Signalisation PI3K/Akt/mTOR
Les inhibiteurs de la signalisation PI3K/Akt/mTOR sont des composés qui ciblent les voies de la phosphoinositide 3-kinase (PI3K), de la kinase Akt et de la cible de la rapamycine chez les mammifères (mTOR). Ces voies sont des régulateurs critiques de la croissance cellulaire, de la survie, du métabolisme et de l'autophagie, ce qui en fait des cibles clés dans la recherche sur le cancer et les troubles métaboliques. Inhiber ces voies peut aider à contrôler la croissance et la prolifération tumorales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies caractérisées par une signalisation cellulaire dysrégulée. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de haute qualité de PI3K/Akt/mTOR pour soutenir vos recherches en oncologie, signalisation cellulaire et maladies métaboliques.
Sous-catégories appartenant à la catégorie "Signalisation PI3K/Akt/mTOR"
- AMPK(158 produits)
- ATM/ATR(71 produits)
- ADN-PK(51 produits)
- EGFR(572 produits)
- MELK(7 produits)
- PDK(9 produits)
- PI3K(242 produits)
- S6 Kinase(9 produits)
- gsk-3(112 produits)
- mTOR(144 produits)
Affichez 2 plus de sous-catégories
1038 produits trouvés pour "Signalisation PI3K/Akt/mTOR"
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FD274
CAS :<p>FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM,</p>Formule :C22H14ClFN6O2SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :480.9HDS 029
CAS :<p>HDS 029 has a wide range of applications in life science related research.</p>Formule :C17H11ClFN5OCouleur et forme :SolidMasse moléculaire :355.76Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Couleur et forme :Odour Solid(R)-VX-984
CAS :<p>(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.</p>Formule :C23H21D2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.49FRATide
CAS :<p>FRATtide inhibits the phosphorylation of Axin and β-catenin, inhibits GSK-3 binding to Axin, and is a peptide derived from the GSK-3 binding protein.</p>Formule :C55H102N2O2Couleur et forme :SolidMasse moléculaire :823.433BMS-599626 2HCL(714971-09-2 Free base)
CAS :<p>BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative.</p>Formule :C27H29Cl2FN8O3Degré de pureté :99.11%Couleur et forme :Odour SolidMasse moléculaire :603.47ARUK2001607
CAS :<p>ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.</p>Formule :C14H13N3O2S2Degré de pureté :99.75%Couleur et forme :SoildMasse moléculaire :319.40Necitumumab
CAS :<p>Necitumumab (IMC-11F8) is a human monoclonal antibody against EGFR, an anti-angiogenic agent used in the treatment of advanced non-small cell lung cancer.</p>Degré de pureté :97.9% (SDS-PAGE); 99.1% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.1% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.5 kDaMulti-target kinase inhibitor 4
<p>Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.</p>Couleur et forme :Odour SolidDuvelisib (R enantiomer) hydrochloride
<p>Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.</p>Formule :C22H18Cl2N6ODegré de pureté :99.88% - >99.99%Couleur et forme :SoildMasse moléculaire :453.32PROTAC EGFR degrader 3
CAS :<p>Potent PROTAC EGFR degrader 3; excellent against H1975/HCC827 cells; lysosome-involved mutant degradation.</p>Formule :C60H77N13O5SCouleur et forme :SolidMasse moléculaire :1092.4GSK-3β inhibitor 1
CAS :<p>GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.</p>Formule :C14H10N2ODegré de pureté :99.40%Couleur et forme :SolidMasse moléculaire :222.24IC 86621
CAS :<p>IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.</p>Formule :C12H15NO3Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :221.25OK2
<p>OK2, a specific inhibitor of the CCN2/EGFR interaction, effectively disrupts this interaction by binding to the CT domain of CCN2.</p>Formule :C42H62N14O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :907.03GSK251
CAS :<p>GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.</p>Formule :C29H37FN6O4SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :584.71DP-C-4
<p>DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].</p>Couleur et forme :LiquidEGFR-IN-140
