Protéasome
Les inhibiteurs du protéasome sont des composés qui inhibent le protéasome, un grand complexe protéique responsable de la dégradation des protéines indésirables ou endommagées dans la cellule. L'inhibition du protéasome conduit à l'accumulation de protéines, ce qui peut induire l'arrêt du cycle cellulaire et l'apoptose, en particulier dans les cellules à division rapide comme les cellules cancéreuses. Les inhibiteurs du protéasome sont essentiels dans la recherche sur le cancer et la thérapie, en particulier dans le traitement du myélome multiple et d'autres hémopathies malignes. Chez CymitQuimica, nous proposons des inhibiteurs du protéasome pour soutenir vos recherches en oncologie, biologie cellulaire et développement de médicaments.
94 produits trouvés pour "Protéasome"
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Trelagliptin
CAS :<p>Trelagliptin (SYR-472) is a highly specific and long-acting DPP-4 inhibitor.</p>Formule :C18H20FN5O2Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :357.38RA190
CAS :<p>RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.</p>Formule :C28H23Cl5N2O2Degré de pureté :97.7%Couleur et forme :SolidMasse moléculaire :596.76Gabexate mesylate
CAS :<p>Gabexate mesylate (FOY) inhibits thrombin, plasmin, kallikrein; used for pancreatitis, DIC, hemodialysis anticoagulant.</p>Formule :C17H27N3O7SDegré de pureté :99.2% - 99.64%Couleur et forme :White CrystalMasse moléculaire :417.48Saxagliptin hydrate
CAS :<p>Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).</p>Formule :C18H25N3O2·H2ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :333.43Arimoclomol maleate
CAS :<p>Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.</p>Formule :C18H24ClN3O7Degré de pureté :99.44% - 99.98%Couleur et forme :SolidMasse moléculaire :429.85UT-34
CAS :<p>UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild</p>Formule :C15H12F4N4O2Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :356.27RAMB4
CAS :<p>RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.</p>Formule :C19H13Cl4NODegré de pureté :98.89% - 99.38%Couleur et forme :SolidMasse moléculaire :413.12Sitagliptin
CAS :<p>Sitagliptin (MK0431), an oral DPP-4 inhibitor, treats type 2 diabetes alone or with metformin/thiazolidinedione by increasing incretins and insulin.</p>Formule :C16H15F6N5ODegré de pureté :99.33% - 99.83%Couleur et forme :Yellow GreaseMasse moléculaire :407.31Gly-Pro-pNA hydrochloride
CAS :<p>Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase</p>Formule :C13H17ClN4O4Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :328.75ML604440
CAS :ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.Formule :C17H24BF3N2O4Degré de pureté :97.06%Couleur et forme :SolidMasse moléculaire :388.19Pepstatin
CAS :<p>Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.</p>Formule :C34H63N5O9Degré de pureté :96.74% - 99.94%Couleur et forme :SolidMasse moléculaire :685.89DBPR108
CAS :<p>DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.</p>Formule :C16H25FN4O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :324.39Proteasome-IN-7
<p>Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.</p>Formule :C48H56N6O10SCouleur et forme :SolidMasse moléculaire :909.06Acetyl-Calpastatin(184-210)(human)
CAS :<p>Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.</p>Formule :C142H230N36O44SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3177.65LMP7/LMP2-IN-1
CAS :<p>LMP7/LMP2-IN-1 (Compound 19) is an orally effective inhibitor targeting the immunoproteasome subunits LMP7 and LMP2, with respective IC50 values of 257 and 10 nM. This compound reduces the production of antibodies and downregulates the B cells in the germinal centers of the spleen and plasma cells in NP-OVA immunized mice. It has potential applications in the study of autoimmune diseases.</p>Formule :C16H27BN4O3Couleur et forme :SoildMasse moléculaire :334.22Procizumab
<p>Procizumab is a humanized IgG1 antibody that targets dipeptidyl peptidase 3 (DPP3). It shows potential for investigating sepsis. For the isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidDazcapistat
CAS :<p>Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.</p>Formule :C21H18FN3O4Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :395.38Phepropeptin C
CAS :<p>Phepropeptin C is a microbial secondary metabolite that acts as a proteasome (proteasome) inhibitor, with an IC50 of 12.5 μg/mL.</p>Formule :C38H60N6O6Couleur et forme :SolidMasse moléculaire :696.92VAMP
<p>VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.</p>Formule :C18H32N4O5SCouleur et forme :SolidMasse moléculaire :416.535Phepropeptin B
CAS :<p>Phepropeptin B is a secondary metabolite derived from microorganisms, functioning as a proteasome (proteasome) inhibitor with an IC50 value of 11 μg/mL.</p>Formule :C40H56N6O6Couleur et forme :SolidMasse moléculaire :716.91Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Couleur et forme :Odour SolidLXE408 fumarate
<p>LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.</p>Formule :C27H22FN7O6Degré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :559.51PROTAC 20S proteasome subunit β5 degrader 2
<p>PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader targeting the 20S proteasome subunit β5 (20Sproteasomesubunit β5), with a DC50 of 0.16 μM. It inhibits the proliferation of FaDu cancer cells, showcasing an IC50 of 0.23 μM. Additionally, PROTAC20Sproteasomesubunit β5 degrader 2 demonstrates antitumor activity in a mouse model.</p>Couleur et forme :Odour Solidβ5i-IN-1
