Neuroscience
Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.
Sous-catégories appartenant à la catégorie "Neuroscience"
- récepteur 5-HT(940 produits)
- ACK(1 produits)
- AChR(574 produits)
- ATP Citrate Lyase(16 produits)
- Récepteur adrénergique(2.942 produits)
- BACE(36 produits)
- Bêta-amyloïde(204 produits)
- CaMK(68 produits)
- COX(562 produits)
- Récepteur de la dopamine(407 produits)
- Récepteur GABA(336 produits)
- Gamma-sécrétase(59 produits)
- GluR(255 produits)
- GlyT(24 produits)
- Récepteur de l'histamine(358 produits)
- LRRK2(33 produits)
- Récepteur de la mélatonine(24 produits)
- NMDAR(28 produits)
- Récepteur OX(40 produits)
- Récepteur opioïde(296 produits)
Affichez 12 plus de sous-catégories
5400 produits trouvés pour "Neuroscience"
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Asenapine citrate
CAS :<p>Asenapine citrate: atypical antipsychotic for schizophrenia, bipolar disorder; targets serotonin, adrenoceptors, dopamine, histamine (pKi: 8.2-10.5).</p>Formule :C23H24ClNO8Couleur et forme :SolidMasse moléculaire :477.89Orexin B, human
CAS :<p>Orexin B, human agonizes Orexin receptors (OX1 Ki=420 nM, OX2 Ki=36 nM), promotes feeding in rats, and is a neuropeptide.</p>Formule :C123H212N44O35SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2899.34Br-PBTC
CAS :<p>Br-PBTC modulates nAChRs; targets α2/β2,4 subtypes; potent with 0.1-0.6 μM EC50; binds α subunit c-tail.</p>Formule :C14H15BrN2OSCouleur et forme :SolidMasse moléculaire :339.25α-Casozepine
CAS :<p>α-Casozepine,Bioactive peptide from milk α-S1 casein. Binds GABA receptors. Anti-anxiety effects.</p>Formule :C60H94N14O16Couleur et forme :SolidMasse moléculaire :1267.47BTMPS
CAS :<p>BTMPS is a usage-dependent nicotinic antagonist capable of reducing acute withdrawal symptoms associated with morphine use.</p>Formule :C28H52N2O4Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :480.72hAChE-IN-6
<p>hAChE-IN-6 (compound 51) is a brain-penetrant acetylcholinesterase (AChE) inhibitor exhibiting an IC50 of 0.16 μM.</p>Couleur et forme :Odour SolidCOX-1/2-IN-9
<p>COX-1/2-IN-9 (Compound 3n) serves as a selective and potent inhibitor of both COX-1 and COX-2, demonstrating IC 50 values of 0.031 µM for COX-1 and 0.01 µM for COX-2. This compound exhibits antibacterial and anti-inflammatory properties, effectively targeting MRSA 1478 (MIC=50 μg/mL) and multidrug-resistant S. lentus (MIC=50 μg/mL). Furthermore, COX-1/2-IN-9 shows promise in relieving MRSA-induced pneumonia in conditions of compromised immunity.</p>Formule :C30H20IN9O13S2Couleur et forme :SolidMasse moléculaire :905.57Triazolomethylindole-3-acetic acid
CAS :<p>Triazolomethylindole-3-acetic acid is a metabolite of Rizatriptan, which acts as an agonist for the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D.</p>Formule :C13H12N4O2Couleur et forme :SolidMasse moléculaire :256.26Pseudocoptisine acetate
CAS :<p>Pseudocoptisine acetate is a quaternary alkaloid isolated from the tubers of Corydalis turtschaninovii,with anti-inflammatory properties.</p>Formule :C21H17NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :379.36COX-2-IN-46
<p>COX-2-IN-46 (compound 5m) serves as a potent anti-inflammatory and analgesic agent. It demonstrates a significant inhibitory action on COX-2, with an IC 50 value of 87.74 nM.</p>Formule :C28H19F2N3SCouleur et forme :SolidMasse moléculaire :467.53Imipramine N-oxide
CAS :<p>Imipramine N-oxide is a tricyclic antidepressant (TCA) and imipramine analogue used to treat depression.</p>Formule :C19H24N2ODegré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :296.41Cevimeline hydrochloride hemihydrate
