ATM/ATR
Les inhibiteurs de l'ATM (Ataxia Telangiectasia Mutated) et de l'ATR (ATM and Rad3-related) ciblent des kinases clés impliquées dans la réponse aux dommages de l'ADN (DDR), activées en réponse aux cassures double brin de l'ADN et au stress de réplication. Ces inhibiteurs perturbent la capacité des kinases à détecter et réparer les dommages de l'ADN, ce qui peut entraîner une instabilité génomique accrue et la mort cellulaire, en particulier dans les cellules cancéreuses qui dépendent de mécanismes de réparation de l'ADN robustes pour survivre. Les inhibiteurs de l'ATM/ATR sont des outils cruciaux dans la recherche et la thérapie contre le cancer, notamment en combinaison avec des agents endommageant l'ADN. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'ATM/ATR de haute qualité pour soutenir vos recherches sur la réponse aux dommages de l'ADN, la biologie du cancer et le développement thérapeutique.
77 produits trouvés pour "ATM/ATR".
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ATR kinase-IN-3
CAS :ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.Formule :C24H27F2N9O2Couleur et forme :SolidMasse moléculaire :511.53ATR-IN-17
CAS :ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).Formule :C22H28N6O2SCouleur et forme :SolidMasse moléculaire :440.56(S)-WSD0628
CAS :(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.Formule :C23H23F2N5O2Couleur et forme :SolidMasse moléculaire :439.458ATR-IN-19
CAS :ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].Formule :C18H19N7OSCouleur et forme :SolidMasse moléculaire :381.45ATR-IN-12
ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.Formule :C22H27N5O3SCouleur et forme :SolidMasse moléculaire :441.55ATR-IN-11
ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.Formule :C25H30N6O2Couleur et forme :SolidMasse moléculaire :446.54XRD-0394
CAS :XRD-0394 is a highly effective and selective dual inhibitor of ATM and DNA-PKcs, exhibiting oral bioactivity. It notably increases tumor cell destruction both in vitro and in vivo when combined with therapeutic ionizing radiation. Furthermore, XRD-0394 enhances the efficacy of PARP and topoisomerase I inhibitors in vitro [1].Formule :C26H30FN5O4SMasse moléculaire :527.61Decarbamoylmitomycin C
CAS :Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.Formule :C14H17N3O4Couleur et forme :SolidMasse moléculaire :291.302ATR-IN-14
CAS :ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.Formule :C20H20FN7OCouleur et forme :SolidMasse moléculaire :393.42ATM Inhibitor-1
CAS :ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.Formule :C27H36N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :492.61KU 59403
CAS :KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).Formule :C29H32N4O4S2Degré de pureté :99.10% - 99.79%Couleur et forme :SolidMasse moléculaire :564.719ATR-IN-32
CAS :ATR-IN-32 is an orally active ATR inhibitor that effectively suppresses the proliferation of MIA PaCa-2 cells. It significantly inhibits tumor growth in mice bearing LOVO and HT-29 xenografts. ATR-IN-32 is applicable for studying cancers mediated by the ATR protein kinase, such as colorectal cancer and pancreatic cancer.Formule :C22H24N6O2Masse moléculaire :404.47ATM-IN-13
CAS :ATM-IN-13 (A36) is an orally active selective ATM kinase inhibitor with a human IC50 of 0.3 nM. It disrupts the ATM-mediated DNA double-strand break repair signaling pathway, reduces phosphorylation levels of ATM and p53, and inhibits the ATM-dependent DNA damage response. ATM-IN-13 is applicable in colorectal cancer research.Formule :C27H33N5OMasse moléculaire :443.58WSD0628
CAS :WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].Formule :C23H23F2N5O2Couleur et forme :SolidMasse moléculaire :439.46ATM Inhibitor-3
ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.Formule :C25H29FN6O3Couleur et forme :SolidMasse moléculaire :480.53ATM Inhibitor-2
ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).Formule :C26H31N7O3Couleur et forme :SolidMasse moléculaire :489.57ATM Inhibitor-4
ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.Formule :C26H29FN6O3Couleur et forme :SolidMasse moléculaire :492.55
