Ligands organométalliques
Sous-catégories appartenant à la catégorie "Ligands organométalliques"
- Ligands de Buchwald(22 produits)
- DPEN(4 produits)
- DPHEN(4 produits)
- JOSIPHOS(4 produits)
- Phosphine(497 produits)
- Porphyrines(75 produits)
2889 produits trouvés pour "Ligands organométalliques"
FG 7142
CAS :Partial inverse agonist of benzodiazepine sites of the GABAA receptors with anxiogenic properties. FG 7142 is a pharmacological stressor which generates anxiety in humans and in experimental animals such as rhesus monkeys and rodents. FG 7142 also reduces food intake and frequency of feeding in male and female rats.Formule :C13H11N3ODegré de pureté :Min. 95%Couleur et forme :Yellow PowderMasse moléculaire :225.25 g/molRN 486
CAS :Bruton's tyrosine kinase antagonist; reduces Fcγ receptor signaling
Formule :C35H35FN6O3Degré de pureté :Min. 95%Masse moléculaire :606.69 g/molUNC 4203
CAS :Potent and specific inhibitor of the tyrosine protein kinase Mer precursor (MERTK) with 38-fold selectivity over the FMS-like protein kinase FLT3. UNC 4203 inhibits MERTK with an IC50 value of 2.4 nM and shows favourable pharmacokinetic properties. In vivo experiments in mice showed that UNC 4203 dramatically decreased the phosphorylation of MERTK in bone marrow leukemia cells.Formule :C30H44N6ODegré de pureté :Min. 95%Couleur et forme :Yellow PowderMasse moléculaire :504.71 g/molCYT 387
CAS :Inhibits JAK1 and JAK2 kinasesFormule :C23H22N6O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :414.46 g/molToceranib phosphate - Bio-X ™
CAS :Produit contrôléToceranib phosphate is a receptor tyrosine kinase inhibitor. Toceranib phosphate has been shown to be effective in the treatment of skin cancer and other types of cancer, including lung cancer and breast cancer. It is approved in the US as a treatment for canine mastocytoma (mast cell tumours).Formule :C22H25FN4O2·H3O4PDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :494.45 g/molCamostat mesylate - Bio-X ™
CAS :Camostat is a serine protease inhibitor that is used for the treatment of chronic pancreatitis. This drug has shown to reduce inflammation and pain. Studies have shown that Camostat has also inhibited the entry of SARS-CoV-2 in lung cells by inhibiting the priming process of S-protein, necessary for the viral entry into host cells.Formule :C20H22N4O5•CH4O3SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :494.52 g/molValiglurax
CAS :Potent and selective positive allosteric modulator (PAM) of metabotropic glutamate receptor mGlu4. Valiglurax is orally bioavailable and CNS-penetrant mGlu4 PAM in preclinical development for the Parkinson’s disease therapy and alleviation of the motor symptoms.Formule :C16H10F3N5Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :329.28 g/molMCC 950 sodium
CAS :Inhibitor of NLRP3 inflammasome and suppressor of the inflammatory cytokine IL-1β secretion. The compound was tested in diabetic mice and was shown to decrease the incidence of cardiac arrythmias, which are common secondary complications in diabetes mellitus. MCC 950 has potential to reverse diabetes-induced pathologies in cardiac electrophysiology.Formule :C20H23N2O5S·NaDegré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :426.46 g/molLY 411575
CAS :Potent inhibitor of γ-secretase. LY 411575 inhibited production of amyloid β (Aβ) peptides with IC50 of 0.078 nM in vitro as well as decreased levels of Aβ40 and Aβ42 amyloids in brain of a mouse model for Alzheimer’s disease. In vitro studies confirmed that LY 411575 inhibited cleavage of Notch receptor at S3 site with IC50 of 0.39 nM, which blocked Notch activation and downstream signalling, leading to apoptosis in primary and immortalized Kaposi's sarcoma cells.Formule :C26H23F2N3O4Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :479.48 g/molMelitracen hydrochloride
CAS :Tricyclic antidepressantFormule :C21H26NClDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :327.89 g/molPonalrestat
CAS :Ponalrestat is an aldose reductase inhibitor, which is a synthetic compound developed for pharmacological purposes. It originates from chemical synthesis designed to target and inhibit the enzyme aldose reductase effectively. The mode of action involves the competitive inhibition of aldose reductase, an enzyme involved in the polyol pathway of glucose metabolism. By preventing the reduction of glucose to sorbitol, it reduces sorbitol accumulation associated with diabetic complications.Formule :C17H12BrFN2O3Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :391.19 g/molIsradipine
CAS :L-type calcium channel blockerFormule :C19H21N3O5Degré de pureté :Min. 95%Couleur et forme :Yellow PowderMasse moléculaire :371.39 g/molDilevalol hydrochloride
CAS :Produit contrôléBeta-adrenoceptor antagonist; anti-hypertensiveFormule :C19H24N2O3·HClDegré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :364.87Azumolene
CAS :Azumolene is a muscle relaxant drug, which is a synthetic derivative of dantrolene originating from hydantoin. The mode of action of Azumolene involves the inhibition of calcium ion release from the sarcoplasmic reticulum of skeletal muscle fibers. By impeding this release, Azumolene effectively reduces muscle contraction, thereby acting as a potent muscle relaxant.Formule :C13H9BrN4O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :349.14 g/molIndomethacin - Bio-X ™
CAS :Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to Indomethacin's anti-inflammatory effects. Indomethacin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formule :C19H16ClNO4Degré de pureté :(%) Min. 95%Couleur et forme :PowderMasse moléculaire :357.79 g/molMelatonin - Bio-X ™
CAS :Melatonin is a neurotransmitter produced by the pineal gland that is involved in the regulation of sleep-wake cycles. It can be used to treat several conditions like shift work disorders, insomnia, jet lag, and alterations of the circadian rhythm. Some authors also proposed the use of melatonin against cognitive disorders. In an interesting research conducted on zebrafish, it was found that memory formation occurs better during daytime compared to nighttime, suggesting a role of melatonin in this process. When melatonin was administered during the daytime it caused reduced memory formation. On the contrary, removing the pineal gland or treating the fish with a melatonin antagonist significantly improves nighttime memory formation.
Formule :C13H16N2O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :232.28 g/mol(R)-ADX 47273
CAS :Positive allosteric modulator of the metabotropic glutamate receptor mGluR5 with EC50 in submicromolar range. The compound is able to increase mGluR5 function in vitro and in vivo. A study showed that ADX-47273 enhanced fear extinction learning as well as improved reversal learning in experimental animals.
Formule :C20H17F2N3O2Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :369.36 g/molS26131
CAS :S26131 is an advanced glycation end product (AGE) inhibitor, which is a synthetic compound designed for laboratory research purposes. It is derived from chemical synthesis processes, offering a robust tool for investigating the biochemical pathways associated with glycation. Its mechanism of action involves the inhibition of AGE formation, which is a post-translational modification resulting from the non-enzymatic reaction between sugars and proteins or lipids. This biochemical modulation is vital for studying the implications of glycation in various physiological and pathological contexts.
Formule :C31H34N2O4Degré de pureté :Min. 95%Masse moléculaire :498.6 g/molNilotinib HCl monohydrate - Bio-X ™
CAS :Nilotinib is a kinase inhibitor that is used for the treatment of Chronic Myeloid Leukemia (CML). This drug is also used for the treatment of CML that is resistant to imatinib. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. It also inhibits PDGFR and c-kit.
Formule :C28H22F3N7O•HCl•H2ODegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :583.99 g/mol
