Antibiotique

<p>Lincomycin-B is a lincosamide antibiotic isolated from the actinomycete Streptomyces lincolnensis.</p>

<p>Deacetylcephalothin Sodium Salt is an impurity in the synthesis of Cefalonium. It used as a long-acting intramammary cerate for the infusion of dairy cows.</p>

<p>Tebipenem is an orally available carbapenem antibiotic. It displays broad-spectrum activity against Gram-positive and -negative bacteria.</p>

<p>N4Py is a good synthetic mimic of the Bleomycins (BLMs), which are a family of natural antibiotics used clinically in the treatment of certain cancers.</p>

<p>L-Azatyrosine from Streptomyces chibaensis is an antitumor antibiotic reversing Ras-transformed cell behavior.</p>

<p>Epitetracycline is an epimer of the antibiotic tetracycline . Epimers of tetracycline form without catalysis and are considered degradation products. Epitetracycline has decreased activity as an antibiotic or a Tet repressor effector but may have stronger toxic effects in animals.</p>

<p>Tauroxicum (Taurox) is formulated by COBAT to reduce fatigue and improve quality of life.</p>

<p>Azaserine (CI-337) is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as an inhibitor of glutamine amidotransferase.</p>

<p>Vincristine, a microtubule disruptor, inhibits mitosis in cancer cells, useful in leukemia research.</p>

<p>Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.</p>

<p>BRD-8000.3 is a narrow-spectrum antimycobacterial targeting EfpA, inhibiting lipid transport in drug-tolerant Mtb and useful in structural and functional.</p>

<p>Riodoxol is an antiviral agent that effectively affects the reproduction and maturation of viruses.</p>

<p>AFK-108 is a fungicide agent.</p>

<p>Phenosulfazole is a potent antiviral agent which has the potential for the research of poliomyelitis virus [1].</p>

<p>Compound 5, an antiviral agent, effectively targets murine norovirus, with potential in infectious disease and oncology research.</p>

<p>Vidarabine phosphate is an adenosine monophosphate analog.</p>

<p>Saquayamycin B, a glycoside, targets Gram-positive bacteria and both adriamycin-sensitive and -resistant P388 leukemia cells.</p>

<p>MptpB-IN-1: orally active, potent MptpB inhibitor; reduces drug-resistant tuberculosis.</p>

<p>Amcinafal is an active diol,and used against virus replication and interferon production.</p>

<p>S 863390 is a renin inhibitor.</p>

<p>RMI 10874 is a tilorone analogue. Tilorone is an orally bioavailable antiviral agent.</p>

<p>Alalevonadifloxacin HCl is a novel l-alanine ester prodrug of levonadifloxacin.</p>

<p>SQ109 (NSC-722041) is an effective inhibitor of the trypomastigote form of the parasite (IC50 = 50 nM). SQ109 is an antitubercular agent and targets MmpL3.</p>

<p>4-((4-((4-Aminophenyl)sulfonyl)phenyl)amino)-4-oxobutanoic acid is a sulfonamide compound that can be used as an anti infective agent [1].</p>

<p>Ormetoprim (Ro 5-9754), an antibiotic approved for use in the United States, is used to prevent the spread of disease in freshwater aquaculture.</p>

<p>Niclosamide Monohydrate is used for the treatment of most tapeworm infections by inhibiting DNA replication.</p>

<p>SSJ-183 is a low-toxicity and orally available and anti-malarial drug with an IC50 = 7.6 nM against P. falciparum and no lethality at doses up to 2000 mg/kg po.</p>

<p>Pyrrofolic acid shows high anti-folate biological activity for S. faecalis.</p>

<p>Linogliride fumarate, a guanidine derivative, stimulates insulin release by blocking ATP-sensitive K+ channels, enhancing glucose tolerance.</p>

<p>Albitiazolium bromide is an antimalarial compound disrupting phosphatidylcholine biosynthesis in Plasmodium, transported via NPP and cation carriers.</p>

