Protéasome
Les inhibiteurs du protéasome sont des composés qui inhibent le protéasome, un grand complexe protéique responsable de la dégradation des protéines indésirables ou endommagées dans la cellule. L'inhibition du protéasome conduit à l'accumulation de protéines, ce qui peut induire l'arrêt du cycle cellulaire et l'apoptose, en particulier dans les cellules à division rapide comme les cellules cancéreuses. Les inhibiteurs du protéasome sont essentiels dans la recherche sur le cancer et la thérapie, en particulier dans le traitement du myélome multiple et d'autres hémopathies malignes. Chez CymitQuimica, nous proposons des inhibiteurs du protéasome pour soutenir vos recherches en oncologie, biologie cellulaire et développement de médicaments.
94 produits trouvés pour "Protéasome"
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LXE408 fumarate
<p>LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.</p>Formule :C27H22FN7O6Degré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :559.51Acetyl-Calpastatin(184-210)(human) TFA
<p>Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.</p>Formule :C144H231F3N36O46SCouleur et forme :SolidMasse moléculaire :3291.65Phepropeptin C
CAS :<p>Phepropeptin C is a microbial secondary metabolite that acts as a proteasome (proteasome) inhibitor, with an IC50 of 12.5 μg/mL.</p>Formule :C38H60N6O6Couleur et forme :SolidMasse moléculaire :696.92DPP8/9-IN-1
<p>DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.</p>Couleur et forme :Odour SolidProtease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Couleur et forme :Odour SolidCerpegin
CAS :<p>Cerpegin, a pyridine ketone fused c-lactone, acts as an inhibitor of the 20S proteasome. It possesses pharmacological properties as a neuropsychiatric sedative, anti-inflammatory, analgesic, and exhibits anti-ulcer activity.</p>Formule :C10H11NO3Couleur et forme :SolidMasse moléculaire :193.2VAMP
<p>VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.</p>Formule :C18H32N4O5SCouleur et forme :SolidMasse moléculaire :416.535DPP-4-IN-14
<p>DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.</p>Formule :C33H27N7O3Couleur et forme :SolidMasse moléculaire :569.613LMP7/LMP2-IN-1
CAS :<p>LMP7/LMP2-IN-1 (Compound 19) is an orally effective inhibitor targeting the immunoproteasome subunits LMP7 and LMP2, with respective IC50 values of 257 and 10 nM. This compound reduces the production of antibodies and downregulates the B cells in the germinal centers of the spleen and plasma cells in NP-OVA immunized mice. It has potential applications in the study of autoimmune diseases.</p>Formule :C16H27BN4O3Couleur et forme :SoildMasse moléculaire :334.22Dazcapistat
CAS :<p>Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.</p>Formule :C21H18FN3O4Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :395.38Phepropeptin A
CAS :<p>Phepropeptin A is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 21 μg/mL.</p>Formule :C37H58N6O6Couleur et forme :SolidMasse moléculaire :682.895-Amino-8-hydroxyquinoline
CAS :<p>5-Amino-8-hydroxyquinoline(5A8HQ),Proteasome inhibitor. Potential anticancer agent.</p>Formule :C9H8N2ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :160.17Teneligliptin D8
CAS :<p>Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.</p>Formule :C22H30N6OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.63H-Pro-Lys-OH TFA
<p>H-Pro-Lys-OH TFA is a dipeptide composed of proline and lysine, serving as a substrate for imino dipeptidase (prolinase). Additionally, it can be utilized in peptide synthesis.</p>Formule :C13H22F3N3O5Couleur et forme :SolidMasse moléculaire :357.33Alogliptin (13CD3)
CAS :<p>Alogliptin (SYR-322) 13CD3 is the deuterium-labeled Alogliptin. Alogliptin is a selective inhibitor of DPP-4.</p>Formule :C18H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :343.44'-Hydroxychalcone
CAS :<p>4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity</p>Formule :C15H12O2Degré de pureté :99.86% - 99.87%Couleur et forme :Yellow-Cream PowderMasse moléculaire :224.25MG-132
CAS :<p>MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!</p>Formule :C26H41N3O5Degré de pureté :95% - 99.99%Couleur et forme :White To Off-White PowderMasse moléculaire :475.62Calpeptin
CAS :<p>Calpeptin is a potent, cell-permeable calpain inhibitor.</p>Formule :C20H30N2O4Degré de pureté :97.06% - 98.33%Couleur et forme :White To Off-White PowderMasse moléculaire :362.46Omarigliptin
CAS :<p>Omarigliptin is a potent and selective oral dipeptidyl peptidase 4 (DPP4) inhibitor with IC50 value of 1.6 nM. Cost-effective and quality-assured.</p>Formule :C17H20F2N4O3SDegré de pureté :99.68% - 99.77%Couleur et forme :SolidMasse moléculaire :398.43Ixazomib citrate
CAS :<p>Ixazomib citrate (MLN9708), a prodrug of Ixazomib (MMLN-2238), is an oral 2nd-gen proteasome inhibitor with anti-cancer potential (IC50: 3.4 nM).</p>Formule :C20H23BCl2N2O9Degré de pureté :98.37% - >99.99%Couleur et forme :SolidMasse moléculaire :517.12
