Composés deutérés

Applications L-Phenyl-d5-alanine-N-FMOC (CAS# 225918-67-2) is a useful isotopically labeled research compound.

Applications 2,4,6-Trimethylpyridine-d11 (CAS# 1219805-54-5) is a useful isotopically labeled research compound.

Applications Sodium Hexadecanoate-16,16,16-d3 (CAS# 347841-37-6) is a useful isotopically labeled research compound.

Applications Ethylene Glycol Monodecanoate-d4 is a deuterated version of Ethylene Glycol Monodecanoate (E917555), a reactant in the synthesis of water-woluble phospholipid analogues as inhibitors of phospholipase C.
References Franklin, Christopher L., et al.: J. of Org. Chem., 68(19), 7298-7307 (2003)

Applications 1-Octene-2-d1 (CAS# 56975-78-1) is a useful isotopically labeled research compound that can be used as a catalyst and in various photochemistry experiments.
References Gao, F. et.al., J. Org. Chem.,26, 9361-9367, (2002); Martin, C., et.al., J. Mol. Catal., 37, 201-212,(1986);

Applications 1,1-Dimethylhydrazine-d8 DCl (CAS# 1219802-85-3) is a useful isotopically labeled research compound.
Chemical Name: 1,1-Dimethylhydrazine-d8 DCl (CAS# 1219802-85-3) is a useful isotopically labeled research compound.

Applications n-Butyl-4,4,4-d3 Alcohol (CAS# 64156-70-3) is a useful isotopically labeled research compound.

Applications 1,10-Decane-d20-diol (CAS# 347841-78-5) is a useful isotopically labeled research compound.

Applications 4-Hydroxy-2,2,6,6-tetramethylpiperidine-d17-1-15N-1-oxyl (CAS# 90429-66-6) is a useful isotopically labeled research compound that is used in various spectroscopic analysis.
References Bales, B. et.al., Appl.Magn.Reson.,48,1399-1445,(2017);

Applications Nonyl 4-Hydroxybenzoate-d4 is labelled Nonyl 4-Hydroxybenzoate which was used to prepare 4-[(aminosulfonyl)oxy] benzoic acid derivatives as potent inhibitors of the enzyme estrone sulfatase (ES). It was also used to synthesize sulfonylbenzoic acid esters as potential inhibitors of oestrone sulphatase with antitumor activities.
References Ahmed, S., et al.: Bioorg. Med. Chem. Lett., 12, 2391 (2002); Owen, C., et al.: J. Pharm. Pharmacol., 55, 85 (2002)

Applications N-Desmethyl Sorafenib-d4 is the isotope labelled analog of N-Desmethyl Sorafenib (D293290); a metabolite of Sorafenib (S676850) that has anti-proliferative activity in human breast cancer cells.
References Cui, P.H., et al.: Biochem. Pharmacol., 86, 419 (2013); Ghassabian, S., et al.: Biochem. Pharmacol., 84, 215 (2012)

Applications A labelled tryptophan metabolite, is a precursor of kynurenic acid, which is an antagonist of N-methyl-aspartate receptor. An amino acid produced in the body from tryptophan.
References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990), Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003), Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003), Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007),

Applications 1,6-Hexane-1,1,6,6-d4-diol (CAS# 6843-76-1) is a useful isotopically labeled research compound.

Applications 1-Iodopropane-2,2-d2 (CAS# 25493-15-6) is a useful isotopically labeled research compound.

Applications 4-(Methyl-d3-amino)butyric-2,2,3,3,4,4-d6 Acid HCl (CAS# 1219805-36-3) is a useful isotopically labeled research compound.

Applications 1-Octadecane-d37-thiol (CAS# 668433-57-6) is a useful isotopically labeled research compound.

Applications rac-N-(2,3-Dihydroxyphenyl)-m-synephrine-d3 is the isotope labelled analog of rac-N-(2,3-Dihydroxyphenyl)-m-synephrine (D454500); a derivative of rac-Synephrine (S920001, HCl salt) which is an α-adrenergic receptor agonist and vasoconstrictor.
References Louw, A., et al.: Biochem. Pharmacol., 53, 189 (1997)

Applications 2,2-Bis(hydroxymethyl-d2)propionic-3,3,3-d3 Acid (CAS# 1219802-03-5) is a useful isotopically labeled research compound.

Applications Glyceryl Tri(octadecanoate-18,18,18-d3) (CAS# 285979-76-2) is a useful isotopically labeled research compound.

