ALK
Les inhibiteurs d'ALK sont des composés qui ciblent spécifiquement et inhibent la kinase du lymphome anaplasique (ALK), une tyrosine kinase réceptrice impliquée dans le développement et la progression de certains cancers, notamment le cancer du poumon non à petites cellules et le neuroblastome. En inhibant ALK, ces composés bloquent les voies de signalisation qui favorisent la croissance et la survie des cellules tumorales. Chez CymitQuimica, nous proposons des inhibiteurs d'ALK pour soutenir vos recherches en oncologie, thérapies ciblées contre le cancer et transduction du signal.
146 produits trouvés pour "ALK".
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SM 16
CAS :SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).Formule :C25H26N4O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :430.5NVP-TAE 684
CAS :NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).Formule :C30H40ClN7O3SDegré de pureté :98% - 99.82%Couleur et forme :White SolidMasse moléculaire :614.2ALK5-IN-10
CAS :Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.Formule :C22H18BrN7Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :460.33Ref: TM-T9837
1mg93,00€5mg182,00€1mL*10mM (DMSO)215,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.099,00€CH5424802 analog
CAS :CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Formule :C28H30N4O2Degré de pureté :98.96%Couleur et forme :White SolidMasse moléculaire :454.56Ref: TM-T9224
1mg124,00€5mg271,00€1mL*10mM (DMSO)324,00€10mg408,00€25mg672,00€50mg945,00€100mg1.279,00€DMH-1
CAS :DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.Formule :C24H20N4ODegré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :380.44ALK kinase inhibitor-1
CAS :SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.Formule :C28H32FN5O3SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :537.65CEP-28122 mesylate salt
CEP-28122 mesylate, a diaminopyrimidine, selectively inhibits ALK with IC50 of 1.9 nM and exhibits antitumor effects.Formule :C29H39ClN6O6SCouleur et forme :SolidMasse moléculaire :635.17AZD-3463
CAS :AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formule :C24H25ClN6ODegré de pureté :99.13% - 99.97%Couleur et forme :Cyan SolidMasse moléculaire :448.95Crizotinib acetate
CAS :Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.Formule :C23H26Cl2FN5O3Couleur et forme :SolidMasse moléculaire :510.39K02288
CAS :K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.Formule :C20H20N2O4Degré de pureté :98% - 99.83%Couleur et forme :SolidMasse moléculaire :352.38CEP-28122
CAS :CEP-28122 is a highly potent and selective orally active ALK inhibitor.Formule :C28H35ClN6O3Degré de pureté :99.87% - >99.99%Couleur et forme :SolidMasse moléculaire :539.07Vactosertib
CAS :Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.Formule :C22H18FN7Degré de pureté :98.85% - 99.81%Couleur et forme :White SolidMasse moléculaire :399.42CAY10594
CAS :CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.Formule :C26H28N4O2Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :428.53LDN-214117
CAS :LDN-214117 is a potent and selective ALK2 inhibitor.Formule :C25H29N3O3Degré de pureté :98% - 99.83%Couleur et forme :SolidMasse moléculaire :419.52LDN193189
CAS :LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Formule :C25H22N6Degré de pureté :98% - 99.86%Couleur et forme :SolidMasse moléculaire :406.48Crizotinib hydrochloride
CAS :Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Formule :C21H23Cl3FN5ODegré de pureté :98.73% - 98.87%Couleur et forme :SolidMasse moléculaire :486.8Ref: TM-T8399
5mg34,00€1mL*10mM (DMSO)35,00€10mg50,00€25mg78,00€50mg94,00€100mg131,00€200mg162,00€500mg215,00€Alectinib
CAS :Alectinib (RG-7853) is an ALK inhibitor that is selective, orally active, and ATP-competitive. Alectinib has antitumor activity. Cost-effective and quality-assured.Formule :C30H34N4O2Degré de pureté :98% - 99.94%Couleur et forme :White SolidMasse moléculaire :482.62Ref: TM-T1936