CAS :<p>Cevimeline hydrochloride hemihydrate is a novel muscarinic receptor agonist, used as a candidate therapeutic drug for xerostomia in Sjogren's syndrome.</p>Formule :C20H38Cl2N2O3S2Degré de pureté :97.00%Couleur et forme :SolidMasse moléculaire :489.55TAT-CN21
<p>TatCN21, with an IC 50 of 77 nM, serves as a potent and selective inhibitor peptide of the calcium/calmodulin-dependent protein kinase II (CaMKII), a ubiquitously-expressed multifunctional serine/threonine protein kinase. It is particularly useful in research pertaining to ischemia and neurodegenerative diseases.</p>Formule :C169H303N69O43Couleur et forme :SolidMasse moléculaire :3989.65Methylatropine (nitrate)
CAS :<p>Methylatropine: Muscarinic antagonist, <0.1 nM IC50, atropine derivative, lowers ACh's effect on BP, affects salivation, pupil dilation, heart rate.</p>Formule :C18H26N2O6Couleur et forme :SolidMasse moléculaire :366.414Methoxy-X04
CAS :<p>Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ).</p>Formule :C23H20O3Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :344.4α-Conotoxin EI
CAS :<p>Selective antagonist of neuromuscular nicotinic receptors α1β1γδ</p>Formule :C83H125N27O27S5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2093.37COX-1-IN-2
<p>COX-1-IN-2 (compound 5h) serves as a potent anti-inflammatory and analgesic agent. This compound demonstrates a significant inhibitory effect on COX-1, with an IC 50 value of 38.76 nM.</p>Formule :C29H22FN3OSCouleur et forme :SolidMasse moléculaire :479.57Xenopus orexin B
CAS :<p>Xenopus orexin B, a neuropeptide identified as an endogenous ligand for an orphan G-protein-coupled receptor, acts as a potent agonist of OX2R [1].</p>Formule :C130H219N45O40S2Couleur et forme :SolidMasse moléculaire :3116.54AChE-IN-45
<p>AChE-IN-45 (Compound 14) is an acetylcholinesterase (AChE) inhibitor exhibiting an IC50 value of 11.57±0.45 nM, and it demonstrates both antioxidant and</p>Couleur et forme :Odour SolidLycoramine hydrobromide
CAS :<p>Lycoramine is a natural alkaloid isolated from Lycoris chinensis.</p>Formule :C17H24BrNO3Couleur et forme :SolidMasse moléculaire :370.28AChE-IN-37
<p>AChE-IN-37 (compound A2) is an acetylcholinesterase inhibitor with an inhibitory concentration (IC50) of 0.23 µM.</p>Formule :C21H12ClNO7SCouleur et forme :SolidMasse moléculaire :457.84hAChE/hBuChE-IN-1
<p>hAChE/hBuChE-IN-1 (compound C2) acts as a dual inhibitor of cholinesterases, exhibiting IC50 values of 514 nM for hAChE and 358 nM for hBuChE. It is orally active and capable of enhancing cognitive function and spatial memory.</p>Formule :C30H31FN2O3Couleur et forme :SolidMasse moléculaire :486.577AC1-IN-1
CAS :<p>AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).</p>Formule :C18H18FN5O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :355.37γ-Secretase modulator 10
CAS :<p>γ-Secretase modulator 10 is a novel γ-secretase modulator.</p>Formule :C25H23F3N4O2Couleur et forme :SolidMasse moléculaire :468.48LBG20304
<p>LBG20304 (compound 2s) serves as a ligand for the homologous GluK5 receptor, demonstrating an IC50 of 432 nM and exhibiting over 40-fold selectivity against the GluK1-3 isoforms. At concentrations below 10 μM, LBG20304 shows neither agonistic nor antagonistic effects on heterologous GluK2/5 receptors. However, at concentrations above 10 μM, it displays minimal agonist activity in neuronal slices (rat).</p>Formule :C19H18N4O5Couleur et forme :SolidMasse moléculaire :382.37mGluR3 modulator-1
