
DUB
Les inhibiteurs de déubiquitinases (DUB) ciblent les enzymes qui retirent les molécules d'ubiquitine des protéines, régulant ainsi la stabilité, la localisation et l'activité des protéines dans la cellule. Les déubiquitinases jouent un rôle essentiel dans divers processus cellulaires, notamment la régulation du cycle cellulaire, la réparation de l'ADN et les réponses immunitaires. La dérégulation de l'activité des DUB est liée au cancer, aux troubles neurodégénératifs et aux infections virales. Les inhibiteurs de DUB peuvent moduler ces processus, offrant des approches thérapeutiques potentielles pour ces conditions. Chez CymitQuimica, nous proposons des inhibiteurs de DUB pour soutenir vos recherches en homéostasie des protéines, en oncologie et en neurobiologie.
103 produits trouvés pour "DUB".
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GRL0617
CAS :GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).Formule :C20H20N2ODegré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :304.39Ref: TM-T11464
1mg34,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg105,00€25mg178,00€50mg313,00€100mg500,00€500mg1.063,00€HBX 19818
CAS :HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).Formule :C25H28ClN3ODegré de pureté :97.71%Couleur et forme :SolidMasse moléculaire :421.96Ref: TM-T15464
1mg35,00€5mg80,00€1mL*10mM (DMSO)89,00€10mg111,00€25mg177,00€50mg253,00€100mg353,00€200mg502,00€MF-094
CAS :MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Formule :C30H37N3O4SDegré de pureté :99.93%Couleur et forme :White SolidMasse moléculaire :535.7Ref: TM-T12024
1mg40,00€5mg93,00€1mL*10mM (DMSO)99,00€10mg137,00€25mg268,00€50mg430,00€100mg620,00€200mg884,00€C527
CAS :C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).Formule :C17H8FNO3Degré de pureté :97.22%Couleur et forme :SolidMasse moléculaire :293.25IU1-47
CAS :IU1-47 是一种特异性 USP14抑制剂,IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5, IC50为 20 μM。Formule :C19H23ClN2ODegré de pureté :98.94%Couleur et forme :White SolidMasse moléculaire :330.85Ref: TM-T15604
1mg34,00€5mg64,00€1mL*10mM (DMSO)70,00€10mg109,00€25mg222,00€50mg358,00€100mg593,00€200mg830,00€OTUB1/USP8-IN-1 HCl
OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemiaFormule :C22H17Cl2FN2O4Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :463.29OTUB2-IN-1
OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).Formule :C19H18N2O6S2Degré de pureté :98.19%Couleur et forme :Red SolidMasse moléculaire :434.49T20-M
T20-M is a precursor peptide with strong binding affinity for UBE2C.Formule :C87H140N22O26SCouleur et forme :SolidMasse moléculaire :1942.24Subquinocin
Subquinocin is a CYLD inhibitor that suppresses deubiquitinating enzymes (DUB) of the USP family. By inhibiting CYLD, Subquinocin enhances the activation of the NF-κB and IFN pathways. Additionally, Subquinocin facilitates the activation of IRF3 and/or IRF7 in the RIG-I-mediated interferon pathway.Formule :C20H27N3O4SCouleur et forme :SolidMasse moléculaire :405.17223Ga-CY03
Ga-CY03 (compound) is a FAP-tracing molecule designed based on the FAP inhibitor QI-18 and labeled with [Ga].Formule :C53H63F2GaN13O15Couleur et forme :SolidMasse moléculaire :1229.87USP7-IN-10 hydrochloride
USP7-IN-10 hydrochloride, also known as compound 1, is a potent inhibitor of the enzyme ubiquitin-specific protease 7 (USP7), exhibiting an IC50 value of 13.39Formule :C26H30Cl2N4O3SCouleur et forme :SolidMasse moléculaire :549.51EN523
CAS :EN523 targets non-catalytic allosteric cysteine C23 in K48 ubiquitin-specific deuquitinase OTUB1.Formule :C12H14N2O3Degré de pureté :99.5%Couleur et forme :White SolidMasse moléculaire :234.25Ref: TM-T9884
1mg34,00€5mg66,00€1mL*10mM (DMSO)67,00€10mg99,00€25mg222,00€50mg356,00€100mg570,00€200mg800,00€UBD1031
UBD1031 exhibits strong affinity for the ubiquitin-binding domain (UBD) of USP16, with a dissociation constant (KD) of 48 nM. It inhibits the interaction between USP16 and ISG15, displaying an effective concentration (EC50) of 1.7 nM. UBD1031 can serve as a chemical probe for investigating USP16 UBD.Couleur et forme :Odour Solid(R)-CMPD-39
