
DUB
Les inhibiteurs de déubiquitinases (DUB) ciblent les enzymes qui retirent les molécules d'ubiquitine des protéines, régulant ainsi la stabilité, la localisation et l'activité des protéines dans la cellule. Les déubiquitinases jouent un rôle essentiel dans divers processus cellulaires, notamment la régulation du cycle cellulaire, la réparation de l'ADN et les réponses immunitaires. La dérégulation de l'activité des DUB est liée au cancer, aux troubles neurodégénératifs et aux infections virales. Les inhibiteurs de DUB peuvent moduler ces processus, offrant des approches thérapeutiques potentielles pour ces conditions. Chez CymitQuimica, nous proposons des inhibiteurs de DUB pour soutenir vos recherches en homéostasie des protéines, en oncologie et en neurobiologie.
84 produits trouvés pour "DUB"
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IU1-47
CAS :<p>IU1-47 是一种特异性 USP14抑制剂,IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5, IC50为 20 μM。</p>Formule :C19H23ClN2ODegré de pureté :98.94%Couleur et forme :SolidMasse moléculaire :330.85C527
CAS :<p>C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).</p>Formule :C17H8FNO3Degré de pureté :97.22%Couleur et forme :SolidMasse moléculaire :293.25HBX 19818
CAS :<p>HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).</p>Formule :C25H28ClN3ODegré de pureté :97.71%Couleur et forme :SolidMasse moléculaire :421.96MF-094
CAS :<p>MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.</p>Formule :C30H37N3O4SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :535.7Subquinocin
<p>Subquinocin is a CYLD inhibitor that suppresses deubiquitinating enzymes (DUB) of the USP family. By inhibiting CYLD, Subquinocin enhances the activation of the NF-κB and IFN pathways. Additionally, Subquinocin facilitates the activation of IRF3 and/or IRF7 in the RIG-I-mediated interferon pathway.</p>Formule :C20H27N3O4SCouleur et forme :SolidMasse moléculaire :405.17223UBD1031
<p>UBD1031 exhibits strong affinity for the ubiquitin-binding domain (UBD) of USP16, with a dissociation constant (KD) of 48 nM. It inhibits the interaction between USP16 and ISG15, displaying an effective concentration (EC50) of 1.7 nM. UBD1031 can serve as a chemical probe for investigating USP16 UBD.</p>Couleur et forme :Odour SolidUbiquitination Compound Library
<p>A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening;</p>Couleur et forme :Odour SolidBAY-728
<p>BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].</p>Formule :C24H28F3N5O2SCouleur et forme :SolidMasse moléculaire :507.57OTUB1/USP8-IN-1 HCl
<p>OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemia</p>Formule :C22H17Cl2FN2O4Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :463.29GK13S
<p>G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.</p>Formule :C21H22N6O2Couleur et forme :SolidMasse moléculaire :390.44MS7131
<p>MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.</p>Couleur et forme :Odour SolidUSP7-IN-16
CAS :<p>USP7-IN-16 (Compound 61) is a selective inhibitor of USP7, with IC50 values of 5.5 nM in the FLINT assay and 2.1 nM in MM.1S cells. This compound exhibits antitumor activity in mice and holds potential for research in the field of oncology.</p>Formule :C43H45N7O6SCouleur et forme :SolidMasse moléculaire :787.93USP7-IN-15
<p>USP7-IN-15 (compound J21) is an inhibitor of USP7, exhibiting an IC50 value of 41.35 ± 2.16 nM.</p>Couleur et forme :Odour SolidUSP8-IN-2
CAS :<p>USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.</p>Formule :C19H20ClF3N4OSDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :444.9USP8-IN-3
CAS :<p>USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.</p>Formule :C18H18F3N5O2SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :425.43OTUB2-IN-1
<p>OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).</p>Formule :C19H18N2O6S2Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :434.49JAMM protein inhibitor 2
CAS :<p>JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.</p>Formule :C21H26N2O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :338.44USP7-IN-10 hydrochloride
<p>USP7-IN-10 hydrochloride, also known as compound 1, is a potent inhibitor of the enzyme ubiquitin-specific protease 7 (USP7), exhibiting an IC50 value of 13.39</p>Formule :C26H30Cl2N4O3SCouleur et forme :SolidMasse moléculaire :549.51GK16S
<p>GK16S, a UCHL1 chemogenomic probe, serves as a complementary tool to GK13S for the investigation of UCHL1 function in cellular studies [1].</p>Formule :C11H15N3OCouleur et forme :SoildMasse moléculaire :205.12151USP8-IN-1
CAS :<p>USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].</p>Formule :C18H21N5O3SDegré de pureté :99.07%Couleur et forme :SoildMasse moléculaire :387.46STD1T
CAS :<p>STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.</p>Formule :C19H19N3O4S2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :417.5ML364