CAS :<p>1-ethyl-3-morpholin-4-yl tetrahydroisoquinoline: mGluR3 modulator, potential for Parkinson's.</p>Formule :C16H21N3ODegré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :271.36AChE/BuChE-IN-6
<p>AChE/BuChE-IN-6 (Compound 11f) is an inhibitor of AChE and BuChE, with IC50 values of 1.24 and 1.85 μg/mL, respectively. It exhibits strong DPPH radical scavenging activity (IC50 = 3.15 μg/mL). In vivo toxicity studies demonstrate that AChE/BuChE-IN-6 is safe, showing no significant differences in blood and biochemical parameters compared to controls, and no abnormalities in liver and kidney tissues. This compound shows potential for Alzheimer's disease research.</p>Formule :C24H20ClN3O3Couleur et forme :SolidMasse moléculaire :433.887AChE-IN-35
<p>AChE-IN-35 (compound 5g) serves as an acetylcholinesterase inhibitor, exhibiting an inhibitory concentration 50 (IC50) value of 5.88 μM [1].</p>Formule :C20H16N8O5Couleur et forme :SolidMasse moléculaire :448.39Bencycloquidium Bromide
CAS :<p>Bencycloquidium bromide is an M3 muscarinic antagonist that reduces nasal secretion in allergic rhinitis and has high affinity for M3 receptors.</p>Formule :C21H32BrNO2Couleur et forme :SolidMasse moléculaire :410.39GAD65(247-266) epitope TFA
<p>GAD65(247-266) epitope TFA, a T cell epitope derived from islet antigens, exhibits competitive binding to the type I diabetes-associated molecule I-A g7, albeit</p>Formule :C111H174F3N27O29S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2535.99β-Amyloid (33-40)
CAS :<p>β-Amyloid (33-40) is a peptide comprising amino acids 33 to 40 of the beta-amyloid protein.</p>Formule :C32H58N8O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :730.92Fasciculic acid A
CAS :<p>Fasciculic acid A is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.</p>Formule :C36H60O8Couleur et forme :SolidMasse moléculaire :620.868hAChE-IN-5
<p>hAChE-IN-5 (compound 49) is a dual inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE), exhibiting inhibitory potency with</p>Degré de pureté :98%Couleur et forme :Odour SolidKRP-199 sodium
<p>KRP-199 sodium sodium is highly potent and selective for AMPA-R in vitro and exhibits good neuroprotection in vivo.</p>Formule :C22H12F3N5Na2O7Degré de pureté :97.27%Couleur et forme :SoildMasse moléculaire :561.33LY836
<p>LY836 is an orally active, neuroprotective compound that effectively inhibits the PSD95-nNOS association in cortical neurons.</p>Degré de pureté :98%Couleur et forme :Odour Solid5-HT6R antagonist 1
<p>Compound 8 (5-HT6R antagonist 1), a 5-HT6R antagonist (K i : 5 nM), not only demonstrates inhibition of platelet aggregation and excellent metabolic stability</p>Formule :C17H22F2N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.39Cinanserin hydrochloride
CAS :<p>Cinanserin hydrochloride (SQ 10643) is a 5-HT2 receptor blocker (Ki: 41 nM) and SARS-CoV 3C-like protease inhibitor.</p>Formule :C20H25ClN2OSDegré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :376.94COX-2-IN-33
<p>COX-2-IN-33 (compound 5f) is a selective COX-2 inhibitor with an IC50 value of 45.5 nM and exhibits potential as an anti-inflammatory agent.</p>Formule :C20H13ClF3N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :479.8Dehydrodiscretamine chloride
CAS :<p>Dehydrodiscretamine chloride, a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibits IC50 values of 17.8 μM and 118.8 μM,</p>Formule :C19H18ClNO4Couleur et forme :SolidMasse moléculaire :359.8Aceclidine (hydrochloride)
CAS :<p>agonist of muscarinic receptors</p>Formule :C9H16ClNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :205.68(S)-3,4-DCPG
