Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
1459 produits trouvés pour "Autophagie"
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SHP2-IN-35
<p>SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy). Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.</p>Formule :C34H32FeO6Couleur et forme :SolidMasse moléculaire :592.46Corynoxine hydrochloride
<p>Corynoxine hydrochloride, from Uncaria macrophylla, enhances autophagy, clearing alpha-synuclein via Akt/mTOR.</p>Formule :C22H29ClN2O4Couleur et forme :SolidMasse moléculaire :420.93Valproic acid sodium salt
CAS :Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.Formule :C8H15NaO2Degré de pureté :98% - 99.78%Couleur et forme :White PowderMasse moléculaire :166.2Tigecycline mesylate
CAS :Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.Formule :C30H43N5O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :681.75Cy5.5-SE (DIPEA)
Cy5.5-SE DIPEA is a water-soluble CY dye often used for labeling proteins and antibodies, with simple mixing for conjugation. Store protected from light.Formule :C53H66N4O16S4Couleur et forme :SolidMasse moléculaire :1143.37p62-ZZ Ligand-Linker Conjugate 1
CAS :<p>p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.</p>Formule :C31H42N2O6Couleur et forme :SolidMasse moléculaire :538.68Peptide R
CAS :<p>Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.</p>Formule :C39H59N13O8S2Couleur et forme :SolidMasse moléculaire :902.1G-quadruplex DNA fluorescence probe 1
<p>Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.</p>Formule :C27H31IN2O3Couleur et forme :SolidMasse moléculaire :558.45Desethylamiodarone hydrochloride
CAS :Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.Formule :C23H26ClI2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :653.72Tetramethylrhodamine-dUTP
Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .Formule :C43H52N6O19P3Couleur et forme :SolidMasse moléculaire :1049.82RK-682 (calcium salt)
CAS :RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.Formule :C42H74CaO10Couleur et forme :SolidMasse moléculaire :779.122TSPO Ligand-Linker Conjugates 1
TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.Formule :C32H55N3O10SCouleur et forme :SolidMasse moléculaire :673.86Cyanine 5 Tyramide methyl indole
<p>Cyanine 5 Tyramide is a red dye used in HRP assays and nucleic acid hybridization. Store away from light.</p>Formule :C40H47N3O8S2Couleur et forme :SolidMasse moléculaire :761.95Acetazolamide
CAS :<p>Acetazolamide (Diamox) is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification of acetazolamide is Sulfonamides.</p>Formule :C4H6N4O3S2Degré de pureté :99.61% - 99.94%Couleur et forme :Crystals From Water 1992)Masse moléculaire :222.25Cy3-dCTP
Cy3-dCTP, a fluorescent cyanine-dye-labeled nucleotide triphosphate, serves as a DNA imaging probe.Formule :C43H51Li4N6O20P3S2Couleur et forme :SolidMasse moléculaire :1156.71(3R,5S)-Fluvastatin
CAS :(3R,5S)-Fluvastatin, a synthetic HMG-CoA reductase inhibitor (IC50: 8 nM), activates Nrf2 for antioxidant defense.Formule :C24H26FNO4Couleur et forme :SolidMasse moléculaire :411.47MeCY5-NHS ester triethylamine
MeCY5-NHS ester (potassium) is a reactive dye optimized for labeling proteins and nucleic acids [1].Formule :C42H56N4O10S2Couleur et forme :SolidMasse moléculaire :841.04ATG16L1 stabilizer-1
<p>ATG16L1 stabilizer-1 (compound A3B) is an FKBP12-independent stabilizer of ATG16L1 that enhances cellular autophagy (Autophagy). Regardless of the presence of FKBP12, it has an inhibitory EC50 value of 12.1 μM for ATG16L1. When used alone, ATG16L1 stabilizer-1 can induce GFP-LC3 puncta formation, with an EC50 value of 12.0 μM.</p>Formule :C45H62N14O5SCouleur et forme :SolidMasse moléculaire :911.13CXCR4 antagonist 1
CAS :CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.Formule :C27H43N7Couleur et forme :SolidMasse moléculaire :465.69DMTr-4'-CF3-5-Me-U-CED phosphoramidite
<p>DMTr-4'-CF3-5-Me-U-CED is a dye for oligonucleotide labeling in RNA research.</p>Formule :C42H50F3N4O8PCouleur et forme :SolidMasse moléculaire :826.84