<p>β5i-IN-1 is a selective inhibitor of β5i, exhibiting potent activity with an IC50 of 8.463 nM.</p>Degré de pureté :98%Couleur et forme :Odour SolidPhepropeptin D
CAS :<p>Phepropeptin D is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 7.8 μg/mL.</p>Formule :C41H58N6O6Couleur et forme :SolidMasse moléculaire :730.94Bortezomib analog
<p>Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.</p>Couleur et forme :Odour SolidDPP-4-IN-14
<p>DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.</p>Formule :C33H27N7O3Couleur et forme :SolidMasse moléculaire :569.613DPP8/9-IN-1
<p>DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.</p>Couleur et forme :Odour SolidPhepropeptin A
CAS :<p>Phepropeptin A is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 21 μg/mL.</p>Formule :C37H58N6O6Couleur et forme :SolidMasse moléculaire :682.89Cerpegin
CAS :<p>Cerpegin, a pyridine ketone fused c-lactone, acts as an inhibitor of the 20S proteasome. It possesses pharmacological properties as a neuropsychiatric sedative, anti-inflammatory, analgesic, and exhibits anti-ulcer activity.</p>Formule :C10H11NO3Couleur et forme :SolidMasse moléculaire :193.2Acetyl-Calpastatin(184-210)(human) TFA
<p>Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.</p>Formule :C144H231F3N36O46SCouleur et forme :SolidMasse moléculaire :3291.65H-Pro-Lys-OH TFA
<p>H-Pro-Lys-OH TFA is a dipeptide composed of proline and lysine, serving as a substrate for imino dipeptidase (prolinase). Additionally, it can be utilized in peptide synthesis.</p>Formule :C13H22F3N3O5Couleur et forme :SolidMasse moléculaire :357.33Alogliptin (13CD3)
CAS :<p>Alogliptin (SYR-322) 13CD3 is the deuterium-labeled Alogliptin. Alogliptin is a selective inhibitor of DPP-4.</p>Formule :C18H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :343.4Teneligliptin D8
CAS :<p>Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.</p>Formule :C22H30N6OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.635-Amino-8-hydroxyquinoline
CAS :<p>5-Amino-8-hydroxyquinoline(5A8HQ),Proteasome inhibitor. Potential anticancer agent.</p>Formule :C9H8N2ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :160.17Brensocatib
CAS :<p>Brensocatib (AZD7986) is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 in human, rat, mouse, rabbit, and dog, respectively).</p>Formule :C23H24N4O4Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :420.4618α-Glycyrrhetinic acid
CAS :<p>18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.</p>Formule :C30H46O4Degré de pureté :98.54% - 99.68%Couleur et forme :SolidMasse moléculaire :470.68TCH-165
CAS :<p>TCH-165 boosts 20S proteasome levels, enhancing IDP breakdown.</p>Formule :C39H37N3O3Degré de pureté :98.2% - 98.75%Couleur et forme :SolidMasse moléculaire :595.73Ixazomib citrate
CAS :<p>Ixazomib citrate (MLN9708), a prodrug of Ixazomib (MMLN-2238), is an oral 2nd-gen proteasome inhibitor with anti-cancer potential (IC50: 3.4 nM).</p>Formule :C20H23BCl2N2O9Degré de pureté :98.37% - >99.99%Couleur et forme :SolidMasse moléculaire :517.12MG-132
CAS :<p>MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!</p>Formule :C26H41N3O5Degré de pureté :95% - 99.99%Couleur et forme :White To Off-White PowderMasse moléculaire :475.62Alloxan monohydrate
CAS :<p>Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.</p>Formule :C4H4N2O5Degré de pureté :99.01% - 99.42%Couleur et forme :Off-White To Beige-Yellowish Crystalline PowderMasse moléculaire :160.09ARV-471
CAS :<p>ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.</p>Formule :C45H49N5O4Degré de pureté :97.15% - >99.99%Couleur et forme :SolidMasse moléculaire :723.9Omarigliptin
CAS :<p>Omarigliptin is a potent and selective oral dipeptidyl peptidase 4 (DPP4) inhibitor with IC50 value of 1.6 nM. Cost-effective and quality-assured.</p>Formule :C17H20F2N4O3SDegré de pureté :99.68% - 99.77%Couleur et forme :SolidMasse moléculaire :398.43Calpeptin
CAS :<p>Calpeptin is a potent, cell-permeable calpain inhibitor.</p>Formule :C20H30N2O4Degré de pureté :97.06% - 98.33%Couleur et forme :White To Off-White PowderMasse moléculaire :362.46Talabostat mesylate
CAS :<p>Talabostat mesylate (PT100): Oral DPP4 inhibitor, IC50 0.18 nM, targets tumor-linked proteins, boosts hematopoiesis.</p>Formule :C10H23BN2O6SDegré de pureté :98% - 99.91%Couleur et forme :SolidMasse moléculaire :310.18PI-1840
CAS :<p>PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.</p>Formule :C22H26N4O3Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :394.474'-Hydroxychalcone
CAS :<p>4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity</p>Formule :C15H12O2Degré de pureté :99.86% - 99.87%Couleur et forme :Yellow-Cream PowderMasse moléculaire :224.25ONX-0914
CAS :<p>ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.</p>Formule :C31H40N4O7Degré de pureté :98.24% - 99.31%Couleur et forme :SolidMasse moléculaire :580.67Bortezomib
CAS :<p>Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.</p>Formule :C19H25BN4O4Degré de pureté :97.79% - >99.99%Couleur et forme :Yellow SolidMasse moléculaire :384.24Epoxomicin
CAS :<p>Epoxomicin, a selective proteasome inhibitor, chiefly blocks CH-L activity, mildly affecting T-L and PGPH at lower rates.</p>Formule :C28H50N4O7Degré de pureté :98.65% - 98.86%Couleur et forme :White To Off-White SolidMasse moléculaire :554.72
