Neuroscience
Les inhibiteurs en neurosciences sont des composés conçus pour moduler l'activité de protéines, d'enzymes ou de récepteurs spécifiques au sein du système nerveux. Ces inhibiteurs sont cruciaux pour étudier les mécanismes moléculaires sous-jacents au fonctionnement neuronal, à la transmission synaptique et aux maladies neurodégénératives. En ciblant les récepteurs des neurotransmetteurs, les canaux ioniques et les voies de signalisation, les inhibiteurs en neurosciences facilitent l'exploration du fonctionnement cérébral et le développement de stratégies thérapeutiques pour des troubles neurologiques tels que la maladie d'Alzheimer, de Parkinson et l'épilepsie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs en neurosciences de haute qualité pour soutenir vos recherches en neurobiologie, neuropharmacologie et sciences cognitives.
Sous-catégories appartenant à la catégorie "Neuroscience"
- récepteur 5-HT(1.025 produits)
- ACK(1 produits)
- AChR(645 produits)
- ATP Citrate Lyase(17 produits)
- Récepteur adrénergique(3.018 produits)
- BACE(37 produits)
- Bêta-amyloïde(228 produits)
- CaMK(73 produits)
- COX(600 produits)
- Récepteur de la dopamine(445 produits)
- Récepteur GABA(372 produits)
- Gamma-sécrétase(61 produits)
- GluR(265 produits)
- GlyT(26 produits)
- Récepteur de l'histamine(385 produits)
- LRRK2(43 produits)
- Récepteur de la mélatonine(26 produits)
- NMDAR(10 produits)
- Récepteur OX(41 produits)
- Récepteur opioïde(327 produits)
Affichez 12 plus de sous-catégories
5530 produits trouvés pour "Neuroscience"
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5-HT2C agonist-3 free base
CAS :5-HT2C agonist-3 ((+)-19) free base, a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM), exhibits antipsychotic drug-like activity and inhibits Amphetamine-Formule :C19H22FNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :315.38BMS 433796
CAS :BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.Formule :C21H20F2N4O4Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :430.45-HT3-In-1
CAS :5-HT3-In-1 (compound example 8) exhabits with 5-HT3 inhibition activity.Formule :C16H21ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :352.82L-AP4
CAS :L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).Formule :C4H10NO5PDegré de pureté :98%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :183.1Zaldaride (free base)
CAS :Zaldaride (free base) is a calmodulin antagonist.Formule :C26H28N4O2Couleur et forme :SolidMasse moléculaire :428.53RPC425 free base
CAS :RPC425 is a noncompetitive inhibitors of the Betaine-γ-Aminobutyric Acid Transporter 1 (BGT1).Formule :C22H27NO2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.595-HT2A antagonist 1
CAS :5-HT2A antagonist 1, from US5728835A & JP 1007727, may treat gastrointestinal and circulatory issues.Formule :C26H28N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.535-HT2 agonist-1 free base
CAS :Compound 24 (5-HT2 agonist-1 free base) is a potent agonist for 5-HT2A, 5-HT2B, and 5-HT2C receptors, exhibiting IC50 values of 10 nM, 8.3 nM, and 1.6 nM,Formule :C19H22N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :310.39MK-8768
CAS :MK-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the mGluR2 class, exhibiting an IC50 of 9.6 nM and characterized byFormule :C21H22F3N5O2Couleur et forme :SolidMasse moléculaire :433.43Abaperidone
CAS :Abaperidone is an atypical antipsychotic, antagonizes 5-HT2A (IC50=6.2 nM) and D2 receptors (IC50=17 nM), reduces hsp70 mRNA in rat brains.Formule :C25H25FN2O5Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :452.47JM-1232
CAS :JM-1232 is a sedative and hypnotic drug being researched as a potential anesthetic.Formule :C24H27N3O2Couleur et forme :SolidMasse moléculaire :389.49AChE-IN-31
