Signalisation PI3K/Akt/mTOR
Les inhibiteurs de la signalisation PI3K/Akt/mTOR sont des composés qui ciblent les voies de la phosphoinositide 3-kinase (PI3K), de la kinase Akt et de la cible de la rapamycine chez les mammifères (mTOR). Ces voies sont des régulateurs critiques de la croissance cellulaire, de la survie, du métabolisme et de l'autophagie, ce qui en fait des cibles clés dans la recherche sur le cancer et les troubles métaboliques. Inhiber ces voies peut aider à contrôler la croissance et la prolifération tumorales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies caractérisées par une signalisation cellulaire dysrégulée. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de haute qualité de PI3K/Akt/mTOR pour soutenir vos recherches en oncologie, signalisation cellulaire et maladies métaboliques.
Sous-catégories appartenant à la catégorie "Signalisation PI3K/Akt/mTOR"
- AMPK(158 produits)
- ATM/ATR(71 produits)
- ADN-PK(51 produits)
- EGFR(572 produits)
- MELK(7 produits)
- PDK(9 produits)
- PI3K(242 produits)
- S6 Kinase(9 produits)
- gsk-3(112 produits)
- mTOR(144 produits)
Affichez 2 plus de sous-catégories
1038 produits trouvés pour "Signalisation PI3K/Akt/mTOR"
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Simotinib hydrochloride
CAS :<p>Simotinib hydrochloride: selective oral EGFR inhibitor, IC50 19.9 nM, potent anticancer agent.</p>Formule :C25H27Cl2FN4O4Couleur et forme :SolidMasse moléculaire :537.41DP-C-4
<p>DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].</p>Couleur et forme :LiquidDNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Couleur et forme :Odour SolidMTX-241F
<p>MTX-241F, a selective small molecule inhibitor, targets members of the EGFR and PI3 kinase families.</p>Formule :C20H14ClFN6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.82IC 86621
CAS :<p>IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.</p>Formule :C12H15NO3Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :221.25mTOR inhibitor 13
CAS :<p>Urea derivative; selective mTOR blocker; IC50: 0.29nM (mTOR), 119nM (PI3Kα).</p>Formule :C24H22N6O2SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :458.54KR-27370
<p>KR-27370 (compound 7f) is an antiviral agent and a selective PI4KIIIβ/PI4KIIIα inhibitor, with IC50 values of 3.1 nM and 15.8 nM, respectively. It exhibits inhibitory activity against human rhinovirus (hRV), Coxsackievirus, and other enteroviruses.</p>Formule :C27H27N3O6S2Masse moléculaire :553.13413740 Y-P(TFA)
<p>740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.</p>Formule :C143H223F3N43O41PS3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3384.73Amdizalisib
CAS :<p>Amdizalisib is a PI3K inhibitor and used for the research of inflammatory disease, autoimmune disease or cancer.</p>Formule :C19H15ClN8Couleur et forme :SolidMasse moléculaire :390.84Tyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Couleur et forme :Odour SolidEGFR-IN-140
<p>EGFR-IN-140 (Compound 31) is an inhibitor of EGFR, effectively targeting both wild-type EGFR and the EGFRL858R/T790M/C797S mutant, with Ki values of 0.95 nM and 2.1 nM, respectively. Additionally, it inhibits EGFRdel19/T790M/C797S in Ba/F3 cells with an IC50 of 56.9 nM and demonstrates antitumor activity in mouse models.</p>Formule :C27H37FN8O2Couleur et forme :SolidMasse moléculaire :524.633GSK3β Inhibitor XI
CAS :<p>GSK3β Inhibitor XI has GSK3β inhibitory effect.</p>Formule :C18H15N5O3Couleur et forme :SolidMasse moléculaire :349.35(R)-VX-984
CAS :<p>(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.</p>Formule :C23H21D2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.49PI3-Kinase α Inhibitor 2 (hydrochloride)
CAS :<p>PI3-Kinase α Inhibitor 2 (hydrochloride) is a PI3-Kinase α inhibitor.</p>Formule :C16H17Cl2N3O2SCouleur et forme :SolidMasse moléculaire :386.3HL-8
CAS :<p>HL-8, a PROTAC targeting PI3K, degrades it fully at 10 μM in 8h, useful in cancer research.</p>Formule :C57H59F2N11O9S2Couleur et forme :SolidMasse moléculaire :1144.27BMS-599626