<p>Chitin synthase inhibitor 2 (2b) has an IC50 of 0.09 mM, K i 0.12 mM, shows in vitro antimicrobial activity and boosts fluconazole/polyoxin B.</p>

<p>Tunicamine is a reversible polyprenol-phosphate inhibitor.</p>

<p>Abimtrelvir exhibited antiviral activity.</p>

<p>Pafuramidine is an orally bioavailable prodrug of formamidine which was developed for the treatment of human African trypanosomiasis.</p>

<p>Exeporfinium chloride(XF-73) is an antimicrobial agent that can weaken bacterial cell walls.</p>

<p>Epirubicin, a doxorubicin derivative, is an antineoplastic, inhibits topoisomerase, DNA/RNA synthesis, and Foxp3, reducing T cell activity.</p>

<p>Ferric citrate as a source of iron used in cell culture applications can provide iron with a less toxic form compared to free iron salts.</p>

<p>Linogliride: a guanidine derivative, inhibits insulin release, and enhances glucose tolerance by blocking ATP-sensitive K+ channels in pancreatic beta cells.</p>

<p>Verticillin A, an apoptosis inducer, inhibits Leiomyosarcoma and Malignant peripheral nerve sheath tumor growth.</p>

<p>Pentachloropseudilin inhibits Myosin-1 and speeds up TGF-β receptor turnover, suppressing TGF-β activity.</p>

<p>FR900098, a fosmidomycin derivative, has potent antimalarial effects, targeting DOXP reductoisomerase and eradicating P. vinckei in mice at &gt;10 mg/kg.</p>

<p>CRK12-IN-1: strong inhibitor of CRK12, kills T.b. brucei &amp; T. congolense (EC50s: 1.3 &amp; 18 nM).</p>

<p>Rosaramicin, a lipid-soluble basic macrolide, is an antibacterial substance similar to erythromycin but with a better activity against Gram-negative bacteria.</p>

<p>Xenalamine is a synthetic compound of antiviral.</p>

<p>Pyrazofurin, a pyrimidine analogue, blocks cell growth and DNA synthesis by targeting UMP synthase &amp; orotate-phosphoribosyltransferase (IC50: 0.06-0.37 μM).</p>

<p>LY 186826 is an antibacterial agent with bicyclic pyrazolidinone properties.</p>

<p>DDD01035881 is a anti-malarial drug that blocks parasite-to-mosquito transmission by targeting the Plasmodium vesicle membrane protein Pfs16.</p>

<p>Lipoxamycin hemisulfate (Lipoxamycin) is an inhibitor of serine palmitoyltransferase (IC50 = 21 nM) with antifungal activity.</p>

<p>Chitin synthase inhibitor 4: a CHS inhibitor with antimicrobial properties, potential fungicide.</p>

<p>Lincophenicol is an Escherichia coli ribosomal peptidyltransferase-catalyzed puromycin reaction inhibitor.</p>

<p>Acyclovir monophosphate, a strong anti-HSV agent, inhibits viral DNA polymerase, blocking DNA synthesis and chain elongation.</p>

<p>Nortopixantrone HCl (BBR 3438) is a novel 9-azacyclonopyrazole that shows antitumor activity in a human prostate cancer model.</p>

<p>Antiviral agent 17, EC50 0.015 μM in human assay, effective against murine norovirus, may aid infectious/malignant disease research.</p>

<p>Carnidazole (ME-108) shows antiprotozoal activity and can be used in studies about the treatment of Trichomonas infection.</p>

<p>Azidamfenicol inhibits ribosomal peptidyltransferase with a Ki of 22 µM. Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic.</p>

<p>Quinupristin, a macrolide-lincosamide-streptogramin antibiotic, inhibits protein synthesis in bacteria.</p>

<p>Clofoctol is a bacteriostatic antibiotic with activity against Gram-positive bacteria, used in the treatment of upper and lower respiratory tract infections.</p>

