Signalisation PI3K/Akt/mTOR
Les inhibiteurs de la signalisation PI3K/Akt/mTOR sont des composés qui ciblent les voies de la phosphoinositide 3-kinase (PI3K), de la kinase Akt et de la cible de la rapamycine chez les mammifères (mTOR). Ces voies sont des régulateurs critiques de la croissance cellulaire, de la survie, du métabolisme et de l'autophagie, ce qui en fait des cibles clés dans la recherche sur le cancer et les troubles métaboliques. Inhiber ces voies peut aider à contrôler la croissance et la prolifération tumorales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies caractérisées par une signalisation cellulaire dysrégulée. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de haute qualité de PI3K/Akt/mTOR pour soutenir vos recherches en oncologie, signalisation cellulaire et maladies métaboliques.
Sous-catégories appartenant à la catégorie "Signalisation PI3K/Akt/mTOR"
- AMPK(158 produits)
- ATM/ATR(71 produits)
- ADN-PK(51 produits)
- EGFR(572 produits)
- MELK(7 produits)
- PDK(9 produits)
- PI3K(242 produits)
- S6 Kinase(9 produits)
- gsk-3(112 produits)
- mTOR(144 produits)
Affichez 2 plus de sous-catégories
1038 produits trouvés pour "Signalisation PI3K/Akt/mTOR"
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EGFR-IN-73
CAS :<p>EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].</p>Formule :C19H17ClFN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.81Selatinib
CAS :<p>Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.</p>Formule :C29H26ClFN4O3SDegré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :565.06CGP52411
CAS :<p>CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM).</p>Formule :C20H15N3O2Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :329.35PI3K/mTOR Inhibitor-4
CAS :<p>Oral PI3K/mTOR Inhibitor-4 targets PI3Kα, γ, δ, mTOR; IC50s: 0.63, 22, 9.2, 13.85 nM. Used in cancer research.</p>Formule :C27H22FN3O6SCouleur et forme :SolidMasse moléculaire :535.54BRD0209
CAS :<p>BRD0209 is a highly selective and potent GSK3 inhibitor.</p>Formule :C22H25N3ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :347.45GSK-3β inhibitor 12
CAS :<p>GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β</p>Formule :C14H13N3OSDegré de pureté :98.58%Couleur et forme :SolidMasse moléculaire :271.34NVS-PI3-4
CAS :<p>NVS-PI3-4: A selective PI3Kγ inhibitor for research in allergies, inflammation, and cancer.</p>Formule :C20H26N4O3SCouleur et forme :SolidMasse moléculaire :402.51TC-G 24
CAS :<p>GSK-3β inhibitor</p>Formule :C15H11ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :330.73JNJ28871063 hydrochloride
CAS :<p>ErbB receptor family inhibitor</p>Formule :C24H28Cl2N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :519.42(S)-PI3Kα-IN-4
CAS :<p>(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM.</p>Formule :C25H23ClFN5O5SCouleur et forme :SolidMasse moléculaire :56018BIOder
CAS :<p>18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.</p>Formule :C9H7ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :210.62Tyrphostin 51
CAS :<p>Tyrphostin 51 is an effective inhibitor of EGFR kinase.</p>Formule :C13H8N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :268.23CHMFL-PI3KD-317
CAS :<p>CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, >10x selective vs. PI3K isoforms, anti-cancer.</p>Formule :C21H24ClN5O3S2Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :494.03MS 39
CAS :<p>MS 39, a selective EGFR depressant, degrades mutant receptors in lung cancer lines without affecting wild-type. Effective in vitro and in mice.</p>Formule :C55H71ClFN9O7SCouleur et forme :SolidMasse moléculaire :1056.72PI3KD/V-IN-01
CAS :<p>PI3KD/V-IN-01 is a potent ATP-competitive PI3Kδ/Vps34 dual inhibitor.</p>Formule :C21H24ClN5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.03AZ2
