Signalisation PI3K/Akt/mTOR
Les inhibiteurs de la signalisation PI3K/Akt/mTOR sont des composés qui ciblent les voies de la phosphoinositide 3-kinase (PI3K), de la kinase Akt et de la cible de la rapamycine chez les mammifères (mTOR). Ces voies sont des régulateurs critiques de la croissance cellulaire, de la survie, du métabolisme et de l'autophagie, ce qui en fait des cibles clés dans la recherche sur le cancer et les troubles métaboliques. Inhiber ces voies peut aider à contrôler la croissance et la prolifération tumorales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies caractérisées par une signalisation cellulaire dysrégulée. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de haute qualité de PI3K/Akt/mTOR pour soutenir vos recherches en oncologie, signalisation cellulaire et maladies métaboliques.
Sous-catégories appartenant à la catégorie "Signalisation PI3K/Akt/mTOR"
- AMPK(158 produits)
- ATM/ATR(71 produits)
- ADN-PK(51 produits)
- EGFR(572 produits)
- MELK(7 produits)
- PDK(9 produits)
- PI3K(242 produits)
- S6 Kinase(9 produits)
- gsk-3(112 produits)
- mTOR(144 produits)
Affichez 2 plus de sous-catégories
1038 produits trouvés pour "Signalisation PI3K/Akt/mTOR"
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Epitinib succinate
CAS :<p>Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.</p>Formule :C28H32N6O6Degré de pureté :98.02% - 99.79%Couleur et forme :SolidMasse moléculaire :548.59JR-AB2-011
CAS :<p>JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.</p>Formule :C17H14Cl2FN3OSDegré de pureté :98.33% - 98.33%Couleur et forme :SolidMasse moléculaire :398.28Falnidamol
CAS :<p>Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.</p>Formule :C18H19ClFN7Degré de pureté :98.816%Couleur et forme :SolidMasse moléculaire :387.84EGFR-IN-9
CAS :<p>EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).</p>Formule :C29H24N4O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :476.53Cloperastine fendizoate
CAS :<p>Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).</p>Formule :C40H38ClNO5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :648.19GS-9901
CAS :<p>GS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.</p>Formule :C22H17ClFN9ODegré de pureté :98.60% - 99.92%Couleur et forme :SolidMasse moléculaire :477.88EGFR-IN-99
CAS :<p>EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor for the study of non-small cell lung cancer (NSCLC).</p>Formule :C25H22FN7O3Degré de pureté :97.75%Couleur et forme :SolidMasse moléculaire :487.49A-935142
CAS :<p>A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.</p>Formule :C18H19F3N2O2Degré de pureté :98.97% - 99.91%Couleur et forme :SolidMasse moléculaire :352.35EMI1
CAS :<p>EMI1 targets mutated EGFR in drug-resistant NSCLC research.</p>Formule :C20H18N2O3Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :334.37PD 174265
CAS :<p>PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.</p>Formule :C17H15BrN4ODegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :371.23GSK-3β inhibitor 11
CAS :<p>GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.</p>Formule :C20H15N3O4SDegré de pureté :97.33%Couleur et forme :SolidMasse moléculaire :393.42Tyrphostin A25
CAS :<p>Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.</p>Formule :C10H6N2O3Degré de pureté :98.76%Couleur et forme :Yellow Green Powder /Off-White SolidMasse moléculaire :202.17SKLB 1028
CAS :<p>SKLB 1028, an oral EGFR/FLT3/Abl inhibitor, excels in AML and CML with Abl mutations.</p>Formule :C24H29N9Degré de pureté :99.90% - >99.99%Couleur et forme :SolidMasse moléculaire :443.55CGP77675
CAS :<p>CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates and</p>Formule :C26H29N5O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :443.54BIP-135
CAS :<p>BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.</p>Formule :C21H13BrN2O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :421.24ARN25068
CAS :<p>ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.</p>Formule :C19H18N6SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :362.45LY 456236 hydrochloride
