Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1428 produits trouvés pour "Autophagie"
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QX77
CAS :<p>QX77 is a chaperone-mediated autophagy (CMA) activator.</p>Formule :C16H13ClN2O2Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :300.74Zoledronic Acid
CAS :<p>Zoledronic Acid (ZOL 446) 是一种含氮二磷酸盐，能抑制破骨细胞的分化和凋亡，具有高效的抗骨质再吸收活性，也有抗癌作用。</p>Formule :C5H10N2O7P2Degré de pureté :98% - 99.93%Couleur et forme :White Crystalline PowderMasse moléculaire :272.09VO-Ohpic trihydrate
CAS :<p>VO-Ohpic trihydrate (VO-Ohpic) is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.</p>Formule :C12H9N2O8V·3H2O·HDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :415.2BGT226
CAS :<p>BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.</p>Formule :C28H25F3N6O2Degré de pureté :95.74% - 99.51%Couleur et forme :SolidMasse moléculaire :534.53UNBS5162
CAS :<p>UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.</p>Formule :C17H18N4O3Degré de pureté :98.37% - 99.97%Couleur et forme :SolidMasse moléculaire :326.35Vinorelbine ditartrate
CAS :<p>Vinorelbine ditartrate (KW-2307) is a natural alkaloid and an anti-mitotic agent. Vinorelbine ditartrate has anti-tumor activity. Cost-effective and quality-assured.</p>Formule :C45H54N4O8·2C4H6O6Degré de pureté :98% - 99.86%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :1079.11PX-478
CAS :<p>PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.</p>Formule :C13H20Cl4N2O3Degré de pureté :97% - 99.79%Couleur et forme :SolidMasse moléculaire :394.12Schisandrin
CAS :<p>Schisandrin (Wuweizi alcohol-A) is a compound with anti-asthmatic, anti-cancer, and anti-inflammatory effects.</p>Formule :C24H32O7Degré de pureté :98.97% - 99.32%Couleur et forme :White PowderMasse moléculaire :432.51MRT68921 HCl
CAS :<p>MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 nM, respectively).</p>Formule :C25H34N6O·HClDegré de pureté :99.86% - 99.98%Couleur et forme :SolidMasse moléculaire :471.04Rotenone
CAS :<p>Rotenone, a plant-derived insecticide, inhibits mitochondrial electron transport, found in Leguminosae.</p>Formule :C23H22O6Degré de pureté :89.58% - 99.88%Couleur et forme :Less To Brownish Crystals Or A White To Brownish-White Crystalline Powder Has Neither Odor Nor Taste (Ntp 1992)Masse moléculaire :394.42NVP-AEW541
CAS :<p>NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based</p>Formule :C27H29N5ODegré de pureté :98.7% - 99.86%Couleur et forme :SolidMasse moléculaire :439.55Oxyresveratrol
CAS :<p>1.</p>Formule :C14H12O4Degré de pureté :98.09% - 99.69%Couleur et forme :Yellow SolidMasse moléculaire :244.24CX546
CAS :<p>CX546 is an AMPA receptor modulator. CX546 enhances cognitive function in rats. It has also been proposed as a treatment for schizophrenia.</p>Formule :C14H17NO3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :247.29BX795
CAS :<p>BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.</p>Formule :C23H26IN7O2SDegré de pureté :98% - 99.57%Couleur et forme :SolidMasse moléculaire :591.47SMER28
CAS :<p>SMER28 triggers autophagy in cells without mTOR, blocking amyloid beta buildup.</p>Formule :C11H10BrN3Degré de pureté :99.94% - >99.99%Couleur et forme :SolidMasse moléculaire :264.12ZSTK474
CAS :<p>PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential</p>Formule :C19H21F2N7O2Degré de pureté :98.29% - 99.95%Couleur et forme :White PowderMasse moléculaire :417.41GW 4064
CAS :<p>GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).</p>Formule :C28H22Cl3NO4Degré de pureté :98% - 99.94%Couleur et forme :SolidMasse moléculaire :542.84Afatinib
CAS :<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Formule :C24H25ClFN5O3Degré de pureté :98.56% - 99.9%Couleur et forme :Off-White SolidMasse moléculaire :485.94Mirdametinib
CAS :<p>Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity.</p>Formule :C16H14F3IN2O4Degré de pureté :99.11% - 99.63%Couleur et forme :White PowderMasse moléculaire :482.19GSK621
CAS :<p>GSK621 is a specific and potent AMPK activator.</p>Formule :C26H20ClN3O5Degré de pureté :97.02% - 97.05%Couleur et forme :SolidMasse moléculaire :489.91Tenovin-1
CAS :<p>Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.</p>Formule :C20H23N3O2SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :369.48Cyclovirobuxine D
CAS :<p>Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.</p>Formule :C26H46N2ODegré de pureté :97.78% - 98%Couleur et forme :SolidMasse moléculaire :402.665-Aminolevulinic acid hydrochloride
CAS :<p>5-Aminolevulinic acid hydrochloride (5-ALA) serves as an intermediate in the body's heme biosynthesis and is the universal precursor of tetrapyrroles.</p>Formule :C5H10ClNO3Degré de pureté :98% - 99.97%Couleur et forme :White To Pale Yellow Crystals OrMasse moléculaire :167.59Idelalisib
CAS :<p>Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).</p>Formule :C22H18FN7ODegré de pureté :98% - 99.39%Couleur et forme :SolidMasse moléculaire :415.42Ulipristal acetate
CAS :Ulipristal acetate (CDB-2914) is an oral selective progesterone modulator used for emergency contraception and suppressing uterine growths.Formule :C30H37NO4Degré de pureté :98.83% - 99.94%Couleur et forme :SolidMasse moléculaire :475.62Azithromycin
