Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1459 produits trouvés pour "Autophagie"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
D-CopA3
CAS :<p>D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 μM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model.</p>Formule :C96H184N30O18S2Couleur et forme :SolidMasse moléculaire :2110.81Tigecycline hydrochloride
CAS :Tigecycline hydrochloride is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.Formule :C29H40ClN5O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :622.11Acridine homodimer
CAS :Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.Formule :C38H42Cl2N6O2Couleur et forme :SolidMasse moléculaire :685.69E70K
E70K, a CXCL8 C-terminal peptide, features a lysine (K) substitution for glutamic acid (E) at position 70 and has demonstrated the ability to attenuateFormule :C108H178N34O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2400.78Desethylamiodarone hydrochloride
CAS :Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.Formule :C23H26ClI2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :653.72NAMPT degrader-1
Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.Formule :C56H68ClN9O5S2Couleur et forme :SolidMasse moléculaire :1046.78p62-ZZ Ligand-Linker Conjugate 1
CAS :<p>p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.</p>Formule :C31H42N2O6Couleur et forme :SolidMasse moléculaire :538.68Clionamine B
CAS :Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.Formule :C27H45NO3Couleur et forme :SolidMasse moléculaire :431.65CXCL-CXCR1/2-IN-1
CAS :<p>CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.</p>Formule :C14H8Cl2N4O3SDegré de pureté :99.4%Couleur et forme :SoildMasse moléculaire :383.21SDF-1α (human)
CAS :SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processesFormule :C356H578N106O93S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7959.34RK-682 (calcium salt)
CAS :RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.Formule :C42H74CaO10Couleur et forme :SolidMasse moléculaire :779.122TSPO Ligand-Linker Conjugates 1
TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.Formule :C32H55N3O10SCouleur et forme :SolidMasse moléculaire :673.86Vimnerixin
CAS :Vimnerixin (AZD4721) is an orally administered CXCR2 antagonist for inflammation studies.Formule :C19H25FN4O5S2Couleur et forme :SolidMasse moléculaire :472.55ATG16L1 stabilizer-1
<p>ATG16L1 stabilizer-1 (compound A3B) is an FKBP12-independent stabilizer of ATG16L1 that enhances cellular autophagy (Autophagy). Regardless of the presence of FKBP12, it has an inhibitory EC50 value of 12.1 μM for ATG16L1. When used alone, ATG16L1 stabilizer-1 can induce GFP-LC3 puncta formation, with an EC50 value of 12.0 μM.</p>Formule :C45H62N14O5SCouleur et forme :SolidMasse moléculaire :911.13Valproic acid sodium salt
CAS :Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.Formule :C8H15NaO2Degré de pureté :98% - 99.78%Couleur et forme :White PowderMasse moléculaire :166.2Tetramethylrhodamine-dUTP
Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .Formule :C43H52N6O19P3Couleur et forme :SolidMasse moléculaire :1049.82PTX80
CAS :<p>PTX80 is an antagonist of p62, with an IC50 value of 31.18 nM. It has been shown to reduce tumor volume in a HCT116 colorectal cancer mouse xenograft model.</p>Formule :C26H26N4O3SCouleur et forme :SolidMasse moléculaire :474.58CXCR7 modulator 1
CAS :<p>CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM.</p>Formule :C48H57F2N7O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :914.074-Amino-D-phenylalanine
CAS :4-Amino-D-phenylalanine ([D-Phe(4-NH2)]) is a cyclic pentapeptide that inhibits the binding of CXCL12 to CXCR4 in FC131, with an IC50 value of 0.1 μM.Formule :C9H12N2O2Couleur et forme :SolidMasse moléculaire :180.2Desethyl chloroquine
CAS :<p>Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity.</p>Formule :C16H22ClN3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :291.82