<p>Trombodipine (PCA-4230) is a platelet aggregation inhibitor with antithrombotic activity and protection against Listeria monocytogenes.</p>

<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>

<p>Rosoxacin (Acrosoxacin) shows antibacterial activities against a broad spectrum of Gram-negative bacteria including Neisseria gonorrhoeae (MIC90 = 0.03mg/ml).</p>

<p>DuP-721: broad-spectrum, oral antibiotic targeting various bacteria, including M. tuberculosis.</p>

<p>Oseltamivir acid methyl ester, a CES1-convertible neuraminidase inhibitor, serves as an antiviral prodrug.</p>

<p>Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.</p>

<p>Myxopyronin A is an inhibitor of bacterial RNA polymerase.</p>

<p>Aranciamycin (Compound 1), an anthracycline antibiotic, exhibits collagenase inhibitory activity (IC50 3.7*10^-7 M) and can inhibit DNA synthesis in tumor cells</p>

<p>β-Lactamase-IN-2 is an inhibitor of β-Lactamase with anti-microbial and anti-bacterial effects.</p>

<p>Gusperimus trihydrochloride is a derivative of the antitumor antibiotic spergualin with immunosuppressant activity.</p>

<p>N-(3-Oxobutanoyl)-L-homoserine lactone (3-oxo-C4-HSL) serves as an autoregulator for carbapenem antibiotic biosynthesis in Erwinia carotovora ATCC 39048 and induces the expression of rhiI in R. leguminosarum [1].</p>

<p>4'-Acetyl-chrysomycin B, a 4'-acetylated analog of chrysomycin B, exhibits anti-Gram-positive bacterial and antimicrobial activities [1].</p>

<p>SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor, demonstrating potent antifungal activity with an inhibition concentration (IC50) of 7.2 μg/mL and an</p>

<p>S-Adenosylhomocysteine (SAH) hydrolase is responsible for the reversible hydrolysis of SAH into adenosine and homocysteine. Inhibition of this enzyme leads to the accumulation of SAH within cells, thereby increasing the SAH to S-adenosylmethionine (SAM) ratio and subsequently inhibiting SAM-dependent methyltransferases. (−)-Neplanocin A, a potent and irreversible inhibitor of SAH hydrolase (Ki= 8.39 nM), exhibits significant antitumor activity against mouse leukemia L1210 cells and holds broad-spectrum antiviral properties. Its efficacy notably surpasses that of the reversible inhibitor 3-deazaneplanocin, especially in combating vesicular stomatitis, evidencing a higher potency with ID50 values of 0.07 μg/ml for Neplanocin A versus 0.3 μg/ml for 3-deazaneplanocin.</p>

<p>Cladosporin, from Cladosporium cladosporioid fungus, halts dermatophyte growth on agar at 75 μg/mL.</p>

<p>Alatrofloxacin is a prodrug of trovafloxacin.</p>

<p>Annamycin, a semi-synthetic doxorubicin derivative, binds DNA, blocks topoisomerase II, and evades MDR, inhibiting DNA/RNA/protein synthesis.</p>

<p>Pristinamycin IA (Mikamycin B) is a substrate for the P-glycoprotein and a cyclo-peptidic macrolactone antibiotic.</p>

<p>AS-2077715, an antifungal agent, exhibits inhibitory activity against Trichophyton species and is derived from the fermentation broth of Capnodium sp. 339855. It is utilized in the study of fungal infections [1].</p>

<p>OM173-αA is a quinone bacterial metabolite that inhibits the growth of the bacteria M.</p>

<p>Berkeleylactone E, a macrolide antibiotic [1], exhibits antimicrobial properties.</p>

<p>N-Acetylpurinomycin is a selective agonist of CB2 receptor.</p>

<p>Nilofabicin (CG-400549) is a potent inhibitor of enoyl-(acyl-carrier-protein) reductase fall(FabI) and can be used in studies about the treatment of complicated</p>