(R)-CMPD-39 is the R-enantiomer of CMPD-39. CMPD-39 acts as a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 with an IC50 of approximately 20 nM and demonstrates high selectivity for other DUB family members at concentrations ranging from 1-100 μM. By inhibiting USP30's deubiquitination activity, CMPD-39 enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP and promotes the accumulation of phosphorylated ubiquitin. This process accelerates both mitophagy and pexophagy. Additionally, CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson’s disease patients.MS7131
MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.Couleur et forme :Odour SolidUSP7 ligand-2
USP7ligand-2 is a target protein ligand that can be utilized in the synthesis of PROTACs, such as [PROTACUSP7 Degrader-2].GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Formule :C21H22N6O2Couleur et forme :SolidMasse moléculaire :390.44USP7-055
CAS :USP7-055 is an inhibitor of USP7, utilized in cancer research.Formule :C27H29ClN4O2SCouleur et forme :SolidMasse moléculaire :509.06USP1-IN-9
USP1-IN-9 (Compound 1m) is a reversible and non-competitive inhibitor of ubiquitin-specific protease (USP1) with an IC50 value of 8.8 nM. It is synthesized based on the structures of ML323 and KSQ-4279 as a pyrido[2,3-d]pyrimidin-7(8H)-one derivative. USP1-IN-9 exhibits excellent inhibition of USP1/UAF and demonstrates strong antiproliferative effects on breast cancer cells. When combined with the PARP inhibitor olaparib, USP1-IN-9 enhances the cytotoxic effect on MDA-MB-436/OP cells. USP1-IN-9 holds potential for research in the field of cancer.Couleur et forme :Odour SolidUSP7-IN-16
CAS :USP7-IN-16 (Compound 61) is a selective inhibitor of USP7, with IC50 values of 5.5 nM in the FLINT assay and 2.1 nM in MM.1S cells. This compound exhibits antitumor activity in mice and holds potential for research in the field of oncology.Formule :C43H45N7O6SCouleur et forme :SolidMasse moléculaire :787.93GK16S
GK16S, a UCHL1 chemogenomic probe, serves as a complementary tool to GK13S for the investigation of UCHL1 function in cellular studies [1].Formule :C11H15N3OCouleur et forme :SolidMasse moléculaire :205.12151USP7-IN-15
USP7-IN-15 (compound J21) is an inhibitor of USP7, exhibiting an IC50 value of 41.35 ± 2.16 nM.Couleur et forme :Odour SolidQ14
Q14 is a polypeptide derived from the transmembrane (TM) domain of USP30 (ubiquitin specific peptidase30) and is capable of inhibiting the deubiquitination activity of USP30 (IC50=57.2 nM). By hindering the interaction between USP30’s transmembrane and catalytic domains, it lowers USP30 activity. The Q14 polypeptide contains an LC3 interaction region (LIR) motif, enabling it to bind with LC3, thereby accelerating autophagosome formation and promoting mitophagy. Q14 is applicable in the study of neurodegenerative diseases, mitochondrial quality control, and cellular metabolism.Formule :C101H168N32O23Couleur et forme :SolidMasse moléculaire :2197.29601USP7 Ligand-Linker Conjugates 1
USP7Ligand-Linker Conjugates 1 is a Target Protein Ligand-Linker Conjugate comprising a USP7 ligand and a PROTAC linker, capable of recruiting E3 ligase. It is utilized in the synthesis of PROTACUSP7 Degrader-1.Couleur et forme :Odour SolidJAMM protein inhibitor 2
CAS :JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Formule :C21H26N2O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :338.44Ubiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening;Couleur et forme :Odour SolidRef: TM-L8600
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderUSP8-IN-3
CAS :USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.Formule :C18H18F3N5O2SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :425.43Ref: TM-T67873
1mg34,00€5mg60,00€1mL*10mM (DMSO)79,00€10mg92,00€25mg195,00€50mg311,00€100mg449,00€500mg888,00€BAY-728
BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].Formule :C24H28F3N5O2SCouleur et forme :SolidMasse moléculaire :507.57USP8-IN-2
CAS :USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.Formule :C19H20ClF3N4OSDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :444.9Ref: TM-T67876
1mg94,00€5mg200,00€1mL*10mM (DMSO)220,00€10mg313,00€25mg520,00€50mg740,00€100mg982,00€UCHL1-IN-1
UCHL1-IN-1 (Compound 46) is an inhibitor of ubiquitin C-terminal hydrolase L1 (UCHL1), with an IC50 of 5.1 μM. This compound is applicable in cancer research.Formule :C11H13Cl2N3O2Couleur et forme :SolidMasse moléculaire :289.03848FT206