CAS :AChE-IN-31 (compound 1), a non-competitive acetylcholinesterase (AChE) inhibitor, exhibits potential for Alzheimer's disease research [1].Formule :C27H44Na2O9S2Couleur et forme :SolidMasse moléculaire :622.74(±)-N-desmethyl Venlafaxine hydrochloride
CAS :(±)-N-desmethyl Venlafaxine, a minor active metabolite of venlafaxine, serves as a selective norepinephrine and serotonin reuptake inhibitor (SNRI). Generated through the metabolization by the cytochrome P450 (CYP) isoform CYP3A4, it exhibits reuptake inhibition of norepinephrine and serotonin in rat synaptosome preparations, demonstrated by IC50 values of 4.7 and 1.6 µM, respectively. Clinically, it has been shown to counteract reserpine-induced hypothermia in mice, displaying efficacy at a minimum effective dose (MED) of 10 mg/kg.Formule :C16H26ClNO2Couleur et forme :SolidMasse moléculaire :299.84Lanabecestat
CAS :Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.Formule :C26H28N4ODegré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :412.53Flesinoxan
CAS :Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).Formule :C22H26FN3O4Couleur et forme :SolidMasse moléculaire :415.46Wf-516
CAS :Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressantFormule :C25H25Cl2N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :502.39FPPQ
CAS :FPPQ blocks 5-HT3 and 5-HT6 receptors (Ki: 0.9 & 3 nM) and may improve psychosis and cognition.Formule :C21H19FN4O2SCouleur et forme :SolidMasse moléculaire :410.462-Methyl-5-HT
CAS :2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.Formule :C11H14N2ODegré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :190.24Ref: TM-T10075
5mg48,00€10mg84,00€25mg177,00€50mg334,00€100mg500,00€500mg1.099,00€1mL*10mM (DMSO)50,00€MAO-B-IN-27
CAS :MAO-B-IN-27 (Compound 12c), a monoamine oxidase B (MAO-B) inhibitor, exhibits a potent and selective inhibitory effect on hMAO-B, with an IC50 value of 8.9 nM,Formule :C16H17ClF3NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :331.76MAO-IN-3
CAS :MAO-IN-3 (Compound 5), a reversible and competitive monoamine oxidase (MAO) inhibitor with inhibition constants (K i) of 0.6 μM for MAO A and 0.2 μM for MAO B,Formule :C42H54N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :678.9NCS-382 sodium
CAS :NCS-382 (sodium) is a potent antagonist of the GABA receptor, exhibiting anti-sedative and anti-hypnotic properties, with applications in neurological diseaseFormule :C13H13NaO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :240.2313,14-dihydro-15-keto Prostaglandin E2
CAS :13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) serves as the predominant metabolite of PGE2 in plasma, created through a 15-keto PGE2 intermediate by the action of 15-oxo-PG Δ13 reductase. Unlike its precursor PGE2, this compound exhibits poor binding affinity towards EP2 and EP4 PGE2 receptors (Ki values of 12 and 57 µM, respectively) in CHO cells and fails to stimulate adenylate cyclase activity therein (EC50s >18 and >38 µM, respectively). Concentrations of 13,14-dihydro-15-keto PGE2 are notably higher in the plasma of pregnant women during their third trimester and at labor and delivery stages, whereas its levels are found to be reduced in the tumor tissues of patients with non-small cell lung cancer (NSCLC) compared to adjacent healthy tissue.Formule :C20H32O5Couleur et forme :SolidMasse moléculaire :352.52-Aminotetralin
CAS :2-Aminotetralin acts as a neuromodulatory agent by inhibiting serotonin (5-HT) and norepinephrine reuptake in the rat brain at a dose of 39.4 mg/kg. It triggers hypothermia in rats through intracisternal or intraperitoneal injection, while the implantation of crystals in the hypothalamus' medial preoptic area leads to hyperthermia. Additionally, it mimics (+)-amphetamine in a two-lever drug discrimination test among rats in a dose-dependent manner.Formule :C10H13NCouleur et forme :SolidMasse moléculaire :147.2169Flesinoxan HCl