CAS :<p>BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.</p>Formule :C27H27FN8O3Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :530.55AG-1478 hydrochloride
CAS :<p>AG1478 HCl is an epidermal growth factor receptor protein inhibitor.</p>Formule :C16H15Cl2N3O2Couleur et forme :SolidMasse moléculaire :352.21Phospho-Glycogen Synthase Peptide-2(substrate)
CAS :<p>Phospho-Glycogen Synthase Peptide-2 is a GSK-3 substrate, useful for serine kinase affinity purification.</p>Formule :C123H191N40O48PCouleur et forme :SolidMasse moléculaire :3029.087ZM 449829
CAS :<p>ZM 449829: Selective JAK3 inhibitor, binds to ATP site. pIC50: 6.8 for JAK3, others < 5.0.</p>Formule :C13H10ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :182.222Azerutamig
<p>Azerutamig is a dual-specificity antibody targeting KLRK1/ERBB2 of type (H-γ1_L-κ)_scFvkh-H-γ1(h-CH2-CH3).</p>Couleur et forme :Odour LiquidARUK2001607
CAS :<p>ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.</p>Formule :C14H13N3O2S2Degré de pureté :99.75%Couleur et forme :SoildMasse moléculaire :319.40GSK2292767 FA
<p>GSK2292767 FA: potent PI3Kδ inhibitor, pIC50=10.1, 500x selectivity, for respiratory research.</p>Formule :C25H30N6O7SDegré de pureté :99.52%Couleur et forme :SoildMasse moléculaire :558.61Umbralisib R-enantiomer
CAS :<p>Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.</p>Formule :C31H24F3N5O3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :571.55JBJ-09-063 TFA
<p>JBJ-09-063 TFA, an EGFR inhibitor selective for EGFR mutations, IC50s: 0.147-0.396 nM, blocks EGFR/Akt/ERK signaling, for EGFR-mutant lung cancer research.</p>Formule :C33H30F4N4O5SCouleur et forme :SolidMasse moléculaire :670.67Cinrebafusp alfa
CAS :<p>Cinrebafusp alfa (PRS 343) is an anticalin-based bispecific drug with high affinity for both CD137/HER2, displaying dissociation constants (Kd) of 0.3 nM to</p>Degré de pureté :98%Couleur et forme :LiquidNecitumumab
CAS :<p>Necitumumab (IMC-11F8) is a human monoclonal antibody against EGFR, an anti-angiogenic agent used in the treatment of advanced non-small cell lung cancer.</p>Degré de pureté :97.9% (SDS-PAGE); 99.1% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.1% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.5 kDaDuligotuzumab
CAS :<p>Duligotuzumab is a dual-targeting anti-EGFR/HER3 mAb that blocks signaling and induces ADCC for tumors with poor prognosis.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidEP26
<p>EP26 is an orally active and potent inhibitor of EGFR and PD-L1, with IC50 values of 48.6 nM and 1.77 µM, respectively. It reduces the protein expression of p-EGFR and induces cell cycle arrest at the G0/G1 phase. EP26 shows potential for glioblastoma research.</p>Formule :C42H42ClFN4O5Masse moléculaire :736.28278DSPE-PEG5000-GE11
<p>DSPE-PEG5000-GE11 is a PEG compound composed of DSPE and the EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells with EGFR overexpression. DSPE-PEG5000-GE11 is utilized in drug delivery.</p>Couleur et forme :Odour SolidPROTAC EGFR degrader 2
<p>Potent PROTAC EGFR degrader 2; IC50: 4.0 nM, DC50: 36.51 nM; inhibits cell growth; for NTR-responsive synthesis.</p>Formule :C58H72ClFN12O8SCouleur et forme :SolidMasse moléculaire :1151.78JYQ-164
<p>JYQ-164 is a small molecule inhibitor targeting human Parkinson's disease protein 7 (PARK7/DJ-1). It functions by covalently and selectively targeting the critical residue Cys106 of PARK7, exhibiting an IC50 of 21 nM. JYQ-164 demonstrates five times greater inhibitory potency against PARK7 compared to the previously reported inhibitor, JYQ-88. It is applicable for research in Parkinson's disease and cancer.</p>Formule :C23H26N6O5S2Masse moléculaire :530.14061Anti-Phospho-EGFR (Tyr1068) Antibody (3Q245)
