ATM/ATR
Les inhibiteurs de l'ATM (Ataxia Telangiectasia Mutated) et de l'ATR (ATM and Rad3-related) ciblent des kinases clés impliquées dans la réponse aux dommages de l'ADN (DDR), activées en réponse aux cassures double brin de l'ADN et au stress de réplication. Ces inhibiteurs perturbent la capacité des kinases à détecter et réparer les dommages de l'ADN, ce qui peut entraîner une instabilité génomique accrue et la mort cellulaire, en particulier dans les cellules cancéreuses qui dépendent de mécanismes de réparation de l'ADN robustes pour survivre. Les inhibiteurs de l'ATM/ATR sont des outils cruciaux dans la recherche et la thérapie contre le cancer, notamment en combinaison avec des agents endommageant l'ADN. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'ATM/ATR de haute qualité pour soutenir vos recherches sur la réponse aux dommages de l'ADN, la biologie du cancer et le développement thérapeutique.
72 produits trouvés pour "ATM/ATR".
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ATR-IN-5
CAS :ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.Formule :C27H32F3N9OCouleur et forme :SolidMasse moléculaire :555.6ATR-IN-8
CAS :ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.Formule :C20H22N6O2SCouleur et forme :SolidMasse moléculaire :410.49ATM-IN-1
CAS :ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.Formule :C30H36N6O3Couleur et forme :SolidMasse moléculaire :528.65ATR-IN-13
CAS :ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).Formule :C24H24FN9OCouleur et forme :SolidMasse moléculaire :473.51AZ 5704
CAS :AZ 5704 (compound 74) is a selective and orally active ATM inhibitor (IC50 = 0.6 nM), which can enhance the anti-tumor activity of irinotecan.Formule :C23H23FN6O2Degré de pureté :99.69%Couleur et forme :White SolidMasse moléculaire :434.47ATR-IN-20
ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.Formule :C29H31N5O4SCouleur et forme :SolidMasse moléculaire :545.65ATR-IN-21
CAS :ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].Formule :C23H27N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.51ATR-IN-29
CAS :ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].Formule :C19H22N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.43ATR-IN-22
CAS :ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM andFormule :C25H31N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.56(S)-Ceralasertib
CAS :(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.Formule :C20H24N6O2SCouleur et forme :SolidMasse moléculaire :412.51ATR-IN-6
CAS :ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.Formule :C28H28FN7O2Couleur et forme :SolidMasse moléculaire :513.57ATR-IN-18
CAS :ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.Formule :C19H22F3N7O5SCouleur et forme :SolidMasse moléculaire :517.48Camonsertib
CAS :Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.Formule :C21H26N6O3Degré de pureté :98.44% - 99.93%Couleur et forme :Yellow SolidMasse moléculaire :410.47Ref: TM-T62083
1mg160,00€1mL*10mM (DMSO)356,00€5mg394,00€10mg573,00€25mg893,00€50mg1.189,00€100mg1.639,00€200mg2.205,00€Lartesertib
CAS :Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancerFormule :C23H21FN6O3Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :448.45Ref: TM-T62684
1mg123,00€2mg177,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg505,00€25mg982,00€50mg1.639,00€100mg2.538,00€AZ31
CAS :AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,Formule :C24H28N4O3Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :420.5ATR kinase-IN-2
CAS :ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.Formule :C24H29F2N9O2Couleur et forme :SolidMasse moléculaire :513.54ATM Inhibitor-11
CAS :ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.Formule :C27H33FN6O2Couleur et forme :SolidMasse moléculaire :492.59ATR kinase-IN-3
CAS :ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.Formule :C24H27F2N9O2Couleur et forme :SolidMasse moléculaire :511.53ATR-IN-19
CAS :ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].Formule :C18H19N7OSCouleur et forme :SolidMasse moléculaire :381.45ATR-IN-11
ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.Formule :C25H30N6O2Couleur et forme :SolidMasse moléculaire :446.54
