PDE
Les phosphodiestérases (PDE) sont des enzymes qui hydrolysent les nucléotides cycliques, tels que l'AMPc et le GMPc, en leurs formes inactives, jouant un rôle clé dans la régulation des voies de signalisation intracellulaire. Les inhibiteurs de PDE sont utilisés dans le traitement de diverses affections, notamment les maladies cardiovasculaires, la dysfonction érectile et les troubles respiratoires, en raison de leur capacité à moduler les niveaux de nucléotides cycliques. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de PDE pour soutenir vos recherches en signalisation cellulaire, pharmacologie et développement thérapeutique.
165 produits trouvés pour "PDE"
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Amrinone
CAS :<p>Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.</p>Formule :C10H9N3ODegré de pureté :98.88% - 99.45%Couleur et forme :SolidMasse moléculaire :187.2N-Methylbenzamide
CAS :<p>N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.</p>Formule :C8H9NODegré de pureté :99.83%Couleur et forme :Physical Description Off-White Crystalline Solid (Ntp 1992)Masse moléculaire :135.16Zatolmilast
CAS :<p>Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).</p>Formule :C21H15ClF3NO2Degré de pureté :98.20%Couleur et forme :SolidMasse moléculaire :405.8Roflumilast
CAS :<p>Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential</p>Formule :C17H14Cl2F2N2O3Degré de pureté :99.76% - 99.86%Couleur et forme :SolidMasse moléculaire :403.21Pumafentrine
CAS :<p>Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.</p>Formule :C29H39N3O3Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :477.64Cilostazol
CAS :<p>Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.</p>Formule :C20H27N5O2Degré de pureté :99.58% - 99.90%Couleur et forme :Off-White SolidMasse moléculaire :369.46Pimobendan
CAS :<p>Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).</p>Formule :C19H18N4O2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :334.37ITI-214
CAS :<p>ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.</p>Formule :C29H29FN7O5PDegré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :605.56T-0156
CAS :<p>T-0156 is a PEG5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.</p>Formule :C31H29N5O7Degré de pureté :98.53% - 98.76%Couleur et forme :SoildMasse moléculaire :583.59EMD57439
CAS :<p>EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).</p>Formule :C22H23N3O4SDegré de pureté :99.38% - 99.57%Couleur et forme :SolidMasse moléculaire :425.5NSP-805
CAS :<p>NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.</p>Formule :C17H19N3O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :297.35ATX inhibitor 1
CAS :<p>ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).</p>Formule :C21H23Cl2N2O6PDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :501.3Carbodenafil
CAS :<p>Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).</p>Formule :C24H32N6O3Degré de pureté :98.96% - 99.89%Couleur et forme :SolidMasse moléculaire :452.55Trapidil
CAS :<p>Trapidil (Avantrin) is a coronary vasodilator agent.</p>Formule :C10H15N5Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :205.26Milrinone
CAS :<p>Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.</p>Formule :C12H9N3ODegré de pureté :99.22% - 99.92%Couleur et forme :SolidMasse moléculaire :211.22MR-L2
CAS :<p>MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).</p>Formule :C19H16Cl3FN4ODegré de pureté :98.09% - 98.94%Couleur et forme :SolidMasse moléculaire :441.71PDE4B-IN-4
<p>PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.</p>Formule :C26H27N5O5Couleur et forme :SolidMasse moléculaire :489.52Acetildenafil
CAS :<p>Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.</p>Formule :C25H34N6O3Couleur et forme :Off-White To Pale Yelow SolidMasse moléculaire :466.58WAY-313170
CAS :<p>WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.</p>Formule :C19H17ClN2O2S2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :404.93FCPR03
CAS :<p>FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively.</p>Formule :C15H19F2NO3Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :299.31BC 11-38
CAS :<p>BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).</p>Formule :C15H16N2OS2Degré de pureté :98.95% - 99.28%Couleur et forme :SolidMasse moléculaire :304.43OPC18750 HCl
CAS :<p>OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.</p>Formule :C20H23ClN2O4Degré de pureté :98.92%Couleur et forme :SoildMasse moléculaire :390.86PDE10A-IN-5
<p>PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.</p>Couleur et forme :Odour SolidDazonone
CAS :<p>Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.</p>Formule :C11H10ClN3ODegré de pureté :99.54% - 99.73%Couleur et forme :SolidMasse moléculaire :235.67PDE5-IN-9
