 nM in HBE cells. It is applicable for research in cystic fibrosis.</p>Formule :C41H57F6N9O16Couleur et forme :SolidMasse moléculaire :1045.93Ion Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Couleur et forme :Odour SolidSolpecainol
CAS :<p>solpecainol is a sodium channel blocker used in the study of neurological and cardiovascular diseases.</p>Formule :C18H23NO3Degré de pureté :99.71%Couleur et forme :SoildMasse moléculaire :301.38Benzonatate (PEGn)
CAS :<p>Benzonatate (PEGn) is a unique non-narcotic cough suppressant featuring sodium channel blocking properties and anesthetic effects on respiratory tract stretch receptors.</p>Formule :(C2H4O)nC12H17NO2Couleur et forme :SolidProTx II
CAS :<p>Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.</p>Formule :C168H250N46O41S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3826.59Mambalgin 1
CAS :<p>ASIC1a inhibitor; IC50: 192 nM (human), 72 nM (dimer); inactive channel binding; selective; pain response delay.</p>Formule :C272H429N85O84S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :6554.51APETx2
CAS :<p>ASIC3 inhibitor; IC50: 63 nM (rat), 175 nM (human). Blocks NaV1.8, NaV1.2; analgesic for acid/inflammatory pain.</p>Formule :C196H280N54O61S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4561.06Zandatrigine
CAS :<p>Zandatrigine (NBI-921352) is a blocker of sodium channel protein type 8 subunit alpha and can be used in studies about nervous system pathologies of epilepsy</p>Formule :C22H25FN4O2S2Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :460.59Mepivacaine hydrochloride
CAS :<p>Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.</p>Formule :C15H22N2O·HClDegré de pureté :98.76% - 99.94%Couleur et forme :White Or Off White Crystalline PowderMasse moléculaire :282.81PF-06456384 trihydrochloride
CAS :<p>PF-06456384 trihydrochloride is a selective NaV1.7 inhibitor acting through protein-ligand binding. intravenous infusion and pain research.</p>Formule :C35H35Cl3F3N7O3S2Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :829.181-(1-Methyl-1h-pyrazol-4-yl)-ethanone
CAS :<p>1-(1-Methyl-1h-pyrazol-4-yl)-ethanone is a high purity biochemical reagent that can be used in research related to life sciences.</p>Formule :C6H8N2ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :124.14Myomodulin
CAS :<p>Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A the</p>Formule :C36H67N11O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :846.12SLC26A3-IN-2
CAS :<p>Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.</p>Formule :C19H13ClN2O2SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :368.84Nav1.3 channel inhibitor 1
<p>Nav1.3 Channel Inhibitor 1 (Compound 15b) is a state-dependent inhibitor of the voltage-gated sodium channel Na v 1.3, with an IC50 value of 20 nM.</p>Formule :C19H15F2N3O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.47Zoniporide hydrochloride
CAS :<p>Zoniporide hydrochloride: selective NHE-1 inhibitor, IC50 14 nM, >150x selectivity over other NHEs, inhibits platelet swelling (IC50 59 nM).</p>Formule :C17H17ClN6ODegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :356.81GpTx-1 TFA
<p>GpTx-1 TFA is a polypeptide NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It exhibits potent inhibitory activity on the NaV1.7 channel with an IC50 value of 10 nM, demonstrating excellent selectivity over NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM) with >20-fold and >950-fold selectivity, respectively.</p>Couleur et forme :Odour SolidVeratridine
CAS :<p>Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.</p>Formule :C36H51NO11Degré de pureté :98.07% - 99.27%Couleur et forme :Yellowish-White Amorphous Powder PowderMasse moléculaire :673.79Ancistrotecine B
<p>Ancistrotecine B (Compound 2), a Nav1.7 channel inhibitor (IC50: 0.73 μM), has been shown to alleviate inflammatory pain in mice [1].</p>Formule :C26H31NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.53Lifarizine FA
