Microbiologie/Virologie

WYFA-15 is an inhibitor of sphingomyelin synthase 1 (SMS1) that has been shown to protect mice from lethal SFTSV infection and reduce the replication and pathogenicity of SARS-CoV-2. WYFA-15 is applicable for antiviral research.

Janthinocin B is a novel macrocyclic peptide lactone antibiotic.

The compound exhibits excellent antifungal and antiviral activities, including against HIV.

Diastovaricin I (30-Hydroxy-naphthomycin C) is an antibiotic that does not exhibit antimicrobial activity. It promotes differentiation in mouse Friend cells.

Polymyxin B2, a significant component of polymyxin B, is an antibiotic cationic lipopeptide initially derived from B.

LIN28-IN-2 (Compound Ln268) blocks the interaction between the zinc finger domain (ZKD) of Lin28 and RNA substrates, inhibiting both Lin28a and Lin28b. It also suppresses the proliferation of Lin28-positive cancer cells and the growth of 3D spheroids.

Calcium lactate (Conclyte) fortifies juice with calcium and aids soybean sprout growth and phytic acid breakdown.

Tropodithietic acid, a sulfur-based antibiotic from Phaeobacter inhibens, targets many bacteria types.

PF-1163A, a depsipeptide antifungal compound isolated from Penicillium, blocks ergosterol synthesis with an IC50 of 12 ng/ml. This compound specifically inhibits the enzyme ERG25p, a C-4 methyl oxidase in the ergosterol biosynthetic pathway, leading to its antifungal activity. Notably, in Saccharomyces cerevisiae modified to express ERG biosynthesis genes, PF-1163A exhibits an inhibition concentration (MIC value) of 12.5 µg/ml against ERG25p, though strains overexpressing ERG25p show resistance. Additionally, PF-1163A effectively suppresses the growth of Candida albicans (MIC = 8 µg/ml), without affecting other Candida species, Aspergillus fumigatus, or HepG2 cells. Remarkably, it enhances the efficacy of fluconazole against azole-resistant C. albicans strains, showing a significant decrease in MICs (1 and 0.0078 µg/ml alone and in combination, respectively). PF-1163A distinguishes itself from PF-1163B by its more polar nature.

Heptaibin is a useful organic compound for research related to life sciences. The catalog number is T125107 and the CAS number is 291311-47-2.

Ceratotoxins B, an antibacterial peptide, is produced by sexually mature females of Ceratitis capitata (medfly).

AMPR-22, an antimicrobial peptide, binds to bacterial membranes to induce permeabilization and has demonstrated efficacy in a murine sepsis model induced by

Antibacterial agent 142, an aromatic hydrazide, exhibits bacteriostatic antibacterial activity and inhibits biofilm formation [1].

Hemsloside Ma 1 is a useful organic compound for research related to life sciences. The catalog number is T123850 and the CAS number is 95851-41-5.

Protactin, a new antibiotic metabolite, is a possible precursor of the actinomycins.

Atropine Oxide is derived from Atropine, a drug that blocks muscarinic receptors and treats nerve agent poisoning and bradycardia.

4-Nitrosodiphenylamine exhibits significant antibacterial activity, with an EC50 value of 5.715 mg/L against [Erwinia amylovora].

Bombinin-like peptide 7, an antimicrobial peptide sourced from the Oriental fire-bellied toad (Bombina orientalis) [1], demonstrates bioactive properties.

Dienone B is a cytotoxic secondary metabolite from tyrosine as isolated from the sponges Verongia aerophoba & Aplysina aerophoba.