ALK
Les inhibiteurs d'ALK sont des composés qui ciblent spécifiquement et inhibent la kinase du lymphome anaplasique (ALK), une tyrosine kinase réceptrice impliquée dans le développement et la progression de certains cancers, notamment le cancer du poumon non à petites cellules et le neuroblastome. En inhibant ALK, ces composés bloquent les voies de signalisation qui favorisent la croissance et la survie des cellules tumorales. Chez CymitQuimica, nous proposons des inhibiteurs d'ALK pour soutenir vos recherches en oncologie, thérapies ciblées contre le cancer et transduction du signal.
112 produits trouvés pour "ALK"
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ZX-29
CAS :<p>ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.</p>Formule :C23H28ClN7O3SDegré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :518.03CEP-28122 mesylate salt (1022958-60-6 free base)
<p>CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).</p>Formule :C29H39ClN6O6SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :635.17ALK-IN-26
CAS :<p>ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.</p>Formule :C24H23NO3SDegré de pureté :99.91%Couleur et forme :SoildMasse moléculaire :405.51Ascrinvacumab
CAS :<p>Ascrinvacumab (PF-03446962): humanized IgG2 anti-ALK-1 antibody, Kd 7 nM, inhibits TGF-β, for HCC research.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:98.18%Couleur et forme :LiquidMasse moléculaire :150 kDaSIAIS164018 hydrochloride
<p>SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R.</p>Formule :C43H49Cl2N10O7PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :919.79CPD-1224
CAS :<p>CPD-1224, an oral ALK inhibitor derivative, binds cereblon, targets EML4-ALK fusions, and degrades ALK plus L1196M/G1202R mutants.</p>Formule :C43H47ClN8O7SCouleur et forme :SolidMasse moléculaire :855.4dALK-3
<p>dALK-3 is a degrader of anaplastic lymphoma kinase (ALK) that effectively induces the degradation of EML4-ALK with a DC50 of 0.182 μM. It exhibits significant antiproliferative activity against H3122 cells and is applicable for tumor research.</p>Formule :C39H45ClN7O5PCouleur et forme :SolidMasse moléculaire :758.245M4K2234
CAS :<p>M4K2234 (26b) inhibits ALK2/ALK5 (IC50: 5/2144 nM), used as a probe for ALK1/2 kinases in cancer research.</p>Formule :C27H31FN4O2Couleur et forme :SolidMasse moléculaire :462.56LAE-102
<p>LAE-102 is a monoclonal antibody that acts as an antagonist of activin receptor II-A (ACTRIIA/ACVR2). It shows potential for research in the fields of endocrine and metabolic disorders, oncology, and respiratory diseases.</p>Couleur et forme :Odour LiquidFDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Couleur et forme :LiquidALK-IN-9
CAS :<p>ALK-IN-9 effectively inhibits cell growth with IC50 <0.2 nM for Ba/F3-EML4-ALK, KM12, KG-1.</p>Formule :C20H21FN6O3Couleur et forme :SolidMasse moléculaire :412.425Multi-kinase-IN-6
<p>Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.</p>Degré de pureté :98%Couleur et forme :Odour SolidTL13-112
CAS :<p>TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).</p>Formule :C49H60ClN9O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1002.57Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Couleur et forme :Odour SolidLDN-193189 2HCl
CAS :<p>LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.</p>Formule :C25H24Cl2N6Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :479.4INCB-000928
CAS :<p>Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia.</p>Formule :C30H38N4O3Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :502.65ALK protein ligand-1
CAS :<p>ALK protein ligand-1 (Compound A1) is an ALK protein ligand, acting as a ligand for the target protein in PROTACs, demonstrating inhibitory effects on ALK. It is also useful in the synthesis of AP-1.</p>Formule :C24H29ClN6O3SCouleur et forme :SolidMasse moléculaire :517.043ALK-IN-29
