Signalisation PI3K/Akt/mTOR
Les inhibiteurs de la signalisation PI3K/Akt/mTOR sont des composés qui ciblent les voies de la phosphoinositide 3-kinase (PI3K), de la kinase Akt et de la cible de la rapamycine chez les mammifères (mTOR). Ces voies sont des régulateurs critiques de la croissance cellulaire, de la survie, du métabolisme et de l'autophagie, ce qui en fait des cibles clés dans la recherche sur le cancer et les troubles métaboliques. Inhiber ces voies peut aider à contrôler la croissance et la prolifération tumorales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies caractérisées par une signalisation cellulaire dysrégulée. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de haute qualité de PI3K/Akt/mTOR pour soutenir vos recherches en oncologie, signalisation cellulaire et maladies métaboliques.
Sous-catégories appartenant à la catégorie "Signalisation PI3K/Akt/mTOR"
- AMPK(158 produits)
- ATM/ATR(71 produits)
- ADN-PK(51 produits)
- EGFR(572 produits)
- MELK(7 produits)
- PDK(9 produits)
- PI3K(242 produits)
- S6 Kinase(9 produits)
- gsk-3(112 produits)
- mTOR(144 produits)
Affichez 2 plus de sous-catégories
1038 produits trouvés pour "Signalisation PI3K/Akt/mTOR"
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SJF 1528
CAS :<p>Potent EGFR & HER2 degrader; DC50 of 39.2 nM in OVCAR8, 736 nM in HeLa; has lapatinib, VHL ligand; inhibits HER2+ breast cancer (IC50=102 nM for SKBr3).</p>Formule :C55H57ClFN7O8SCouleur et forme :SolidMasse moléculaire :1030.61CZY43
<p>CZY43 is an HER3 degrader that effectively induces degradation of HER3 in breast cancer SKBR3 cells in a dose- and time-dependent manner. It efficiently inhibits HER3-dependent signaling and cancer cell growth, outperforming Bosutinib.</p>Formule :C42H53Cl2N5O3Couleur et forme :SolidMasse moléculaire :746.808Lumretuzumab
CAS :<p>Lumretuzumab (RG-7116) is a humanized anti-HER3 monoclonal antibody with antitumor activity.</p>Degré de pureté :95.3% (SDS-PAGE); 96.4% (SEC-HPLC) - 95.3% (SDS-PAGE); 96.4% (SEC-HPLC)Couleur et forme :LiquidGSK-3β inhibitor 1
CAS :<p>GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.</p>Formule :C14H10N2ODegré de pureté :99.40%Couleur et forme :SolidMasse moléculaire :222.24PROTAC PI3K/110β degrader-1
CAS :<p>PROTACPI3K/110β degrader-1 (J-9) acts as a PROTAC degrader specifically targeting PI3K/110β.</p>Formule :C51H65N9O9SCouleur et forme :SolidMasse moléculaire :980.18AMX-818
<p>AMX-818 is a conditionally activated, masked T cell engager (TCE) that targets HER2. It demonstrates potent T cell cytotoxicity against HER2-positive tumor cell lines and can induce tumor regression in vivo. AMX-818 holds promise for research into HER2-positive solid tumors.</p>Couleur et forme :Odour LiquidZenocutuzumab
CAS :<p>Zenocutuzumab (MCLA-128) is a humanized antibody targeting HER2, used for research on tumors driven by NRG1 gene rearrangement.</p>Degré de pureté :97%Couleur et forme :LiquidGefitinib N-oxide hydrochloride
<p>Gefitinib N-oxide hydrochloride is an N-oxide of EGFR inhibitor Gefitinib with IC50 of 2-37 nM.</p>Formule :C22H24ClFN4O41·5HClCouleur et forme :SolidMasse moléculaire :517.59EGFR-IN-128
<p>EGFR-IN-128 (compound 28) is a potent and selective molecule targeting wild-type EGFREx20Ins, demonstrating therapeutic efficacy across various human xenograft models and capable of penetrating the blood-brain barrier in preclinical species.</p>Formule :C27H20N4OCouleur et forme :SolidMasse moléculaire :416.47mTOR inhibitor WYE-28
CAS :<p>Compound 28 (mTOR inhibitor WYE-28) is a selective inhibitor of mTOR (IC50=0.08 nM). Also inhibits PI3Kα (IC50 6 nM).</p>Formule :C30H34N8O5Couleur et forme :SolidMasse moléculaire :586.653GSK-3 Inhibitor 5