CAS :Flesinoxan HCl is the salt form of Flesinoxan, which is a selective 5-HT1A receptor agonist.Formule :C22H27ClFN3O4Couleur et forme :SolidMasse moléculaire :451.92CP-409092
CAS :CP-409092 is a partial GABAA receptor agonist. It has anti-anxiety activity.Formule :C17H19N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :297.35FK-1052
CAS :FK-1052 is a serotonin 3 & 4 dual receptor antagonist.Formule :C18H19N3OCouleur et forme :SolidMasse moléculaire :293.361-Carboxycyclohexaneacetic Acid
CAS :1-Carboxycyclohexaneacetic acid may be present as a potential impurity in commercial gabapentin, an antiepileptic drug. Furthermore, it serves as a precursor for synthesizing antagonists targeting the serotonin (5-HT) receptor subtype 5-HT2A.Formule :C9H14O4Couleur et forme :SolidMasse moléculaire :186.207TPA 023
CAS :TPA 023 is a selective agonist of GABAA α2/α3 subtype (Kis = 0.19 - 0.41 nM).Formule :C20H22FN7ODegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :395.43Osemozotan Free Base
CAS :Osemozotan Free Base is a 5-HT(1A) receptor agonist.Formule :C19H21NO5Couleur et forme :SolidMasse moléculaire :343.37A-424274
CAS :A-424274 is a positive allosteric modulator of α4β2 neuronal nicotinic receptor.Formule :C14H15N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :225.29L 687306
CAS :L 687306 is a partial agonist of muscarinic M1 receptors. It is also a highly competitive antagonist at cardiac M2 receptors and ileal M3 muscarinic receptors.Formule :C11H15N3OCouleur et forme :SolidMasse moléculaire :205.26PHP 501 trifluoroacetate
CAS :GABAA antagonistFormule :C20H21N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.46,2'-Dihydroxyflavone
CAS :6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor.Formule :C15H10O4Degré de pureté :99.44% - 99.67%Couleur et forme :SolidMasse moléculaire :254.24LY2033298
CAS :LY2033298 enhances oximoline's effect on hamster circadian rhythms, aiding neurosystem disorders.Formule :C13H14ClN3O2SDegré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :311.79AAK1-IN-4
CAS :AAK1-IN-4 selectively inhibits AAK1 with IC50 of 4.6 nM; penetrates CNS, oral bioactive, potential for studying neuropathic pain.Formule :C20H28N4O3Couleur et forme :SolidMasse moléculaire :372.46QM-FN-SO3
CAS :QM-FN-SO3 is a blood-brain barrier (BBB)-penetrable, near-infrared (NIR) probe with aggregation-induced emission (AIE) activity, specifically designed for the detection of Aβ plaques. It exhibits ultra-high signal-to-noise (S/N) ratio, binding affinity, and high-performance NIR emission, making it suitable for in vivo detection of Aβ plaques [1].Formule :C29H25N4NaO3S2Couleur et forme :SolidMasse moléculaire :564.65MAO-B-IN-13
CAS :MAO-B-IN-13: a potent, reversible MAO-B inhibitor with BBB penetration, neuroprotective effects; used in Parkinson’s research (IC50=10nM).Formule :C18H19NO3Couleur et forme :SolidMasse moléculaire :297.35AAK1-IN-2
CAS :AAK1-IN-2, a potent (IC50=5.8 nM) AAK1 inhibitor, selective & brain-penetrant, is used for neuropathic pain studies.Formule :C20H20N4Couleur et forme :SolidMasse moléculaire :316.4P11149
CAS :P11149: oral AChE inhibitor, crosses BBB, IC50 1.3 μM, based on Galanthamine, aims Alzheimer's research.Formule :C27H34ClNO4Couleur et forme :SolidMasse moléculaire :472.02LY320954
CAS :LY320954 is an antagonist of 5-HT2A receptor.Formule :C21H26N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :382.46eeAChE-IN-2
CAS :eeAChE-IN-2 is a potent inhibitor of eeAChE, exhibiting inhibitory potency with an IC50 of 2 nM.Formule :C37H40N8O5SCouleur et forme :SolidMasse moléculaire :708.83NAS-181
CAS :NAS-181 is a potent and selective rat 5-hydroxytryptamine 1B (r5-HT1B) antagonist (Ki: 47 nM).NAS-181 enhances the accumulation of 5-HTP in rat brain regions.Formule :C20H30N2O7SCouleur et forme :SolidMasse moléculaire :442.53N-Demethyl MK-6884