<p>Lifarizine FA is a sodium channel blocker used in the treatment of neurological disorders and cardiovascular diseases, study of stroke.</p>Formule :C30H34N4O2Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :482.62GX 201
CAS :<p>GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.</p>Formule :C25H27ClF4N2O4SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :563Phrixotoxin 3
CAS :<p>Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.</p>Formule :C176H269N51O48S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4059.74OD1
<p>Activates rat Nav1.7, human Nav1.4, rat Nav1.6 (EC50: 7, 10, 47 nM); minimal on Nav1.2, 1.3, 1.5 (EC50 >3 μM); blocks fast inactivation; triggers pain.</p>Formule :C308H466N90O95S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7206.1Huwentoxin-IV
CAS :<p>Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.</p>Formule :C174H278N52O51S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4106.79ProTx II TFA
<p>ProTx-II TFA is a potent and highly selective Nav1.7 sodium channel blocker, exhibiting an IC50 of 0.3 nM and demonstrating at least 100-fold selectivity over</p>Formule :C168H250N46O41S8·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3826.59 (free base)NHE-1-IN-2
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. It mitigates left ventricular systolic dysfunction in mouse models of heart failure.Formule :C23H20ClN3O3Couleur et forme :SolidMasse moléculaire :421.11932Halazone
CAS :<p>Halazone (Pantocid) is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.</p>Formule :C7H5Cl2NO4SDegré de pureté :98.64%Couleur et forme :Physical Description Fine White Powder With An Odor Of Chlorine (Ntp 1992)Masse moléculaire :270.09Analgesic agent-2
<p>Analgesic Agent-2, a selective orally active inhibitor of the NaV1.8 channel, demonstrates an IC50 of 50.18 nM in HEK293 cells that stably express the human</p>Formule :C21H21ClF2N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.87Bulleyaconitine A
CAS :<p>Bulleyaconitine A, an analgesic and antiinflammatory drug isolated from Aconitum plants, has several potential targets, such as voltage-gated Na+ channels.</p>Formule :C35H49NO9Degré de pureté :99.56% - 99.76%Couleur et forme :SolidMasse moléculaire :627.76AM-2099
CAS :<p>AM-2099 is a selective voltage-gated sodium channel Nav1.7 inhibitor used in pain research.</p>Formule :C19H13F3N4O3S2Couleur et forme :SolidMasse moléculaire :466.46Dibucaine hydrochloride
CAS :<p>Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.</p>Formule :C20H30ClN3O2Degré de pureté :99.66%Couleur et forme :White PowderMasse moléculaire :379.92Poneratoxin acetate
<p>Poneratoxin acetate is a neurotoxic peptide and modulator of NaV1.6/NaV1.7, lowering the activation threshold of voltage-gated sodium channels and causing pain.</p>Formule :C129H215N33O31S·xC2H4O2Couleur et forme :SolidMasse moléculaire :2756.35 (free base)PF-04856264
CAS :<p>PF-04856264 is a Nav1.7 blocker.,modulates intracellular Ca 2+ signaling and chondrocyte secretome, raises the threshold of mechanical pain analgesic.</p>Formule :C20H15N5O3S2Degré de pureté :97.43%Couleur et forme :SolidMasse moléculaire :437.5Ethacizine hydrochloride
CAS :<p>Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity and can be used to study arrhythmias and myocardial infarction.</p>Formule :C22H28ClN3O3SDegré de pureté :98.08% - 98.08%Couleur et forme :SolidMasse moléculaire :449.99Mexiletine-d6 hydrochloride
CAS :<p>Mexiletine D6 hydrochloride is a non-selective voltage-gated sodium channel blocker,is a Class IB antianhythmic.</p>Formule :C11H18ClNODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :221.76Mepivacaine
CAS :<p>Mepivacaine (Carbocaine) is an amide local anesthetic, blocking sodium channels for nerve blocks and epidurals.</p>Formule :C15H22N2ODegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :246.35Triamterene D5