Applications Tetrahydrofuran-2,2,5,5-d4 (CAS# 20665-63-8) is a useful isotopically labeled research compound.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 3-​Methylbutyryl-​d9 Chloride is an intermediate for the synthesis of Isovaleryl L-Carnitine-d9 Chloride (I917582), which is labelled Isovaleryl L-Carnitine Chloride (I917580), and it is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.
References Gong, X., et al.: J. Chem. Res., 6, 327 (2008)

Applications Loratadine-d5 (ethyl-d5) (CAS# 1398065-63-8) is a useful isotopically labeled research compound.

Applications n-Heptyl-d15 Alcohol (CAS# 194793-95-8) is a useful isotopically labeled research compound.

Applications 2,3-Dimethylphenol-13C8 is an isotope labelled analog of 2,3-Dimethylphenol. 2,3-Dimethylphenol is a useful synthetic intermediate. It was used in the synthesis of hydroxychalcones and flavones with antiinflammatory activities. It was also used to prepare 3,3-bisaryloxindole analogs as mineralocorticoid receptor antagonists.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ballesteros, J., et al.: J. Med. Chem., 38, 2794 (1995); Neel, D., et al.: Bioorg. Med. Chem. Lett., 15, 2553 (2005)

Applications 4,4,5,5-Tetramethyl-2-[4-(2,2,2-trifluoroethyl)phenyl]-1,3,2-dioxaborolane-d4 is labelled 4,4,5,5-Tetramethyl-2-[4-(2,2,2-trifluoroethyl)phenyl]-1,3,2-dioxaborolane (T305500) which is an intermediate used to prepare fused imidazolone derivatives as possible allosteric modulators for metabotropic glutamate receptor subtype 2 (mGlu2 receptor).
References Matsuda, Y., et al.: PCT Int. Appl., WO 2013062074 A1 20130502 (2013)

Applications 3,5-Dimethyl-d6-cyclohexanone-3,4,4,5-d4 (mixture of isomers) (CAS# 1219804-55-3) is a useful isotopically labeled research compound.

Applications Ethylene Glycol-D6 (D, 98%) (cas# 15054-86-1) is a useful research chemical.

Applications 2-(1-Cyanoethyl)indole-13C215N is an isotope labelled intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals.
References Pezzuto, J.M., et al.: Biochem., 20, 298 (1981), Takeda, K., et al.: Chem. Pharm. Bull., 29, 1280 (1981),

Applications n-Tetradecyltrimethylammonium-d38 Bromide (CAS# 95523-72-1) is a useful isotopically labeled research compound.

Applications 2,4,6-Trimethyl-1,3-benzenediamine-15N2 is the isotope labelled analogue of 2,4,6-Trimethyl-1,3-benzenediamine, a compound used in the synthesis of various polymers.
References Fritsch, D., et al.: Macromolec. Chem. Phys., 197, 701 (1996);

Applications N-(Ethyl-d2)-N-(propyl-d2)benzenemethanamine is an intermediate in the synthesis of N-Ethyl-N-nitroso-1-propanamine-d4 (E817997) and isotope labelled version of N-Ethyl-N-nitroso-1-propanamine. N-Ethyl-N-nitroso-1-propanamine is a derivative of N-Nitrosodiethylamine (N525465),a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.
References Shirakami, Y., et al.: Bitamin, 87, 156 (2013); Fujii, Y., et al.: Toxicol., 305, 30 (2013); Uehara, T., et al.: Toxicol. Sci., 132, 53 (2013);

Applications O-Demethoxypropane Aliskiren-d6 is the labeled analog of O-Demethoxypropane Aliskiren is an impurity of Aliskiren Hemifumarate (A536001), an orally active, synthetic nonpeptide renin inhibitor. Antihypertensive.
References Kumar, N.U., et. al.: Chem. Biol. Interface, 3, 304 (2013); Lefevre, G., et al.: J. Immunoassay, 21, 65 (2000); Allikments, K., et al.: Curr. Opin. Invest. Drugs, 3, 1479 (2002); Wood, J.M., et al.: Biochem. Biophys. Res. Commun., 308, 698 (2003); Grandman, A.H., et al.: Circulation, 111, 1012 (2005)

Applications O-Desaryl Ranolazine-d5 is the isotope labelled analog of O-Desaryl Ranolazine (D422050); a metabolite of Ranolazine (R122500).
References Chaitman, B.R., et al.: J. Am. Coll. Cardial., 43, 1375 (2004); McCormack, J.G., et al.: Gen. Pharmacol., 30, 639 (1998); Schofield, J.A.H., et al.: Expert Opin. Invest. Drugs, 11, 117 (2002)

Applications Ledipasvir-d6 is labelled Ledipasvir (L320100) which is most commonly used in combination with sofosbuvir for treatment in chronic hepatitis C genotype 1 patients. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.
References Lawitz, E., et al.: J. Hepatol., 57, 24 (2012); Afdhal, N., et al.: New England J. Med., 370, 1889 (2014)

Applications n-Hexyl-d13 Alcohol (CAS# 204244-84-8) is a useful isotopically labeled research compound.