2mg44,00€5mg65,00€1mL*10mM (DMSO)70,00€10mg82,00€50mg100,00€100mg159,00€200mg245,00€500mg414,00€CEP-37440
CAS :CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Formule :C30H38ClN7O3Degré de pureté :98.86% - 99.98%Couleur et forme :White SolidMasse moléculaire :580.12GSK1838705A
CAS :GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Formule :C27H29FN8O3Degré de pureté :98.89% - >99.99%Couleur et forme :Yellow SolidMasse moléculaire :532.57Entrectinib
CAS :Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formule :C31H34F2N6O2Degré de pureté :98.03% - 99.61%Couleur et forme :SolidMasse moléculaire :560.64Ref: TM-T3678
2mg39,00€5mg56,00€1mL*10mM (DMSO)65,00€10mg84,00€25mg105,00€50mg159,00€100mg268,00€500mg655,00€BIBF0775
CAS :BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).Formule :C31H34N4O2Degré de pureté :99.45% - 99.79%Couleur et forme :SolidMasse moléculaire :494.63Ref: TM-T5197
1mg40,00€1mL*10mM (DMSO)90,00€5mg92,00€10mg128,00€25mg205,00€50mg288,00€100mg414,00€200mg578,00€Lorlatinib
CAS :Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogeneFormule :C21H19FN6O2Degré de pureté :99.77% - 99.95%Couleur et forme :SolidMasse moléculaire :406.41Ref: TM-T3061
1mg34,00€2mg42,00€5mg60,00€1mL*10mM (DMSO)66,00€10mg89,00€25mg137,00€50mg212,00€100mg374,00€Crizotinib
CAS :Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.Formule :C21H22Cl2FN5ODegré de pureté :99% - 99.87%Couleur et forme :White SolidMasse moléculaire :450.34ALK-IN-1
CAS :ALK-IN-1 is a potent ALK inhibitor, demonstrating the ability to overcome Crizotinib resistance mediated by an L1196M mutation.Formule :C26H34ClN6O2PDegré de pureté :99.74% - 99.80%Couleur et forme :White SolidMasse moléculaire :529.01A 83-01
CAS :A 83-01 (ALK5 Inhibitor IV) is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7.Formule :C25H19N5SDegré de pureté :97% - 98.2%Couleur et forme :SolidMasse moléculaire :421.52SB-505124
CAS :SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.Formule :C20H21N3O2Degré de pureté :97.19% - 99.92%Couleur et forme :SolidMasse moléculaire :335.4Ref: TM-T2462
1mg38,00€2mg50,00€5mg84,00€10mg120,00€1mL*10mM (DMSO)132,00€25mg210,00€50mg354,00€100mg518,00€500mg1.099,00€Alectinib hydrochloride
CAS :Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)Formule :C30H35ClN4O2Degré de pureté :99.74% - 99.96%Couleur et forme :SolidMasse moléculaire :519.08Ceritinib
CAS :Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.Formule :C28H36ClN5O3SDegré de pureté :98.52% - 99.77%Couleur et forme :SolidMasse moléculaire :558.14Ensartinib
CAS :Ensartinib (X-396) is a potent and orally active dual ALK/MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).Formule :C26H27Cl2FN6O3Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :561.44D4476
CAS :D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).Formule :C23H18N4O3Degré de pureté :99.7% - 99.96%Couleur et forme :SolidMasse moléculaire :398.41Ceritinib dihydrochloride
CAS :Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable, ATP-competitive inhibitor of ALK tyrosine kinase with antitumour effect.Formule :C28H38Cl3N5O3SDegré de pureté :99.85% - 99.99%Couleur et forme :Yellow SolidMasse moléculaire :631.06Belizatinib
CAS :Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.Formule :C33H44FN5O3Degré de pureté :99.33% - 99.44%Couleur et forme :SolidMasse moléculaire :577.73Ref: TM-T4257
1mg40,00€2mg54,00€5mg93,00€1mL*10mM (DMSO)105,00€10mg133,00€25mg259,00€50mg358,00€100mg500,00€HG-14-10-04
CAS :HG-14-10-04 is a potent and specific ALK inhibitor.Formule :C29H34ClN7ODegré de pureté :99.75% - >99.99%Couleur et forme :White SolidMasse moléculaire :532.08Ref: TM-T4015
1mg49,00€5mg92,00€1mL*10mM (DMSO)111,00€10mg152,00€25mg222,00€50mg289,00€100mg409,00€200mg590,00€Ensartinib hydrochloride