CAS :<p>Triamterene D5 is a deuterium-labeled Triamterene and can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, used as a mild diuretic.</p>Formule :C12H11N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :258.29BI-9627
CAS :<p>BI-9627 is an inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) (EC50: 31 nM).</p>Formule :C16H19F3N4O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :356.34Pilsicainide HCl
CAS :<p>Pilsicainide HCl (SUN 1165) is a pure sodium channel blocker</p>Formule :C17H25ClN2ODegré de pureté :99.01% - 99.80%Couleur et forme :SolidMasse moléculaire :308.85Ropivacaine hydrochloride monohydrate
CAS :<p>Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction through inhibiting sodium ion influx reversibly.</p>Formule :C17H29ClN2O2Degré de pureté :99.94% - 99.95%Couleur et forme :White SolidMasse moléculaire :328.88GNE-131
CAS :<p>GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).</p>Formule :C23H30N4O3SDegré de pureté :98.54% - 99.59%Couleur et forme :SolidMasse moléculaire :442.57Flecainide acetate
CAS :<p>Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).</p>Formule :C19H24F6N2O5Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :474.39Fosphenytoin disodium
CAS :<p>Fosphenytoin disodium (ACC-9653) is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker</p>Formule :C16H13N2Na2O6PDegré de pureté :99.97%Couleur et forme :White Crystalline PowderMasse moléculaire :406.24DS-1971a
CAS :<p>DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.</p>Formule :C20H21ClFN5O3SDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :465.93Cariporide
CAS :<p>Cariporide (HOE-642), an NHE1 inhibitor, reduces human platelet degranulation, platelet-leukocyte aggregates, and GPIIb/IIIa activation.</p>Formule :C12H17N3O3SDegré de pureté :95.4% - 99.88%Couleur et forme :SolidMasse moléculaire :283.35Rimeporide hydrochloride
CAS :<p>Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.</p>Formule :C11H16ClN3O5S2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :369.84Licarbazepine
CAS :<p>Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial</p>Formule :C15H14N2O2Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :254.28Nav1.8-IN-1
CAS :<p>Nav1.8-IN-1 (CHEMBL1270208) is an inhibitor of human NaV1.8</p>Formule :C20H15ClF3N3O2Degré de pureté :97.59%Couleur et forme :SolidMasse moléculaire :421.8QX-222 chloride
CAS :<p>QX-222 chloride (Lidocaine N-Methyl Hydrochloride) is a sodium channel blocker.</p>Formule :C13H21ClN2ODegré de pureté :97.37%Couleur et forme :SolidMasse moléculaire :256.77Carbamazepine
CAS :<p>Carbamazepine: a tricyclic with anticonvulsant and analgesic effects, treats trigeminal neuralgia.</p>Formule :C15H12N2ODegré de pureté :99.78% - 99.79%Couleur et forme :SolidMasse moléculaire :236.27λ-Cyhalothrin
CAS :<p>λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group.</p>Formule :C23H19ClF3NO3Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :449.85Rimeporide
CAS :<p>Rimeporide (EMD-87580) (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.</p>Formule :C11H15N3O5S2Degré de pureté :97.66%Couleur et forme :SolidMasse moléculaire :333.38Flecainide hydrochloride
CAS :<p>Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.</p>Formule :C17H21ClF6N2O3Degré de pureté :97.79%Couleur et forme :SolidMasse moléculaire :450.81Raxatrigine
CAS :<p>Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.</p>Formule :C18H19FN2O2Degré de pureté :98% - 99.43%Couleur et forme :SolidMasse moléculaire :314.35N-Me-aminopyrimidinone9
CAS :<p>N-Me-aminopyrimidinone9 is a sodium channel antagonist</p>Formule :C16H21N3OSDegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :303.42Levobupivacaine
CAS :<p>Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide.</p>Formule :C18H28N2ODegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :288.43Propafenone hydrochloride
CAS :<p>Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial.</p>Formule :C21H27NO3·HClDegré de pureté :99.67%Couleur et forme :White SolidMasse moléculaire :377.9Benzocaine xHCl(94-09-7(free base))