CAS :<p>LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM.</p>Formule :C16H16ClN3O2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :317.77GSK-3 Inhibitor XIII
CAS :<p>GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.</p>Formule :C18H15N5Degré de pureté :99.85% - 99.86%Couleur et forme :SolidMasse moléculaire :301.35Larotinib
CAS :<p>Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.</p>Formule :C24H26ClFN4O4Degré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :488.94AZ044
CAS :<p>AZ044 is a potent, selective inhibitor of type III phosphatidylinositol-4-kinase alpha-subtype (PI4KIIIalpha).</p>Formule :C24H27N3O3SDegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :437.55YKL-06-062
CAS :<p>YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor that inhibits SIK1, SIK2 and SIK3 with IC50s of 2.12 nM, 1.40 nM and 2.86 nM.</p>Formule :C31H39N7ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :525.69PQR514
CAS :<p>PQR514: more potent pan-PI3K inhibitor than predecessor PQR309, exhibits strong anticancer activity in vitro and in OVCAR-3 model.</p>Formule :C16H20F2N8O2Degré de pureté :98.77% - 99.19%Couleur et forme :SolidMasse moléculaire :394.38MELK-8a hydrochloride
CAS :<p>MELK-8a hydrochloride is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK, IC50 = 2 nM). </p>Formule :C25H33ClN6ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :469.02PKI-166
CAS :<p>PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth & spread of many human cancers, including pancreatic.</p>Formule :C20H18N4ODegré de pureté :99.2%Couleur et forme :SolidMasse moléculaire :330.38RS1-PDK1 inhibitor
CAS :<p>RS1-PDK1 inhibitor (RS 1) is a selective inhibitor of the protein kinase PDK1 that can be used to treat and prevent disease or disorders.</p>Formule :C15H9ClN2O2S3Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :380.89TGX-115
CAS :<p>TGX-115 inhibits PI 3-K p110β (IC50=0.13μM) & p110δ (IC50=0.63μM), treats various cardiovascular diseases.</p>Formule :C20H20N2O3Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :336.38Rezivertinib
CAS :<p>Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.</p>Formule :C27H30N6O3Degré de pureté :99.26% - 99.89%Couleur et forme :SolidMasse moléculaire :486.57NVP-BAG956
CAS :<p>NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ).</p>Formule :C28H21N5Degré de pureté :99.25% - 99.80%Couleur et forme :SolidMasse moléculaire :427.5(R)-(-)-Rolipram
CAS :<p>(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.</p>Formule :C16H21NO3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :275.34PF-249
CAS :<p>PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.</p>Formule :C17H16ClN3O3Degré de pureté :97.01%Couleur et forme :SolidMasse moléculaire :345.78SRX3207
CAS :<p>SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.</p>Formule :C29H29N7O3SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :555.65GSK-3β inhibitor 2
CAS :<p>GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50</p>Formule :C14H14N4O3SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :318.35YLF-466D
CAS :<p>YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.</p>Formule :C29H20ClNO3Degré de pureté :97.74%Couleur et forme :SolidMasse moléculaire :465.93Sunvozertinib
CAS :<p>Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2.Cost-effective and quality-assured.</p>Formule :C29H35ClFN7O3Degré de pureté :98.11% - 99.63%Couleur et forme :SolidMasse moléculaire :584.08ABC1183
CAS :<p>ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.</p>Formule :C18H14N4OSDegré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :334.39(Z)-RG-13022
CAS :<p>(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor that preferentially inhibits the TK activity of the EGF receptor, restricting the EGF-stimulated growth of cultured cells. It demonstrates an IC50 of 11 μM for DNA synthesis in HN5 cells, showcasing thrice the potency of its isomer, (E)-RG-13022 (IC50 = 38 μM). This compound is applied in breast cancer cell research [1] [2].</p>Formule :C16H14N2O2Couleur et forme :SolidMasse moléculaire :266.29PI3Kδ-IN-17
