DUB
Les inhibiteurs de déubiquitinases (DUB) ciblent les enzymes qui retirent les molécules d'ubiquitine des protéines, régulant ainsi la stabilité, la localisation et l'activité des protéines dans la cellule. Les déubiquitinases jouent un rôle essentiel dans divers processus cellulaires, notamment la régulation du cycle cellulaire, la réparation de l'ADN et les réponses immunitaires. La dérégulation de l'activité des DUB est liée au cancer, aux troubles neurodégénératifs et aux infections virales. Les inhibiteurs de DUB peuvent moduler ces processus, offrant des approches thérapeutiques potentielles pour ces conditions. Chez CymitQuimica, nous proposons des inhibiteurs de DUB pour soutenir vos recherches en homéostasie des protéines, en oncologie et en neurobiologie.
104 produits trouvés pour "DUB".
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USP7-IN-12
CAS :USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].Formule :C29H28ClFN4O2SCouleur et forme :SolidMasse moléculaire :551.07USP1-IN-3
CAS :USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.Formule :C27H24F3N7OCouleur et forme :SolidMasse moléculaire :519.52USP1-IN-5
CAS :USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less thanFormule :C27H23F3N8OCouleur et forme :SolidMasse moléculaire :532.52USP1-IN-6
CAS :USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.Formule :C29H27F3N8OCouleur et forme :SolidMasse moléculaire :560.57CT1113
CAS :CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDXFormule :C25H29N5O2SCouleur et forme :SolidMasse moléculaire :463.6USP7-IN-1
CAS :USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Formule :C23H24ClN3O3Degré de pureté :99.82%Couleur et forme :White SolidMasse moléculaire :425.91Ref: TM-T13268
1mg84,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg249,00€25mg425,00€50mg605,00€100mg800,00€FT671
CAS :FT671 is a non-covalent, selective USP7 inhibitor, disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, inhibits tumor growth.Formule :C24H23F4N7O3Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :533.48USP7-IN-3
CAS :USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Formule :C29H31F3N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :568.59IMP-1710
CAS :IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Formule :C23H19N5ODegré de pureté :99.3%Couleur et forme :White SolidMasse moléculaire :381.43USP7-797
CAS :USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.Formule :C27H28ClN3O3SDegré de pureté :95.90% - 95.90%Couleur et forme :SolidMasse moléculaire :510.05MS5105
CAS :MS5105 is a covalent ligand for the deubiquitinating enzyme OTUB1, and it can be used to construct DUBTACs, such as MS8588.Formule :C15H21N3O2SMasse moléculaire :307.41USP1-IN-4
CAS :USP1-IN-4 (compound 10) serves as a potent inhibitor of USP1, exhibiting an IC 50 of 2.44 nM. It demonstrates anticancer properties and operates synergistically with various anticancer drugs [1].Formule :C26H23F3N6Couleur et forme :SolidMasse moléculaire :476.50MTX115325
CAS :MTX115325 (Example 1) is a brain-penetrant USP30 inhibitor with an IC 50 of 12 nM, administered orally and exhibiting neuroprotective properties. It enhances ubiquitination (EC 50 =32 nM) of TOM20, a mitochondrial outer membrane protein and USP30 substrate, thereby promoting mitophagy. Additionally, MTX115325 prevents dopaminergic neuron loss and maintains striatal dopamine [1].Formule :C18H16N6O2Couleur et forme :SolidMasse moléculaire :348.36USP7-IN-10
CAS :USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.Formule :C26H29ClN4O3SCouleur et forme :SolidMasse moléculaire :513.05USP1-IN-7
CAS :USP1-IN-7 (Compound 3), a potent inhibitor of ubiquitin specific peptidase 1 (USP1) and its cofactor UAF1, exhibits an inhibition concentration (IC 50) of ≤50 nM. It also effectively inhibits the proliferation of MDA-MB-436 cells at similar concentrations [1].Formule :C27H23F4N7O2Couleur et forme :SolidMasse moléculaire :553.51USP7 activator 1
CAS :USP7activator 1 (compound MS-8) is an activator of USP7 that interacts with the allosteric C-terminal binding pocket of USP7.Formule :C22H32N4O3Couleur et forme :SolidMasse moléculaire :400.514USP7-IN-6
CAS :USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).Formule :C41H43N7O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :729.89FT3967385
FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.Formule :C21H19N5O2Couleur et forme :SolidMasse moléculaire :373.41WWQ-03-012
CAS :WWQ-03-012 is a selective inhibitor of deSUMOylating isopeptidase DESI2, with an IC50 of 47.3 μM. It induces ubiquitination-proteasome degradation of JAK2-V617F without significantly affecting wild-type JAK2. This compound can disrupt the JAK2-STAT3/5 signaling pathway, inhibit cell proliferation, and induce apoptosis. When used in combination with Ruxolitinib, WWQ-03-012 demonstrates a synergistic effect, enhancing cytotoxicity against JAK2 mutant cells. It is applicable in cancer research, specifically in studying myeloproliferative neoplasms.Formule :C20H16N4O3SMasse moléculaire :392.43FT709
CAS :FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.Formule :C23H22N4O7SDegré de pureté :98.13%Couleur et forme :White SolidMasse moléculaire :498.51
