PDE
Les phosphodiestérases (PDE) sont des enzymes qui hydrolysent les nucléotides cycliques, tels que l'AMPc et le GMPc, en leurs formes inactives, jouant un rôle clé dans la régulation des voies de signalisation intracellulaire. Les inhibiteurs de PDE sont utilisés dans le traitement de diverses affections, notamment les maladies cardiovasculaires, la dysfonction érectile et les troubles respiratoires, en raison de leur capacité à moduler les niveaux de nucléotides cycliques. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de PDE pour soutenir vos recherches en signalisation cellulaire, pharmacologie et développement thérapeutique.
165 produits trouvés pour "PDE"
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MR-L2
CAS :<p>MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).</p>Formule :C19H16Cl3FN4ODegré de pureté :98.09% - 98.94%Couleur et forme :SolidMasse moléculaire :441.71T-0156
CAS :<p>T-0156 is a PEG5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.</p>Formule :C31H29N5O7Degré de pureté :98.53% - 98.76%Couleur et forme :SoildMasse moléculaire :583.59Milrinone
CAS :<p>Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.</p>Formule :C12H9N3ODegré de pureté :99.22% - 99.92%Couleur et forme :SolidMasse moléculaire :211.22Cilostazol
CAS :<p>Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.</p>Formule :C20H27N5O2Degré de pureté :99.58% - 99.90%Couleur et forme :Off-White SolidMasse moléculaire :369.46Pumafentrine
CAS :<p>Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.</p>Formule :C29H39N3O3Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :477.64N-Methylbenzamide
CAS :<p>N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.</p>Formule :C8H9NODegré de pureté :99.83%Couleur et forme :Physical Description Off-White Crystalline Solid (Ntp 1992)Masse moléculaire :135.16Trapidil
CAS :<p>Trapidil (Avantrin) is a coronary vasodilator agent.</p>Formule :C10H15N5Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :205.26Pimobendan
CAS :<p>Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).</p>Formule :C19H18N4O2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :334.37Zatolmilast
CAS :<p>Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).</p>Formule :C21H15ClF3NO2Degré de pureté :98.20%Couleur et forme :SolidMasse moléculaire :405.8EMD57439
CAS :<p>EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).</p>Formule :C22H23N3O4SDegré de pureté :99.38% - 99.57%Couleur et forme :SolidMasse moléculaire :425.5NSP-805
CAS :<p>NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.</p>Formule :C17H19N3O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :297.35ATX inhibitor 1
CAS :<p>ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).</p>Formule :C21H23Cl2N2O6PDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :501.3Roflumilast
CAS :<p>Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential</p>Formule :C17H14Cl2F2N2O3Degré de pureté :99.76% - 99.86%Couleur et forme :SolidMasse moléculaire :403.21ITI-214
CAS :<p>ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.</p>Formule :C29H29FN7O5PDegré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :605.56Amrinone
CAS :<p>Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.</p>Formule :C10H9N3ODegré de pureté :98.88% - 99.45%Couleur et forme :SolidMasse moléculaire :187.2Carbodenafil
CAS :<p>Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).</p>Formule :C24H32N6O3Degré de pureté :98.96% - 99.89%Couleur et forme :SolidMasse moléculaire :452.55OPC18750 HCl
CAS :<p>OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.</p>Formule :C20H23ClN2O4Degré de pureté :98.92%Couleur et forme :SoildMasse moléculaire :390.86cis-Tadalafil
CAS :<p>Tadalafil: a carboline-based PDE5 inhibitor, treats erectile dysfunction, prostatic hyperplasia, and pulmonary hypertension.</p>Formule :C22H19N3O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :389.4Acetildenafil
CAS :<p>Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.</p>Formule :C25H34N6O3Couleur et forme :Off-White To Pale Yelow SolidMasse moléculaire :466.58FCPR03
CAS :<p>FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively.</p>Formule :C15H19F2NO3Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :299.31BC 11-38
CAS :<p>BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).</p>Formule :C15H16N2OS2Degré de pureté :98.95% - 99.28%Couleur et forme :SolidMasse moléculaire :304.43BI 1015550
CAS :<p>Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM.Cost-effective and quality-assured.</p>Formule :C20H25ClN6O2SDegré de pureté :98.06% - 99.71%Couleur et forme :SoildMasse moléculaire :448.97Arofylline
CAS :<p>Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.</p>Formule :C14H13ClN4O2Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :304.73Theodrenaline hydrochloride
