Glutaminase
Les inhibiteurs de la glutaminase sont des composés qui inhibent la glutaminase, une enzyme qui catalyse la conversion de la glutamine en glutamate, une étape cruciale dans le métabolisme cellulaire, en particulier dans les cellules cancéreuses. La glutaminase joue un rôle clé dans l'apport d'énergie et de précurseurs biosynthétiques pour les cellules en prolifération rapide. Les inhibiteurs de la glutaminase sont essentiels pour explorer les dépendances métaboliques des cellules cancéreuses et développer des stratégies thérapeutiques potentielles. Chez CymitQuimica, nous fournissons des inhibiteurs de la glutaminase pour soutenir vos recherches en métabolisme du cancer, bioénergétique cellulaire et découverte thérapeutique.
44 produits trouvés pour "Glutaminase"
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BJJF078
CAS :BJJF078, an aminopiperidine, inhibits human/mouse TG2 (IC50: 41/54 nM) and TG1 (IC50: 0.16 μM), may be used in MS studies.Formule :C27H29N3O6SDegré de pureté :99.56%Couleur et forme :SoildMasse moléculaire :523.6LDN-27219
CAS :LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.Formule :C20H16N4O2S2Degré de pureté :99.01% - 99.38%Couleur et forme :SolidMasse moléculaire :408.5Ref: TM-T11831
1mg35,00€5mg66,00€10mg92,00€25mg160,00€50mg234,00€100mg351,00€200mg515,00€1mL*10mM (DMSO)71,00€Glutaminase C-IN-2
Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), exhibits potent inhibitory activity with an IC50 of 10.64 nM.
Formule :C24H23N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.55LM11
LM11 is a transglutaminase 2 (TG2) inhibitor that exhibits activity against glioblastoma cells by maintaining TG2 in a cytotoxic conformational state.
Formule :C26H18Cl2N4O5Masse moléculaire :536.06543PROTAC TG2 degrader-1
PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 μM.Formule :C55H73N9O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1052.29Trivalent hydroxyarsinothricn
Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.Formule :C4H10AsNO4Masse moléculaire :210.98258HB-2-30
CAS :HB-2-30 is a far-red fluorescent transglutaminase 2 (TG2) probe for in vitro and in vivo endocytosis imaging. HB-2-30 complexes with TG2 and α2-macroglobulin for efficient endocytosis via the LRP1 pathway.Formule :C66H86N10O14S2Masse moléculaire :1307.58PROTAC TG2 degrader-2
PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM.Formule :C47H57N9O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :876.08GLS1 Inhibitor-7
GLS1 Inhibitor-7 (compound 4d) serves as a GLS1 antagonist with an IC50 value of 46.7 μM, demonstrating potential applications in anticancer, antiaging, andFormule :C20H17F3N4O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :482.56-Diazo-5-oxo-L-nor-Leucine
CAS :6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM).Formule :C6H9N3O3Degré de pureté :98.04% - 98.93%Couleur et forme :SolidMasse moléculaire :171.15L-Methionine-DL-sulfoximine
CAS :MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.Formule :C5H12N2O3SDegré de pureté :99.56% - ≥98%Couleur et forme :White Crystalline PowderMasse moléculaire :180.23Glutaminase-IN-1
CAS :Glutaminase-IN-1 (CB839 derivative), a glutaminase (KGA) inhibitor, has antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.Formule :C26H24F3N7O3SeDegré de pureté :98.65% - 98.65%Couleur et forme :SolidMasse moléculaire :618.47Glutaminase-IN-3
CAS :Glutaminase-IN-3 is a potent Glutaminase 1 inhibitor with potential antitumor activity and inhibits GLS1 for cancer research.Formule :C19H19F3N6O2SDegré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :452.45Telaglenastat
CAS :Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.Formule :C26H24F3N7O3SDegré de pureté :97.57% - 99.89%Couleur et forme :SolidMasse moléculaire :571.57Ref: TM-T6797
1g1.071,00€2mg35,00€5mg49,00€10mg74,00€25mg119,00€50mg200,00€100mg333,00€500mg782,00€1mL*10mM (DMSO)62,00€Glutaminase C-IN-1
CAS :Glutaminase C-IN-1 (Compound 968) is a Glutaminase C allosteric inhibitor.Formule :C27H27BrN2ODegré de pureté :99.68% - >99.99%Couleur et forme :SolidMasse moléculaire :475.42Ref: TM-T3964
2mg42,00€5mg60,00€10mg87,00€25mg162,00€50mg273,00€100mg378,00€200mg557,00€1mL*10mM (DMSO)67,00€GK921
CAS :GK921 is a transglutaminase 2 (TGase) inhibitor.Formule :C21H20N4ODegré de pureté :97.44% - 99.49%Couleur et forme :SolidMasse moléculaire :344.41BPTES
CAS :BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.Formule :C24H24N6O2S3Degré de pureté :95.83% - 99.64%Couleur et forme :SolidMasse moléculaire :524.68Ref: TM-T6791
1mg37,00€2mg52,00€5mg69,00€10mg88,00€25mg150,00€50mg217,00€100mg324,00€200mg472,00€500mg772,00€1mL*10mM (DMSO)88,00€L-Albizziin
CAS :L-Albizziin (L-beta-Ureidoalanine) is a glutamase inhibitor and is a glutaminyl-tRNA synthetase inhibitor.Formule :C4H9N3O3Degré de pureté :99.98%Couleur et forme :White PowderMasse moléculaire :147.13Irbesartan-d4
CAS :Irbesartan-d4 (Irbesartan D4), a deuterated compound of Irbesartan, is an angiotensin receptor blocker and is used in the study of cardiovascular disease.Formule :C25H28N6ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :432.55JHU-083
CAS :JHU-083 is a glutaminase antagonist that improves cognition and normalizes aberrant hippocampal glutaminase activity in APOE4 mice.Formule :C14H24N4O4Degré de pureté :97.89% - 99.53%Couleur et forme :SolidMasse moléculaire :312.37