CAS :<p>AZ2 is a highly selective, active PI3Kγ inhibitor (pIC50=9.3) for use in inflammatory and immune disorders.</p>Formule :C20H23N3O2SDegré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :369.48Gefitinib N-oxide
CAS :<p>Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.</p>Formule :C22H24ClFN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.9Cazpaullone
CAS :<p>Cazpaullone inhibits GSK-3 and briefly boosts Pax4 mRNA expression.</p>Formule :C16H10N4OCouleur et forme :SolidMasse moléculaire :274.28DBPR112
CAS :<p>DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.</p>Formule :C32H31N5O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :533.62AM-0687
CAS :<p>AM-0687: Strong PI3Kδ blocker; pAKT IC50=0.7nM, u(pAKT) IC50=4.6nM; Rat IgG ED50=0.026mg/kg, IgM ED50=0.016mg/kg; Clu=2.3L/hr/kg.</p>Formule :C23H19FN8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.45VP3.15
CAS :<p>VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).</p>Formule :C20H22N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.48GSK3-IN-2
CAS :<p>GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.</p>Formule :C17H19N3OSDegré de pureté :98.8%Couleur et forme :SolidMasse moléculaire :313.423,5-dimethyl PIT-1
CAS :<p>PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as</p>Formule :C16H15N3O4SCouleur et forme :SolidMasse moléculaire :345.37Aloisine B
CAS :<p>Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.</p>Formule :C15H14ClN3Degré de pureté :95.15%Couleur et forme :SolidMasse moléculaire :271.74PI3K/mTOR Inhibitor-2
CAS :<p>Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.</p>Formule :C20H13ClF2N4O4SDegré de pureté :96.16%Couleur et forme :SolidMasse moléculaire :478.86PI3Kdelta inhibitor 1
CAS :<p>PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.</p>Formule :C27H38N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.69Mutated EGFR-IN-3
CAS :<p>Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.</p>Formule :C31H29FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.59Nazartinib mesylate
CAS :<p>Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).</p>Formule :C27H35ClN6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.12DNA-PK-IN-4
CAS :<p>DNA-PK-IN-4, an imidazolinone, targets DNA-PKcs to hinder tumor DNA repair and induce apoptosis, showing cancer research potential.</p>Formule :C20H24N6O3Couleur et forme :SolidMasse moléculaire :396.44EGFR/HER2-IN-9
CAS :<p>EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFR</p>Formule :C25H25ClFN5O4Couleur et forme :SolidMasse moléculaire :513.95Lavendustin C6
CAS :<p>Lavendustin C6 is a effective tyrosine kinase inhibitor.</p>Formule :C20H25NO5Couleur et forme :SolidMasse moléculaire :359.42Leniolisib phosphate
CAS :<p>Leniolisib phosphate is an effective PI3K inhibitor.</p>Formule :C21H28F3N6O6PCouleur et forme :SolidMasse moléculaire :548.45BAY 2476568
CAS :<p>BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).</p>Formule :C24H27FN4O4Couleur et forme :SolidMasse moléculaire :454.49EGFR-IN-55
CAS :<p>"EGFR-IN-55 targets EGFRWT (70 nM IC50) & EGFRL858R/T790M (3.9 nM IC50), halts NCI-H1975 cell cycle in G0/G1, showing anticancer properties."</p>Formule :C25H25Cl2N7O2Couleur et forme :SolidMasse moléculaire :526.42PKI-179
CAS :<p>PKI-179: Dual PI3K/mTOR inhibitor, orally active, IC50s: 0.42-77 nM, targets E545K and H1047R, antitumor in vivo.</p>Formule :C25H28N8O3Couleur et forme :SolidMasse moléculaire :488.54EGFR-IN-28
CAS :<p>EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .</p>Formule :C31H39BrN10O3SCouleur et forme :SolidMasse moléculaire :711.68SIKs-IN-1
CAS :<p>SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in the M1/M2</p>Formule :C27H31F2N7OCouleur et forme :SolidMasse moléculaire :507.58PI3K-IN-36