ALK-IN-29 (compound 4c) exhibits inhibitory effects on tyrosine protein kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, displaying a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is applicable in cancer research.Formule :C29H32FN3OCouleur et forme :SolidMasse moléculaire :457.58ALK/ROS1-IN-3
<p>ALK/ROS1-IN-3 (compound C01) is a dual inhibitor targeting ROS1 and ALK, with IC50 values of 42.3 nM for ROS1G2032R and 49.1 nM for ALKG1202R.</p>Formule :C32H32N4O2Masse moléculaire :504.25253LDN 193688
CAS :<p>LDN 193688 is a BMP kinase inhibitor preferential for the ALK2 site, acting by binding to the ALK site,progressive osseous fibrodysplasia.</p>Formule :C22H16N4ODegré de pureté :99.16%Couleur et forme :SoildMasse moléculaire :352.39ALK/ROS1-IN-5
<p>ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.</p>Formule :C32H28F2N4O3Couleur et forme :SolidMasse moléculaire :554.586ALK-IN-12
CAS :<p>ALK-IN-12: potent ALK inhibitor (IC50: 0.18 nM), affects IGF1R and InsR (IC50: 20.3/90.6 nM), potential for cancer therapy.</p>Formule :C24H30ClN6O2PCouleur et forme :SolidMasse moléculaire :500.97PROTAC ALK degrader-3
<p>PROTAC ALK degrader-3 (4B) is an orally active PROTAC-based ALK degrader, efficiently inducing sustained degradation of ALK fusion protein and significant inhibition of downstream pathways in Karpas 299 cells with an IC50 of 119.33 nM. This compound exhibits antitumor activity.</p>Formule :C50H60ClN9O7SCouleur et forme :SolidMasse moléculaire :966.59ALK-IN-13
CAS :<p>ALK-IN-13 is an ALK inhibitor.</p>Formule :C29H39ClN7O2PCouleur et forme :SolidMasse moléculaire :584.12-Keto Crizotinib
CAS :<p>2-Keto Crizotinib is an active lactam metabolite of crizotinib.</p>Formule :C21H20Cl2FN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.32TL13-12
CAS :<p>TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).</p>Formule :C45H53ClN10O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :961.49TL13-110
CAS :<p>Negative control for TL 13-112 . Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).</p>Formule :C49H62ClN9O9SCouleur et forme :SolidMasse moléculaire :988.59ALKBH5-IN-5
CAS :<p>ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.</p>Formule :C13H13NO3Degré de pureté :99.54%Couleur et forme :SoildMasse moléculaire :231.25ALK5 Inhibitor II (hydrochloride)
CAS :<p>ALK5 Inhibitor II has IC50s: 4 nM (auto), 18 nM (TGF-β assay), 23 nM (binding, HepG2).</p>Formule :C17H13N5·HClDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :323.8TL13-22
CAS :<p>TL13-22 is a potent inhibitor of ALK and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 .</p>Formule :C45H55ClN10O9SDegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :947.5LDN-193189 Tetrahydrochloride
CAS :<p>LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.</p>Formule :C25H26Cl4N6Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :552.33EW-7195
CAS :<p>EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.</p>Formule :C23H18N8Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :406.44R-268712
CAS :<p>R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.</p>Formule :C20H18FN5ODegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :363.39A 77-01
CAS :<p>A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.</p>Formule :C18H14N4Degré de pureté :98.82% - ≥95%Couleur et forme :SolidMasse moléculaire :286.33GW788388
CAS :<p>GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.</p>Formule :C25H23N5O2Degré de pureté :98.03% - 99.58%Couleur et forme :SolidMasse moléculaire :425.48ML347
CAS :<p>ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.</p>Formule :C22H16N4ODegré de pureté :99.30% - ≥95%Couleur et forme :SolidMasse moléculaire :352.395-phenylthieno[2,3-d]pyrimidin-4-amine
