Canal sodique
Les canaux sodiques sont des protéines membranaires essentielles qui permettent le passage des ions sodium (Na+) à travers la membrane cellulaire, générant et propageant des signaux électriques dans les neurones, les cellules musculaires et d'autres tissus excitables. Ces canaux sont vitaux pour l'initiation et la conduction des potentiels d'action, ce qui les rend cruciaux dans des processus tels que la transmission de l'influx nerveux, la contraction musculaire et la fonction cardiaque. La dysrégulation des canaux sodiques peut entraîner des troubles neurologiques, des arythmies et des conditions de douleur chronique. Chez CymitQuimica, nous proposons une variété de modulateurs de canaux sodiques pour soutenir vos recherches en neurobiologie, cardiologie et gestion de la douleur.
273 produits trouvés pour "Canal sodique".
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Brompheniramine maleate
CAS :Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.Formule :C16H19BrN2·C4H4O4Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :435.31Ceratotoxin-1
Ceratotoxin-1 (CcoTx1) is a peptide toxin that functions as an inhibitor of various voltage-gated sodium channel subtypes.Formule :C172H256N52O50S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4044.58Anthopleurin-A
CAS :Anthopleurin-A, a sodium channel toxin, is selective for cardiac channels and has a cardiotonic effect. It can be isolated from the sea anemone [1] [2].Formule :C220H326N64O67S6Couleur et forme :SolidMasse moléculaire :5131.72XPC-7724
XPC-7724 is a selective inhibitor of the Nav1.6 channel, with an IC50 value of 0.078 μM. It is useful in research related to neurological disorders.Formule :C25H30FN5O2SMasse moléculaire :483.21042Benzonatate (PEGn)
CAS :Benzonatate (PEGn) is a unique non-narcotic cough suppressant featuring sodium channel blocking properties and anesthetic effects on respiratory tract stretch receptors.Formule :(C2H4O)nC12H17NO2Couleur et forme :SolidHm1a
Hm1a, a disulfide-rich spider-venom peptide and NaV1.1 activator, reestablishes the function of inhibitory interneurons in a Dravet syndrome (DS) mouse model [1Formule :C170H239N47O54S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3997.39Veratridine
CAS :Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.Formule :C36H51NO11Degré de pureté :98.07% - 99.27%Couleur et forme :SolidMasse moléculaire :673.79Ion Channel Targeted Library
A unique collection of xnum compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;Couleur et forme :Odour SolidRef: TM-L2300
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderTrapencaine
CAS :Trapencaine is a newly synthesized carbamate type local anesthetic that induces conformational changes in sodium channels on hypertrophic cell membranes.Formule :C22H34N2O3Degré de pureté :97.68%Couleur et forme :SolidMasse moléculaire :374.52GpTx-1
CAS :GpTx-1 exhibits potent selectivity as a NaV1.7 antagonist, demonstrating an inhibition concentration (IC50) of 10 nM [1].Formule :C176H271N53O45S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4073.82Zoniporide
CAS :Zoniporide (CP-597396) is an NHE-1 inhibitor that inhibits platelet swelling and can be used in the study of cardiovascular diseases.Formule :C17H16N6ODegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :320.35Sodium Channel Targeted Library
A unique collection of xnum sodium channel blockers and agonists for high throughput and high content screening;Couleur et forme :Odour SolidRef: TM-L7400
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderGpTx-1 TFA
GpTx-1 TFA is a polypeptide NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It exhibits potent inhibitory activity on the NaV1.7 channel with an IC50 value of 10 nM, demonstrating excellent selectivity over NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM) with >20-fold and >950-fold selectivity, respectively.Couleur et forme :Odour SolidProTx II
CAS :Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.Formule :C168H250N46O41S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3826.59Mambalgin 1
CAS :ASIC1a inhibitor; IC50: 192 nM (human), 72 nM (dimer); inactive channel binding; selective; pain response delay.Formule :C272H429N85O84S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :6554.51APETx2
CAS :ASIC3 inhibitor; IC50: 63 nM (rat), 175 nM (human). Blocks NaV1.8, NaV1.2; analgesic for acid/inflammatory pain.Formule :C196H280N54O61S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4561.06Sodium Channel inhibitor 5
Sodium Channel inhibitor5 (compound 7d) is a potent sodium channel inhibitor with an IC50 of 2.7 μM, playing a significant role in antiarrhythmic research.Formule :C24H23F3N4O2Couleur et forme :SolidMasse moléculaire :456.17731Batrachotoxin
CAS :Batrachotoxin (BTX), a potent neurotoxin and cardiotoxin, is found in the skin of the Colombian dart frog (Phyllobates aurotaenia). As an activator of sodium channels (sodium channel), it interferes with normal sodium channel closure by binding to voltage-gated sodium channels (sodium channel) on the cell membrane. This interaction causes a continuous influx of sodium ions into the cells, leading to persistent depolarization.Formule :C31H42N2O6Couleur et forme :SolidMasse moléculaire :538.67Nav1.8-IN-6
Nav1.8-IN-6 (Compound 2j) is a novel pyridinone amide Nav1.8 channel inhibitor with IC50 values of 513.33 nM in the resting state and 471.81 nM in the partially activated state. Nav1.8-IN-6 also exhibits analgesic activity.Formule :C19H17F6N3O2Couleur et forme :SolidMasse moléculaire :433.1225Solpecainol
CAS :solpecainol is a sodium channel blocker used in the study of neurological and cardiovascular diseases.Formule :C18H23NO3Degré de pureté :99.71%Couleur et forme :White OilMasse moléculaire :301.38
