Oligosaccharides

Glycosaminoglycans (GAGs) are polysaccharides that are found in the extracellular matrix and on the surface of cells. GAGs consist of a linear chain of repeating disaccharide units, with one or more sugar molecules linked by a glycosidic bond. They have been shown to be important for the function and structure of tissues, including those in the gastrointestinal tract. GAGs have been shown to stimulate cellular growth, regulate inflammatory responses, and promote wound healing. They have also been shown to inhibit activity of polymorphonuclear leucocytes (PMN), which play an important role in inflammation. One type of GAG is dextran sulfate, which has been used as a biological scaffold for tissue engineering applications. Glycosaminoglycans may also play a role in regulating immune responses through interaction with toll-like receptor 4 (TLR4).

<p>2-Hydroxypropyl-b-cyclodextrin is a water-soluble drug that is chemically stable in aqueous media. It has been shown to be safe for use in the eye, with no significant side effects. 2-Hydroxypropyl-b-cyclodextrin has been shown to have anti-inflammatory properties and will not cause hemolytic activity. 2-Hydroxypropyl-b-cyclodextrin binds to retinoic acid receptors, which are found on cells of the corneal surface and in human spermatozoa. The binding of retinoic acid inhibits the production of enzymes that break down retinoids and prevents cell proliferation. This agent also interacts with other cellular components such as proteins, lipids, carbohydrates, nucleic acids, and hormones.</p>

<p>GD1b oligosaccharide (shown as ammonium salt) is the carbohydrate moiety in one of the major gangliosides in neuronal and glial membranes; it has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with its two sialic acids linked α2,3/α2,8 to the inner galactose residue (Ledeen, 2009). GD1b ganglioside acts as a receptor for BK virus as well as for heat-labile LTII-a toxin, produced by enteropathogenic E. coli. GD1b ganglioside also interacts with tetanus neurotoxin (TeNT) and is crucial for its entry into cells (Kolter, 2012). The functional significance of ammonia in the brain is not yet fully understood. However, NH4 + stimulates Na+, K+ activated ATPase causing stabilization of the neuronal membranes of which gangliosides are major structural components. Further, ammonia is known to inhibit lysosomal enzymes which include enzymes degrading gangliosides (Modi, 1994).</p>

<p>Lewis Y-PAA-biotin is a complex carbohydrate which is synthesized using Click chemistry. This compound has been modified to include a biotin moiety. Lewis Y-PAA-biotin has been shown to be resistant to enzymatic degradation and can be used as a saccharide in the synthesis of polysaccharides. Lewis Y-PAA-biotin is synthesized by attaching poly(acrylamide) (PAA) chains to the sugar moieties of Lewis Y. The carbonyl group on the PAA chains can be fluorinated, which makes it useful for click modification reactions with fluorinated compounds.</p>

<p>Produced by the reverse hydrolysis of a mannose substrate</p>

Fructo-octasaccharide (FOS) is a synthetic, high-purity carbohydrate that is used in the production of various food and beverage products. FOS is produced by enzymatic synthesis from sucrose and has been modified to include a fluorination step. FOS can be used as a sugar substitute and is found in many foods such as breads, beverages, yogurt, ice cream, candy, and chewing gum. FOS has been shown to stimulate the growth of beneficial bacteria in the gastrointestinal tract and may help promote healthy digestion.

Lacto-N-fucopentaose I-BSA is a Glycosylation, Oligosaccharide, sugar, Synthetic, Fluorination, Custom synthesis, Methylation, Monosaccharide, Polysaccharide, saccharide.

<p>Occurs by epimerisation of maltose and transglucosylation</p>

GM4-ganglioside (sodium salt) is a disaccharide of sialic acid linked α2,4 to galactose and ceramide linked β to position 1 on the galactose (Ledeen, 2009). Demyelinated plaques in multiple sclerosis have decreased amounts of GM4-ganglioside, localized in myelin and oligodendroglia of the central nervous system. It has been found that the myelin basic protein is capable of releasing large quantities of entrapped [14C]glucose from multilamellar liposomes containing GM4. If the conformation of GM4 ganglioside in liposomal membranes resembles that of GM4 ganglioside in its natural environment, basic protein and GM4 may be associated within the myelin sheath of the central nervous system and their interactions are altered in demyelinating diseases, such as, multiple sclerosis (Mullin, 1981).

