ALK
Les inhibiteurs d'ALK sont des composés qui ciblent spécifiquement et inhibent la kinase du lymphome anaplasique (ALK), une tyrosine kinase réceptrice impliquée dans le développement et la progression de certains cancers, notamment le cancer du poumon non à petites cellules et le neuroblastome. En inhibant ALK, ces composés bloquent les voies de signalisation qui favorisent la croissance et la survie des cellules tumorales. Chez CymitQuimica, nous proposons des inhibiteurs d'ALK pour soutenir vos recherches en oncologie, thérapies ciblées contre le cancer et transduction du signal.
112 produits trouvés pour "ALK"
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CAY10594
CAS :<p>CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.</p>Formule :C26H28N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.53LDN-214117
CAS :<p>LDN-214117 is a potent and selective ALK2 inhibitor.</p>Formule :C25H29N3O3Degré de pureté :98% - 99.82%Couleur et forme :SolidMasse moléculaire :419.52LDN193189
CAS :<p>LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.</p>Formule :C25H22N6Degré de pureté :98% - 99.86%Couleur et forme :SolidMasse moléculaire :406.48BIBF0775
CAS :<p>BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).</p>Formule :C31H34N4O2Degré de pureté :99.45% - 99.79%Couleur et forme :SolidMasse moléculaire :494.63A 83-01
CAS :<p>A 83-01 (ALK5 Inhibitor IV) is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7.</p>Formule :C25H19N5SDegré de pureté :97% - 98.2%Couleur et forme :SolidMasse moléculaire :421.52SB-505124
CAS :<p>SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.</p>Formule :C20H21N3O2Degré de pureté :97.19% - 99.92%Couleur et forme :SolidMasse moléculaire :335.4Alectinib hydrochloride
CAS :<p>Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)</p>Formule :C30H35ClN4O2Degré de pureté :99.61% - 99.96%Couleur et forme :SolidMasse moléculaire :519.08Ensartinib
CAS :<p>Ensartinib (X-396) is a potent and orally active dual ALK/MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).</p>Formule :C26H27Cl2FN6O3Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :561.44HG-14-10-04
CAS :<p>HG-14-10-04 is a potent and specific ALK inhibitor.</p>Formule :C29H34ClN7ODegré de pureté :99.75% - >99.99%Couleur et forme :SolidMasse moléculaire :532.08SB-431542
CAS :<p>SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective.</p>Formule :C22H16N4O3Degré de pureté :99.035% - >99.99%Couleur et forme :SolidMasse moléculaire :384.39LDN-212854
CAS :<p>LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors.</p>Formule :C25H22N6Degré de pureté :98% - 98.71%Couleur et forme :SolidMasse moléculaire :406.48Blu-782
CAS :<p>Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)</p>Formule :C31H42N6O4Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :562.7SB 525334
CAS :<p>SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).</p>Formule :C21H21N5Degré de pureté :98.39% - ≥95%Couleur et forme :SolidMasse moléculaire :343.42LDN-193189 HCl
CAS :<p>LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor.</p>Formule :C25H22N6·HClDegré de pureté :99.49% - 99.53%Couleur et forme :SolidMasse moléculaire :442.94Vactosertib Hydrochloride
CAS :<p>Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.</p>Formule :C22H19ClFN7Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :435.89A 83-01 sodium salt
CAS :<p>A 83-01 sodium salt inhibits ALK5, ALK4, and ALK7 kinases with IC50s: 12, 45, 7.5 nM.</p>Formule :C25H19N5NaSCouleur et forme :SolidMasse moléculaire :444.51AZ 12799734
CAS :<p>AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.</p>Formule :C18H18N4O3SDegré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :370.43SB-505124 hydrochloride
CAS :<p>SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.</p>Formule :C20H22ClN3O2Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :371.86Itacnosertib
CAS :<p>Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells,antitumor and antileukemic.</p>Formule :C26H28N8ODegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :468.55ALK5-IN-79
CAS :<p>ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.</p>Formule :C23H27N7OCouleur et forme :SolidMasse moléculaire :417.51KRCA-0713
CAS :<p>KRCA-0713 is a ALK inhibitor.</p>Formule :C26H32ClN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :530.08WY-135
CAS :<p>WY-135 is a dual inhibitor of ALK and ROS1 (IC50 of 1.4 nM and 1.1 nM, respectively).</p>Formule :C28H34ClN9O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :612.15ALK2-IN-5
CAS :<p>ALK2-IN-5, a pyrazolopyrimidine compound, serves as an inhibitor of ALK2 and FGFR, targeting disorders linked with their activity, including cancer [1].</p>Formule :C24H32N8O2Couleur et forme :SolidMasse moléculaire :464.56ALK-IN-5
CAS :<p>ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).</p>Formule :C24H25FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.49TGFBR1-IN-1