<p>Compound 6d (Antibacterial agent 159) is an antibiotic effective against impetigo and Clostridium difficile infection (CDI), with no observed recurrence for CDI</p>

<p>Caerulomycin A (Caerulomycin) (Cerulomycin; Caerulomycin) is an antifungal compound.</p>

<p>CcpA-IN-1 is a Staphylococcus aureus antibiotic exhibiting significant bactericidal activity (MICs=460 nM) [1].</p>

<p>Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A.</p>

<p>Neocryptolepine-Cl (compound Z24) is an inhibitor of Bcthi4, demonstrating excellent antifungal activity against B. cinerea, with an EC50 value of 0.56 μg/mL.</p>

<p>Mal-PEG4-VA-PBD is a drug-linker conjugate for Antibody-Drug Conjugates (ADCs), comprising the antitumor antibiotic Pyrrolobenzodiazepine (PBD), connected</p>

<p>Myxothiazol blocks mitochondrial complex III and triggers SESN2, a gene important for stress response.</p>

<p>Ganaplacide hydrochloride (KAF156 HCl) is an orally administered imidazopyrimidine antimalarial agent that inhibits Plasmodium PI4K activity.</p>

<p>Imidocarb dihydrochloride monohydrate is an effective antiprotozoal agent against the parasite B. bovis (IC50: 87 μg/ml).</p>

<p>Ceftolozane TFA is a cephalosporin class antibiotic (antibiotic) designed to inhibit Gram-negative bacterial infections. Additionally, it can be utilized in the synthesis of novel antibiotics (antibiotic) that are more efficacious and safer.</p>

<p>TAN-1057C is a potent antibiotic with antimicrobial activity against both Gram-negative and Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA).</p>

<p>Cefamandole (lithium), a second-generation broad-spectrum cephalosporin antibiotic, exhibits antimicrobial activity. Upon metabolism in the body, it releases free NMTT, which can lead to hypoprothrombinemia.</p>

<p>Anti-MRSA agent 19 (Compound 1) is an antibiotic that exhibits activity against Staphylococcus aureus. It is active against 40 clinical isolates from the CDC, representing diverse bacterial species with various resistance factors, including resistance to vancomycin, aminoglycoside/tetracycline, and oxazolidinone (median MIC=4 μg/mL).</p>

<p>Carbonic anhydrase inhibitor28 (Compound 11) serves as an inhibitor for the Pseudomonas aeruginosa carbonic anhydrase. It exhibits antibacterial activity, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 0.5 and 1 μg/mL, respectively, against P. aeruginosa. Carbonic anhydrase inhibitor28 is utilized in research focused on anti-infection applications.</p>

<p>Methacycline, a tetracycline antibiotic, inhibits bacterial protein synthesis and effectively suppresses epithelial-mesenchymal transition (EMT). It blocks EMT in vitro and inhibits fibrogenesis in vivo without directly affecting the TGF-β1Smad signaling pathway. As an antimicrobial agent, Methacycline holds potential for research in pulmonary fibrosis.</p>

<p>MLEB-22043 is a synthetic siderophore-monocyclic β-lactam conjugate which enters bacteria through TonB-dependent transport proteins utilizing its siderophore component, subsequently exerting antibacterial activity via its β-lactam portion. This compound acts as a broad-spectrum antibiotic, exhibiting significant inhibitory activity against pathogens such as Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa.</p>

<p>DRF-8417 is an oxazolidinone antibiotic, active against both Gram-positive bacteria and fastidious Gram-negative bacteria. The MIC50 and MIC90 values of DRF-8417 for Gram-positive pathogens range between 0.06-1 mg/L.</p>

<p>Bleomycin Free Base, a glycopeptide antibiotic, halts DNA function and treats solid tumors.</p>

<p>Cilastatin ammonium salt is an antibiotic that is particularly effective against Gram-positive cocci, with a half-life of 3-4 hours.</p>

<p>Acetomycin, a γ-lactone from S. ramulosus, halts HCT-8 colon and L1210 leukemia cell growth.</p>