<p>Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel(IC50 of 0.8 mM tested with a potential of +30 mV).</p>Formule :C9H11NO2·xHClDegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :N/AVX-150
CAS :<p>VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).</p>Formule :C21H17F4N2O7PDegré de pureté :97.58%Couleur et forme :SolidMasse moléculaire :516.34PF-01247324
CAS :<p>PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).</p>Formule :C13H10Cl3N3ODegré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :330.6PF 05089771
CAS :<p>PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV.</p>Formule :C18H12Cl2FN5O3S2Degré de pureté :99.03% - 99.42%Couleur et forme :SolidMasse moléculaire :500.35PF-05186462
CAS :<p>PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.</p>Formule :C19H10ClF4N5O3S2Degré de pureté :99.10% - 99.37%Couleur et forme :SolidMasse moléculaire :531.89Ralfinamide mesylate
CAS :<p>Ralfinamide mesylate (FCE-26742A (mesylate)) is an orally available Na+ channel blocker.</p>Formule :C18H23FN2O5SDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :398.45Ajmaline
CAS :<p>Ajmaline, a class Ia anti-arrhythmic, diagnoses Brugada syndrome and treats tachycardia; inhibits cardiac Kv1.5/Kv4.3 channels.</p>Formule :C20H26N2O2Degré de pureté :99.67% - 99.87%Couleur et forme :SolidMasse moléculaire :326.43ICA-121431
CAS :<p>ICA-121431: a potent Nav1.7 inhibitor (IC50=19 nM for rat), minimal effect on human Nav1.5/Nav1.7.</p>Formule :C23H19N3O3S2Degré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :449.55(+)-Kavain
CAS :<p>(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.</p>Formule :C14H14O3Degré de pureté :97% - ≥95%Couleur et forme :White Fine PowderMasse moléculaire :230.26Benzamil
CAS :<p>Benzamil blocks ENaC, inhibiting sodium transport (IC50=4 nM) and binds with Kd=5 nM to bovine kidney membranes.</p>Formule :C13H14ClN7ODegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :319.7520(S)-Ginsenoside Rg3
CAS :<p>20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.</p>Formule :C42H72O13Degré de pureté :98.11% - 99.93%Couleur et forme :SolidMasse moléculaire :785.01Dronedarone
CAS :<p>Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.</p>Formule :C31H44N2O5SDegré de pureté :98.85% - 99.58%Couleur et forme :SolidMasse moléculaire :556.76Evenamide
CAS :<p>Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.</p>Formule :C16H26N2O2Degré de pureté :96.74% - 99.15%Couleur et forme :SolidMasse moléculaire :278.39Metaflumizone
CAS :<p>Metaflumizone (BAS-320I) is a sodium channel blocker insecticide.</p>Formule :C24H16F6N4O2Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :506.40Cyfluthrin
CAS :<p>Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pests</p>Formule :C22H18Cl2FNO3Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :434.29A-803467
CAS :<p>A-803467 is a selective NaV1.8 channel blocker.</p>Formule :C19H16ClNO4Degré de pureté :96.94% - 98%Couleur et forme :SolidMasse moléculaire :357.79Metergoline
CAS :<p>Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist.</p>Formule :C25H29N3O2Degré de pureté :99.83% - 99.97%Couleur et forme :SolidMasse moléculaire :403.52Tenapanor
CAS :<p>Tenapanor (RDX 5791), an NHE3 inhibitor, regulates sodium in the gut and kidney with a strong preclinical safety record and minimal side effects.</p>Formule :C50H66Cl4N8O10S2Degré de pureté :99.49% - 99.85%Couleur et forme :SolidMasse moléculaire :1145.05Dimethyl lithospermate B
CAS :<p>Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.</p>Formule :C38H34O16Degré de pureté :98.34% - 99.62%Couleur et forme :SolidMasse moléculaire :746.67Eslicarbazepine Acetate
CAS :<p>Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use as an adjunctive therapy for partial-onset seizures.</p>Formule :C17H16N2O3Degré de pureté :99.58% - >99.99%Couleur et forme :White To Off-White SolidMasse moléculaire :296.32Nicainoprol