Applications Glyceryl Tri(octanoate-d15) (CAS# 352431-24-4) is a useful isotopically labeled research compound.

Applications β-(p-Nitrophenyl)ethyl Bromide-d4 (cas# 1794971-35-9) is a compound useful in organic synthesis.

Applications 1-Bromopentane-1-d1 (CAS# 148404-92-6) is a useful isotopically labeled research compound.

Applications (S)-Isopropyl-2-aminopropanoate-d7 Hydrochloride is an intermediate in the synthesis of Desphenyl Tenofovir Alafenamide-d7 Ammonium Salt (D297044). Desphenyl Tenofovir Alafenamide-d7 Ammonium Salt is labeled form of Desphenyl Tenofovir Alafenamide (D297043), which belongs to a group of tenofovir diesters compounds, which can inhibit HIV-1 virus replication. Desphenyl Tenofovir Alafenamide can also be used to investigate the effect of oral absorption and lymphoid cell loading of GS-7340 (a prodrug of tenofovir). (S)-Isopropyl-2-aminopropanoate-d7 Hydrochloride is also the labelled form of (S)-Isopropyl-2-aminopropanoate Hydrochloride (I822220), which is a chemical reagent used in the synthesis of anti-HCV prodrugs based on imidazotriazine and pyrrolotriazine molecules.
References You, G., et al.: PCT Int. Appl. WO 2014026582 A1 2014022 (2014); Babusis, D., et al.: Mol. Pharm. 10, 459 (2013); Tyndall, E. Bioorg. Med. Chem. Lett., 25, 869 (2015)

Applications n-Hexyl-5,5,6,6,6-d5 Alcohol (CAS# 64118-18-9) is a useful isotopically labeled research compound.

Applications N-Acetyl-2,6-dichlorodiphenylamine-d5 is labelled N-Acetyl-2,6-dichlorodiphenylamine (A173570) which is an impurity of diclofenac (D436450, Na salt), a nonsteroidal anti-inflammatory compound and decycloxygenase (COX) inhibitor.
References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004); Sasaki, A., et al.: J. Pharmacol. Sci., 108, 266 (2008); Dalvie, D., et al.: Chem. Res. Toxicol., 22, 357 (2009)

Applications 4-​(Dimethyloxidoamino)​butanoic Acid-d6 Hydrochloride is the labelled form of 4-​(Dimethyloxidoamino)​butanoic Acid (D447160). 4-​(Dimethyloxidoamino)​butanoic Acid is a metabolite of Lauramine Oxide (L178530), which is a frequently used amine oxide surfactant. It is strongly hydrophilic , and it forms normal micelles and normal liquid crystalline phases.
References Kocherbitov, v., et al.: J. Molec. Struct.: Theochem., 808, 111 (2007); Kocherbitov, v., et al.: J. Phys. Chem. B., 110 (27), 13649 (2006); Turan, T.S., et al.: Xenobiotica, 11, 447 (1981)

Applications 2-Hydroxyacetonitrile-13C2 is an intermediate in the synthesis of Indole-3-carboxaldehyde-13C8 (I614993), the labelled version of Indole-3-carboxaldehyde (I615020) which is a tryptophan (T947200) metabolite from Streptomyces staurosporeus and it is chemical constituent from Inula wissmanniana. Indole-3-carboxaldehyde and other tryptophan metabolites play an important role in mammalian gut immune homeostasis.
References Yang, S., et al.: J. Nat. Prod., 60, 44 (1997); Cheng, X. et al.: Chem. Nat. Compd., 49, 815 (2013); Zelante, T., et al,: Immunity, 39, 372 (2013)

Applications Hexadecanoic-11,11,12,12-d4 Acid (CAS# 75736-57-1) is a useful isotopically labeled research compound.

Applications 4-n-Butylaniline-2,3,5,6-d4,ND2 (CAS# 1219794-75-8) is a useful isotopically labeled research compound.