CAS :<p>ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.</p>Formule :C24H18F3N3O3S2Degré de pureté :99.35% - >99.99%Couleur et forme :SolidMasse moléculaire :517.54DUB-IN-3
CAS :<p>DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.</p>Formule :C16H9N5ODegré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :287.28GNE-6640
CAS :<p>GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).</p>Formule :C20H18N4ODegré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :330.38IU1-248
CAS :<p>IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].</p>Formule :C20H23N3O2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :337.42GNE-6776
CAS :<p>GNE-6776 is a selective USP7 inhibitor.</p>Formule :C20H20N4O2Degré de pureté :96.59% - 98.2%Couleur et forme :SolidMasse moléculaire :348.4P 22077
CAS :<p>P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.</p>Formule :C12H7F2NO3S2Degré de pureté :97.9% - 99.58%Couleur et forme :SolidMasse moléculaire :315.32STAMBP-IN-1
CAS :<p>STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after</p>Formule :C27H28N4O4SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :504.6EOAI3402143
CAS :<p>EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.</p>Formule :C25H28Cl2N4O3Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :503.42TCID
CAS :<p>TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.</p>Formule :C9H2Cl4O2Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :283.92USP25/28 inhibitor AZ1
CAS :<p>USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.</p>Formule :C17H16BrF4NO2Degré de pureté :99.79% - 99.79%Couleur et forme :SolidMasse moléculaire :422.21USP7-IN-8
CAS :<p>Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.</p>Formule :C21H21N3O2Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :347.41XL177A
CAS :<p>XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.</p>Formule :C48H57ClN8O5Degré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :861.47USP7/USP47 inhibitor
CAS :<p>USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,</p>Formule :C18H11Cl2N3O3S3Degré de pureté :98.5% - 98.71%Couleur et forme :SolidMasse moléculaire :484.4ML-323
CAS :<p>ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.</p>Formule :C23H24N6Degré de pureté :99.87% - 99.96%Couleur et forme :SolidMasse moléculaire :384.48DUB-IN-1
CAS :<p>DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).</p>Formule :C20H11N5ODegré de pureté :98.33% - 98.96%Couleur et forme :SolidMasse moléculaire :337.33VLX1570
CAS :<p>VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.</p>Formule :C23H17F2N3O6Degré de pureté :98.53% - 99.91%Couleur et forme :SolidMasse moléculaire :469.39P005091
CAS :<p>P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.</p>Formule :C12H7Cl2NO3S2Degré de pureté :99.53% - 99.87%Couleur et forme :SolidMasse moléculaire :348.22NSC632839
CAS :<p>NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2</p>Formule :C21H22ClNODegré de pureté :99.74% - 99.88%Couleur et forme :SolidMasse moléculaire :339.86DUB-IN-2
CAS :<p>Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.</p>Formule :C15H9N5ODegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :275.26SJB2-043
CAS :<p>SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).</p>Formule :C17H9NO3Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :275.26USP1-IN-2
CAS :<p>USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.</p>Formule :C26H22F4N6ODegré de pureté :99.69% - 99.88%Couleur et forme :SolidMasse moléculaire :510.486BC-1471
CAS :<p>BC-1471 is a STAMBP deubiquitinase inhibitor that blocks NALP7 inflammasome activity.</p>Formule :C27H32N4O4SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :508.63POSH-IN-1
CAS :<p>POSH-IN-1 (Compound 108) is an inhibitor of the POSH polypeptide (e3 ligase) and has antiviral, anticancer, and neurodegenerative disease potential.</p>Formule :C14H8FNO3SDegré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :289.28LCAHA
CAS :<p>LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.</p>Formule :C24H41NO3Couleur et forme :SolidMasse moléculaire :391.59USP28-IN-3
CAS :<p>USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Formule :C23H20Cl2N2O3SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :475.39USP28-IN-4
CAS :<p>USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Formule :C22H18Cl2N2O3SDegré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :461.368RK64
CAS :<p>8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .</p>Formule :C14H16N8O2SCouleur et forme :SolidMasse moléculaire :360.4USP7-IN-4
CAS :<p>USP7-IN-4 is a non-competitive, potent and selective inhibitor of USP7, up-regulates p53 and p21, down-regulates MDM2,anti-proliferativity RS4;11 (leukemia) .</p>Formule :C29H34N6O3Degré de pureté :98.27% - 99.09%Couleur et forme :SolidMasse moléculaire :514.62FT827
CAS :<p>FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.</p>Formule :C27H28N6O5SDegré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :548.61