CAS :<p>WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.</p>Formule :C18H14N4SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :318.4Enpp-1-IN-14
CAS :<p>Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.</p>Formule :C15H22ClN5O4SDegré de pureté :99.83%Couleur et forme :SoildMasse moléculaire :403.88Oglemilast
CAS :<p>Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.</p>Formule :C20H13Cl2F2N3O5SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :516.3BAY 2666605
CAS :<p>BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.</p>Formule :C17H12F4N2O2Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :352.28ONO-8430506
CAS :<p>ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.</p>Formule :C27H28FN3O3Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :461.53BI 1015550
CAS :<p>Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM.Cost-effective and quality-assured.</p>Formule :C20H25ClN6O2SDegré de pureté :98.06% - 99.71%Couleur et forme :SoildMasse moléculaire :448.97Arofylline
CAS :<p>Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.</p>Formule :C14H13ClN4O2Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :304.73cis-Tadalafil
CAS :<p>Tadalafil: a carboline-based PDE5 inhibitor, treats erectile dysfunction, prostatic hyperplasia, and pulmonary hypertension.</p>Formule :C22H19N3O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :389.4UK 227786
CAS :<p>UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.</p>Formule :C22H22Cl2N4O4Degré de pureté :99.9%Couleur et forme :SoildMasse moléculaire :477.34(1R,2R)-MK-8189
CAS :<p>(1R,2R)-MK-8189 is an isomer of MK-8189, a potent and selective pyrimidine PDE10A inhibitor.</p>Formule :C19H22N6OSDegré de pureté :>99.99% - >99.99%Couleur et forme :SoildMasse moléculaire :382.48Theodrenaline hydrochloride
CAS :<p>Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.</p>Formule :C17H22ClN5O5Degré de pureté :98% - 98.18%Couleur et forme :SoildMasse moléculaire :411.84Anti-ALDH7A1 Antibody (3P955)
<p>Anti-ALDH7A1 Antibody (3P955) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (3P955) can be used in WB,ELISA,IP.</p>Couleur et forme :Odour LiquidALDH7A1 Protein, Human, Recombinant (His)
<p>ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :56 kDa (predicted); 56 kDa (reducing conditions)PF-05180999
CAS :<p>α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is an α-2,3-sialyltransferase inhibitor with anticancer activity.</p>Formule :C19H17F3N8Degré de pureté :99.43% - 99.82%Couleur et forme :SolidMasse moléculaire :414.39Anti-ALDH7A1 Antibody-FITC (5P692)
<p>Anti-ALDH7A1 Antibody-FITC (5P692) is a FITC-conjugated Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody-FITC (5P692) can be used in FCM.</p>Couleur et forme :Odour LiquidBAY 73-6691 racemate
CAS :<p>BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor, useful for studying Parkinson’s disease.</p>Formule :C15H12ClF3N4OCouleur et forme :SolidMasse moléculaire :356.73Anti-ALDH7A1 Antibody (6G475)
<p>Anti-ALDH7A1 Antibody (6G475) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (6G475) can be used in IHC-P.</p>Couleur et forme :Odour LiquidAutotaxin modulator 1
CAS :<p>Autotaxin modulator 1 is a new modulator of Autotaxin.</p>Formule :C28H31F6NO3Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :543.54ENPP1 Inhibitor C
CAS :<p>ML-354 (VU0099704) is an antagonist with and PAR4 for the study of cardiovascular diseases.</p>Formule :C15H18N6Degré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :282.34Anti-ALDH7A1 Antibody (1G435)
<p>Anti-ALDH7A1 Antibody (1G435) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (1G435) can be used in ELISA.</p>Couleur et forme :Odour LiquidN-Ethyl tadalafil
CAS :<p>N-Ethyl tadalafil (NEthyl tadalafil) is a PDE inhibitor used in the study of cardiovascular disease.</p>Formule :C23H21N3O4Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :403.43Anti-ALDH7A1 Antibody (5P692)
<p>Anti-ALDH7A1 Antibody (5P692) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (5P692) can be used in FCM,ICC/IF.</p>Couleur et forme :Odour LiquidBay 60-7550
CAS :<p>Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.</p>Formule :C27H32N4O4Degré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :476.57PF-05085727
CAS :<p>PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11.</p>Formule :C20H18F3N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :413.4THPP-1
CAS :<p>THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).</p>Formule :C23H21ClN6O3Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :464.9PF-8380
CAS :<p>PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood).</p>Formule :C22H21Cl2N3O5Degré de pureté :98.70% - 99.25%Couleur et forme :SolidMasse moléculaire :478.33PQ-10