<p>N-Glycolylneuraminic acid-spacer-BSA is a synthetic, monosaccharide oligosaccharide, complex carbohydrate. The glycosylation of BSA with N-glycolylneuraminic acid has been shown to be an effective method for the protection of biomolecules against fluoroquinolones. Glycosylation with N-glycolylneuraminic acid can be used as a method for the protection of biomolecules from fluoroquinolone antibiotics and other chemical reagents that are known to react with sugars.</p>

Lewis Y tetrasaccharide is a type of antigen that is used as a pharmacological agent. It has been shown to be effective in treating carcinoma cell lines and primary sclerosing cholangitis. Lewis Y tetrasaccharide has also been shown to be an antigen for the mouse monoclonal antibody, which is used in cancer research. The Lewis Y tetrasaccharide stimulates the immune system by interacting with certain cells called dendritic cells and macrophages, which are responsible for activating T-cells. This interaction promotes the production of chemoattractant proteins, which are proteins that attract white blood cells to fight infection and promote healing. Lewis Y tetrasaccharide has also been shown to cause cancer cell death by lysing cells through apoptosis or necrosis depending on the tissue type.

Drug carrier for cancer therapy & imaging, biocompatible, soluble, biodegradable

<p>Monofucosyl-para-lacto-N-hexaose IV is a trisaccharide that belongs to the group of blood group antigens. It is found in human milk and can be used as an indicator for infant nutrition. Monofucosyl-para-lacto-N-hexaose IV is found in the cells of streptococcus, lactobacillus, and clostridium. It has been shown to be a potential biomarker for inflammatory bowel disease (IBD). This molecule has been used as an antigen in immunological assays. The sequences of monofucosyl-para-lacto-N-hexaose IV have been determined using chromatograms and profiles.</p>

<p>6'-Sialyllactose-sp-biotin is a custom synthesis of a 6'-sialyllactose with a biotin moiety attached to the reducing end. The modification was done through fluorination, methylation, and monosaccharide synthesis. This product has CAS No. 1384441-62-6 and is an oligosaccharide saccharide that is polysaccharide containing glycosylated sugar. It is also a complex carbohydrate that contains many sugars in one molecule.</p>

<p>Lividamine is a protein synthesis inhibitor that has biphasic responses in animal studies. Lividamine inhibits the enzyme catalysis of aminoglycosides, which are used for the treatment of bacterial infections. It also blocks the biosynthesis of polypeptides, which are essential for cell growth and division. Lividamine binds to the hydroxyl group or carboxylate group on an amino acid, cleaving it from the peptide chain and stopping protein synthesis. Lividamine has been shown to be effective against bacteria in vitro assays. Further research is required to determine its clinical properties.</p>

Complex glucan (a 1-6) from Leuconostoc spp.; extender in blood transfusions

<p>Monofucosyl (1-2)-iso-lacto-N-octaose I is an oligosaccharide found in human milk</p>

<p>Lewis B pentasaccharide is a custom-synthesized carbohydrate that belongs to the Modification, saccharide, Oligosaccharide, sugar category. It is an oligosaccharide with a non-reducing end and a reducing end. Lewis B pentasaccharide is a complex carbohydrate that is synthesized from monosaccharides by glycosylation and methylation reactions. This product has high purity and it can be used in research for its fluoroquinolone resistance properties.</p>

<p>Fructodecasaccharide is a methylated, custom-synthesized oligosaccharide that is a polysaccharide with the molecular formula C10H17O11. Fructodecasaccharide is a complex carbohydrate that consists of a monosaccharide and two disaccharides. It has been modified to include fluorine atoms in the glycosidic linkages between the sugar residues. This modification can alter the physical properties of fructodecasaccharide, such as increasing its solubility and stabilizing its structure. Fructodecasaccharide is used in many industries as a high-purity, synthetic product for use in medical applications, including pharmaceuticals and cosmetics.</p>