CAS :<p>Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.</p>Formule :C21H27N3O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :369.46Sodium ionophore III
CAS :<p>Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the test of sodium activity in plasma, serum, and blood.</p>Formule :C34H52N2O4Degré de pureté :99.51% - 99.78%Couleur et forme :SolidMasse moléculaire :552.79BI 01383298
CAS :<p>BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).</p>Formule :C19H19Cl2FN2O3SDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :445.34GS967
CAS :<p>GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).</p>Formule :C14H7F6N3ODegré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :347.22Ranolazine
CAS :<p>Ranolazine (RS 43285-003) inhibits calcium uptake, treats chronic angina by targeting sodium/calcium channels to modulate intracellular sodium.</p>Formule :C24H33N3O4Degré de pureté :98.13%Couleur et forme :White SolidMasse moléculaire :427.54AZ194
CAS :<p>CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.</p>Formule :C34H31F2N3O3Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :567.62RY785
CAS :<p>RY785 is a potent and selective inhibitor of voltage-gated potassium channel such as KV2.2 (IC50 = 50 nM). RY785 may be used in pain relief studies.</p>Formule :C21H20N4O2SDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :392.476-Benzoylheteratisine
CAS :<p>6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid.</p>Formule :C29H37NO6Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :495.61Benzonatate
CAS :<p>Benzonatate is an antagonist of sodium channel protein.</p>Formule :C30H53NO11Degré de pureté :99.92%Couleur et forme :Colorless To Faintly Yellow Oil LiquidMasse moléculaire :603.74PF-06869206
CAS :<p>PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).</p>Formule :C15H14ClF3N4O2Degré de pureté :99.79% - 99.88%Couleur et forme :SolidMasse moléculaire :374.75Levobupivacaine hydrochloride
CAS :<p>Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.</p>Formule :C18H28N2O·HClDegré de pureté :99.74%Couleur et forme :White Crystalline PowderMasse moléculaire :324.893-Deoxyaconitine
CAS :<p>3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus</p>Formule :C34H47NO10Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :629.74Ralfinamide
CAS :<p>Ralfinamide (Priralfinamide) is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.</p>Formule :C17H19FN2O2Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :302.34Riluzole
CAS :<p>Riluzole (RP-54274) is an anticonvulsant, glutamate antagonist, and prolongs ALS patient survival.</p>Formule :C8H5F3N2OSDegré de pureté :99.71% - 99.88%Couleur et forme :PowderMasse moléculaire :234.2N-Formylguanidine
CAS :Produit contrôléFormule :C2H5N3OCouleur et forme :Off-WhiteMasse moléculaire :87.081Benzocaine N-Glucoside (a/b mixture)
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications The N-Glucoside of Benzocaine (B202970) with anesthetic activity. A potential sun-screening agent.<br>References Rybczynska, B. et al.: Parfum. Kosm., 48, 125 (1967); Nikolin, A. et al.: Glas. Hemi. Tehnol. Bosne Herceg., 16, 93 (1968);<br></p>Formule :C15H21NO7Couleur et forme :NeatMasse moléculaire :327.33Propoxycaine hydrochloride
CAS :<p>Propoxycaine hydrochloride is an ester local anesthetic that inhibits voltage-gated sodium channels, modulates nerve impulses, and induces loss of sensation.</p>Formule :C16H27ClN2O3Degré de pureté :97.25%Couleur et forme :SolidMasse moléculaire :330.85Eleclazine
CAS :<p>Eleclazine (GS-6615) is a novel and selective voltage-gated sodium channel inhibitor with antiarrhythmic properties that reduces peak sodium current (INaP).</p>Formule :C21H16F3N3O3Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :415.37Deacetamide Acetonitrile-pentisomide