CAS :<p>PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.</p>Formule :C22H21N5O3Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :403.43Roflumilast N-oxide
CAS :<p>Roflumilast N-oxide is an inhibitor of PDE type 4.</p>Formule :C17H14Cl2F2N2O4Degré de pureté :98.19% - 99.69%Couleur et forme :SolidMasse moléculaire :419.21Balipodect
CAS :<p>Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.</p>Formule :C23H17FN6O2Degré de pureté :98% - 99.79%Couleur et forme :SolidMasse moléculaire :428.42Irsogladine
CAS :<p>Irsogladine (Dicloguamine) is an anti-ulcer agent that promotes gap junction intercellular communication via M1 muscarinic acetylcholine receptor binding.</p>Formule :C9H7Cl2N5Degré de pureté :99.74% - 99.91%Couleur et forme :White Or Colorless Crystal Or Crystalline Powder Odorless Slightly BitterMasse moléculaire :256.09K-Ras-PDEδ-IN-1
CAS :<p>K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).</p>Formule :C25H26FN5O2Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :447.5Cilomilast
CAS :<p>Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.</p>Formule :C20H25NO4Degré de pureté :97.37% - 99.52%Couleur et forme :White SolidMasse moléculaire :343.42ICI 63197
CAS :<p>ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.</p>Formule :C9H13N5ODegré de pureté :99.70%Couleur et forme :White SolidMasse moléculaire :207.23IBMX
CAS :<p>IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μM</p>Formule :C10H14N4O2Degré de pureté :98% - >99.99%Couleur et forme :Off-WhiteMasse moléculaire :222.242,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS :<p>2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.</p>Formule :C9H9Cl2F2NO3SDegré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :320.14Olprinone
CAS :<p>Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate</p>Formule :C14H10N4ODegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :250.26HA130
CAS :<p>HA130 is a selective ATX (autotaxin) inhibitor.</p>Formule :C24H19BFNO5SDegré de pureté :98.26% - ≥95%Couleur et forme :SolidMasse moléculaire :463.29Ro 20-1724
CAS :<p>Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1</p>Formule :C15H22N2O3Degré de pureté :98.82% - 99.79%Couleur et forme :SolidMasse moléculaire :278.35Mardepodect
CAS :<p>Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE.</p>Formule :C25H20N4ODegré de pureté :99.81% - 99.94%Couleur et forme :SolidMasse moléculaire :392.45BW-A 78U
CAS :<p>BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.</p>Formule :C13H12FN5Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :257.27MBCQ
CAS :<p>MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.</p>Formule :C16H12ClN3O2Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :313.74HA 155
CAS :<p>HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.</p>Formule :C24H19BFNO5SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :463.29Ibudilast
CAS :<p>Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.</p>Formule :C14H18N2ODegré de pureté :99.83% - >99.99%Couleur et forme :White SolidMasse moléculaire :230.31ML-030
CAS :<p>ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.</p>Formule :C20H20N4O4SDegré de pureté :97.93%Couleur et forme :SolidMasse moléculaire :412.46SEP-0372814
CAS :<p>SEP-0372814 is a potent inhibitor of PDE10.</p>Formule :C21H19N7Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :369.42YM976
CAS :<p>YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)</p>Formule :C17H16ClN3ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :313.78Cilostamide
CAS :<p>Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)</p>Formule :C20H26N2O3Degré de pureté :98.87%Couleur et forme :White To Off-White SolidMasse moléculaire :342.43D159687
CAS :<p>D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant benefit.</p>Formule :C21H19ClN2O2Degré de pureté :97.57%Couleur et forme :SolidMasse moléculaire :366.84RS-25344 hydrochloride
CAS :<p>RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitor</p>Formule :C19H14ClN5O4Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :411.8BRL-50481
CAS :<p>BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.</p>Formule :C9H12N2O4SDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :244.27Piclamilast
CAS :<p>Piclamilast (RP 73401) is a PDE4 inhibitor.</p>Formule :C18H18Cl2N2O3Degré de pureté :98.28% - 99.57%Couleur et forme :SolidMasse moléculaire :381.25Ensifentrine
CAS :<p>Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that</p>Formule :C26H31N5O4Degré de pureté :99.76% - 99.94%Couleur et forme :SolidMasse moléculaire :477.56Z-HA155
CAS :<p>Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.</p>Formule :C24H19BFNO5SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :463.29Crisaborole
CAS :<p>Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.</p>Formule :C14H10BNO3Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :251.05Udenafil