CAS :Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFormule :C26H29Cl4FN6O3Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :634.36Ref: TM-T22324
1mg54,00€5mg114,00€1mL*10mM (DMSO)158,00€10mg177,00€25mg356,00€50mg580,00€100mg888,00€X-376
CAS :X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase ALK with potential antineoplastic activity.Formule :C25H25Cl2FN6O3Degré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :547.41Ref: TM-T3550
1mg34,00€2mg48,00€5mg93,00€1mL*10mM (DMSO)100,00€10mg113,00€25mg244,00€50mg405,00€100mg550,00€R-268712
CAS :R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Formule :C20H18FN5ODegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :363.39Ref: TM-T16708
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg130,00€25mg250,00€50mg378,00€100mg537,00€200mg762,00€Repotrectinib
CAS :Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01/5.3/1.08/1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.Formule :C18H18FN5O2Degré de pureté :99.92% - >99.99%Couleur et forme :SolidMasse moléculaire :355.37Ref: TM-T4071
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg133,00€25mg260,00€50mg394,00€100mg592,00€200mg827,00€LDN-212854
CAS :LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors.Formule :C25H22N6Degré de pureté :98% - 98.71%Couleur et forme :White SolidMasse moléculaire :406.48Ref: TM-T1900
1mg47,00€2mg62,00€5mg92,00€1mL*10mM (DMSO)102,00€10mg172,00€25mg294,00€50mg439,00€100mg660,00€200mg945,00€Blu-782
CAS :Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)Formule :C31H42N6O4Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :562.7SB 525334
CAS :SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).Formule :C21H21N5Degré de pureté :98.39% - ≥95%Couleur et forme :SolidMasse moléculaire :343.42LDN-193189 HCl
CAS :LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor.Formule :C25H22N6·HClDegré de pureté :99.49% - 99.53%Couleur et forme :SolidMasse moléculaire :442.94Ref: TM-T6158
1mg34,00€2mg46,00€5mg66,00€1mL*10mM (DMSO)81,00€10mg88,00€25mg147,00€50mg215,00€100mg358,00€200mg537,00€Vactosertib Hydrochloride
CAS :Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.Formule :C22H19ClFN7Degré de pureté :98.03%Couleur et forme :White SolidMasse moléculaire :435.89Ref: TM-T15262
1mg34,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg92,00€25mg152,00€50mg230,00€100mg356,00€200mg522,00€A 83-01 sodium salt
CAS :A 83-01 sodium salt inhibits ALK5, ALK4, and ALK7 kinases with IC50s: 12, 45, 7.5 nM.Formule :C25H19N5NaSCouleur et forme :SolidMasse moléculaire :444.51SB-505124 hydrochloride
CAS :SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.Formule :C20H22ClN3O2Degré de pureté :98.64%Couleur et forme :Yellow SolidMasse moléculaire :371.86AZ 12799734
CAS :AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.Formule :C18H18N4O3SDegré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :370.43ALKBH5-IN-3
CAS :ALKBH5-IN-3 (Compound 20m) is a selective ALKBH5 inhibitor (IC50=21 nM), effectively stabilizes ALKBH5 in HepG2 cells and elevates m6A levels in intact cells.Formule :C11H7F3N2O3Degré de pureté :98.32%Couleur et forme :Yellow SolidMasse moléculaire :272.18ALK5-IN-79
CAS :ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.Formule :C23H27N7OCouleur et forme :SolidMasse moléculaire :417.51Prafnosbart
CAS :Prafnosbart is an anti-ACVR1 (ALK2) antibody used for research on Fibrodysplasia Ossificans Progressiva (FOP).Couleur et forme :LiquidALK-IN-5
CAS :ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).Formule :C24H25FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.49ALK5-IN-26
CAS :ALK5-IN-26 (EX-22) is an ALK (Activin receptor-like kinase) inhibitor. ALK5-IN-26 inhibits ALK5 (IC50 ≤ 1 nM).Formule :C24H25FN8Couleur et forme :SolidMasse moléculaire :444.51