Stability Volatile
Applications tert-Butylamine is common reagent in pharmaceuticals syntheses. Used in the preparation of aminoBODIPY compounds for chemical analyses. Also it aids in the synthesis of benzylurea-based insecticides containing amide and sulfonate groups. It has also been used in the synthesis of BPTES analogs, that act as glutaminase inhibitors, which can attenuate the growth of human lymphoma B cells. This is the labeled analog.
E0
References Osorio-Martinez, C. et al.: J. Org. Chem., 77, 5434 (2012); Sun, R. et al.: J. Agri. Food, Chem., 61, 517 (2013); Shukla, K. et al.: J. Med. Chem., 55, 10551 (2012);

Applications Bis(1-ethylpentyl) Phthalate-d4, is the labeled analogue of Bis(1-ethylpentyl) Phthalate (B433990), one of the phthalate esters, which are ubiquitous environmental contaminants that interact with peroxisome proliferator-activated receptors (PPARs), a family of nuclear receptors. It is used as a plasticizer to impart softness and flexibility to PVC products.
References Kaya, T., et al.: Chem. Res. Toxic., 19 (8), 999 (2006); Matter, H., et al.: Bioorg. Med. Chem., 20 (18), 5352 (2012);

Applications 1-(2-Aminophenyl)-2-chloroethanone-13C8 is an intermediate in the synthesis of Indole-3-carboxaldehyde-13C8 (I614993), the labelled version of Indole-3-carboxaldehyde (I615020) which is a tryptophan (T947200) metabolite from Streptomyces staurosporeus and it is chemical constituent from Inula wissmanniana. Indole-3-carboxaldehyde and other tryptophan metabolites play an important role in mammalian gut immune homeostasis.
References Yang, S., et al.: J. Nat. Prod., 60, 44 (1997); Cheng, X. et al.: Chem. Nat. Compd., 49, 815 (2013); Zelante, T., et al,: Immunity, 39, 372 (2013)

Applications Pyrrolidine-2,2,5,5-d4 (CAS# 42403-25-8) is a useful isotopically labeled research compound.

Applications Tetraethoxy-d20-silane (CAS# 272778-10-6) is a useful isotopically labeled research compound.

Applications Cuprous Cyanide-15N is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;

Applications N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide -d4 is labelled N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide (C988880) which was shown to exhibit regulatory effects towards the expression of pH sensing G protein-coupled receptor-68 and is now a new drug target for ischemic heart disease.
References Russell, J.L., et al.: ACS. Chem. Biol., 7, 1077 (2012); Schneider, J.W., et al.: ACS. Chem. Neurosci., 3, 557 (2012);

Applications A trapping agent used in the desulfenylation of 3-indolyl sulfides.
References Miller, C., et al.: Environ. Sci. Technol., 43, 8548 (2009), Mecinovic, J., et al.: Anal. Biochem., 393, 215 (2009), Zarghi, A., et al.: Bioorg., Med., Chem., 17, 5369 (2009),

Applications Labelled Lactose Monohydrate (L114000), which is used in the synthesis of casing for various methods of oral drug delivery, including dissolving pellets, and long-lasting pellets.
References Kamble, M. et al.: Int. J. Pharm. Chem. Biol. Sci., 3, 55 (2013); Hiorth, M. et al.: Int. J. Pharm., 441, 544 (2013);

Applications D-Mannose is a carbohydrate that is important in the glycosylation of molecules in a variety of cellular processes. It is involved in N and O glycosylation of bovine why protein products, used in infant formulas. It is also responsible for the O-glycosylation of the T helper cell-derived cytokine interlukin-17A, an important cell-signaling molecule. This is the labeled analog.
References Van Leeuwen, S. et al.: J. Agri. Food Chem., 60, 12553 (2012); Geoghegan, K. et al.: Prot. Express. Purif., 87, 27 (2013);

Applications 4-Nitrobiphenyl-2’,3’,4’,5’,6’-d5 (cas# 64421-02-9) is a compound useful in organic synthesis.

Applications Bis(1,3-dithian-2-yl)methane-d2 (cas# 105479-87-6) is a compound useful in organic synthesis.

Applications Iodoethane-2-d1 (CAS# 57460-45-4) is a useful isotopically labeled research compound.

Applications Chlorobenzene-d5 is the labeled analogue of Chlorobenzene (C364530). Chlorobenzene-d5 is used to increase quantification of data from gas chromatography and mass spectrometric analysis of micropollutants in water.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References James, H.A., et. al.: Adv. Mass Spec., 8B, 1429 (1980)

Applications 1-Phenylpentadecane-d36 (CAS# 352431-31-3) is a useful isotopically labeled research compound.