CAS :<p>PI3Kδ-IN-17 (Compound S5) is a potent PI3K δ inhibitor, exhibiting an IC50 value of 2.82 nM and demonstrates significant efficacy in suppressing the</p>Formule :C23H24F3N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :487.48MTI-31
CAS :<p>MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, >5,000-fold selectivity, and an IC50 of 39 nM.</p>Formule :C26H30N6O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :474.55PI3K/mTOR Inhibitor-14
CAS :<p>PI3K/mTOR Inhibitor-14 (compound Y-2) serves as a dual inhibitor of PI3K and mTOR, exhibiting IC50 values of 171.4 nM and 10.1 nM , respectively, and</p>Formule :C28H30N8O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.66PI3K/mTOR Inhibitor-7
CAS :<p>Potent PI3K/mTOR inhibitor, 4.7x stronger than gedatolisib; IC50: 1.4 μM (PI3K), 0.3 μM (mTOR); impacts PI3K/Akt/mTOR pathway; research in cancer.</p>Formule :C29H33N9O4Couleur et forme :SolidMasse moléculaire :571.63LAS191954
CAS :<p>LAS191954 is a selective, potent and orally active PI3Kδ inhibitor for inflammatory diseases treatment(IC50 : 2.6 nM).</p>Formule :C20H15N9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :397.39MIPS-21335
CAS :<p>MIPS-21335 is a potent PI3KC2α inhibitor with an IC50 value of 7 nM and additionally exhibits inhibitory activity against PI3KC2β, p110α, p110β, and p110δ with</p>Formule :C24H21N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :487.47MP7
CAS :<p>MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).</p>Formule :C28H22F2N4O4Degré de pureté :99.84% - 99.89%Couleur et forme :SolidMasse moléculaire :516.5ZL-2201
CAS :<p>ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM.</p>Formule :C20H25N9O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :503.54EGFR-IN-1
CAS :<p>EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.</p>Formule :C28H30N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.58MSC2360844
CAS :<p>MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).</p>Formule :C26H27FN4O5SDegré de pureté :99.54% - 99.9%Couleur et forme :SolidMasse moléculaire :526.58SAR-260301
CAS :<p>SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).</p>Formule :C19H22N4O3Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :354.4EGFR-IN-33
CAS :<p>EGFR-IN-33, a low-toxicity acrylamide, inhibits EGFR, aiding against cancer, especially NSCLC (from WO2021185348A1, comp. 13).</p>Formule :C26H25ClN6O2Couleur et forme :SolidMasse moléculaire :488.97PIK-inhibitors
CAS :<p>PIK-inhibitors (MDK34597) is a pan PI3K inhibitors, an analog of PI-103.</p>Formule :C19H17N5O2Degré de pureté :96.98%Couleur et forme :SolidMasse moléculaire :347.37EGFR-IN-71
CAS :<p>EGFR-IN-71 is a potent inhibitor of epidermal growth factor receptor (EGFR) (IC50= 3.7 μM). EGFR-IN-71 has research value in chordoma.</p>Formule :C16H9ClIN3Couleur et forme :SolidMasse moléculaire :405.62PI5P4K-β-IN-1
CAS :<p>PI5P4K-β-IN-1 (compound vs1) is a potent PI5P4K-β inhibitor with an IC50 of 0.80 μM [1].</p>Formule :C23H17Cl2N3O2Couleur et forme :SolidMasse moléculaire :438.31BGB-102
CAS :<p>BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.</p>Formule :C22H25BrN4O2Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :457.36Tenalisib R Enantiomer
CAS :<p>Tenalisib R Enantiomer is an R enantiomer of Tenalisib .</p>Formule :C23H18FN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.42JND3229
CAS :<p>JND3229 inhibits EGFRC797S; IC50: 5.8-30.5 nM; halts cell growth; effective in non-small cell lung cancer study.</p>Formule :C33H41ClN8O2Degré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :617.18mTOR inhibitor-11
CAS :<p>mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6.</p>Formule :C21H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.47DNA-PK-IN-10
CAS :<p>DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].</p>Formule :C25H28N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.53BRD5648
CAS :<p>BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.</p>Formule :C20H23N3ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :321.42GNE-490