CAS :N-Demethyl MK-6884 (compound 34) is an M4 mAChR modulator for Alzheimer's and related disease research.Formule :C24H23N5OCouleur et forme :SolidMasse moléculaire :397.47Brilaroxazine
CAS :Brilaroxazine (RP5063): multimodal dopamine/5-HT modulator, partial agonist at D2/D3/D4, 5-HT1A/2A, and antagonist at 5-HT2B/7.Formule :C22H25Cl2N3O3Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :450.36Ref: TM-T14782
1mg100,00€5mg236,00€10mg385,00€25mg663,00€50mg954,00€100mg1.305,00€200mg1.738,00€1mL*10mM (DMSO)268,00€JNJ-46281222
CAS :JNJ-46281222: mGlu2-selective, potent PAM, Kd = 1.7 nM, pEC50 = 7.71.Formule :C23H25F3N4Couleur et forme :SolidMasse moléculaire :414.47BMS-983970
CAS :BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.Formule :C26H26F4N4O3Couleur et forme :SolidMasse moléculaire :518.5YM348
CAS :YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).Formule :C14H17N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :243.3PQM130
CAS :PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity.Formule :C23H27NO4Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :381.46BACE1-IN-1
CAS :BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).Formule :C18H14F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.33GABA-IN-2
CAS :GABA-IN-2 (Compound 5), a GABA inhibitor, exhibits both larvicidal and insecticidal properties, achieving an 87% mortality rate at a concentration of 50 mg/L [1Formule :C12H4Cl2F6N4SeCouleur et forme :SolidMasse moléculaire :468.044-Chloro-L-phenylalanine
CAS :4-Chloro-L-phenalanine (L-PCPA) is an inhibitor of 5-HT biosynthesis and a non-specific antagonist of tryptophan hydroxylases (TPH1 and TPH2).Formule :C9H10ClNO2Degré de pureté :99.76% - 99.96%Couleur et forme :SolidMasse moléculaire :199.63GYKI-46903 HCl
CAS :GYKI-46903 is a noncompetitive 5-HT3 receptor antagonist.Formule :C17H21ClFNO2Couleur et forme :SolidMasse moléculaire :325.81MAO-B-IN-1
CAS :MAO-B-IN-1 is a monoamine oxidase B inhibitor and can be used for the research of neurological diseases.Formule :C16H14F3N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.36Timepidium bromide
CAS :Timepidium bromide is an agent of anticholinergic.Formule :C17H22BrNOS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.4(-)-Bicuculline methochloride
CAS :(-)-Bicuculline methochloride is a potent antagonist of GABAA receptor.
Formule :C21H20ClNO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.84AMG-8718
CAS :AMG-8718, an oral BACE1 blocker (IC50: 0.0007 μM), also inhibits BACE2 (IC50: 0.005 μM), lowering CSF and Aβ40 brain levels.Formule :C25H19FN4O3Couleur et forme :SolidMasse moléculaire :442.44NAS181
CAS :rat 5-HT1B receptor antagonistFormule :C21H34N2O10S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.63PZ-II-029
CAS :PZ-II-029 is a modulator of α6β3γ2-selective GABAA channel.Formule :C18H15N3O3Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :321.33Ref: TM-T28479
1mg50,00€5mg105,00€10mg167,00€25mg289,00€50mg447,00€100mg685,00€500mg1.378,00€1mL*10mM (DMSO)192,00€Facinicline hydrochloride
CAS :Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM).Formule :C15H19ClN4ODegré de pureté :98.70%Couleur et forme :SolidMasse moléculaire :306.79VU6005649
CAS :VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).Formule :C16H12F5N3ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :357.28Nemonapride
CAS :Nemonapride is a dopamine D2-like receptor antagonist.Formule :C21H26ClN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.9UNC9994 hydrochloride
CAS :UNC9994 hydrochloride is a selective β-arrestin-biased D2R agonist, Ki of 79 nM, that stimulates β-arrestin and modulates cAMP.Formule :C21H23Cl3N2OSCouleur et forme :SolidMasse moléculaire :457.84L 663581
CAS :L 663581 is the benzodiazepine receptor partial agonist.Formule :C17H16ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.79Muscarine tosylate