CAS :<p>(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a selective agonist of human metabotropic glutamate receptor 8a (mGluR8a).</p>Formule :C10H9NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :239.18AChE-IN-42
<p>Compound AChE-IN-42, also known as Compound 28, is an acetylcholinesterase (AChE) inhibitor with an inhibition constant (K i) of 0.44 μM [1].</p>Couleur et forme :Odour SolidMAO-B-IN-18
<p>MAO-B-IN-18 is a potent, selective inhibitor of MAO B, demonstrating IC50 values of 52 nM for hMAO B and 14 μM for hMAO A.</p>Formule :C25H22N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.47rac-Desethyl Oxybutynin (hydrochloride)
CAS :<p>rac-Desethyl oxybutynin, active oxybutynin metabolite, binds to mAChRs; K_i values 3.12-16 nM; lowers rat micturition pressure.</p>Formule :C20H28ClNO3Couleur et forme :SolidMasse moléculaire :365.89(Met(O2)35)-Amyloid β-Protein (1-42)
<p>(Met(O2)35)-Amyloid β-Protein (1-42) is a peptide [1] .</p>Formule :C203H311N55O62SCouleur et forme :SolidMasse moléculaire :4546.04LP 12 hydrochloride
CAS :<p>LP 12 hydrochloride is a selective 5-HT7 receptor agonist (Ki=0.13 nM).</p>Formule :C32H40ClN3OCouleur et forme :SolidMasse moléculaire :518.14RuBi-GABA
CAS :<p>Ruthenium-bipyridine-triphenylphosphine caged GABA</p>Formule :C42H39F6N5O2P2RuDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :922.81H-Indole-3-carboxylic acid, 5-[2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propoxy]-2-methyl-1-(4-methylphenyl)-, ethyl ester
CAS :<p>Compound 5936-0108对β-淀粉样蛋白可能具有调节作用。</p>Formule :C26H34N2O7Degré de pureté :99.44%Couleur et forme :SoildMasse moléculaire :486.56β-Amyloid (10-35), amide
CAS :<p>β-Amyloid (10-35), amide, is a chemical compound consisting of 26 amino acids, specifically residues 10-35 of the Aβ peptide.</p>Formule :C133H205N35O36SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2902.33AHN-683
CAS :<p>AHN-683 is a fluorescent ligand. It was used for peripheral-type benzodiazepine receptors.</p>Formule :C42H32FN3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :709.72Anabaseine
CAS :<p>Anabaseine is a broad nicotinic agonist, favoring alpha-7 AChRs in muscle/brain, and weakly stimulates alpha-4 beta-2 nAChRs.</p>Formule :C10H12N2Couleur et forme :SolidMasse moléculaire :160.224-Methoxyphenyl isothiocyanate
CAS :<p>4-Methoxyphenyl isothiocyanate (4-Methylphenyl ITC) is recognized as an antioxidant demonstrating an IC50 of 1.25 mM for scavenging DPPH free radicals. Its antioxidant capacity, as shown by the ORAC test, is 11.7 mM TE, equivalent to the efficacy of 11.7 mmol Trolox under similar conditions. Additionally, it extends the oxidation process in the Briggs–Rauscher reaction by approximately 9180 seconds. The compound also exhibits moderate cholinesterase inhibitory activity, with an inhibition rate of 30.4% for acetylcholinesterase (AChE) and 17.9% for butyrylcholinesterase (BChE). Research suggests 4-Methoxyphenyl isothiocyanate holds promise for applications in antioxidant and neurological disorder studies.</p>Formule :C8H7NOSCouleur et forme :SolidMasse moléculaire :165.21α-Bungarotoxin
CAS :<p>Neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs).</p>Formule :C338H529N97O105S11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7984.141,8-Cineole