CAS :<p>Udenafil is an inhibitor of PDE5 .</p>Formule :C25H36N6O4SDegré de pureté :99.90%Couleur et forme :Off-White SolidMasse moléculaire :516.66GSK256066
CAS :<p>GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold</p>Formule :C27H26N4O5SDegré de pureté :99.60% - 99.66%Couleur et forme :SolidMasse moléculaire :518.58Nortadalafil
CAS :<p>Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.</p>Formule :C21H17N3O4Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :375.38Homo Sildenafil
CAS :<p>Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.</p>Formule :C23H32N6O4SDegré de pureté :99.88%Couleur et forme :White SolidMasse moléculaire :488.6GEBR-7b
CAS :<p>GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.</p>Formule :C13H16O3Degré de pureté :99.533%Couleur et forme :SolidMasse moléculaire :220.26Enoximone
CAS :<p>Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.</p>Formule :C12H12N2O2SDegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :248.3MY-5445
CAS :<p>MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).</p>Formule :C20H14ClN3Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :331.8Amino Tadalafil
CAS :<p>Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.</p>Formule :C21H18N4O4Degré de pureté :99.85%Couleur et forme :White PowderMasse moléculaire :390.39Sildenafil Mesylate
CAS :<p>Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.</p>Formule :C22H30N6O4S·xCH4O3SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :570.68Lodenafil
CAS :<p>Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)</p>Formule :C23H32N6O5SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :504.6[11C]MP 10
CAS :<p>[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.</p>Formule :C25H20N4ODegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :391.45Osoresnontrine
CAS :<p>Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.</p>Formule :C16H17N5O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :311.34CP671305
CAS :<p>CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.</p>Formule :C23H19FN2O7Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :454.4Ziritaxestat
CAS :<p>Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.</p>Formule :C30H33FN8O2SDegré de pureté :97% - 99.85%Couleur et forme :SolidMasse moléculaire :588.7PDE10-IN-1
CAS :<p>PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.</p>Formule :C21H19N7Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :369.42RS-25344
CAS :<p>RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.</p>Formule :C19H13N5O4Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :375.34Lotamilast
CAS :<p>Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.</p>Formule :C26H24N4O5Degré de pureté :97.03% - 99.29%Couleur et forme :SolidMasse moléculaire :472.49Enpp-1-IN-1
CAS :<p>Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)</p>Formule :C17H17N3O3SDegré de pureté :97.52%Couleur et forme :SolidMasse moléculaire :343.4GSK256066 Trifluoroacetate
CAS :<p>GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.</p>Formule :C29H27F3N4O7SCouleur et forme :SolidMasse moléculaire :632.61Crisaborole-d4
<p>Crisaborole-d4 (AN-2728-d4) is the deuterated form of Crisaborole. Crisaborole is a PDE4 inhibitor and also a cytokine release inhibitor.</p>Formule :C14H6D4BNO3Couleur et forme :SolidMasse moléculaire :255.07ent-Tadalafil
CAS :<p>ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).</p>Formule :C22H19N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.4Deltarasin
CAS :<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Formule :C40H37N5ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :603.75K134
CAS :<p>K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.</p>Formule :C22H29N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :399.48PAT-048
CAS :<p>PAT-048 is an effective and selective autotaxin inhibitor.</p>Formule :C22H18ClF2N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.91Propentofylline
CAS :<p>Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.</p>Formule :C15H22N4O3Degré de pureté :99.76% - 99.86%Couleur et forme :Off-White SolidMasse moléculaire :306.36Deltasonamide 2
CAS :<p>Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.</p>Formule :C30H39ClN6O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.25Deltasonamide 2 (TFA)
CAS :<p>Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.</p>Formule :C32H40ClF3N6O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :761.28PDE9-IN-1
CAS :<p>PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).</p>Formule :C17H23FN6O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :362.4Tilivapram
CAS :<p>Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.</p>Formule :C16H15Cl2N3O4Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :384.21AN3199
