Signalisation PI3K/Akt/mTOR
Les inhibiteurs de la signalisation PI3K/Akt/mTOR sont des composés qui ciblent les voies de la phosphoinositide 3-kinase (PI3K), de la kinase Akt et de la cible de la rapamycine chez les mammifères (mTOR). Ces voies sont des régulateurs critiques de la croissance cellulaire, de la survie, du métabolisme et de l'autophagie, ce qui en fait des cibles clés dans la recherche sur le cancer et les troubles métaboliques. Inhiber ces voies peut aider à contrôler la croissance et la prolifération tumorales, offrant ainsi des stratégies thérapeutiques potentielles pour divers cancers et autres maladies caractérisées par une signalisation cellulaire dysrégulée. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de haute qualité de PI3K/Akt/mTOR pour soutenir vos recherches en oncologie, signalisation cellulaire et maladies métaboliques.
Sous-catégories appartenant à la catégorie "Signalisation PI3K/Akt/mTOR"
- AMPK(171 produits)
- ATM/ATR(72 produits)
- ADN-PK(48 produits)
- EGFR(591 produits)
- MELK(7 produits)
- PDK(9 produits)
- PI3K(233 produits)
- S6 Kinase(8 produits)
- gsk-3(110 produits)
- mTOR(162 produits)
Affichez 2 plus de sous-catégories
1007 produits trouvés pour "Signalisation PI3K/Akt/mTOR"
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O-Desmethyl gefitinib
CAS :O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.Formule :C21H22ClFN4O3Degré de pureté :97.17%Couleur et forme :SolidMasse moléculaire :432.88Ref: TM-T16369
1mg56,00€5mg111,00€10mg170,00€25mg343,00€50mg547,00€100mg783,00€1mL*10mM (DMSO)120,00€LCH-7749944
CAS :LCH-7749944 suppresses human gastric cancer cell growth, induces apoptosis, and inhibits PAK4 with IC50 of 14.93 μM.Formule :C20H22N4O2Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :350.41Ref: TM-T11826
1mg49,00€5mg108,00€10mg164,00€25mg284,00€50mg424,00€100mg615,00€200mg830,00€1mL*10mM (DMSO)116,00€PI4KIIIbeta-IN-9
CAS :PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .Formule :C23H25N3O5S2Degré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :487.59Ref: TM-T12469
1mg80,00€5mg188,00€10mg283,00€25mg512,00€50mg715,00€100mg938,00€1mL*10mM (DMSO)À demanderHyT36
CAS :HyT36: hydrophobic tag that destabilizes fusion proteins & Her3 pseudokinase; treats cells with acute erht.Formule :C25H44ClNO3Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :442.07Ref: TM-T72075
1mg56,00€5mg119,00€10mg188,00€25mg393,00€50mg628,00€100mg908,00€1mL*10mM (DMSO)131,00€Lyso-Monosialoganglioside GM3
CAS :Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analog of Ganglioside GM3 with antitumor properties. It inhibits the increase in EGFR kinase activity induced by EGF in A431 epithelial cancer cells.Formule :C41H74N2O20Couleur et forme :SolidMasse moléculaire :915.028RMC-4529
CAS :RMC-4529 is a chemical compound that demonstrates potent inhibition, with an IC50 value of 1.0 nM, against p-4E-BP1-(T37/46) in mTOR kinase cellular assays.Formule :C90H139N13O23Couleur et forme :SolidMasse moléculaire :1771.17PI3K-IN-22
CAS :PI3K-IN-22 is a dual kinase inhibitor of PI3Kα and mTOR, with IC50s of 0.9 and 0.6 nM respectively. PI3K-IN-22 could be used in cancer.Formule :C31H35F3N8O3Couleur et forme :SolidMasse moléculaire :624.66Anticancer agent 271
Anticanceragent 271 (compound 5C) exhibits antiproliferative activity against lung cancer (A549), colon cancer (Caco-2) cell lines, and human lung fibroblasts (WI38), with an IC50 value of 9.18 μM for A549 cells. This compound can downregulate PI3K and mTOR gene expression and is applicable in cancer research.Couleur et forme :Odour SolidVarlitinib Tosylate
CAS :Varlitinib Tosylate is a selective and potent inhibitor of ErbB1(EGFR) and ErbB2(HER2).Formule :C36H35ClN6O8S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :811.34PI3Kα-IN-25
PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.Formule :C21H19ClN4O4Couleur et forme :SolidMasse moléculaire :426.853mTOR inhibitor WYE-28
CAS :Compound 28 (mTOR inhibitor WYE-28) is a selective inhibitor of mTOR (IC50=0.08 nM). Also inhibits PI3Kα (IC50 6 nM).Formule :C30H34N8O5Couleur et forme :SolidMasse moléculaire :586.653EGFR-IN-124
EGFR-IN-124 (compound 10A) is an EGFR inhibitor with an IC50 value of 0.54 μM, utilized in cancer research.Couleur et forme :Odour SolidDA-143
DA-143 is a selective inhibitor of DNA-PKcs (IC50: 2.5 nM), demonstrating disparate inhibitory effects on mTOR, PI3KΔ, and ATM, with IC50 values of 280 nM, 106 nM, and 6,594 nM, respectively. This compound effectively blocks the phosphorylation of DNA-PKcs substrates and enhances the sensitivity of cancer cells to doxorubicin.Couleur et forme :Odour SolidEGFR-IN-127
EGFR-IN-127 is an ATP-competitive inhibitor targeting EGFR, with IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds potential for the study of non-small cell lung cancer (NSCLC).Couleur et forme :Odour SolidIBI-334
IBI-334 is a bispecific antibody targeting both B7-H3 and EGFR. It features an EGFR arm responsible for signal blocking, connected to a modified B7-H3 arm that ensures optimal affinity and binding. The antibody is afucosylated to enhance its antibody-dependent cellular cytotoxicity (ADCC) effects. IBI-334 is widely applicable in EGFR-driven solid tumors.Couleur et forme :Odour LiquidTephrosin
CAS :Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors, has potent antitumor activities.Formule :C23H22O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :410.42Multi-target kinase inhibitor 4
<p>Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.</p>Couleur et forme :Odour SolidYH32367
<p>YH32367 (ABL105) is a bispecific antibody targeting HER2 and 4-1BB. It induces the secretion of IFN-γ, resulting in the death of tumor cells when co-cultured with hPBMC and HER2-expressing tumor cells. YH32367 demonstrates notable antitumor activity.</p>Couleur et forme :Odour LiquidDuligotuzumab
CAS :Duligotuzumab is a dual-targeting anti-EGFR/HER3 mAb that blocks signaling and induces ADCC for tumors with poor prognosis.Degré de pureté :97.7% (SDS-PAGE); 96.3% (SEC-HPLC) - ≥95% (SDS-PAGE); 95.19% (SEC-HPLC)Couleur et forme :LiquidALKBH1-IN-3 prodrug
<p>ALKBH1-IN-4 prodrug (Compound 29E) is a prodrug of an inhibitor targeting the DNA N6-methyladenine demethylase enzyme ALKBH1. It works by significantly increasing the cellular abundance of 6mA and enhancing the AMPK signaling pathway, which suppresses the vitality of gastric cancer cells. ALKBH1-IN-4 prodrug displays excellent cellular activity and favorable metabolic exposure in vivo, making it a promising candidate for research in gastric cancer-related areas.</p>Couleur et forme :Odour Solid