CAS :<p>5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.</p>Formule :C12H9N3SDegré de pureté :97%Couleur et forme :SolidMasse moléculaire :227.29RepSox
CAS :<p>RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).</p>Formule :C17H13N5Degré de pureté :98.8% - 99.73%Couleur et forme :SolidMasse moléculaire :287.32Brigatinib
CAS :<p>Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.</p>Formule :C29H39ClN7O2PDegré de pureté :97.18% - >99.99%Couleur et forme :SolidMasse moléculaire :584.09SM 16
CAS :<p>SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).</p>Formule :C25H26N4O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :430.5N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
CAS :<p>Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.</p>Formule :C22H18BrN7Degré de pureté :99.935%Couleur et forme :SolidMasse moléculaire :460.33CH5424802 analog
CAS :<p>CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.</p>Formule :C28H30N4O2Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :454.56DMH-1
CAS :<p>DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.</p>Formule :C24H20N4ODegré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :380.44ALK kinase inhibitor-1
CAS :<p>SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.</p>Formule :C28H32FN5O3SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :537.65CEP-28122 mesylate salt
<p>CEP-28122 mesylate, a diaminopyrimidine, selectively inhibits ALK with IC50 of 1.9 nM and exhibits antitumor effects.</p>Formule :C29H39ClN6O6SCouleur et forme :SolidMasse moléculaire :635.17AZD-3463
CAS :<p>AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.</p>Formule :C24H25ClN6ODegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :448.95Crizotinib acetate
CAS :<p>Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.</p>Formule :C23H26Cl2FN5O3Couleur et forme :SolidMasse moléculaire :510.39K02288
CAS :<p>K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.</p>Formule :C20H20N2O4Degré de pureté :98% - 99.83%Couleur et forme :SolidMasse moléculaire :352.38CEP-28122
CAS :<p>CEP-28122 is a highly potent and selective orally active ALK inhibitor.</p>Formule :C28H35ClN6O3Degré de pureté :99.87% - >99.99%Couleur et forme :SolidMasse moléculaire :539.07Vactosertib
CAS :<p>Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.</p>Formule :C22H18FN7Degré de pureté :98.85% - 99.81%Couleur et forme :SolidMasse moléculaire :399.42CAY10594
CAS :<p>CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.</p>Formule :C26H28N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.53LDN-214117
CAS :<p>LDN-214117 is a potent and selective ALK2 inhibitor.</p>Formule :C25H29N3O3Degré de pureté :98% - 99.82%Couleur et forme :SolidMasse moléculaire :419.52LDN193189
CAS :<p>LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.</p>Formule :C25H22N6Degré de pureté :98% - 99.86%Couleur et forme :SolidMasse moléculaire :406.48BIBF0775
CAS :<p>BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).</p>Formule :C31H34N4O2Degré de pureté :99.45% - 99.79%Couleur et forme :SolidMasse moléculaire :494.63A 83-01
CAS :<p>A 83-01 (ALK5 Inhibitor IV) is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7.</p>Formule :C25H19N5SDegré de pureté :97% - 98.2%Couleur et forme :SolidMasse moléculaire :421.52SB-505124
CAS :<p>SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.</p>Formule :C20H21N3O2Degré de pureté :97.19% - 99.92%Couleur et forme :SolidMasse moléculaire :335.4Alectinib hydrochloride
CAS :<p>Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)</p>Formule :C30H35ClN4O2Degré de pureté :99.61% - 99.96%Couleur et forme :SolidMasse moléculaire :519.08Ensartinib
CAS :<p>Ensartinib (X-396) is a potent and orally active dual ALK/MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).</p>Formule :C26H27Cl2FN6O3Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :561.44HG-14-10-04