CAS :Produit contrôlé<p>Applications Deacetamide Acetonitrile-pentisomide is an intermediate in the synthesis of Pentisomide (P275600). Pentisomide is a sodium channel blocker; derivative of disopyramide. Antiarrhythmic (class I).<br>References Kuhlkamp, V., et al.: Int. J. Cardiol., 36, 69 (1992); Yuan, S., et al.: Cardiovasc. Drug Rev., 11, 74 (1993)<br></p>Formule :C19H31N3Couleur et forme :NeatMasse moléculaire :301.47N-(Chloroacetyl)-2,5-dimethylaniline
CAS :Produit contrôlé<p>Applications N-(Chloroacetyl)-2,5-dimethylaniline is an intermediate in the synthesis of impurities of Lidocaine (L397800), an anesthetic local agent and antiarrythmic class IB agent.<br>References Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985), Davies, P.S., et al.: Drugs, 64, 937 (2004),<br></p>Formule :C10H12ClNOCouleur et forme :NeatMasse moléculaire :197.663-(2-Chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene
CAS :Produit contrôlé<p>Applications 3-(2-Chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene is an intermediate in the synthesis of Articaine-d7 Hydrochloride which is the labelled form of Articaine Hydrochloride (A777905). Articaine Hydrochloride is the Hydrochloride Salt of Articaine (A777900). Articaine is an amide based short-acting local anesthetic use for regional anaesthesia in day-case settings such arthroscopy, hand, food surgery and in dentistry.<br>References Malamed, S.F., et al.: J. Am. Dent. Assoc., 132, 177 (2001); Luan, F., et al.: Bioorg. Med. Chem., 21, 1870 (2013)<br></p>Formule :C10H12ClNO3SCouleur et forme :NeatMasse moléculaire :261.73Methocarbamol D5
CAS :<p>Methocarbamol is a central muscle relaxant. Methocarbamol D5 is deuterium labeled Methocarbamol.</p>Formule :C11H15NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :246.27Propafenone D7 hydrochloride
CAS :<p>Propafenone D7 hydrochloride is the deuterium labeled Propafenone, and is a classic anti-arrhythmic medication.</p>Formule :C21H28ClNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :384.953-Deoxyyunaconitine
CAS :Produit contrôlé<p>Applications 3-Deoxyyunaconitine is a metabolite of Aconitine (A189875), a neurotoxin that binds, activates tetrodotoxin-sensitive Na+ channels and prolongs the opening of the sodium-ion channel by suppressing conformational changes.<br>References Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),<br></p>Formule :C35H49NO10Couleur et forme :NeatMasse moléculaire :643.761,2,4-Oxadiazol-3-amine
CAS :Produit contrôlé<p>Applications 1,2,4-oxadiazol-3-amine (cas# 39512-64-6) is a useful research chemical.<br></p>Formule :C2H3N3OCouleur et forme :NeatMasse moléculaire :85.066-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)hexanamide
Produit contrôlé<p>Applications 6-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)-hexanamide is a derivative of Bupivacaine (B689560), a sodium channel blocker, local anesthetic.<br>References Wilson, T.D., et al.: Anal. Profiles Drug Subs., 19, 59 (1990), McClellan, K.J., et al.: Drugs, 56, 355 (1998),<br></p>Formule :C17H28N2O2Couleur et forme :NeatMasse moléculaire :292.416Halofuginone
CAS :<p>Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.</p>Formule :C16H17BrClN3O3Degré de pureté :99.53%Couleur et forme :Off-White SolidMasse moléculaire :414.68Clopamide
CAS :<p>Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.</p>Formule :C14H20ClN3O3SDegré de pureté :99.71%Couleur et forme :White To Yellowish Crystalline PowderMasse moléculaire :345.84Nav1.7 inhibitor
CAS :<p>Nav1.7 inhibitor is a Nav1.7 inhibitor for research in the field of pain and anesthesia.</p>Formule :C15H11Cl3FNO4SDegré de pureté :97.52%Couleur et forme :SolidMasse moléculaire :426.68GX-585
CAS :<p>GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2.</p>Formule :C24H25Cl2FN4O3SDegré de pureté :99.02% - 99.03%Couleur et forme :SolidMasse moléculaire :539.45(5R)-BW-4030W92
CAS :<p>(5R)-BW-4030W92 is the R-type of BW-4030W92, the active enantiomer.</p>Formule :C11H9Cl2FN4Degré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :287.12Sodium Channel inhibitor 2
CAS :<p>Sodium Channel inhibitor 2 is a blocker of sodium channel.</p>Formule :C26H25Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :466.4GNE-0439