CAS :<p>Eucalyptol, a natural monoterpenoid and cyclic ether found in eucalyptus species, effectively controls excessive airway mucus secretion and asthma by inhibiting pro-inflammatory cytokines. It serves as an efficacious treatment for non-purulent sinusitis, reducing inflammation and pain when applied topically, and demonstrating leukemic cell-killing capabilities in vitro.</p>Formule :C10H18ODegré de pureté :97.44% - 97.44%Couleur et forme :SolidMasse moléculaire :154.25LY3027788 hydrochloride
CAS :<p>LY3027788 HCl, potent oral prodrug of LY3020371, targets mGlu2/3 with antidepressant effects.</p>Formule :C25H32ClF2NO11SCouleur et forme :SolidMasse moléculaire :628.03Syk Inhibitor II hydrochloride
CAS :<p>Syk signaling is key in lupus. Syk inhibitors reduce inflammation and sepsis severity in FcgRIIb-/- mice, lowering cytokines and organ damage.</p>Formule :C14H16ClF3N6ODegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :376.77Isograndifoliol
CAS :<p>Isograndifoliol: BChE inhibitor (IC50=0.9μM), weaker AChE inhibitor (IC50=342.9μM), with vasorelaxant and anti-tumor properties.</p>Formule :C19H26O3Couleur et forme :SolidMasse moléculaire :302.41(Met(O)35)-Amyloid β-Protein (1-42)
<p>(Met(O)35)-Amyloid β-Protein (1-42) represents the oxidized form of Methionine 35 in Aβ42, capable of producing an oligomer size distribution akin to that of</p>Formule :C203H311N55O61SCouleur et forme :SolidMasse moléculaire :4530.04LY3027788
CAS :<p>LY3027788, potent oral prodrug of LY3020371, is a strong mGlu2/3 antagonist with notable antidepressant effects.</p>Formule :C25H31F2NO11SCouleur et forme :SolidMasse moléculaire :591.58Coumarinic acid
CAS :<p>Coumarinic acid serves as a brain-penetrating inhibitor of AChE (acetylcholinesterase) and β-amyloid, with applications in anti-Alzheimer's drug research [1].</p>Formule :C9H8O3Couleur et forme :SolidMasse moléculaire :164.16OM99-2 TFA
CAS :<p>OM99-2 TFA, an 8-residue inhibitor of brain memapsin 2, has a Ki of 9.58 nM, showing promise in Alzheimer's research.</p>Formule :C43H65F3N8O16Couleur et forme :SolidMasse moléculaire :1007.028MAO-B-IN-20
<p>MAO-B-IN-20, potent with 0.037 μM IC50, is stable and BBB permeable, useful for Parkinson's research.</p>Formule :C20H18F2N2O2Couleur et forme :SolidMasse moléculaire :356.37COX-2-IN-34
CAS :<p>COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.</p>Formule :C13H11NO4Degré de pureté :98.08%Couleur et forme :SoildMasse moléculaire :245.23DOAM
CAS :<p>DOAM is an antagonist of the 5-HT2 receptor.</p>Formule :C16H27NO2Couleur et forme :SolidMasse moléculaire :265.39mcK6A1
<p>mcK6A1 serves as an inhibitor of amyloid-β (Aβ) aggregation, selectively binding to the 16KLVFFA21 fragment of Aβ42, leading to the formation of an extended β-sheet structure and preventing the formation of Aβ42 oligomers. This compound is valuable for research into Alzheimer's disease and other amyloid-related disorders.</p>Formule :C71H99N17O16Couleur et forme :SolidMasse moléculaire :1446.65TC-2559 difumarate
CAS :<p>TC-2559 difumarate: Oral α4β2 nAChR partial agonist, CNS-selective, EC50 0.18 μM, prefers α4β2 over α2β4/α4β4/α3β4, antinociceptive.</p>Formule :C20H26N2O9Couleur et forme :SolidMasse moléculaire :438.43Orexin B, rat, mouse TFA
<p>Orexin B, rat/mouse TFA, activates OX1-R & OX2-R receptors, influencing food intake, energy, and sleep regulation.</p>Formule :C128H216F3N45O36SCouleur et forme :SolidMasse moléculaire :3050.42Small Cardioactive Peptide B (SCPB)
CAS :<p>SCPB: neurally active peptide, boosts adenylate cyclase in heart/gills, EC50s: 0.1 μM (heart), 1.0 μM (gills).</p>Formule :C52H80N14O11S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1141.41Anti-Amyloid β Antibody (scFv59)