CAS :<p>HG-14-10-04 is a potent and specific ALK inhibitor.</p>Formule :C29H34ClN7ODegré de pureté :99.75% - >99.99%Couleur et forme :SolidMasse moléculaire :532.08SB-431542
CAS :<p>SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective.</p>Formule :C22H16N4O3Degré de pureté :99.035% - >99.99%Couleur et forme :SolidMasse moléculaire :384.39LDN-212854
CAS :<p>LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors.</p>Formule :C25H22N6Degré de pureté :98% - 98.71%Couleur et forme :SolidMasse moléculaire :406.48Blu-782
CAS :<p>Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)</p>Formule :C31H42N6O4Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :562.7SB 525334
CAS :<p>SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).</p>Formule :C21H21N5Degré de pureté :98.39% - ≥95%Couleur et forme :SolidMasse moléculaire :343.42LDN-193189 HCl
CAS :<p>LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor.</p>Formule :C25H22N6·HClDegré de pureté :99.49% - 99.53%Couleur et forme :SolidMasse moléculaire :442.94Vactosertib Hydrochloride
CAS :<p>Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.</p>Formule :C22H19ClFN7Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :435.89A 83-01 sodium salt
CAS :<p>A 83-01 sodium salt inhibits ALK5, ALK4, and ALK7 kinases with IC50s: 12, 45, 7.5 nM.</p>Formule :C25H19N5NaSCouleur et forme :SolidMasse moléculaire :444.51AZ 12799734
CAS :<p>AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.</p>Formule :C18H18N4O3SDegré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :370.43SB-505124 hydrochloride
CAS :<p>SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.</p>Formule :C20H22ClN3O2Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :371.86Itacnosertib
CAS :<p>Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells,antitumor and antileukemic.</p>Formule :C26H28N8ODegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :468.55ALK5-IN-79
CAS :<p>ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.</p>Formule :C23H27N7OCouleur et forme :SolidMasse moléculaire :417.51KRCA-0713
CAS :<p>KRCA-0713 is a ALK inhibitor.</p>Formule :C26H32ClN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :530.08WY-135
CAS :<p>WY-135 is a dual inhibitor of ALK and ROS1 (IC50 of 1.4 nM and 1.1 nM, respectively).</p>Formule :C28H34ClN9O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :612.15ALK2-IN-5
CAS :<p>ALK2-IN-5, a pyrazolopyrimidine compound, serves as an inhibitor of ALK2 and FGFR, targeting disorders linked with their activity, including cancer [1].</p>Formule :C24H32N8O2Couleur et forme :SolidMasse moléculaire :464.56ALK-IN-5
CAS :<p>ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).</p>Formule :C24H25FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.49TGFBR1-IN-1
CAS :<p>TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).</p>Formule :C23H17N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :427.48EML4-ALK kinase inhibitor 1
CAS :<p>Potent oral EML4-ALK inhibitor with a 1 nM IC50.</p>Formule :C31H48N8O3Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :580.76ALK2-IN-2
CAS :<p>ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.</p>Formule :C28H27N5O2SDegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :497.61OD36
CAS :<p>OD36: Potent RIPK2 inhibitor, IC50=5.3 nM; hinders ALK2 signaling and osteogenesis, KD=37 nM; targets ALK2 ATP pocket.</p>Formule :C16H15ClN4O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :330.77OD36 hydrochloride
CAS :<p>OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently</p>Formule :C16H16Cl2N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :367.23J-1048
CAS :<p>J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/</p>Formule :C23H17FN6S2Couleur et forme :SolidMasse moléculaire :460.55CJ-2360
