Cystéine protéase
Les inhibiteurs de protéases à cystéine sont des composés qui ciblent et inhibent les protéases à cystéine, une classe d'enzymes qui décomposent les protéines en clivant les liaisons peptidiques dans lesquelles un résidu de cystéine agit comme nucléophile. Ces enzymes sont impliquées dans divers processus physiologiques, tels que l'apoptose, la réponse immunitaire et le renouvellement des protéines. Les inhibiteurs de protéases à cystéine sont essentiels pour l'étude de maladies telles que le cancer, les troubles neurodégénératifs et les infections parasitaires. Chez CymitQuimica, nous fournissons des inhibiteurs de protéases à cystéine pour soutenir vos recherches en protéolyse, régulation cellulaire et découverte de médicaments.
143 produits trouvés pour "Cystéine protéase".
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PMSF
CAS :PMSF (Phenylmethylsulfonyl fluoride) is an irreversible inhibitor of serine/cysteine protease , preparation of cell lysates. High-Quality, Low-Cost!Formule :C7H7FO2SDegré de pureté :97.75% - 99.88%Couleur et forme :White SolidMasse moléculaire :174.193N-CBZ-Phe-Arg-AMC
CAS :Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.Formule :C33H37ClN6O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :649.136Cathepsin D/E Substrate, Fluorogenic
CathepsinD/E Substrate, Fluorogenic, is an 11-amino acid peptide specifically designed as a substrate for cathepsins D and E, demonstrating selectivity by not acting as a substrate for cathepsins B, H, or L.Formule :C83H119N21O18Couleur et forme :SolidMasse moléculaire :1697.9042Z-Phe-Tyr(tBu)-diazomethylketone
CAS :Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.Formule :C31H34N4O5Couleur et forme :SolidMasse moléculaire :542.636RO5461111
CAS :RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.Formule :C27H24F6N4O4SCouleur et forme :SolidMasse moléculaire :614.56FGA139
FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.Formule :C48H58BF2N7O5Couleur et forme :SolidMasse moléculaire :861.456056,6′-Dihydroxythiobinupharidine
CAS :6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-foldFormule :C30H42N2O4SCouleur et forme :SolidMasse moléculaire :526.73Leupeptin
CAS :Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.Formule :C20H38N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.562FGA146
FGA146 is a selective inhibitor of Mpro and human Cathepsin L, with Ki values of 2.19 μM for Mal-Mpro, 0.96 μM for pET21-Mpro, and 0.87 μM for Cathepsin L. It exhibits antiviral activity against SARS-CoV-2.Formule :C24H31N5O6Masse moléculaire :485.22743CTSL/CAPN1-IN-1
CTSL/CAPN1-IN-1 (compound 14a) is an orally active inhibitor targeting CTSL and CAPN1, with IC50 values of 3.34 nM and 375.1 nM, respectively. It exhibits both anti-coronavirus and anti-inflammatory activities.Formule :C34H33FN4O6Couleur et forme :SolidMasse moléculaire :612.23841Cathepsin L-IN-3 TFA
CathepsinL-IN-3 (Compound cat L inh. 7) TFA is a selective, non-covalent inhibitor of cathepsin L, with a Ki value of 4.3 nM.Acetyl-Calpastatin (184-210)(human) acetate
Acetyl-Calpastatin acetate inhibits µ-calpain (Ki=0.2nM) and cathepsin L (Ki=6μM) selectively and reversibly.Formule :C144H234N36O46SDegré de pureté :98.16% - 99.05%Couleur et forme :SolidMasse moléculaire :3237.68FGA145
FGA145 is a dual inhibitor of Mpro and human Cathepsin L, with Ki values of 3.71 μM for Mal-Mpro, 9.82 μM for pET21-Mpro, and 53 nM for Cathepsin L. Additionally, FGA145 exhibits multi-target antiviral activity.Formule :C23H30N4O5Masse moléculaire :442.22162Protease Inhibitor Library
A unique collection of xnum protease and proteasome inhibitors for research in chemical genomics, and drug screening;Couleur et forme :Odour SolidZ-L(D-Val)G-CHN2
Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase.Formule :C22H31N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.51N-CBZ-Phe-Arg-AMC TFA
N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.Formule :C35H37F3N6O8Degré de pureté :99.88%Couleur et forme :White SolidMasse moléculaire :726.7SARS-CoV-2-IN-77
SARS-CoV-2-IN-77 (compound 11e) is an inhibitor of cathepsin L and cathepsin S, with Ki values of 111 nM and 103 nM, respectively. It effectively inhibits SARS-CoV-2 in Calu-3 cells with an EC50 value of 38.4 nM and does not exhibit cytotoxicity.Formule :C23H25Cl2N3O3Masse moléculaire :461.1273Cathepsin C-IN-6
Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastaseFormule :C24H35N5O4·xC2HF3O2Couleur et forme :SolidSmCB1-IN-1
SmCB1-IN-1 (Compound 2h) is an inhibitor of the Schistosoma mansoni cathepsin B1 (SmCB1) with a Ki of 0.05 μM. It demonstrates selectivity towards non-target human proteases, showing inhibition rates of 29% for CatB and 37% for CatL at 20 μM. At 1 μM, SmCB1-IN-1 inhibits 68% of Schistosoma mansoni.Formule :C26H25NO6SCouleur et forme :SolidMasse moléculaire :479.14026Relacatib
CAS :Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.Formule :C27H32N4O6SCouleur et forme :SolidMasse moléculaire :540.631