<p>Anti-Amyloid Beta Antibody (scFv59) is a human-derived antibody produced in CHO cells that targets Amyloid-β. For isotype control, please refer to Human IgG1 kappa, Isotype Control.</p>Couleur et forme :Odour LiquidFITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)
<p>FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium) is a FITC-labeled amyloid beta monomer, Alzheimer’s research, drug screening, and biomolecular studies.</p>Formule :C227H330N58O66S2Couleur et forme :SolidMasse moléculaire :4991.53(R)-Citalopram oxalate
CAS :<p>(R)-Citalopram oxalate is a weak selective serotonin reuptake inhibitor (SSRI) that antagonises its S-isomer (escitalopram), anticonvulsant and antidepressant</p>Formule :C22H23FN2O5Degré de pureté :99.76%Couleur et forme :White SolidMasse moléculaire :414.43β-Amyloid (1-43)(human) TFA
<p>β-Amyloid (1-43)(human) TFA exhibits greater aggregation tendencies and heightened toxicity compared to its well-established counterpart, Aβ1-42.</p>Formule :C209H319F3N56O64SCouleur et forme :SolidMasse moléculaire :4729.21(Gln22)-Amyloid β-Protein (1-42)
CAS :<p>(Gln22)-Amyloid β-Protein (1-42), a Dutch mutation (E22Q) variant of β-Amyloid (1-42), demonstrates increased fibrillogenic and pathogenic characteristics [1].</p>Formule :C203H312N56O59SCouleur et forme :SolidMasse moléculaire :4513.05AChE/BChE-IN-20
<p>AChE/BChE-IN-20 (compound 3m) serves as an inhibitor for both acetylcholinesterase (AChE, IC50=34.81 µM) and butyrylcholinesterase (BChE, IC50=20.66 µM). The affinity for the critical enzyme pockets and the favorable interaction profiles were established through molecular docking and kinetics simulation, making it relevant for the study of Alzheimer's disease.</p>Couleur et forme :Odour SolidEndosulfan I
CAS :<p>Endosulfan I is one of the two major stereoisomers of the broad-spectrum insecticide Endosulfan inhibi the GABA/benzodiazepine/picrotoxin complex</p>Formule :C9H6Cl6O3SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :406.935-HT2C agonist-4
CAS :<p>Compound 3i, a 5-HT2C agonist-4, acts as an agonist for the 5-HT2C receptor with an EC50 of 5.7 nM. It is capable of reducing locomotor activity in zebrafish larvae.</p>Formule :C24H25N5OCouleur et forme :SolidMasse moléculaire :399.49Emraclidine
CAS :<p>Emraclidine (CVL-231) is a novel, highly selective allosteric modulator of the muscarinic M4 receptor positive receptor.Cost-effective and quality-assured.</p>Formule :C20H21F3N4ODegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :390.4BACE1-IN-15
<p>BACE1-IN-15 (Compound 72) is a selective β-secretase 1 (BACE-1) inhibitor with oral bioavailability and blood-brain barrier permeability, exhibiting an IC50 value of 121.65 nM, and an IC50 of 480.92 nM for BACE-2. BACE1-IN-15 is applicable for research in the field of Alzheimer's disease.</p>Couleur et forme :Odour Solid5β-Cholanic acid
CAS :<p>5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.</p>Formule :C24H40O2Degré de pureté :98.91% - 99.89%Couleur et forme :SoildMasse moléculaire :360.57NF023 hexasodium
CAS :<p>NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2</p>Formule :C35H26N4Na6O21S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1168.92α-Conotoxin PIA TFA
<p>α-Conotoxin PIA TFA, targeting nicotinic acetylcholine receptor (nAChR) subtypes with α6 and α3 subunits, acts as an antagonist.</p>Formule :C81H126F3N27O27S4Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :2095.3pCPA methyl ester hydrochloride
CAS :<p>pCPA methyl ester HCl inhibits tryptophan hydroxylase, 5-HT synthesis, crosses blood-brain barrier, lowers central 5-HT.</p>Formule :C10H13Cl2NO2Degré de pureté :99.73% - 99.88%Couleur et forme :SolidMasse moléculaire :250.12Calmodulin-Dependent Protein Kinase II 290-309 acetate