CAS :<p>AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.</p>Formule :C17H18BNO5Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :327.14Imazodan hydrochloride
CAS :<p>Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.</p>Formule :C13H13ClN4ODegré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :276.72BAY 73-6691
CAS :<p>BAY 73-6691 is an inhibitor of brain penetrant PDE9A.</p>Formule :C15H12ClF3N4OCouleur et forme :SolidMasse moléculaire :356.73Lirimilast
CAS :<p>Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.</p>Formule :C17H12Cl2N2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.26WAY127093B racemate
CAS :<p>WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.</p>Formule :C23H28N4O4Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :424.49PDE7-IN-2
CAS :<p>PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.</p>Formule :C14H11ClN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :322.77(R)-DNMDP
CAS :<p>(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.</p>Formule :C15H20N4O3Couleur et forme :SolidMasse moléculaire :304.34Autotaxin-IN-1
CAS :<p>Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.</p>Formule :C21H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.45Senazodan hydrochloride
CAS :<p>Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.</p>Formule :C15H15ClN4ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :302.76KD-027
CAS :<p>KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.</p>Formule :C25H35N7O6SDegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :561.65ATX inhibitor 5
CAS :<p>ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.</p>Formule :C22H18ClF3N6ODegré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :474.87PF-04822163
CAS :<p>PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.</p>Formule :C19H17ClN2O2Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :340.8Imazodan
CAS :<p>Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.</p>Formule :C13H12N4ODegré de pureté :98% - 98.31%Couleur et forme :SolidMasse moléculaire :240.26PDE IV-IN-1
CAS :<p>PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary disease</p>Formule :C20H23ClN4O2Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :386.88Tanimilast
CAS :<p>Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.</p>Formule :C30H30Cl2F2N2O8SDegré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :687.54uk-50001
CAS :<p>UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.</p>Formule :C26H24F3N3O4Degré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :499.48PDE4B-IN-2
CAS :<p>PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.</p>Formule :C19H18ClN3O2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :387.88Nanterinone
CAS :<p>Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.</p>Formule :C15H15N3ODegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :253.3Dovramilast
CAS :<p>Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.</p>Formule :C24H28N2O6SDegré de pureté :98.75% - 99.62%Couleur et forme :SolidMasse moléculaire :472.55Verofylline
CAS :<p>Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for the</p>Formule :C12H18N4O2Degré de pureté :98.33% - 98.83%Couleur et forme :SolidMasse moléculaire :250.3Carbazeran
CAS :<p>Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.</p>Formule :C18H24N4O4Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :360.41AWD 12-281
CAS :<p>AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).</p>Formule :C22H14Cl2FN3O3Degré de pureté :99.25% - 99.85%Couleur et forme :SolidMasse moléculaire :458.27Autotaxin-IN-3
CAS :<p>Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.</p>Formule :C22H21N9O2Degré de pureté :99.54% - 99.79%Couleur et forme :SolidMasse moléculaire :443.46Filaminast
CAS :<p>Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.</p>Formule :C15H20N2O4Degré de pureté :98.53% - 98.93%Couleur et forme :SolidMasse moléculaire :292.33MK-0873
CAS :<p>MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.</p>Formule :C25H18N4O3Degré de pureté :98.40%Couleur et forme :SolidMasse moléculaire :422.44Mopidamol
CAS :<p>Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimental</p>Formule :C19H31N7O4Degré de pureté :99.05% - 99.78%Couleur et forme :SolidMasse moléculaire :421.49Isomazole
CAS :<p>Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.</p>Formule :C14H13N3O2SDegré de pureté :98.66%Couleur et forme :SolidMasse moléculaire :287.34Tofimilast
CAS :<p>Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.</p>Formule :C18H21N5SDegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :339.46Dasantafil
CAS :<p>Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.</p>Formule :C22H28BrN5O5Degré de pureté :99.4% - 99.50%Couleur et forme :SolidMasse moléculaire :522.39PF-04447943