CAS :<p>PI3K-IN-36 is a potent inhibitor of PI3K, suitable for research applications in follicular lymphoma (FL).</p>Formule :C30H36F2N8OCouleur et forme :SolidMasse moléculaire :562.66PI3Kγ inhibitor 6
CAS :<p>PI3Kγ Inhibitor 6, a specific inhibitor of PI3Kγ, is utilized in the study of inflammatory and autoimmune diseases.</p>Formule :C16H11NO5SCouleur et forme :SolidMasse moléculaire :329.33PKI-179 hydrochloride
CAS :<p>PKI-179: oral PI3K/mTOR inhibitor; IC50: PI3Kα/β/δ/γ (8-74 nM), PI3Kα mutants (11-14 nM), mTOR (0.42 nM); selective; inhibits cancer cell growth.</p>Formule :C25H29ClN8O3Couleur et forme :SolidMasse moléculaire :525PI3K-IN-28
CAS :<p>PI3K-IN-28, a potent PI3K inhibitor with low toxicity in MCF-10a, has IC50 values of 5.8, 2.3, 7.9 μM and high selectivity index of 39.</p>Formule :C26H16F9N3O3S2Couleur et forme :SolidMasse moléculaire :653.54DNA-PK-IN-5
CAS :<p>DNA-PK-IN-5: potent DNA-PK inhibitor, reduces tumor repair, induces apoptosis, enhances radiotherapy, overcomes resistance.</p>Formule :C21H22N8O2Couleur et forme :SolidMasse moléculaire :418.45CAY10717
CAS :<p>CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.</p>Formule :C29H25F3N6O3Couleur et forme :SolidMasse moléculaire :562.54UNC-CA359
CAS :<p>UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.</p>Formule :C18H14ClN3O2Couleur et forme :SolidMasse moléculaire :339.78EGFR-IN-49
CAS :<p>EGFR-IN-49 selectively inhibits EGFR mutations T790M (IC50: 65 nM) & T790M/L858R (IC50: 13.6 nM), triggering apoptosis dose-dependently.</p>Formule :C22H15N5O2SCouleur et forme :SolidMasse moléculaire :413.45EGFR-IN-75
<p>EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.</p>Formule :C10H6N6S2Couleur et forme :SolidMasse moléculaire :274.32PI3Kα-IN-4
CAS :<p>PI3Kα-IN-4 is a potent, selective, and orally active PI3Kα inhibitor, demonstrating an IC50 of 1.8 nM and exhibiting antitumor activity[1].</p>Formule :C25H23ClFN5O5SCouleur et forme :SolidMasse moléculaire :560(E/Z)-AG490
CAS :<p>(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.</p>Formule :C17H14N2O3Couleur et forme :SolidMasse moléculaire :294.3PI3K-IN-2
CAS :<p>PI3K-IN-2 inhibits PI3Kβ/δ (IC50: 7.1, 8.6 nM) with greater selectivity over PI3Kσ/γ (IC50: 13, 190 nM) and is orally active.</p>Formule :C28H29F2N3O5Couleur et forme :SolidMasse moléculaire :525.54PD 173955-Analog1
CAS :<p>PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.</p>Formule :C21H14Cl2N4O3Couleur et forme :SolidMasse moléculaire :441.27NVP-BBD130
CAS :<p>NVP-BBD130 is a stable, ATP-competitive, potent, orally active inhibitor of PI3K and mTOR.</p>Formule :C28H21N5OCouleur et forme :SolidMasse moléculaire :443.5EGFR/HER2-IN-3
CAS :<p>EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.</p>Formule :C26H23N5O3Couleur et forme :SolidMasse moléculaire :453.49DNA-PK-IN-7
CAS :<p>DNA-PK-IN-7 is a potent DNA-PK inhibitor (IC50= 1 nM) (WO2021104277A1, compound 5).</p>Formule :C19H21N9O2Couleur et forme :SolidMasse moléculaire :407.43eCF-309
CAS :<p>eCF-309 is a potent mTOR inhibitor with IC50 value of 15 nM.</p>Formule :C18H21N7O3Couleur et forme :SolidMasse moléculaire :383.4EGFR-IN-31
CAS :<p>EGFR-IN-31: Potent EGFR inhibitor, targets mutations & overexpression in NSCLC; potential cancer research compound. (WO2021185298A1, 2)</p>Formule :C32H36FN7O2Couleur et forme :SolidMasse moléculaire :569.67PDZ1i
CAS :<p>PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.</p>Formule :C28H26N8O4Couleur et forme :SolidMasse moléculaire :538.56BIBX 1382 Dihydrochloride
CAS :<p>BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.</p>Formule :C18H21Cl3FN7Couleur et forme :SolidMasse moléculaire :460.76LDC0496
