
DUB
Les inhibiteurs de déubiquitinases (DUB) ciblent les enzymes qui retirent les molécules d'ubiquitine des protéines, régulant ainsi la stabilité, la localisation et l'activité des protéines dans la cellule. Les déubiquitinases jouent un rôle essentiel dans divers processus cellulaires, notamment la régulation du cycle cellulaire, la réparation de l'ADN et les réponses immunitaires. La dérégulation de l'activité des DUB est liée au cancer, aux troubles neurodégénératifs et aux infections virales. Les inhibiteurs de DUB peuvent moduler ces processus, offrant des approches thérapeutiques potentielles pour ces conditions. Chez CymitQuimica, nous proposons des inhibiteurs de DUB pour soutenir vos recherches en homéostasie des protéines, en oncologie et en neurobiologie.
104 produits trouvés pour "DUB".
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Capzimin
CAS :Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.Formule :C30H24N6O2S4Degré de pureté :98.31% - 99.32%Couleur et forme :SolidMasse moléculaire :628.81XL-188
CAS :XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.Formule :C32H42N6O4Couleur et forme :SolidMasse moléculaire :574.71USP7-IN-4
CAS :USP7-IN-4 is a non-competitive, potent and selective inhibitor of USP7, up-regulates p53 and p21, down-regulates MDM2,anti-proliferativity RS4;11 (leukemia) .Formule :C29H34N6O3Degré de pureté :98.27% - 99.09%Couleur et forme :SolidMasse moléculaire :514.62USP28-IN-2
CAS :USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.Formule :C23H20Cl2N2O3SCouleur et forme :SolidMasse moléculaire :475.39HBX28258
CAS :HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.Formule :C26H30ClN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.99BAP1-IN-1
CAS :BAP1-IN-1 is an inhibitor of the catalytic activity of BRCA1-associated protein 1 (BAP1), which is related to cancer and can be used to study cancer.Formule :C18H16N2O2Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :292.33I-138
CAS :I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Formule :C26H23F3N6ODegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :492.5Ref: TM-T73560
1mg105,00€5mg210,00€1mL*10mM (DMSO)230,00€10mg295,00€25mg424,00€50mg587,00€100mg880,00€USP28-IN-4
CAS :USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formule :C22H18Cl2N2O3SDegré de pureté :98.39%Couleur et forme :Yellow SolidMasse moléculaire :461.36USP28-IN-3
CAS :USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formule :C23H20Cl2N2O3SDegré de pureté :99.92%Couleur et forme :White SolidMasse moléculaire :475.39GSK2643943A
CAS :GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Formule :C17H12FN3Degré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :277.3Ref: TM-T11485
1mg39,00€2mg50,00€5mg82,00€1mL*10mM (DMSO)90,00€10mg120,00€25mg236,00€50mg356,00€100mg537,00€200mg762,00€USP22-IN-1
CAS :USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Formule :C22H18N4Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :338.41SJB3-019A
CAS :SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFormule :C16H8N2O3Degré de pureté :99.72%Couleur et forme :Yellow SolidMasse moléculaire :276.25Ref: TM-T12926
1mg77,00€2mg101,00€5mg168,00€10mg253,00€25mg416,00€50mg580,00€100mg783,00€200mg1.054,00€P22074
CAS :P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Formule :C12H9NO3S2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :279.33Ref: TM-T28284
1mg137,00€1mL*10mM (DMSO)239,00€5mg314,00€10mg427,00€25mg600,00€50mg798,00€100mg1.099,00€200mg1.468,00€USP30 inhibitor 11
CAS :USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Formule :C17H16N6O2SDegré de pureté :98.49% - 98.84%Couleur et forme :SolidMasse moléculaire :368.416RK73
CAS :6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).Formule :C13H17N5O2SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :307.37Ref: TM-T10188
1mg137,00€5mg281,00€1mL*10mM (DMSO)310,00€10mg484,00€25mg782,00€50mg1.071,00€100mg1.431,00€500mg2.898,00€OTUB1/USP8-IN-1
CAS :OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Formule :C22H16ClFN2O4Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :426.83LDN-91946
CAS :LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Formule :C15H10N2O4SDegré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :314.32USP30 inhibitor 18
CAS :USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Formule :C26H28FN3O4SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :497.58Ref: TM-T36682
1mg137,00€5mg281,00€1mL*10mM (DMSO)309,00€10mg447,00€25mg713,00€50mg1.018,00€100mg1.369,00€500mg2.673,00€USP7-IN-13
CAS :USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].Formule :C24H28N4O3Couleur et forme :SolidMasse moléculaire :420.5DUB-IN-7
CAS :DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].Formule :C17H19N5OCouleur et forme :SolidMasse moléculaire :309.37