CAS :<p>GNE-0439 is a Nav1.7-selective inhibitor (IC50 0.34 μM), also targeting Nav1.5 and mutant N1742K channels, valuable for ion channel research.</p>Formule :C21H31NO3Degré de pureté :99.60%Couleur et forme :SolidMasse moléculaire :345.48E 0747
CAS :<p>E 0747 is an antiarrhythmic agent of class 1C type. E-0747 suppresses arrhythmia by inhibiting the Na channels of cardiac cells.</p>Formule :C21H28ClN3O4Degré de pureté :95.17%Couleur et forme :SolidMasse moléculaire :421.92GX-674
CAS :<p>GX-674 is a highly potent and selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 value of 0.1 nM measured at -40 mV for the study of</p>Formule :C21H13ClF2N6O3S2Degré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :534.95DPI 201-106
CAS :<p>DPI 201-106: cardioselective h1 Na channel inhibitor, enhances heart contraction, blocks potassium and calcium currents.</p>Formule :C29H30N4O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :466.57PF 05089771 tosylate
CAS :<p>PF-05089771 inhibits Nav1.7 channels (IC50: 11-33 nM), selective over Nav1.1-1.6/1.8, Ca+, K+ channels, TRPV1; 1000x affinity for half-inactivated state.</p>Formule :C18H12Cl2FN5O3S2·C7H8O3SDegré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :672.56NHE3-IN-2
CAS :<p>NHE3-IN-2 is an inhibitor of NHE3 (Na+/H+ exchanger-3), applicable for treating hypertension, thrombosis, and ischaemic diseases.</p>Formule :C15H12ClN5Couleur et forme :SolidMasse moléculaire :297.74Halofuginone hydrobromide
CAS :<p>Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.</p>Formule :C16H17BrClN3O3·HBrDegré de pureté :97.01% - 99.73%Couleur et forme :SolidMasse moléculaire :495.59Phenamil
CAS :<p>Phenamil is an inhibitor of epithelial sodium channels, activates the osteomorphin protein pathway to promote bone repair and induces significant fat formation.</p>Formule :C12H12ClN7ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :305.72GDC-0276
CAS :<p>GDC-0276 is an orally active, selective, and potent NaV1.7 inhibitor that can be used for the study of pain-related diseases.</p>Formule :C24H31FN2O4SDegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :462.58KR-32568
CAS :<p>KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM).</p>Formule :C13H12FN3O2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :261.25Nisoxetine hydrochloride
CAS :<p>Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor</p>Formule :C17H21NO2·HClDegré de pureté :99.21%Couleur et forme :White SolidMasse moléculaire :307.82Silperisone HCl
CAS :<p>Silperisone HCl is a muscle relaxant and vasodilator, treating myoclonus, hypertonia, dystonia, and myospasm by blocking Na+ and Ca2+ channels.</p>Formule :C15H25ClFNSiDegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :301.9Elpetrigine
CAS :<p>Elpetrigine (GW273293) is a potential sodium channel blocker with antiepileptic activity that can be used to study epilepsy.</p>Formule :C10H7Cl3N4Degré de pureté :99.04% - 99.43%Couleur et forme :SolidMasse moléculaire :289.55NaV1.2/1.6 channel blocker-1
CAS :<p>NaV1.2/1.6 channel blocker-1 is a NaV1.2/1.6 channel blocker that inhibits rNaV1.6 and can be used to study generalised epilepsy and movement disorders.</p>Formule :C14H14N2OSDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :258.34NHE3-IN-1
CAS :<p>NHE3-IN-1 是钠/质子交换剂 3 (NHE-3) 的抑制剂。</p>Formule :C12H10ClN3SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :263.75TC-N 1752
CAS :<p>TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.</p>Formule :C25H27F3N6O3Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :516.52Ralitoline
CAS :<p>Ralitoline (Ralitolinum) is an anticonvulsant with anticancer activity and sodium channel blocking activity.</p>Formule :C13H13ClN2O2SDegré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :296.77(Rac)-AMG8379
CAS :<p>(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.</p>Formule :C25H16ClF2N3O5SDegré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :543.93SLC13A5-IN-1