CAS :<p>LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.</p>Formule :C32H35N5O3Couleur et forme :SolidMasse moléculaire :537.65EGFR-IN-69
CAS :<p>EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.</p>Formule :C31H37Cl2N7O3SCouleur et forme :SolidMasse moléculaire :658.64PfGSK3/PfPK6-IN-2
CAS :<p>PfGSK3/PfPK6-IN-2 inhibits Plasmodium falciparum GSK3/PK6 (IC50: 172 nM/11 nM) for Malaria research.</p>Formule :C24H25Cl2N5OSCouleur et forme :SolidMasse moléculaire :502.46EGFR-IN-63
CAS :<p>EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).</p>Formule :C20H12BrN5SCouleur et forme :SolidMasse moléculaire :434.31PI3Kδ-IN-3
CAS :<p>PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.</p>Formule :C28H24N6O3Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :492.53EMI48
CAS :<p>EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].</p>Formule :C21H20N2O3Couleur et forme :SolidMasse moléculaire :348.4OXA-01
CAS :<p>OXA-01 is a potent mTORC1 and mTORC2 inhibitor, with IC 50 values of 29 nM and 7 nM, respectively [1]. OXA-01 demonstrates broad anti-tumor activity.</p>Formule :C21H20ClN5O2Couleur et forme :SolidMasse moléculaire :409.87BRD1652
CAS :<p>BRD1652 is a highly selective and potent GSK3 inhibitor.</p>Formule :C20H20F3N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :375.39CC260
CAS :<p>CC260 selectively inhibits PI5P4Kα/β (Ki: 40/30 nM), with minimal effect on Plk1/RSK2, useful for metabolic, diabetes, and cancer studies.</p>Formule :C24H29Cl2N5O2Couleur et forme :SolidMasse moléculaire :490.43AS2541019
CAS :<p>AS2541019 is a selective Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibitor.</p>Formule :C26H33F2N7O3Couleur et forme :SolidMasse moléculaire :529.58CHMFL-PI4K-127
CAS :<p>CHMFL-PI4K-127 (15g) selectively inhibits PfPI4K (IC50=0.9 nM), potent against Plasmodium 3D7 (EC50=25.1 nM), with oral anti-malaria activity.</p>Formule :C18H15ClN4O3SCouleur et forme :SolidMasse moléculaire :402.85EGFR-IN-54
CAS :<p>EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.</p>Formule :C17H14N4O4S3Couleur et forme :SolidMasse moléculaire :434.51EGFR-IN-25
CAS :<p>EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.</p>Formule :C34H43N9O2Couleur et forme :SolidMasse moléculaire :609.76EMI56
CAS :<p>EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].</p>Formule :C21H20N2O3Couleur et forme :SolidMasse moléculaire :348.4EGFR-IN-39
CAS :<p>EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.</p>Formule :C24H25ClN6O3Couleur et forme :SolidMasse moléculaire :480.95JBJ-09-063 hydrochloride
<p>JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.</p>Formule :C31H30ClFN4O3SCouleur et forme :SolidMasse moléculaire :593.11EGFR/HER2-IN-2
CAS :<p>EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual EGFR and HER2 inhibitor that acts on both EGFR (IC50: 5.02 μM) and HER2 (IC50: 0.83 μM).</p>Formule :C26H23N5O3Couleur et forme :SolidMasse moléculaire :453.49SIC-19
CAS :<p>SIC-19, a SIK2 inhibitor, functions by promoting the degradation of SIK2 protein via the ubiquitination pathway. It inhibits the growth of cancer cells and sensitizes cells, ovarian cancer organoids, and xenograft models to PARP inhibitors (such as Olaparib).</p>Formule :C29H26N4O5S2Couleur et forme :SolidMasse moléculaire :574.67EGFR-IN-21
CAS :<p>EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.</p>Formule :C36H44BrN10O2PCouleur et forme :SolidMasse moléculaire :759.68PI3Ka-IN-5
CAS :<p>PI3Ka-IN-5 is a potent PI3Kα/mTOR inhibitor, with an IC 50 of 0.7 nM and 3.3 nM, respectively. PI3Ka-IN-5 can be used for the research of colorectal cancer .</p>Formule :C30H35N9O5Couleur et forme :SolidMasse moléculaire :601.66EGFR mutant-IN-2
CAS :<p>EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].</p>Formule :C27H27F3N6O2SCouleur et forme :SolidMasse moléculaire :556.6ON 146040