CAS :<p>4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.</p>Formule :C9H6BrNODegré de pureté :99.58%Couleur et forme :Off-White To Light Yellow Crystalline PowderMasse moléculaire :224.05CYH33
CAS :<p>CYH33: Oral PI3Kα inhibitor, IC50=5.9 nMα/598 nMβ/78.7 nMδ/225 nMγ; blocks Akt, ERK; causes G1 arrest in breast/lung cancer; effective on solid tumors.</p>Formule :C24H29F3N8O5SCouleur et forme :SolidMasse moléculaire :598.6MS9427 TFA
<p>MS9427 TFA: PROTAC EGFR degrader, Kd 7.1 nM (WT), 4.3 nM (L858R), targets mutant EGFR, inhibits NSCLC cell growth, for cancer research.</p>Formule :C50H59ClF4N8O14Couleur et forme :SolidMasse moléculaire :1107.5GSK251
CAS :<p>GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.</p>Formule :C29H37FN6O4SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :584.71S14161
CAS :<p>S14161 has a wide range of applications in life science related research.</p>Formule :C17H14FNO4Couleur et forme :SolidMasse moléculaire :315.3DSPE-PEG1000-GE11
<p>DSPE-PEG1000-GE11 is a PEG compound made up of DSPE and an EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells overexpressing EGFR. DSPE-PEG1000-GE11 serves a role in drug delivery.</p>Couleur et forme :Odour SolidFAP-PI3KI1
CAS :<p>FAP-PI3KI1: A FAP-targeted PI3K inhibitor reducing collagen synthesis in human IPF cells.</p>Formule :C52H48F4N10O12S3Couleur et forme :SolidMasse moléculaire :1177.19FD274
CAS :<p>FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM,</p>Formule :C22H14ClFN6O2SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :480.9PX-13-17OH
CAS :<p>PX-13-17OH has a wide range of applications in life science related research.</p>Formule :C29H42N2O8Couleur et forme :SolidMasse moléculaire :546.65Istiratumab
CAS :<p>Istiratumab (M-6495) is a bispecific antibody against IGF-1R/ErbB3 for cancer research, promoting receptor degradation.</p>Couleur et forme :LiquidRMC-6272
CAS :<p>RMC-6272 (RM-006) is a bi-steric mTORC1 inhibitor with selective potency over mTORC2 and shows greater effects than Rapamycin on TSC2-deficient tumors.</p>Formule :C95H141FN6O27SCouleur et forme :SolidMasse moléculaire :1850.25Varlitinib
CAS :<p>Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.</p>Formule :C22H19ClN6O2SDegré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :466.94MS9449
CAS :<p>MS9449 is a powerful EGFR PROTAC; Kd: 17 nM (WT), 10 nM (L858R); targets mutant EGFRs via UPS and autophagy; hinders NSCLC cell growth.</p>Formule :C60H76ClFN10O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1151.82PI3Kγ inhibitor 5
CAS :<p>PI3Kγ inhibitor 5 is a potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ), exhibiting an exceptional IC50 value of 34 nM.</p>Formule :C28H32F2N6O4Couleur et forme :SolidMasse moléculaire :554.599Amdizalisib
CAS :<p>Amdizalisib is a PI3K inhibitor and used for the research of inflammatory disease, autoimmune disease or cancer.</p>Formule :C19H15ClN8Couleur et forme :SolidMasse moléculaire :390.84740 Y-P(TFA)
<p>740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.</p>Formule :C143H223F3N43O41PS3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3384.73Inetetamab
<p>Inetetamab is a recombinant humanized antibody targeting HER2 receptor domain IV, with anticancer activity, inducing pyroptosis in lung adenocarcinoma.</p>Degré de pureté :96.54% (SEC-HPLC) - 96.54% (SEC-HPLC)Couleur et forme :Odour LiquidCHIR-98023
CAS :<p>CHIR-98023 is a bio-active chemical.</p>Formule :C20H16Cl2N8O2Couleur et forme :SolidMasse moléculaire :471.30U3-1565
<p>U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.</p>Couleur et forme :LiquidMasse moléculaire :144.82 kDa (Predicted)HDS 029