CAS :<p>GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.</p>Formule :C18H22N6O2SDegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :386.47TCS 21311
CAS :<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Formule :C27H25F3N4O4Degré de pureté :99.39% - ≥98%Couleur et forme :SolidMasse moléculaire :526.51LDHA/PDKs-IN-1
CAS :<p>Compound 20e inhibits PDKs (IC50: 0.8 μM) & LDHA (IC50: 0.15 μM), halts A549 cell growth, lowers lactate, boosts oxygen use.</p>Formule :C19H21FN2O4Couleur et forme :SolidMasse moléculaire :360.38(Rac)-BRD0705
CAS :<p>(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.</p>Formule :C20H23N3ODegré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :321.42MS 154
CAS :<p>MS 154 is a potent PROTAC® targeting mutant EGFR in lung cancer, sparing WT-EGFR; effective in mice, with DC50 of 11-25 nM.</p>Formule :C46H54ClFN8O8Couleur et forme :SolidMasse moléculaire :901.42WYE-23
CAS :<p>WYE-23 is an inhibitor of mammalian target of rapamycin (mTOR).</p>Formule :C26H32N8O4Couleur et forme :SolidMasse moléculaire :520.58T-00127_HEV1
CAS :<p>T-00127_HEV1 is an inhibitor of phosphatidylinositol 4-kinase III beta(PI4KIIIβ, IC50 = 60 nM).</p>Formule :C22H29N5O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :411.5mTOR inhibitor 9d
CAS :<p>mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia,</p>Formule :C21H23N5O3SDegré de pureté :99.08%Couleur et forme :SoildMasse moléculaire :425.517β-Hydroxywortmannin
CAS :<p>17β-Hydroxywortmannin is an orally active phosphatidylinositol-3-kinase (PI-3-kinase) inhibitor, exhibiting an IC50 of 0.5 nM and notably suppresses osteoclast resorption at an IC50 of 10 nM. Additionally, it demonstrates antitumor activity.</p>Formule :C23H26O8Couleur et forme :SolidMasse moléculaire :430.45EGFR-IN-74
<p>EGFR-IN-74 is a potent inhibitor targeting EGFR, specifically effective against the L858R/T790M mutations, exhibiting an IC50 value of 138 nM.</p>Formule :C32H28BrF3N6O4SCouleur et forme :SolidMasse moléculaire :729.57mTOR inhibitor 9b
CAS :<p>mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTOR</p>Formule :C21H23N5O2SDegré de pureté :99.52%Couleur et forme :SoildMasse moléculaire :409.5Dezapelisib
CAS :<p>Dezapelisib, an oral delta PI3K inhibitor, blocks PIP3 production and PI3K/AKT pathway, hindering tumor cell growth and survival.</p>Formule :C20H16FN7OSCouleur et forme :SolidMasse moléculaire :421.45Labuxtinib
CAS :<p>Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].</p>Formule :C20H16FN5O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :377.37SU-11752
CAS :<p>SU-11752 selectively inhibits DNA-PK by competing with ATP, enhances ionizing radiation sensitivity without affecting cell cycle or ATM activity.</p>Formule :C26H27N3O5SCouleur et forme :SolidMasse moléculaire :493.57PAT-505
CAS :<p>PAT-505 is an autologous epidermal growth factor inhibitor.</p>Formule :C23H18ClF2N3O2SDegré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :473.92BMS-599626 Hydrochloride
CAS :<p>BMS-599626 HCl (AC480 HCl) is an oral inhibitor of HER1, HER2, HER4 kinases, potentially blocking tumor growth. IC50: 22/32/190 nM.</p>Formule :C27H28ClFN8O3Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :567.01ZLN024
CAS :<p>ZLN024 is an activator of AMPK allosteric.</p>Formule :C13H13BrN2OSDegré de pureté :99.751%Couleur et forme :SolidMasse moléculaire :325.22PI3K/mTOR Inhibitor-1
CAS :<p>PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)</p>Formule :C18H22FN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.46CAL-130 Racemate
CAS :<p>CAL-130 Racemate is the racemate of CAL-130. CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formule :C23H22N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.47HKI-357
CAS :<p>HKI-357 irreversibly inhibits EGFR/ERBB2 (IC50: 34/33 nM), blocks EGFR Y1068 autophosphorylation, and AKT/MAPK phosphorylation.</p>Formule :C31H29ClFN5O3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :574.05PF-06459988
CAS :<p>PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor.</p>Formule :C19H22ClN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.88mTOR inhibitor-3