CAS :<p>Azithromycin (CP 62993) is a macrolide antibiotic that primarily targets the 50S subunit of bacterial ribosomes. High-Quality, Low-Cost!</p>Formule :C38H72N2O12Degré de pureté :99.9% - 99.97%Couleur et forme :White To Off-White Solid CrystallineMasse moléculaire :748.98Carfilzomib
CAS :<p>Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome.</p>Formule :C40H57N5O7Degré de pureté :99.6% - 99.84%Couleur et forme :SolidMasse moléculaire :719.91UM-164
CAS :<p>UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.</p>Formule :C30H31F3N8O3SDegré de pureté :98.72% - 99.52%Couleur et forme :SolidMasse moléculaire :640.68Nidufexor
CAS :<p>Nidufexor is an agonist for the farnesoid X receptor (FXR).</p>Formule :C27H22ClN3O4Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :487.93E-64
CAS :<p>E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.</p>Formule :C15H27N5O5Degré de pureté :98% - 99.95%Couleur et forme :White SolidMasse moléculaire :357.41Berberine
CAS :<p>1.</p>Formule :C20H18NO4Degré de pureté :95.71% - 99.67%Couleur et forme :SolidMasse moléculaire :336.36PF-06454589
CAS :<p>PF-06454589 is a potent inhibitor of LRRK2.</p>Formule :C14H16N6ODegré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :284.32SBI-0206965
CAS :<p>SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.</p>Formule :C21H21BrN4O5Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :489.32OSI-027
CAS :<p>OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.</p>Formule :C21H22N6O3Degré de pureté :97.42%Couleur et forme :SolidMasse moléculaire :406.44Omipalisib
CAS :<p>Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.</p>Formule :C25H17F2N5O3SDegré de pureté :98% - 99.8%Couleur et forme :SolidMasse moléculaire :505.5UNC1999
CAS :<p>UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).</p>Formule :C33H43N7O2Degré de pureté :99.19% - >99.99%Couleur et forme :SolidMasse moléculaire :569.74Spautin-1
CAS :<p>Spautin-1 is an autophagy inhibitor that can suppress the deubiquitination activity of ubiquitin-specific peptidase USP10 and USP13. Cost-effective and quality-assured.</p>Formule :C15H11F2N3Degré de pureté :97.69% - 98.99%Couleur et forme :SolidMasse moléculaire :271.26URMC-099
CAS :<p>URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.</p>Formule :C27H27N5Degré de pureté :99.32% - 99.98%Couleur et forme :SolidMasse moléculaire :421.54PF-543 hydrochloride
CAS :<p>PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2</p>Formule :C27H32ClNO4SDegré de pureté :98.9% - 99.93%Couleur et forme :SolidMasse moléculaire :502.1Mycro 3
CAS :<p>Mycro 3 is potent and selective for c-Myc in whole cell assays.</p>Formule :C24H17ClF2N6O4Degré de pureté :99.51% - 99.61%Couleur et forme :SolidMasse moléculaire :526.88Berbamine dihydrochloride
CAS :<p>Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.</p>Formule :C37H42Cl2N2O6Degré de pureté :95% - 99.99%Couleur et forme :SolidMasse moléculaire :681.65AZD1208
CAS :<p>AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.</p>Formule :C21H21N3O2SDegré de pureté :97.24% - 99.83%Couleur et forme :SolidMasse moléculaire :379.48Tubastatin A Hydrochloride
CAS :<p>Tubastatin A Hydrochloride (TSA HCl) is an effective and specific HDAC6 inhibitor (IC50: 15 nM).</p>Formule :C20H21N3O2·HClDegré de pureté :97.24% - 99.15%Couleur et forme :SolidMasse moléculaire :371.86Bergapten
CAS :<p>Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.</p>Formule :C12H8O4Degré de pureté :99.48% - ≥95%Couleur et forme :Needles From Alcohol; Soln In Sulfuric Acid Is Yellow-Gold Physical Description Grayish-White Micr°Crystalline Powder Or Yellow Fluffy Solid (Ntp 1992)Masse moléculaire :216.19Dimethyl fumarate
CAS :<p>Dimethyl fumarate (DMF) is an orally Nrf2 activator. Dimethyl fumarate has antimicrobial and anti-inflammatory activities. Cost-effective and quality-assured.</p>Formule :C6H8O4Degré de pureté :90.51% - >99.99%Couleur et forme :White To Off-White Powder White Crystalline PowderMasse moléculaire :144.13Clematichinenoside AR
CAS :<p>Clematichinenoside AR is anti-inflammatory, immunosuppressive, and combats arthritis via PI3K/Akt and TNF-α pathways.</p>Formule :C82H134O43Degré de pureté :99.04% - 99.69%Couleur et forme :SolidMasse moléculaire :1807.92Ginkgolide K
CAS :<p>Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.</p>Formule :C20H22O9Degré de pureté :99.44% - 99.72%Couleur et forme :SolidMasse moléculaire :406.38Telaglenastat
CAS :<p>Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.</p>Formule :C26H24F3N7O3SDegré de pureté :97.57% - 99.89%Couleur et forme :SolidMasse moléculaire :571.57Fulvestrant
CAS :<p>Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30.</p>Formule :C32H47F5O3SDegré de pureté :99.1% - >99.99%Couleur et forme :White PowderMasse moléculaire :606.77Resatorvid
CAS :<p>Resatorvid (TAK-242) inhibits TLR4, with IC50s for IL-6, TNF-R, NO at 1.3, 1.9, 1.8 nM respectively.</p>Formule :C15H17ClFNO4SDegré de pureté :99.31% - >99.99%Couleur et forme :SolidMasse moléculaire :361.82
