Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1427 produits trouvés pour "Autophagie"
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LC3-mHTT-IN-AN1
CAS :<p>LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B.</p>Formule :C15H9Br2NO3Degré de pureté :97.26%Couleur et forme :SolidMasse moléculaire :411.04Tezacaftor
CAS :<p>Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.</p>Formule :C26H27F3N2O6Degré de pureté :98.84% - >99.99%Couleur et forme :SolidMasse moléculaire :520.5AS-605240
CAS :<p>AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).</p>Formule :C12H7N3O2SDegré de pureté :97% - 99.91%Couleur et forme :SolidMasse moléculaire :257.273-Bromopyruvic acid
CAS :<p>3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition.</p>Formule :C3H3BrO3Degré de pureté :95% - 99.644%Couleur et forme :White To Pale Yellow Crystalline PowderMasse moléculaire :166.96ML327
CAS :<p>ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).</p>Formule :C19H18N4O4Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :366.37Dorsomorphin
CAS :<p>Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive.</p>Formule :C24H25N5ODegré de pureté :98% - 99.06%Couleur et forme :SolidMasse moléculaire :399.49Rac-Belinostat
CAS :<p>Rac-Belinostat (PX-105684) is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.</p>Formule :C15H14N2O4SDegré de pureté :99.67% - 99.96%Couleur et forme :SolidMasse moléculaire :318.35PHA-665752
CAS :<p>PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs.</p>Formule :C32H34Cl2N4O4SDegré de pureté :97.05% - 98.82%Couleur et forme :SolidMasse moléculaire :641.61Alisertib
CAS :<p>Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.</p>Formule :C27H20ClFN4O4Degré de pureté :98.31% - >99.99%Couleur et forme :SolidMasse moléculaire :518.92LYS01
CAS :<p>LYS01 free base is a new lysosomal autophagy inhibitor.</p>Formule :C23H23Cl2N5Degré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :440.37Polydatin
CAS :<p>Polydatin, a resveratrol glycoside from Polygonum cuspidatum, inhibits platelet aggregation, alters lipid ratios, and modulates cell functions.</p>Formule :C20H22O8Degré de pureté :97.2% - 98.94%Couleur et forme :White Fine PowderMasse moléculaire :390.38Juglanin
CAS :<p>Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.</p>Formule :C20H18O10Degré de pureté :98.8% - 99.33%Couleur et forme :SolidMasse moléculaire :418.35Tubastatin A
CAS :<p>Tubastatin A: Selective HDAC6 inhibitor, IC50 of 15 nM, 1000x less effective on other isozymes except HDAC8.</p>Formule :C20H21N3O2Degré de pureté :97.22% - 99.51%Couleur et forme :SolidMasse moléculaire :335.4Meglutol
CAS :<p>Meglutol, a cholesterol and triglyceride reducing antilipemic, hinders key enzymes in cholesterol biosynthesis.</p>Formule :C6H10O5Degré de pureté :99.73% - 99.94%Couleur et forme :SolidMasse moléculaire :162.14Retro-2
CAS :<p>Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) is a plant toxin ricin inhibitor, it protects HeLa cells against Ricin, Stx1 and Stx2.</p>Formule :C19H16N2OSDegré de pureté :98.15%Couleur et forme :SolidMasse moléculaire :320.41NVP-AEW541
CAS :<p>NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based</p>Formule :C27H29N5ODegré de pureté :98.7% - 99.86%Couleur et forme :SolidMasse moléculaire :439.55Lys05
CAS :<p>Lys05, a potent autophagy inhibitor, outperforms HCQ in cancer treatment, showing promise for drug development.</p>Formule :C23H26Cl5N5Degré de pureté :99.13% - 99.55%Couleur et forme :SolidMasse moléculaire :549.75MK-2206 dihydrochloride