CAS :<p>ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.</p>Formule :C24H23N7O3SDegré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :489.55P-2281
CAS :<p>P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cell</p>Formule :C9H8ClN3ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :209.63PI3K/mTOR Inhibitor-13
CAS :<p>PI3K/mTOR Inhibitor-13, an oral dual blocker of PI3K and mTOR, may treat sexual diseases, solid tumors, and IPF.</p>Formule :C20H13F2N5O3SCouleur et forme :SolidMasse moléculaire :441.41PI3Kα/mTOR-IN-1
CAS :<p>PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR.</p>Formule :C16H18N6ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :310.35EGFR-IN-2
CAS :<p>EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.</p>Formule :C26H33N9O3SDegré de pureté :98.52% - 99.79%Couleur et forme :SolidMasse moléculaire :551.66Mutated EGFR-IN-2
CAS :<p>Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.</p>Formule :C29H35FN8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.64PI3K/mTOR Inhibitor-8
CAS :<p>PI3K/mTOR Inhibitor-8: Dual PI3Kα (IC50: 0.46 nM) & mTOR (IC50: 12 nM) inhibitor; blocks G1/S phase & induces apoptosis in HCT-116 cells.</p>Formule :C23H22N8O4SCouleur et forme :SolidMasse moléculaire :506.54PI3K-IN-38
CAS :<p>PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.</p>Formule :C20H24N6O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :380.44AMPK activator 4
CAS :<p>Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.</p>Formule :C24H21ClN2O3Degré de pureté :99.46% - 99.65%Couleur et forme :SolidMasse moléculaire :420.89Tyrphostin AG 112
CAS :<p>Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.</p>Formule :C13H8N4ODegré de pureté :97.01%Couleur et forme :SolidMasse moléculaire :236.23PI3K-IN-9
CAS :<p>PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM).</p>Formule :C19H23N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.43EGFR-IN-53
CAS :<p>EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].</p>Formule :C14H13N3O2SCouleur et forme :SolidMasse moléculaire :287.34PI3K-IN-10
CAS :<p>PI3K-IN-10 is a potent inhibitor of pan-PI3K .</p>Formule :C23H19ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.89PI3Kγ inhibitor 1
CAS :<p>PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.</p>Formule :C32H26N8O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.67EGFR/C797S-IN-1
CAS :<p>EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.</p>Formule :C28H30N4O3Couleur et forme :SolidMasse moléculaire :470.56PI3-Kinase α Inhibitor 2
CAS :<p>Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and</p>Formule :C16H15N3O2SCouleur et forme :SolidMasse moléculaire :313.37EGFR-IN-5
CAS :<p>EGFR-IN-5 inhibits EGFR & mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.</p>Formule :C31H38FN9ODegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :571.69PI3Kδ/γ-IN-1
CAS :<p>PI3Kδ/γ-IN-1 is a selective and effective inhibitor of PI3Kδ/γ that can be used in the treatment of hematologic malignancies.</p>Formule :C25H28N6O4SCouleur et forme :SolidMasse moléculaire :508.59PP30
CAS :<p>PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.</p>Formule :C18H19N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.45PI3K/mTOR Inhibitor-3
CAS :<p>PI3K/mTOR Inhibitor-3, a potent dual-action anti-cancer imidazoline, targets PI3K and mTOR.</p>Formule :C22H23N5OCouleur et forme :SolidMasse moléculaire :373.45DIF-3
CAS :<p>DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.</p>Formule :C13H17ClO4Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :272.72EHT 1610
CAS :<p>EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.</p>Formule :C18H14FN5O2SDegré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :383.4