CAS :<p>HDS 029 has a wide range of applications in life science related research.</p>Formule :C17H11ClFN5OCouleur et forme :SolidMasse moléculaire :355.76Tyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Couleur et forme :Odour SolidMCX 28
CAS :<p>MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity.</p>Formule :C25H19N5O4S3Couleur et forme :SolidMasse moléculaire :549.64PF-06465603
CAS :<p>PF-06465603 is a metabolite of PF-04691502, a highly potent and selective ATP competitive kinase inhibitor of class 1 PI3Ks and mTOR.</p>Formule :C22H25N5O5Couleur et forme :SolidMasse moléculaire :439.46BI-4732
CAS :<p>DL-Homocystine is a mutagen secreted by F. nucleatum.</p>Formule :C32H36N10O2Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :592.69HL-8
CAS :<p>HL-8, a PROTAC targeting PI3K, degrades it fully at 10 μM in 8h, useful in cancer research.</p>Formule :C57H59F2N11O9S2Couleur et forme :SolidMasse moléculaire :1144.27EGFR/VEGFR2-IN-5
<p>EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2, exhibiting an IC50 value of 1.15 µM for VEGFR2 and 0.28 µM for EGFRT790M. This compound demonstrates significant anticancer activity.</p>Formule :C17H15N7O5SCouleur et forme :SolidMasse moléculaire :429.41Caxmotabart
<p>Caxmotabart is a humanized IgG1κ antibody targeting ERBB2, with HumanIgG1kappa, Isotype Control as its corresponding isotype control.</p>Couleur et forme :Odour LiquidSelf-assembling peptide pY1
<p>Self-assembling peptide pY1, which aggregates around cancer cells, specifically targets the EGFR receptor. When co-cultured with Ovalbumin (OVA), pY1 effectively inhibits the endocytosis of OVA.</p>Formule :C104H125N24O29PCouleur et forme :SolidMasse moléculaire :2206.22BMP agonist 1
<p>BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells.</p>Formule :C21H16N2O6Couleur et forme :SolidMasse moléculaire :392.36HER2-IN-13
CAS :<p>HER2-IN-13 (Compound 33) serves as an effective HER2 inhibitor, exhibiting an IC50 value of 8 nM, and additionally demonstrates inhibition of wt-EGFR with an</p>Formule :C26H23ClF2N8O3Couleur et forme :SolidMasse moléculaire :568.96HN2210
<p>Compound HN2210 (compund HN2210) is an inhibitor of mTORC2.</p>Couleur et forme :Odour SolidPI3Kδ-IN-9
CAS :<p>PI3Kδ-IN-9 is a selective PI3Kδ inhibitor with an IC 50 value of 3.8 nM.</p>Formule :C24H26FN9OCouleur et forme :SolidMasse moléculaire :475.532JBJ-09-063 TFA
<p>JBJ-09-063 TFA, an EGFR inhibitor selective for EGFR mutations, IC50s: 0.147-0.396 nM, blocks EGFR/Akt/ERK signaling, for EGFR-mutant lung cancer research.</p>Formule :C33H30F4N4O5SCouleur et forme :SolidMasse moléculaire :670.67QL-IX-55
CAS :<p>QL-IX-55 has a wide range of applications in life science related research.</p>Formule :C24H14F4N4OCouleur et forme :SolidMasse moléculaire :450.39Befotertinib
CAS :<p>Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer.</p>Formule :C29H32F3N7O2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :567.61PI3Kγ ligand 1
CAS :<p>PI3Kγ ligand 1 serves as a PROTAC target protein ligand (Ligand for Target Protein for PROTAC).</p>Formule :C26H29N5O3SCouleur et forme :SolidMasse moléculaire :491.61FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Couleur et forme :LiquidPI3K-IN-46
CAS :<p>PI3K-IN-46 is a specific inhibitor of PI3Kγ.</p>Formule :C13H9N3OSDegré de pureté :97.51%Couleur et forme :SoildMasse moléculaire :255.3Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Couleur et forme :Odour SolidEGFR-IN-138
<p>EGFR-IN-138 (compound 19) is a potent inhibitor of EGFR, with IC50 values of 37, 2.6, and 1.9 nM for the wild-type, L858R, and T790M EGFR, respectively.</p>Formule :C42H37N7O5Couleur et forme :SolidMasse moléculaire :719.79