CAS :<p>MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent and</p>Formule :C25H23Cl2N5ODegré de pureté :99.228% - 99.94%Couleur et forme :SolidMasse moléculaire :480.39Bicyclol
CAS :<p>Bicyclol is an oral anti-hepatitis drug, decreasing ALT/AST levels by 50% and inhibiting HBV/HCV, boosting efficacy with interferon/lamivudine/adefovir.</p>Formule :C19H18O9Degré de pureté :99.64% - 99.85%Couleur et forme :SolidMasse moléculaire :390.34Fasudil dihydrochloride
CAS :<p>Fasudil dihydrochloride (HA-1077/AT877) is a RhoA/ROCK inhibitor with kinase-blocking properties and acts as a vasodilator.</p>Formule :C14H19Cl2N3O2SCouleur et forme :SolidMasse moléculaire :364.29Diosgenin glucoside
CAS :<p>Diosgenin glucoside (Trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis</p>Formule :C33H52O8Degré de pureté :97.17% - 99.44%Couleur et forme :SolidMasse moléculaire :576.76PD146176
CAS :<p>PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.</p>Formule :C15H11NSDegré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :237.32Quisinostat dihydrochloride
CAS :<p>Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) 是一种有口服活性，高效的 pan-HDAC 抑制剂，具有广泛的抗肿瘤活性。它对 HDAC1、HDAC2、HDAC4、HDAC10和HDAC11 的IC50值分别为 0.11 nM、0.33 nM、0.64 nM、0.46 nM 和 0.37 nM。</p>Formule :C21H28Cl2N6O2Degré de pureté :97.13%Couleur et forme :SolidMasse moléculaire :467.39MRT68921 dihydrochloride
CAS :<p>MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).</p>Formule :C25H36Cl2N6ODegré de pureté :98.91% - 99.92%Couleur et forme :SolidMasse moléculaire :507.499FIPI HCl
CAS :<p>FIPI: Selective phospholipase D inhibitor, blocks mercury-induced lipid signals, protects aortic cells.</p>Formule :C23H25ClFN5O2Couleur et forme :SolidMasse moléculaire :457.93Schisandrol B
CAS :<p>Schisandrol B fights neuroinflammation, liver/renal damage, and reduces cell growth via multiple signaling pathways.</p>Formule :C23H28O7Degré de pureté :99.14% - 99.95%Couleur et forme :SolidMasse moléculaire :416.46Lapatinib tosylate
CAS :<p>Lapatinib tosylate (GW572016) is an oral ErbB-2/EGFR inhibitor with IC50s of 10.2 nM (EGFR) & 9.8 nM (ErbB-2).</p>Formule :C36H34ClFN4O7S2Couleur et forme :SolidMasse moléculaire :753.26Brefeldin A
CAS :<p>Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM).</p>Formule :C16H24O4Degré de pureté :96.45% - 99.89%Couleur et forme :White SolidMasse moléculaire :280.36Sanguinarine
CAS :<p>Sanguinarine (Pseudochelerythrine) is a specific inhibitor of Rac1b with anti-microbial, anti-oxidant and anti-inflammatory properties.</p>Formule :C20H14NO4Degré de pureté :99.04% - 99.76%Couleur et forme :SolidMasse moléculaire :332.33Idarubicin
CAS :<p>Idarubicin, a potent oral anthracycline, halts DNA/RNA replication and synthesis, damages DNA, and inhibits microbial growth.</p>Formule :C26H27NO9Couleur et forme :SolidMasse moléculaire :497.49FIPI
CAS :<p>FIPI, a halopemide derivative, strongly blocks PLD1 and PLD2 (IC50s: 25 nM, 20 nM) and hinders PLD-mediated cell activity.</p>Formule :C23H24FN5O2Degré de pureté :97.21% - 98.68%Couleur et forme :SolidMasse moléculaire :421.47MRT68921 HCl
CAS :<p>MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 nM, respectively).</p>Formule :C25H34N6O·HClDegré de pureté :99.86% - 99.98%Couleur et forme :SolidMasse moléculaire :471.04ABT-737
CAS :<p>ABT-737 is a BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w. ABT-737 exhibits antitumor activity and anti-aging activity. Cost-effective and quality-assured.</p>Formule :C42H45ClN6O5S2Degré de pureté :98.15% - >99.99%Couleur et forme :SolidMasse moléculaire :813.43Dinoprost tromethamine salt