CAS :<p>CJ-2360 is a potent ALK inhibitor, effective on wild-type and various mutants, with IC50 values ranging from 2.2 to 8.9 nM, also targeting 468 kinases.</p>Formule :C27H30FN5O2Couleur et forme :SolidMasse moléculaire :475.56ALK-IN-22
CAS :<p>ALK-IN-22 suppresses ALK and mutants (IC50: 2.3-3.7 nM), hinders phosphorylation, and induces apoptosis in tumor studies.</p>Formule :C24H24ClN7O2Couleur et forme :SolidMasse moléculaire :477.95RIPK2-IN-1
CAS :<p>RIPK2-IN-1 (compound 18f) is a potent inhibitor of RIPK2 (IC50: 51 nM) and also inhibits ALK2 (IC50: 5 nM).</p>Formule :C23H27N5O3SCouleur et forme :SolidMasse moléculaire :453.56ALK-IN-21
CAS :<p>ALK-IN-21 (B10) inhibits ALK WT (IC50: 4.59nM), L1196M (2.07nM), G1202R (5.95nM); curbs Karpas299, H2228 cell growth; for ALCL research.</p>Formule :C35H45ClN6O6S4Couleur et forme :SolidMasse moléculaire :809.48Con B-1
CAS :<p>ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells .</p>Formule :C38H52ClN7O6SCouleur et forme :SolidMasse moléculaire :770.38SMU-B
CAS :<p>SMU-B is a well-tolerated c-Met/ALK dual inhibitor.</p>Formule :C26H25Cl2FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.41Ficonalkib
CAS :<p>Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.</p>Formule :C29H39N7O3SCouleur et forme :SolidMasse moléculaire :565.73ALK5-IN-30
CAS :<p>ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM).</p>Formule :C24H25FN8Couleur et forme :SolidMasse moléculaire :444.51XST-14
CAS :<p>XST-14 is a ULK1 inhibitor.XST-14 induces apoptosis and inhibits the growth of HCC cells.</p>Formule :C16H21NO4Degré de pureté :99.84% - 99.84%Couleur et forme :SolidMasse moléculaire :291.34TRK/ALK-IN-1
<p>TRK/ALK-IN-1: Potent dual TRK & ALK inhibitor; IC50s: 2.2nM (TRKA), 9.3nM (ALK WT), 38nM (ALK L1196M); cancer research potential.</p>Formule :C31H35ClF2N8O2SCouleur et forme :SolidMasse moléculaire :657.18ALK5-IN-29
CAS :<p>ALK5-IN-29: selective ALK inhibitor, IC50 ≤ 10 nM, curbs tumor growth, aids in cancer research.</p>Formule :C24H25FN8Couleur et forme :SolidMasse moléculaire :444.51TP0427736 hydrochloride
CAS :<p>TP0427736 hydrochloride is a novel and selective ALK5 inhibitor, capable of inhibiting Smad2/3 phosphorylation in A549 cells.</p>Formule :C14H11ClN4S2Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :334.85UNC5293
CAS :<p>UNC5293: potent oral MERTK inhibitor, Ki=190 pM, IC50=0.9 nM; selective vs Axl/Tyro3/Flt3; good mouse PK; used in leukemia research.</p>Formule :C30H42N6O2Couleur et forme :SolidMasse moléculaire :518.69ALK-IN-6
CAS :<p>ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L).</p>Formule :C26H29ClD3N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :533.1ALK/EGFR-IN-3
CAS :<p>ALK/EGFR-IN-3 is a dual ALK and EGFR inhibitor that demonstrates potent anti-proliferative effects on various cancer cell lines, including H1975, PC9, and Baf3-</p>Formule :C27H34ClN7O3SCouleur et forme :SolidMasse moléculaire :572.12ALK/ROS1-IN-1
CAS :<p>ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).</p>Formule :C30H35F3N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :584.63ALK/EGFR-IN-1
CAS :<p>ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation.</p>Formule :C27H34ClN7O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.12ALK/EGFR-IN-2
CAS :<p>ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells.</p>Formule :C27H34ClN7O3SCouleur et forme :SolidMasse moléculaire :572.12ALK-IN-27
CAS :<p>Neladalkib (NVL-655) is an ALK inhibitor with antitumor activity for the study of non-small cell cancers.</p>Formule :C23H22ClFN6ODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :452.91KER047
CAS :<p>ALK2-IN-4, a highly effective ALK2 inhibitor.</p>Formule :C26H30FN7ODegré de pureté :98.49% - >99.99%Couleur et forme :SolidMasse moléculaire :475.56
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