CAS :Muscarine ((+)-Muscarine) tosylate, a prototype mAChR agonist, serves as a parasympathetic nervous system stimulant and is recognized for its toxic properties [1] [2].Formule :C16H27NO5SCouleur et forme :SolidMasse moléculaire :345.45Befiradol
CAS :Befiradol (NLX-112) is an agonist of 5-HT1A receptor.Formule :C20H22ClF2N3OCouleur et forme :SolidMasse moléculaire :393.86Dothiepin
CAS :Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancingFormule :C19H21NSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.44ABT-418 hydrochloride
CAS :ABT-418 HCl enhances cognition and reduces anxiety as a selective nAChRs agonist, researched for Alzheimer's.Formule :C9H15ClN2OCouleur et forme :SolidMasse moléculaire :202.68LY-426965
CAS :LY-426965 is a selective, potent, orally bioavailable 5-HT1A antagonist.Formule :C28H38N2O2Couleur et forme :SolidMasse moléculaire :434.61SB 258719
CAS :SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.Formule :C18H30N2O2SDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :338.51Ref: TM-T12855
2mg34,00€5mg52,00€10mg85,00€25mg155,00€50mg240,00€100mg355,00€200mg502,00€1mL*10mM (DMSO)58,00€mGAT3/4-IN-2
CAS :mGAT3/4-IN-2 are potent inhibitors of mGAT3/mGAT4 with their pIC50 values of 5.44 and 5.25, respectively.Formule :C26H32ClN3OS2Couleur et forme :SolidMasse moléculaire :502.13Tiotropium Bromide hydrate
CAS :Tiotropium Bromide hydrate is a potent, long-lasting anticholinergic bronchodilator for COPD, with high affinity for muscarinic receptors M1, M2, and M3.Formule :C19H24BrNO5S2Degré de pureté :98.44% - 99.41%Couleur et forme :SolidMasse moléculaire :490.43VU0360172
CAS :VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).Formule :C18H15FN2ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :294.32NAD 299 hydrochloride
CAS :Selective, high affinity 5-HT1A receptor antagonistFormule :C18H24ClFN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.85GR 127935 hydrochloride
CAS :5-HT1B/1D receptor antagonistFormule :C29H32ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.05RAGE/SERT-IN-1
CAS :RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM andFormule :C38H41ClN4OSCouleur et forme :SolidMasse moléculaire :637.285-HT2 agonist-1
CAS :Compound 24, a 5-HT2 agonist-1, selectively activates 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively.Formule :C19H23ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :346.85Frovatriptan
CAS :Frovatriptan, potent 5-HT 1B/D agonist, shows high cerebroselectivity and efficacy for migraine with aura.Formule :C14H17N3ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :243.3VU6007477
CAS :VU6007477 is a brain-penetrant M1 muscarinic receptor PAM (EC50 230 nM) used for research on CNS exposure and seizure-related models.Formule :C24H26N6O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :430.5SB 649915
CAS :SB 649915 is a serotonin reuptake inhibitor and 5-HT1A and 5-HT1B receptor antagonist.Formule :C26H29N3O3Couleur et forme :SolidMasse moléculaire :431.53Biphenylindanone A
CAS :Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.Formule :C30H30O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.565-HT2C agonist-3
CAS :5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC 50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-inducedFormule :C19H23ClFNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.84MRK-560
CAS :MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.Formule :C19H17ClF5NO4S2Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :517.92(S)-Bexicaserin
CAS :(S)-Bexcaserin (compound 2) serves as a 5-HT2C receptor agonist, presenting research possibilities in obesity and psychiatric disorders [1].Formule :C15H19F2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.335-HT2A receptor agonist-3
CAS :5-HT2A receptor agonist-3 represents the highest selectivity for the human 5-HT2A receptor currently identified, exhibiting a K i of 2.5 nM.Formule :C21H26BrNO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.34Indeloxazine hydrochloride
