
DUB
Les inhibiteurs de déubiquitinases (DUB) ciblent les enzymes qui retirent les molécules d'ubiquitine des protéines, régulant ainsi la stabilité, la localisation et l'activité des protéines dans la cellule. Les déubiquitinases jouent un rôle essentiel dans divers processus cellulaires, notamment la régulation du cycle cellulaire, la réparation de l'ADN et les réponses immunitaires. La dérégulation de l'activité des DUB est liée au cancer, aux troubles neurodégénératifs et aux infections virales. Les inhibiteurs de DUB peuvent moduler ces processus, offrant des approches thérapeutiques potentielles pour ces conditions. Chez CymitQuimica, nous proposons des inhibiteurs de DUB pour soutenir vos recherches en homéostasie des protéines, en oncologie et en neurobiologie.
94 produits trouvés pour "DUB".
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MF-095
CAS :MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.Formule :C27H31N3O4SCouleur et forme :SolidMasse moléculaire :493.62I-138
CAS :I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Formule :C26H23F3N6ODegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :492.5Ref: TM-T73560
1mg105,00€5mg210,00€1mL*10mM (DMSO)230,00€10mg295,00€25mg424,00€50mg587,00€100mg880,00€LCAHA
CAS :LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.Formule :C24H41NO3Couleur et forme :SolidMasse moléculaire :391.59Capzimin
CAS :Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.Formule :C30H24N6O2S4Degré de pureté :98.31% - 99.32%Couleur et forme :SolidMasse moléculaire :628.81SJB3-019A
CAS :SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFormule :C16H8N2O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :276.25Ref: TM-T12926
1mg77,00€2mg101,00€5mg168,00€10mg253,00€25mg416,00€50mg580,00€100mg783,00€200mg1.054,00€USP30 inhibitor 11
CAS :USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Formule :C17H16N6O2SDegré de pureté :98.49% - 98.84%Couleur et forme :SolidMasse moléculaire :368.416RK73
CAS :6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).Formule :C13H17N5O2SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :307.37Ref: TM-T10188
1mg137,00€5mg281,00€1mL*10mM (DMSO)310,00€10mg484,00€25mg782,00€50mg1.071,00€100mg1.431,00€500mg2.898,00€P22074
CAS :P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Formule :C12H9NO3S2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :279.33Ref: TM-T28284
1mg137,00€1mL*10mM (DMSO)239,00€5mg314,00€10mg427,00€25mg600,00€50mg798,00€100mg1.099,00€200mg1.468,00€GSK2643943A
CAS :GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Formule :C17H12FN3Degré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :277.3Ref: TM-T11485
1mg39,00€2mg50,00€5mg82,00€1mL*10mM (DMSO)90,00€10mg120,00€25mg236,00€50mg356,00€100mg537,00€200mg762,00€USP22-IN-1
CAS :USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Formule :C22H18N4Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :338.41OTUB1/USP8-IN-1
CAS :OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Formule :C22H16ClFN2O4Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :426.83USP30 inhibitor 18
CAS :USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Formule :C26H28FN3O4SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :497.58Ref: TM-T36682
1mg137,00€5mg281,00€1mL*10mM (DMSO)309,00€10mg447,00€25mg713,00€50mg1.018,00€100mg1.369,00€500mg2.673,00€CT1113
CAS :CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDXFormule :C25H29N5O2SCouleur et forme :SolidMasse moléculaire :463.6USP7-IN-12
CAS :USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].Formule :C29H28ClFN4O2SCouleur et forme :SolidMasse moléculaire :551.07USP7-IN-13
CAS :USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].Formule :C24H28N4O3Couleur et forme :SolidMasse moléculaire :420.5DUB-IN-7
CAS :DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].Formule :C17H19N5OCouleur et forme :SolidMasse moléculaire :309.37FT206
CAS :FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].Formule :C25H29N5OSCouleur et forme :SolidMasse moléculaire :447.6USP7-IN-1
CAS :USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Formule :C23H24ClN3O3Degré de pureté :99.82%Couleur et forme :White SolidMasse moléculaire :425.91Ref: TM-T13268
1mg84,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg249,00€25mg425,00€50mg605,00€100mg800,00€USP1-IN-3
CAS :USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.Formule :C27H24F3N7OCouleur et forme :SolidMasse moléculaire :519.52FT671
CAS :FT671 is a non-covalent, selective USP7 inhibitor, disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, inhibits tumor growth.Formule :C24H23F4N7O3Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :533.48