CAS :<p>PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.</p>Formule :C20H25N7O2Degré de pureté :99.36% - 99.59%Couleur et forme :SolidMasse moléculaire :395.46GSK356278
CAS :<p>GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.</p>Formule :C21H25N7O2SDegré de pureté :99.90% - 99.97%Couleur et forme :SolidMasse moléculaire :439.53MK-8189
CAS :<p>MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.</p>Formule :C19H22N6OSDegré de pureté :99.38% - 99.67%Couleur et forme :SolidMasse moléculaire :382.48Autotaxin-IN-5
CAS :<p>Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.</p>Formule :C30H29N9O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :547.61Gisadenafil
CAS :<p>Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.</p>Formule :C23H33N7O5SDegré de pureté :98.82% - 99.50%Couleur et forme :SolidMasse moléculaire :519.62PDE5-IN-2
CAS :<p>PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)</p>Formule :C25H21N3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :491.52CI-1044
CAS :<p>CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).</p>Formule :C23H19N5O2Couleur et forme :SolidMasse moléculaire :397.43BIO-32546
CAS :<p>BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.</p>Formule :C28H31F6NO3Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :543.54Gisadenafil besylate
CAS :<p>Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.</p>Formule :C29H39N7O8S2Couleur et forme :SolidMasse moléculaire :677.79Difamilast
CAS :<p>Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).</p>Formule :C23H24F2N2O5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :446.44Siguazodan
CAS :<p>Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.</p>Formule :C14H16N6ODegré de pureté :99.62% - 99.87%Couleur et forme :SolidMasse moléculaire :284.32Adibendan
CAS :<p>Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.</p>Formule :C16H14N4ODegré de pureté :99.52% - >99.99%Couleur et forme :SolidMasse moléculaire :278.31Autotaxin-IN-4
CAS :<p>Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.</p>Formule :C22H21N9O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.46PF-04957325
CAS :<p>PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.</p>Formule :C14H15F3N8OSDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :400.38PDE9-IN-(S)-C33
CAS :<p>PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.</p>Formule :C18H20ClN5ODegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :357.84Enpp-1-IN-16
CAS :<p>Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.</p>Formule :C23H32N4O4Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :428.52TPN171
CAS :<p>TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary</p>Formule :C24H35N5O3Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :441.57AMG 579
CAS :<p>AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).</p>Formule :C25H23N5O3Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :441.48Cudetaxestat
CAS :<p>Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.</p>Formule :C21H15Cl2F2N3O2SDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :482.33TP-10
CAS :<p>TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.</p>Formule :C26H19F3N4ODegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :460.45Thioquinapiperifil dihydrochloride
CAS :<p>Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.</p>Formule :C24H29ClN6OSDegré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :485.05PF-00489791
CAS :<p>PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.</p>Formule :C20H28N8O4SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :476.55Deltasonamide 2 hydrochloride
<p>Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.</p>Formule :C30H40Cl2N6O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :683.71ASP9831
CAS :<p>ASP9831 is an orally active PDE4 inhibitor. It suppresses LPS-induced TNF-α production and exhibits anti-inflammatory properties. ASP9831 is useful in the study of steatohepatitis.</p>Formule :C20H23N3O3Couleur et forme :SolidMasse moléculaire :353.42Tovinontrine
CAS :<p>Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.</p>Formule :C21H26N6O2Degré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :394.47BMS-341400 mesylate
CAS :<p>BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.</p>Formule :C24H26ClN9O5SCouleur et forme :SolidMasse moléculaire :588.039TAK-915
CAS :<p>TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.</p>Formule :C19H18F4N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.36Z21090
CAS :<p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>Formule :C12H14ClN3O3Couleur et forme :SolidMasse moléculaire :283.71NHTD
CAS :<p>NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).</p>Formule :C24H26N2O5Couleur et forme :SolidMasse moléculaire :422.47
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