CAS :Indeloxazine HCl: Serotonin releaser, NE reuptake inhibitor, NMDA antagonist; antidepressant that boosts acetylcholine in rats.Formule :C14H18ClNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.75BACE1-IN-13
CAS :BACE1-IN-13 (Compound 36), an orally active inhibitor of BACE1, exhibits high potency with an IC50 of 2.9 nM and demonstrates greater efficacy in hAβ42 cells (Formule :C20H17FN8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.45-HT2A&5-HT2C agonist-1
CAS :5-HT2A&5-HT2C agonist-1 (Example 2) is a dual-acting agent targeting the 5-HT2A and 5-HT2C receptors with respective IC50 values of 196 nM and 0.9 nM.Formule :C14H20N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :232.32Octahydroaminoacridine succinate
CAS :Octahydroaminoacridine succinate, an acetylcholinesterase inhibitor, is used potentially for the treatment of Alzheimer's disease.Formule :C17H24N2O4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :320.38AAK1-IN-3
CAS :AAK1-IN-3: Brain-penetrant AAK1 inhibitor for neuropathic pain research; IC50=11 nM.Formule :C20H20N4Couleur et forme :SolidMasse moléculaire :316.4BMT-124110
CAS :BMT-124110: AAK1 inhibitor, IC50=0.9 nM, pain relief. BMT-090605: BIKE inhibitor, IC50=17 nM; GAK inhibitor, IC50=99 nM.Formule :C21H27N3O3Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :369.46VU0029251
CAS :VU0029251 serves as a partial antagonist of mGluR5, exhibiting a binding affinity with a K i of 1.07 μM.Formule :C10H11N3S2Couleur et forme :SolidMasse moléculaire :237.34FPTQ
CAS :FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].Formule :C17H12FN5Degré de pureté :99.68% - 99.88%Couleur et forme :SolidMasse moléculaire :305.31Ref: TM-T5509
1mg52,00€2mg70,00€5mg105,00€10mg152,00€25mg294,00€50mg398,00€100mg527,00€500mgÀ demander1mL*10mM (DMSO)110,00€NO-711ME
CAS :NO-711ME (N-O711 Methyl ester) is a prodrug of NO-711. It also is a potent and selective GABA uptake inhibitor.Formule :C22H24N2O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :364.44Ref: TM-T24540
1mg64,00€5mg129,00€10mg188,00€25mg299,00€50mg427,00€100mg575,00€200mg767,00€1mL*10mM (DMSO)138,00€COR659
CAS :COR659: suppresses alcohol/chocolate intake in rats; enhances GABAB receptor, blocks CB1 receptor.Formule :C16H16ClNO3SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :337.82Ref: TM-T36520
1mg38,00€5mg86,00€10mg123,00€25mg215,00€50mg299,00€100mg411,00€200mg560,00€1mL*10mM (DMSO)94,00€U 89843A
CAS :U 89843A is a positive allosteric modulator of gamma-aminobutyric acid (GABA)A receptors.Formule :C16H23N5Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :285.39rTRD01
CAS :rTRD01 is a TDP-43 ligand that selectively binds to the RRM1 and RRM2 domains of TDP-43, exhibiting a dissociation constant (Kd) of 89 µM for TDP-43 102–269.Formule :C18H21FN4O2Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :344.38(1R,4R)-N-desmethyl Sertraline hydrochloride
CAS :"(1R,4R)-N-desmethyl Sertraline, a metabolite of the selective serotonin reuptake inhibitor (SSRI) sertraline, plays a key role in its pharmacological effects."Formule :C16H15Cl2NHClCouleur et forme :SolidMasse moléculaire :328.66Zamifenacin fumarate
CAS :Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor.Formule :C31H33NO7Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :531.6Ref: TM-T13385
2mg34,00€5mg50,00€10mg75,00€25mg128,00€50mg200,00€100mg304,00€200mg424,00€1mL*10mM (DMSO)58,00€NAS-181 free base
CAS :NAS-181 free base is a 5-HT(1B) receptor antagonist.Formule :C19H26N2O4Couleur et forme :SolidMasse moléculaire :346.42Tolterodine Dimer
CAS :Tolterodine Dimer is a derivative of Tolterodine -- a muscarinic receptor antagonist that is used to treat patients with overactive bladder.Formule :C35H41NO2Couleur et forme :SolidMasse moléculaire :507.71