CAS :FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].Formule :C25H29N5OSCouleur et forme :SolidMasse moléculaire :447.6STD1T
CAS :STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.Formule :C19H19N3O4S2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :417.5USP8-IN-1
CAS :USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].Formule :C18H21N5O3SDegré de pureté :99.07%Couleur et forme :SoildMasse moléculaire :387.46Ref: TM-T60146
1mg50,00€5mg110,00€1mL*10mM (DMSO)122,00€10mg156,00€25mg264,00€50mg371,00€100mg537,00€P 22077
CAS :P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.Formule :C12H7F2NO3S2Degré de pureté :97.9% - 99.64%Couleur et forme :Yellow SolidMasse moléculaire :315.32EOAI3402143
CAS :EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.Formule :C25H28Cl2N4O3Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :503.42Ref: TM-T11209
1mg63,00€5mg137,00€1mL*10mM (DMSO)152,00€10mg215,00€25mg423,00€50mg680,00€100mg1.009,00€NSC632839
CAS :NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2Formule :C21H22ClNODegré de pureté :99.74% - 99.88%Couleur et forme :SolidMasse moléculaire :339.86TCID
CAS :TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Formule :C9H2Cl4O2Degré de pureté :98.87% - 99.34%Couleur et forme :SolidMasse moléculaire :283.92P005091
CAS :P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.Formule :C12H7Cl2NO3S2Degré de pureté :99.53% - 99.87%Couleur et forme :SolidMasse moléculaire :348.22SJB2-043
CAS :SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).Formule :C17H9NO3Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :275.26ML364
CAS :ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.Formule :C24H18F3N3O3S2Degré de pureté :99.35% - >99.99%Couleur et forme :SolidMasse moléculaire :517.54USP7/USP47 inhibitor
CAS :USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,Formule :C18H11Cl2N3O3S3Degré de pureté :98.5% - 98.71%Couleur et forme :SolidMasse moléculaire :484.4Ref: TM-T4338
1mg40,00€1mL*10mM (DMSO)94,00€5mg96,00€10mg152,00€25mg268,00€50mg429,00€100mg703,00€200mg954,00€IU1-248
CAS :IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Formule :C20H23N3O2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :337.42Ref: TM-T9375
1mg48,00€5mg92,00€1mL*10mM (DMSO)102,00€10mg152,00€25mg301,00€50mg424,00€100mg605,00€200mg845,00€DUB-IN-2
CAS :Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.Formule :C15H9N5ODegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :275.26VLX1570
CAS :VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Formule :C23H17F2N3O6Degré de pureté :98.53% - 99.91%Couleur et forme :SolidMasse moléculaire :469.39Ref: TM-T4067
1mg90,00€2mg146,00€5mg245,00€1mL*10mM (DMSO)251,00€10mg385,00€25mg645,00€50mg888,00€100mg1.234,00€GNE-6776
CAS :GNE-6776 is a selective USP7 inhibitor.Formule :C20H20N4O2Degré de pureté :96.59% - 98.2%Couleur et forme :SolidMasse moléculaire :348.4DUB-IN-1
CAS :DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Formule :C20H11N5ODegré de pureté :98.33% - 98.96%Couleur et forme :SolidMasse moléculaire :337.33Ref: TM-T11110
1mg62,00€5mg110,00€1mL*10mM (DMSO)122,00€10mg173,00€25mg334,00€50mg469,00€100mg618,00€200mg848,00€GNE-6640
CAS :GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).Formule :C20H18N4ODegré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :330.38Ref: TM-T5461
1mg66,00€2mg96,00€5mg144,00€1mL*10mM (DMSO)158,00€10mg236,00€25mg507,00€50mg730,00€100mg1.018,00€USP7-IN-8
CAS :Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.Formule :C21H21N3O2Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :347.41Ref: TM-T9217
1mg46,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg147,00€25mg269,00€50mg389,00€100mg532,00€200mg705,00€DUB-IN-3
CAS :DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Formule :C16H9N5ODegré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :287.28Ref: TM-T11112
1mg130,00€2mg178,00€5mg309,00€1mL*10mM (DMSO)324,00€10mg442,00€25mg705,00€50mg982,00€100mg1.333,00€500mg2.655,00€USP25/28 inhibitor AZ1
CAS :USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.Formule :C17H16BrF4NO2Degré de pureté :99.81% - 99.86%Couleur et forme :White SolidMasse moléculaire :422.21Ref: TM-T7685
10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander1mg34,00€5mg66,00€1mL*10mM (DMSO)73,00€