CAS :<p>TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).</p>Formule :C23H17N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :427.48EML4-ALK kinase inhibitor 1
CAS :<p>Potent oral EML4-ALK inhibitor with a 1 nM IC50.</p>Formule :C31H48N8O3Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :580.76ALK2-IN-2
CAS :<p>ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.</p>Formule :C28H27N5O2SDegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :497.61OD36
CAS :<p>OD36: Potent RIPK2 inhibitor, IC50=5.3 nM; hinders ALK2 signaling and osteogenesis, KD=37 nM; targets ALK2 ATP pocket.</p>Formule :C16H15ClN4O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :330.77OD36 hydrochloride
CAS :<p>OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently</p>Formule :C16H16Cl2N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :367.23J-1048
CAS :<p>J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/</p>Formule :C23H17FN6S2Couleur et forme :SolidMasse moléculaire :460.55CJ-2360
CAS :<p>CJ-2360 is a potent ALK inhibitor, effective on wild-type and various mutants, with IC50 values ranging from 2.2 to 8.9 nM, also targeting 468 kinases.</p>Formule :C27H30FN5O2Couleur et forme :SolidMasse moléculaire :475.56ALK-IN-22
CAS :<p>ALK-IN-22 suppresses ALK and mutants (IC50: 2.3-3.7 nM), hinders phosphorylation, and induces apoptosis in tumor studies.</p>Formule :C24H24ClN7O2Couleur et forme :SolidMasse moléculaire :477.95RIPK2-IN-1
CAS :<p>RIPK2-IN-1 (compound 18f) is a potent inhibitor of RIPK2 (IC50: 51 nM) and also inhibits ALK2 (IC50: 5 nM).</p>Formule :C23H27N5O3SCouleur et forme :SolidMasse moléculaire :453.56ALK-IN-21
CAS :<p>ALK-IN-21 (B10) inhibits ALK WT (IC50: 4.59nM), L1196M (2.07nM), G1202R (5.95nM); curbs Karpas299, H2228 cell growth; for ALCL research.</p>Formule :C35H45ClN6O6S4Couleur et forme :SolidMasse moléculaire :809.48Con B-1
CAS :<p>ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells .</p>Formule :C38H52ClN7O6SCouleur et forme :SolidMasse moléculaire :770.38SMU-B
CAS :<p>SMU-B is a well-tolerated c-Met/ALK dual inhibitor.</p>Formule :C26H25Cl2FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.41Ficonalkib
CAS :<p>Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.</p>Formule :C29H39N7O3SCouleur et forme :SolidMasse moléculaire :565.73ALK5-IN-30
CAS :<p>ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM).</p>Formule :C24H25FN8Couleur et forme :SolidMasse moléculaire :444.51XST-14
CAS :<p>XST-14 is a ULK1 inhibitor.XST-14 induces apoptosis and inhibits the growth of HCC cells.</p>Formule :C16H21NO4Degré de pureté :99.84% - 99.84%Couleur et forme :SolidMasse moléculaire :291.34TRK/ALK-IN-1
<p>TRK/ALK-IN-1: Potent dual TRK & ALK inhibitor; IC50s: 2.2nM (TRKA), 9.3nM (ALK WT), 38nM (ALK L1196M); cancer research potential.</p>Formule :C31H35ClF2N8O2SCouleur et forme :SolidMasse moléculaire :657.18ALK5-IN-29
CAS :<p>ALK5-IN-29: selective ALK inhibitor, IC50 ≤ 10 nM, curbs tumor growth, aids in cancer research.</p>Formule :C24H25FN8Couleur et forme :SolidMasse moléculaire :444.51TP0427736 hydrochloride
CAS :<p>TP0427736 hydrochloride is a novel and selective ALK5 inhibitor, capable of inhibiting Smad2/3 phosphorylation in A549 cells.</p>Formule :C14H11ClN4S2Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :334.85UNC5293
CAS :<p>UNC5293: potent oral MERTK inhibitor, Ki=190 pM, IC50=0.9 nM; selective vs Axl/Tyro3/Flt3; good mouse PK; used in leukemia research.</p>Formule :C30H42N6O2Couleur et forme :SolidMasse moléculaire :518.69ALK-IN-6
CAS :<p>ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L).</p>Formule :C26H29ClD3N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :533.1ALK/EGFR-IN-3
CAS :<p>ALK/EGFR-IN-3 is a dual ALK and EGFR inhibitor that demonstrates potent anti-proliferative effects on various cancer cell lines, including H1975, PC9, and Baf3-</p>Formule :C27H34ClN7O3SCouleur et forme :SolidMasse moléculaire :572.12ALK/ROS1-IN-1
CAS :<p>ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).</p>Formule :C30H35F3N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :584.63ALK/EGFR-IN-1
CAS :<p>ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation.</p>Formule :C27H34ClN7O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.12ALK/EGFR-IN-2
CAS :<p>ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells.</p>Formule :C27H34ClN7O3SCouleur et forme :SolidMasse moléculaire :572.12ALK-IN-27
CAS :<p>Neladalkib (NVL-655) is an ALK inhibitor with antitumor activity for the study of non-small cell cancers.</p>Formule :C23H22ClFN6ODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :452.91KER047
CAS :<p>ALK2-IN-4, a highly effective ALK2 inhibitor.</p>Formule :C26H30FN7ODegré de pureté :98.49% - >99.99%Couleur et forme :SolidMasse moléculaire :475.56