<p>Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM).</p>Formule :C105H189N31O26SDegré de pureté :96.7%Couleur et forme :SolidMasse moléculaire :2333.88VU6028418
CAS :<p>VU6028418 is a highly selective, potent, orally active M4mAChR antagonist that acts on hM4 (IC50: 4.1 nM).</p>Couleur et forme :Solidγ-Secretase Modulators
CAS :<p>gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β.</p>Formule :C26H24F3N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :483.484-fluoro MBZP
CAS :<p>4-fluoro MBZP is a novel psychoactive substance in the phenylpiperazine class, utilized for studies on the 5-HT2 receptors in the central nervous system.</p>Formule :C12H17FN2Couleur et forme :SolidMasse moléculaire :208.28AChE-IN-46
<p>AChE-IN-46 (compound 4), a β-cyclocostunolide, functions as an acetylcholinesterase (AChE) inhibitor [1].</p>Formule :C15H22O2Couleur et forme :SolidMasse moléculaire :234.33Guanylyl Imidodiphosphate (lithium salt)
CAS :<p>Guanylyl Imidodiphosphate (lithium salt) is a non-hydrolyzable GTP analog that increases adenylate cyclase activity.</p>Formule :C10H13Li4N6O13P3Couleur et forme :SolidMasse moléculaire :545.93mGluR5 modulator 1
CAS :<p>mGluR5 modulator 1 is a positive modulator for mGluR5, used in schizophrenia and cognitive research.</p>Formule :C18H19ClFN3O2Couleur et forme :SolidMasse moléculaire :363.82MPPG
CAS :<p>MPPG is a selective L-AP4-sensitive receptor antagonist (kD=9.2 μM).</p>Formule :C9H12NO5PCouleur et forme :SolidMasse moléculaire :245.171sabcomeline
CAS :<p>Sabcomeline: potent, selective M1 agonist; boosts cognition; for Alzheimer's study.</p>Formule :C10H15N3OCouleur et forme :SolidMasse moléculaire :193.25β-Amyloid (1-28)
CAS :<p>β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding.</p>Formule :C145H209N41O46Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3262.51Epiboxidine
CAS :<p>Epiboxidine: Potent, selective nAChR agonist; Ki 0.46/1.2 nM for rat/human α4β2; analogous to Epibatidine and ABT 418.</p>Formule :C10H14N2OCouleur et forme :SolidMasse moléculaire :178.23Aβ-IN-8
<p>Aβ-IN-8, also known as compound 7e, is a potent inhibitor of Aβ aggregation [1].</p>Formule :C22H16F3N3O3SCouleur et forme :SolidMasse moléculaire :459.44AZD4694 Precursor
CAS :<p>AZD4694 Precursor used for synthesizing [18F]AZD4694, a high-affinity amyloid-β imaging agent.</p>Formule :C22H25N3O7Couleur et forme :SolidMasse moléculaire :443.454-Chloromethamphetamine hydrochloride
CAS :<p>4-Chloromethamphetamine hydrochloride is a novel psychoactive substance belonging to the amphetamine class.</p>Formule :C10H15Cl2NCouleur et forme :SolidMasse moléculaire :220.14Ro60-0175
CAS :<p>Ro60-0175 is a selective 5-HT2B and 5-HT2C serotonin receptor agonist, often used as fumarate.</p>Formule :C11H12ClFN2Degré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :226.68SB-408124
CAS :<p>SB408124: Non-peptide, OX1 receptor antagonist, Ki 57 nM (whole cell) and 27 nM (membrane), 50x more selective than OX2.</p>Formule :C19H18F2N4ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :356.37CGP 35348
CAS :<p>CGP 35348 是 GABAB 受体的选择性拮抗剂 (EC50 = 34 μM)。 CGP 35348 可用于研究白化新生小鼠脑损伤后的神经肌肉协调和空间学习。</p>Formule :C8H20NO4PDegré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :225.22JF-NP-26
<p>Releases pain-blocking raseglurant under 405 nm light. Inhibits Quisqualate. Analgesic in vivo. Quantum yield: 0.18.</p>Couleur et forme :Solid
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