CAS :<p>SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).</p>Formule :C19H19Cl3N2O3SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :461.79PF 04531083
CAS :<p>PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.</p>Formule :C17H16ClN5O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :357.79Aneratrigine
CAS :<p>Aneratrigine is a blocker of the sodium channel protein type 9 subunit alpha, utilized in research on neuropathic pain diseases [1].</p>Formule :C19H20ClF2N5O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :487.97Sodium Channel inhibitor 4
CAS :<p>Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].</p>Formule :C19H18ClN3O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :451.95Co 102862
CAS :<p>Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.</p>Formule :C14H12FN3O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :273.26GDC-0310
CAS :<p>GDC-0310 is a selective, orally available Nav1.7 inhibitor with an IC50 of 0.6 nM for human Nav1.7, suitable for pain research.</p>Formule :C25H29Cl2FN2O4SDegré de pureté :99.877%Couleur et forme :SolidMasse moléculaire :543.486-Iodoamiloride
CAS :<p>6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.</p>Formule :C6H8IN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.08Aneratrigine hydrochloride
CAS :<p>Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.</p>Formule :C19H21Cl2F2N5O2S2Degré de pureté :98.37% - 99.16%Couleur et forme :SolidMasse moléculaire :524.43VGSCs-IN-1
CAS :<p>VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.</p>Formule :C12H12F3N3OSDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :303.3Funapide
CAS :<p>Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.</p>Formule :C22H14F3NO5Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :429.35PF-05661014
CAS :<p>PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.</p>Formule :C17H16N4O3S2Couleur et forme :SolidMasse moléculaire :388.46Olisutrigine bromide
CAS :<p>Olisutrigine bromide is a sodium channel blocker used as an analgesic.</p>Formule :C25H35BrN2Couleur et forme :SolidMasse moléculaire :443.463N-Depropylpropafenone
CAS :<p>N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.</p>Formule :C18H21NO3Couleur et forme :SolidMasse moléculaire :299.36Vormatrigine
CAS :<p>Vormatrigine effectively inhibits sodium channels (sodium channel).</p>Formule :C16H12F6N4O2Couleur et forme :SolidMasse moléculaire :406.28Tizolemide
CAS :<p>Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.</p>Formule :C11H14ClN3O3S2Couleur et forme :SolidMasse moléculaire :335.83Lubeluzole dihydrochloride
CAS :<p>Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.</p>Formule :C22H27Cl2F2N3O2SCouleur et forme :SolidMasse moléculaire :506.44Quinacainol dihydrochloride
CAS :<p>Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.</p>Formule :C21H32Cl2N2OCouleur et forme :SolidMasse moléculaire :399.398Zilvetrigine
CAS :<p>Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.</p>Formule :C20H20ClN3O2Couleur et forme :SolidMasse moléculaire :369.845(R)-Duloxetine
CAS :<p>(R)-Duloxetine, an isomer of Duloxetine, induces tonic and use-dependent blockade of neuronal Na+ channels. This compound is utilized in pain research.</p>Formule :C18H19NOSCouleur et forme :SolidMasse moléculaire :297.42Olorigliflozin
CAS :<p>Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.</p>Formule :C23H27ClO7Couleur et forme :SolidMasse moléculaire :450.909ErSO-TFPy
CAS :<p>ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.</p>Formule :C19H13F7N2O2Couleur et forme :SolidMasse moléculaire :434.307Suzetrigine
CAS :<p>Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.</p>Formule :C21H20F5N3O4Degré de pureté :98.08% - 99.27%Couleur et forme :SolidMasse moléculaire :473.39SYM2206
CAS :<p>SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated</p>Formule :C20H22N4O3Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :366.41