CAS :<p>Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.</p>Formule :C17H22ClN5O5Degré de pureté :98% - 98.18%Couleur et forme :SoildMasse moléculaire :411.84UK 227786
CAS :<p>UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.</p>Formule :C22H22Cl2N4O4Degré de pureté :99.9%Couleur et forme :SoildMasse moléculaire :477.34(1R,2R)-MK-8189
CAS :<p>(1R,2R)-MK-8189 is an isomer of MK-8189, a potent and selective pyrimidine PDE10A inhibitor.</p>Formule :C19H22N6OSDegré de pureté :>99.99% - >99.99%Couleur et forme :SoildMasse moléculaire :382.48PDE4B-IN-4
<p>PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.</p>Formule :C26H27N5O5Couleur et forme :SolidMasse moléculaire :489.52PDE10A-IN-5
<p>PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.</p>Couleur et forme :Odour SolidOglemilast
CAS :<p>Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.</p>Formule :C20H13Cl2F2N3O5SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :516.3ONO-8430506
CAS :<p>ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.</p>Formule :C27H28FN3O3Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :461.53Enpp-1-IN-14
CAS :<p>Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.</p>Formule :C15H22ClN5O4SDegré de pureté :99.83%Couleur et forme :SoildMasse moléculaire :403.88WAY-313170
CAS :<p>WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.</p>Formule :C19H17ClN2O2S2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :404.93PDE5-IN-9
CAS :<p>WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.</p>Formule :C18H14N4SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :318.4Dazonone
CAS :<p>Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.</p>Formule :C11H10ClN3ODegré de pureté :99.54% - 99.73%Couleur et forme :SolidMasse moléculaire :235.67BAY 2666605
CAS :<p>BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.</p>Formule :C17H12F4N2O2Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :352.28ALDH7A1 Protein, Human, Recombinant (His)
<p>ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :56 kDa (predicted); 56 kDa (reducing conditions)PF-05085727
CAS :<p>PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11.</p>Formule :C20H18F3N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :413.4Autotaxin modulator 1
CAS :<p>Autotaxin modulator 1 is a new modulator of Autotaxin.</p>Formule :C28H31F6NO3Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :543.54N-Ethyl tadalafil
CAS :<p>N-Ethyl tadalafil (NEthyl tadalafil) is a PDE inhibitor used in the study of cardiovascular disease.</p>Formule :C23H21N3O4Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :403.43Anti-ALDH7A1 Antibody (1G435)
<p>Anti-ALDH7A1 Antibody (1G435) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (1G435) can be used in ELISA.</p>Couleur et forme :Odour LiquidBay 60-7550
CAS :<p>Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.</p>Formule :C27H32N4O4Degré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :476.57PF-05180999
CAS :<p>α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is an α-2,3-sialyltransferase inhibitor with anticancer activity.</p>Formule :C19H17F3N8Degré de pureté :99.43% - 99.82%Couleur et forme :SolidMasse moléculaire :414.39Anti-ALDH7A1 Antibody (6G475)
<p>Anti-ALDH7A1 Antibody (6G475) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (6G475) can be used in IHC-P.</p>Couleur et forme :Odour LiquidAnti-ALDH7A1 Antibody-FITC (5P692)
<p>Anti-ALDH7A1 Antibody-FITC (5P692) is a FITC-conjugated Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody-FITC (5P692) can be used in FCM.</p>Couleur et forme :Odour LiquidAnti-ALDH7A1 Antibody (3P955)
<p>Anti-ALDH7A1 Antibody (3P955) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (3P955) can be used in WB,ELISA,IP.</p>Couleur et forme :Odour LiquidAnti-ALDH7A1 Antibody (5P692)
<p>Anti-ALDH7A1 Antibody (5P692) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (5P692) can be used in FCM,ICC/IF.</p>Couleur et forme :Odour LiquidENPP1 Inhibitor C
CAS :<p>ML-354 (VU0099704) is an antagonist with and PAR4 for the study of cardiovascular diseases.</p>Formule :C15H18N6Degré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :282.34BAY 73-6691 racemate
CAS :<p>BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor, useful for studying Parkinson’s disease.</p>Formule :C15H12ClF3N4OCouleur et forme :SolidMasse moléculaire :356.73D159687
CAS :<p>D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant benefit.</p>Formule :C21H19ClN2O2Degré de pureté :97.57%Couleur et forme :SolidMasse moléculaire :366.84HA 155
CAS :<p>HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.</p>Formule :C24H19BFNO5SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :463.29