CAS :<p>mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.</p>Formule :C25H30N8O2Degré de pureté :99% - 99.64%Couleur et forme :SolidMasse moléculaire :474.56Zandelisib
CAS :<p>Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.</p>Formule :C31H38F2N8ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :576.68Alpelisib hydrochloride
CAS :<p>Alpelisib hydrochloride (BYL-719) is an oral, selective PI3Kα inhibitor with anticancer properties.</p>Formule :C19H23ClF3N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :477.93PI3Kδ-IN-1
CAS :<p>PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).</p>Formule :C22H20F3N7O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :471.44EGFR-IN-29
CAS :<p>EGFR-IN-29 is a potent EGFR inhibitor.</p>Formule :C36H46BrN8O2PCouleur et forme :SolidMasse moléculaire :733.685-Iodo-indirubin-3'-monoxime
CAS :<p>5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s</p>Formule :C16H10IN3O2Couleur et forme :SolidMasse moléculaire :403.17Ampkinone
CAS :<p>Ampkinone is an indirect AMPK activator.</p>Formule :C31H23NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.52BPIQ-I
CAS :<p>BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.</p>Formule :C16H12BrN5Couleur et forme :SolidMasse moléculaire :354.2LDHA/PDKs-IN-2
CAS :<p>Compound 20k is a dual LDHA/PDKs inhibitor; IC50: 0.7/1.6 μM. It boosts O2 use, cuts lactate, and slows A549 cancer cell growth (EC50: 15.7 μM).</p>Formule :C17H20N2O5Couleur et forme :SolidMasse moléculaire :332.35PI3K/mTOR Inhibitor-6
CAS :<p>Potent, stable PI3K/mTOR Inhibitor-6 surpasses gedatolisib in gastric fluid; 10 μM hinders PI3K/Akt/mTOR pathway, aids cancer research.</p>Formule :C30H34N10O4Couleur et forme :SolidMasse moléculaire :598.66NVP-QAV-572
CAS :<p>NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).</p>Formule :C17H19F2N7O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.5Lifirafenib
CAS :<p>Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant</p>Formule :C25H17F3N4O3Degré de pureté :98% - 98.25%Couleur et forme :SolidMasse moléculaire :478.42SAR502250
CAS :<p>SAR502250: potent, selective GSK3 inhibitor, IC50=12nM, oral, brain-penetrant, potential for AD research, antidepressant-like properties.</p>Formule :C19H18FN5O2Couleur et forme :SolidMasse moléculaire :367.38HER2-IN-5
CAS :<p>HER2-IN-5 is an effective inhibitor of orally active HER-2.</p>Formule :C27H33N7O3Couleur et forme :SolidMasse moléculaire :503.6CC214-1
CAS :<p>CC214-1 is an mTOR inhibitor that inhibits protein translation, induces autophagy, and is an in vitro tool compound for exploring the biology of mTOR kinases.</p>Formule :C20H21N7O2Degré de pureté :97.16%Couleur et forme :SolidMasse moléculaire :391.43Antitrypanosomal agent 14
CAS :<p>Antitrypanosomal agent 14 (Compound 1), a potent T.</p>Formule :C14H23N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :281.42A 1070722
CAS :<p>A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.</p>Formule :C17H13F3N4O2Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :362.31PT-65
CAS :<p>PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].</p>Formule :C51H63N13O12SCouleur et forme :SolidMasse moléculaire :1082.19PI5P4Kα-IN-1
CAS :<p>PI5P4Kα-IN-1 (Compound 13) is a phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) inhibitor, displaying IC50 values of 2 μM for PI5P4Kα and 9.4 μM for PI5P4Kβ</p>Formule :C20H17N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :363.43PI3K/mTOR Inhibitor-5
CAS :<p>PI3K/mTOR Inhibitor-5 is a potent dual inhibitor of PI3K and mTOR, displaying IC50 values of 86.9 nM (for PI3K) and 14.6 nM (for mTOR), respectively.</p>Formule :C32H40N10O3Couleur et forme :SolidMasse moléculaire :612.73Nazartinib S-enantiomer
CAS :<p>Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.</p>Formule :C26H31ClN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :495.02PI3Kγ inhibitor 2
CAS :<p>PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).</p>Formule :C20H18F3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.38