<p>Anti-Phospho-EGFR (Tyr1068) Antibody (3Q245) is an antibody targeting Phospho-EGFR (Tyr1068). Anti-Phospho-EGFR (Tyr1068) Antibody (3Q245) can be used in ELISA, WB.</p>Couleur et forme :Odour LiquidAnti-EGFR Antibody (3B845)
<p>Anti-EGFR Antibody (3B845) is an antibody targeting EGFR. Anti-EGFR Antibody (3B845) can be used in ELISA, WB, IHC.</p>Couleur et forme :Odour LiquidAnti-Phospho-EGFR (Tyr1092) Antibody (9I899)
<p>Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) is an antibody targeting Phospho-EGFR (Tyr1092). Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) can be used in ELISA, WB.</p>Couleur et forme :Odour LiquidAnti-EGFR Antibody (9S619)
<p>Anti-EGFR Antibody (9S619) is an antibody targeting EGFR. Anti-EGFR Antibody (9S619) can be used in ELISA, IHC, FCM.</p>Couleur et forme :Odour LiquidAnti-EGFR Antibody (7X976)
<p>Anti-EGFR Antibody (7X976) is an antibody targeting EGFR. Anti-EGFR Antibody (7X976) can be used in ELISA, WB, IHC, IF, FCM.</p>Couleur et forme :Odour LiquidPF-06843195
CAS :<p>PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .</p>Formule :C20H25F3N8O4Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :498.46RMC-5552
CAS :<p>RMC-5552 selectively inhibits mTORC1 with ~40-fold selectivity over mTORC2, demonstrating anticancer activity and research utility.</p>Formule :C93H136N10O24Couleur et forme :SolidMasse moléculaire :1778.16Osimertinib dimesylate
CAS :<p>Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).</p>Formule :C30H41N7O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :691.82Mavelertinib
CAS :<p>Mavelertinib (PF-06747775) is an EGFR tyrosine kinase (EGFR TKI) inhibitor that inhibits T790M/L858R and can be used to study tumours.</p>Formule :C18H22FN9O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :415.42BI-4142
CAS :<p>BI-4142 is a HER2 inhibitor that inhibits cancer cell proliferation, suppresses her2-dependent cell lines and inhibits downstream signalling.</p>Formule :C28H27N9O2Degré de pureté :97.21% - 98.09%Couleur et forme :SolidMasse moléculaire :521.57AV-412 free base
CAS :<p>AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).</p>Formule :C27H28ClFN6OCouleur et forme :SolidMasse moléculaire :507Tucatinib hemiethanolate
CAS :<p>Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM.</p>Formule :C54H54N16O5Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :1007.11Kinetin triphosphate tetrasodium
<p>Kinetin triphosphate tetrasodium is salt form of Kinetin triphosphate KTP, an ATP analog that enhances activity of Parkinson's disease-associated mutant PINK1.</p>Formule :C15H16N5Na4O14P3Degré de pureté :96.80%Couleur et forme :SoildMasse moléculaire :675.19Ceftriaxone Sodium
CAS :<p>Ceftriaxone Sodium is a sporotaxin antibiotic that inhibits GSK3β and Aurora B. It is used in the study of sepsis and infective endocarditis.</p>Formule :C18H17N8NaO7S3Couleur et forme :SolidMasse moléculaire :576.562Tyrphostin 8
CAS :<p>Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein</p>Formule :C10H6N2ODegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :170.17Neratinib maleate
CAS :<p>Neratinib maleate is a selective HER2/EGFR inhibitor (IC50: 59/92 nM) used in breast and prostate cancer studies.</p>Formule :C34H33ClN6O7Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :673.11(3S,4S)-PF-06459988
CAS :<p>(3S, 4S)-PF-06459988, a less active S enantiomer, specifically inhibits T790M mutant EGFR with high selectivity.</p>Formule :C19H22ClN7O3Couleur et forme :SolidMasse moléculaire :431.88PI3K-IN-30
CAS :<p>PI3K-IN-30 (compound 6d) 是一种 PI3K 的有效抑制剂，能够作用于 PI3Kα (IC50: 5.1 nM)、PI3Kβ (IC50: 136 nM)、PI3Kγ (IC50: 30.7 nM) 和 PI3Kδ (IC50: 8.9 nM)。</p>Formule :C20H25F2N7O3Couleur et forme :SolidMasse moléculaire :449.45Rociletinib hydrobromide
CAS :<p>Rociletinib hydrobromide is an orally delivered inhibitor of the mutant form of EGFR kinase (Kis: 21.5 nM and 303.3 nM for EGFR L858R/T790M and EGFR WT).</p>Formule :C27H29BrF3N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :636.46