CAS :<p>Dinoprost tromethamine salt (PGF2α THAM) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.</p>Formule :C24H45NO8Degré de pureté :99.73%Couleur et forme :Natural Form Crystals SolidMasse moléculaire :475.62Fasudil hydrochloride hydrate
CAS :<p>Fasudil HCl hydrate is a ROCK inhibitor that hinders mature CCM development and lowers portal pressure in cirrhotic rats.</p>Formule :C28H38Cl2N6O5S2Couleur et forme :SolidMasse moléculaire :673.67Calcimycin
CAS :<p>Calcimycin (A-23187) is a polyether antibiotic that transports Ca²⁺, uncouples phosphorylation, and inhibits ATPase in mitochondria.</p>Formule :C29H37N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.62Sophocarpine
CAS :<p>Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.</p>Formule :C15H22N2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :246.35Oprozomib
CAS :<p>Oprozomib inhibits 20S proteasome β5/LMP7, is orally available, and may have cancer-fighting properties. IC50: β5 - 36 nM; LMP7 - 82 nM.</p>Formule :C25H32N4O7SDegré de pureté :98% - 99.87%Couleur et forme :SolidMasse moléculaire :532.61Paris saponin VII
CAS :<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Formule :C51H82O21Degré de pureté :99.51% - 99.63%Couleur et forme :SolidMasse moléculaire :1031.18Quercitrin
CAS :<p>Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities.</p>Formule :C21H20O11Degré de pureté :98.89% - 99.66%Couleur et forme :Yellow Crystals From Dil Methanol Or Ethanol SolidMasse moléculaire :448.38Everolimus
CAS :<p>Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.</p>Formule :C53H83NO14Degré de pureté :97.76% - 99.78%Couleur et forme :Off-White To Light Yellow PowdMasse moléculaire :958.22Vandetanib
CAS :<p>Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 (IC50: 40 nM). It also inhibits VEGFR3 and EGFR.</p>Formule :C22H24BrFN4O2Degré de pureté :99.7% - >99.99%Couleur et forme :White SolidMasse moléculaire :475.35Nutlin-3a
CAS :<p>Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a has antitumor activity. Cost-effective and quality-assured.</p>Formule :C30H30Cl2N4O4Degré de pureté :95.62% - 99.71%Couleur et forme :SolidMasse moléculaire :581.49NS1643
CAS :<p>NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.</p>Formule :C15H10F6N2O3Degré de pureté :98.37% - 99.31%Couleur et forme :SolidMasse moléculaire :380.24PD168393
CAS :<p>PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.</p>Formule :C17H13BrN4ODegré de pureté :99.13% - 99.83%Couleur et forme :SolidMasse moléculaire :369.22Schisandrin
CAS :<p>Schisandrin (Wuweizi alcohol-A) is a compound with anti-asthmatic, anti-cancer, and anti-inflammatory effects.</p>Formule :C24H32O7Degré de pureté :98.97% - 99.32%Couleur et forme :White PowderMasse moléculaire :432.51Tacrolimus monohydrate
CAS :<p>Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FKBP to form a complex.</p>Formule :C44H71NO13Degré de pureté :97.07% - 98.05%Couleur et forme :SolidMasse moléculaire :822.05GLPG1837
CAS :<p>GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.</p>Formule :C16H20N4O3SDegré de pureté :99.64% - 99.91%Couleur et forme :SolidMasse moléculaire :348.42DPN
CAS :<p>DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) .</p>Formule :C15H13NO2Degré de pureté :99.01%Couleur et forme :Off-White SolidMasse moléculaire :239.27UBCS039
CAS :<p>UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)</p>Formule :C16H13N3Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :247.29