<p>EGFR-IN-140 (Compound 31) is an inhibitor of EGFR, effectively targeting both wild-type EGFR and the EGFRL858R/T790M/C797S mutant, with Ki values of 0.95 nM and 2.1 nM, respectively. Additionally, it inhibits EGFRdel19/T790M/C797S in Ba/F3 cells with an IC50 of 56.9 nM and demonstrates antitumor activity in mouse models.</p>Formule :C27H37FN8O2Couleur et forme :SolidMasse moléculaire :524.633MS9427
CAS :<p>MS9427: PROTAC EGFR degrader, 7.1 nM (WT), 4.3 nM (L858R); targets mutant via UPS and autophagy; inhibits NSCLC cell growth; anticancer research.</p>Formule :C48H58ClFN8O12Couleur et forme :SolidMasse moléculaire :993.47GSK3β/mTOR modulator 1
<p>GSK3β/mTOR modulator 1 (derivative 2) is an agent that modulates the GSK3β/mTOR signaling pathway. It is applicable in research related to acute lung injury (ALI) and inflammation.</p>Formule :C19H28O5Couleur et forme :SolidMasse moléculaire :336.19367AZ14240475
<p>AZ14240475 is a potent, selective, brain-penetrant inhibitor of EGFREx20Ins mutants (EGFREx20Ins mutants) with a pIC50 of 7.6, playing a significant role in cancer research.</p>Formule :C23H15ClF2N6O2Couleur et forme :SolidMasse moléculaire :480.854GSK3β Inhibitor XI
CAS :<p>GSK3β Inhibitor XI has GSK3β inhibitory effect.</p>Formule :C18H15N5O3Couleur et forme :SolidMasse moléculaire :349.35QL-IX-55
CAS :<p>QL-IX-55 has a wide range of applications in life science related research.</p>Formule :C24H14F4N4OCouleur et forme :SolidMasse moléculaire :450.39CHIR-98023
CAS :<p>CHIR-98023 is a bio-active chemical.</p>Formule :C20H16Cl2N8O2Couleur et forme :SolidMasse moléculaire :471.30DSPE-PEG2000-GE11
<p>DSPE-PEG2000-GE11 is a PEG compound composed of DSPE and an EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells that overexpress EGFR. DSPE-PEG2000-GE11 is utilized in drug delivery.</p>Couleur et forme :Odour SolidPROTAC EGFR degrader 2
<p>Potent PROTAC EGFR degrader 2; IC50: 4.0 nM, DC50: 36.51 nM; inhibits cell growth; for NTR-responsive synthesis.</p>Formule :C58H72ClFN12O8SCouleur et forme :SolidMasse moléculaire :1151.78Phosphatidylinositol 4,5-bisphosphate
CAS :<p>Phosphatidylinositol 4,5-bisphosphate, a cell membrane phospholipid, is a PLC and PI3K substrate and a messenger.</p>Formule :C47H85O19P3Couleur et forme :SolidMasse moléculaire :1047.09DSPE-PEG1000-GE11
<p>DSPE-PEG1000-GE11 is a PEG compound made up of DSPE and an EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells overexpressing EGFR. DSPE-PEG1000-GE11 serves a role in drug delivery.</p>Couleur et forme :Odour SolidVarlitinib
CAS :<p>Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.</p>Formule :C22H19ClN6O2SDegré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :466.94RMC-4627
CAS :<p>RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.</p>Formule :C93H141N11O23Couleur et forme :SolidMasse moléculaire :1781.17GSK-3β inhibitor 23
<p>GSK-3β inhibitor23 (Compound 11726169) is an inhibitor of glycogen synthase kinase 3 (GSK-3), effectively inhibiting GSK-3β and GSK-3α with IC50 values of 12.1 nM and 18.8 nM, respectively. It demonstrates antiviral activity against HIV1 and exhibits good metabolic stability in mouse and human liver microsomes and plasma, although it has poor permeability in Caco-2 cells, indicating potentially low oral bioavailability.</p>Formule :C18H13Cl2N5O2SCouleur et forme :SolidMasse moléculaire :434.299EGFR/PI3Kα-IN-1
<p>EGFR/PI3Kα-IN-1 (compound 30k), a dual EGFR/PI3Kα inhibitor, exhibits potent activity with IC 50 values of 3.6 nM (EGFRL858R/T790M) and 30 nM (PI3Kα). It effectively inhibits tumor cell proliferation and demonstrates significant anticancer activity.</p>Formule :C50H49N11O5SCouleur et forme :SolidMasse moléculaire :916.06mTOR inhibitor WYE-28
CAS :<p>Compound 28 (mTOR inhibitor WYE-28) is a selective inhibitor of mTOR (IC50=0.08 nM). Also inhibits PI3Kα (IC50 6 nM).</p>Formule :C30H34N8O5Couleur et forme :SolidMasse moléculaire :586.653EGFR-IN-162
<p>EGFR-IN-162 (compound 20) is an effective EGFR inhibitor that enhances both early and late apoptosis (EGFR) as well as necrosis (necrosis). It shows potential for use in breast cancer research.</p>Formule :C27H31N3O2Couleur et forme :SolidMasse moléculaire :429.24163Lumretuzumab
CAS :<p>Lumretuzumab (RG-7116) is a humanized anti-HER3 monoclonal antibody with antitumor activity.</p>Degré de pureté :95.3% (SDS-PAGE); 96.4% (SEC-HPLC) - 95.3% (SDS-PAGE); 96.4% (SEC-HPLC)Couleur et forme :LiquidPI3K-IN-22
CAS :<p>PI3K-IN-22 is a dual kinase inhibitor of PI3Kα and mTOR, with IC50s of 0.9 and 0.6 nM respectively. PI3K-IN-22 could be used in cancer.</p>Formule :C31H35F3N8O3Couleur et forme :SolidMasse moléculaire :624.66PI3Kα-IN-25
<p>PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.</p>Formule :C21H19ClN4O4Couleur et forme :SolidMasse moléculaire :426.853RMC-4529
CAS :<p>RMC-4529 is a chemical compound that demonstrates potent inhibition, with an IC50 value of 1.0 nM, against p-4E-BP1-(T37/46) in mTOR kinase cellular assays.</p>Formule :C90H139N13O23Couleur et forme :SolidMasse moléculaire :1771.17Pertuzumab
CAS :<p>Pertuzumab (anti-HER2) a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors impairs the ability of HER2</p>Degré de pureté :98.00%Couleur et forme :LiquidMasse moléculaire :148 kDaGSK-3β inhibitor 19
<p>GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.</p>Formule :C15H12N4O2SCouleur et forme :SolidMasse moléculaire :312.35AMX-818
<p>AMX-818 is a conditionally activated, masked T cell engager (TCE) that targets HER2. It demonstrates potent T cell cytotoxicity against HER2-positive tumor cell lines and can induce tumor regression in vivo. AMX-818 holds promise for research into HER2-positive solid tumors.</p>Couleur et forme :Odour LiquidWAY-270360
CAS :<p>WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.</p>Formule :C22H19N3O3Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :373.4MS9427 TFA
<p>MS9427 TFA: PROTAC EGFR degrader, Kd 7.1 nM (WT), 4.3 nM (L858R), targets mutant EGFR, inhibits NSCLC cell growth, for cancer research.</p>Formule :C50H59ClF4N8O14Couleur et forme :SolidMasse moléculaire :1107.5IHMT-PI3K-315
<p>IHMT-PI3K-315 (20e) serves as a potent, selective inhibitor of PI3Kγ/δ, exhibiting IC 50 values of 4.0 nM for PI3Kγ and 9.1 nM for PI3Kδ. Additionally, it demonstrates antitumor activity.</p>Formule :C22H20F2N6O4Couleur et forme :SolidMasse moléculaire :470.43GSK-3 Inhibitor 5
CAS :<p>4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.</p>Formule :C9H6BrNODegré de pureté :99.58%Couleur et forme :Off-White To Light Yellow Crystalline PowderMasse moléculaire :224.05EGFR-IN-76
CAS :<p>EGFR-IN-76 is a potent EGFR inhibitor.</p>Formule :C30H30ClFN6O2Degré de pureté :97.02% - 97.72%Couleur et forme :SolidMasse moléculaire :561.05EGFR/VEGFR2-IN-5
<p>EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2, exhibiting an IC50 value of 1.15 µM for VEGFR2 and 0.28 µM for EGFRT790M. This compound demonstrates significant anticancer activity.</p>Formule :C17H15N7O5SCouleur et forme :SolidMasse moléculaire :429.41GW 583340
CAS :<p>GW 583340 is a potent and selective dual inhibitor of EGFR/ErbB2 tyrosine kinase with the advantage of oral dosability and antitumor effects.</p>Formule :C28H25ClFN5O3S2Degré de pureté :98.68%Couleur et forme :SoildMasse moléculaire :598.11Simotinib hydrochloride
CAS :<p>Simotinib hydrochloride: selective oral EGFR inhibitor, IC50 19.9 nM, potent anticancer agent.</p>Formule :C25H27Cl2FN4O4Couleur et forme :SolidMasse moléculaire :537.41Lyso-Monosialoganglioside GM3
CAS :<p>Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analog of Ganglioside GM3 with antitumor properties. It inhibits the increase in EGFR kinase activity induced by EGF in A431 epithelial cancer cells.</p>Formule :C41H74N2O20Couleur et forme :SolidMasse moléculaire :915.028EGFR-TK-IN-5
<p>EGFR-TK-IN-5 (Compound NCE 2) is a thiazolyl pyrazoline derivative with significant inhibitory activity and stability against EGFR. It is applicable in tumor research.</p>Formule :C26H20ClFN4OSCouleur et forme :SolidMasse moléculaire :490.98
