Composés deutérés

<p>Applications N-Acetyl-2,6-dichlorodiphenylamine-d5 is labelled N-Acetyl-2,6-dichlorodiphenylamine (A173570) which is an impurity of diclofenac (D436450, Na salt), a nonsteroidal anti-inflammatory compound and decycloxygenase (COX) inhibitor.<br>References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004); Sasaki, A., et al.: J. Pharmacol. Sci., 108, 266 (2008); Dalvie, D., et al.: Chem. Res. Toxicol., 22, 357 (2009)<br></p>

<p>Applications Isotope labelled N-(Phenyl)-1-napthyl Amine is a chemical reactant used in the preparation of aryl halides and diarylamines. Also forms oligomers used as hole transport for green electrophosphorescence.<br>References Yamamoto, T. et al.: Tetrahedron Lett., 39, 2367 (1998); Zhang, S. et al.: Dyes and Pigments., 118, 1 (2015);<br></p>

<p>Applications 2,4-Dimethylphenol is used both as a pesticide to ward of insects or other common pests from crops from crops as well as in the synthesis of anti-oxidant compounds due to the phenol moiety in the structure. This is a labelled analog.<br>References Liu, B. et al.: J. Agri. Chem., 58, 2673 (2010); Guillen, M. et al.: J. Agri. Chem., 47, 3016 (1999); Guillen, M. et al.: J. Agri. Chem., 46, 1276 (1999); Kim, S. et al.: J. Agri. Chem., 59, 4570 (2011);<br></p>

<p>Applications Isotope labelled Hexadecyltrimethylammonium Bromide (CTAB) (H293860), is a cationic surfactant used as a template in the synthesis of Mesoporous γ-Fe2O3.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yu, H.-h., et al.: Gongneng Cailiao, 42, 2005 (2011),<br></p>

<p>Applications Labelled Azilsartan (A926900). An analgesic and antiinflammatory drugs containing angiotensin II antagonists.<br>References Kohara, Y. et al.: J. Med. Chem., 39, 5228 (1996); Plomgaard, P. et al.: Diabetes, 54, 2939 (2005); Fenton, C. et al.: Drugs, 2005, 65, 537;<br></p>

<p>Applications Isotope labelled Ethyl Octanoate used in the preparation of β-cyclodextrins as nano-drug delivery encasements. Also used in the synthesis of second generation biodiesels via palladium catalysis.<br>References Gervaise, C. et al.: New J. Chem., 36, 2417 (2012); Han, J. et al.: Green Chem., 12, 463 (2010);<br></p>

<p>Stability Volatile<br>Applications tert-Butylamine is common reagent in pharmaceuticals syntheses. Used in the preparation of aminoBODIPY compounds for chemical analyses. Also it aids in the synthesis of benzylurea-based insecticides containing amide and sulfonate groups. It has also been used in the synthesis of BPTES analogs, that act as glutaminase inhibitors, which can attenuate the growth of human lymphoma B cells. This is the labeled analog.<br> E0<br>References Osorio-Martinez, C. et al.: J. Org. Chem., 77, 5434 (2012); Sun, R. et al.: J. Agri. Food, Chem., 61, 517 (2013); Shukla, K. et al.: J. Med. Chem., 55, 10551 (2012);<br></p>

<p>Applications 1-Bromohexane-2,2,3,3,4,4,5,5,6,6,6-d11 (CAS# 2159-17-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Uracil-6-d1 (CAS# 24897-51-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4,4'-Dimethoxybenzophenone-d8 (rings-d8) (CAS# 350818-55-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromo-2,4-difluorobenzene-d3 (CAS# 1219803-87-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ursolic Acid-d3 is labelled Ursolic Acid(U850100) which is a Triterpene acid used in cosmetics. It also has STAT3 pathway inhibiting properties.<br>References Lee, C., et al.: Bioorg. Med. Chem. Lett., 20, 7354 (2010), Lee, A., et al.: J. Agric. Food Chem., 58, 12941 (2010), Pethakamsetty, L., et al.: J. Pharm. Res., 3, 193 (2010),<br></p>

<p>Applications Deferasirox Ethyl Ester-d5 is the isotope labelled analog of Deferasirox Ethyl Ester (D228655); a derivative of Deferasirox (D228650) which is an orally active tridentate iron chelator.<br>References Hershko, C., et al.: Blood, 97, 1115 (2001); Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003); Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003)<br></p>

<p>Applications Benzyl-d7-amine HCl (CAS# 352431-27-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl Cyanoacetate-d2 is the deuterated form of Ethyl Cyanoacetate (E905555), which is a reagent used in the labeled pyrimidine and purine synthesis;Also, it is an intermediate used in the synthesis of N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-β-alanine-d4 (C424342), which is an isotope labeled N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-β-alanine is a metabolite of Tianeptine (T436800), a tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Das, S., et al.: J. Med. Chem., 52, 5937 (2009), Kim, K., et al.: Bioorg. Med. Chem. Lett., 19, 5225 (2009); Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991), Nair, M. et al.: Analyst, 123, 2267 (1998)<br></p>

<p>Applications (±)-2-Ethylhexanoic-d15 Acid (CAS# 352431-38-0) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications 6-N-Acetyl-L-lysine-d8 is an isotopic analog of N-Acetyl-L-lysine (E588725(P)), which is used in the metabolomics study on the combined effect of cocaine and ethanol via liquid chromatography-mass spectrometry metabolomics approach.<br>References Sanchez-Lopez, E., et al.: J. Pharm. Biomed. Anal., 140, 313 (2017)<br></p>

<p>Applications 3-Benzoylpropanoic Acid-13C6 (cas# 1346600-75-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Fluorobenzoyl-d4 Chloride (CAS# 1071809-52-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Homotaurine-d6 is the isotope labelled analog of Homotaurine (H656200). Homotaurine is an important GABA mimetic agent. It evokes neurological responses similar to those elicited by g-aminobutyric acid.<br>References Riv. Farmacol. Ter., 7, 155 (1976), Neuropharmacology, 17, 13 (1978), Br. J. Pharmacol., 59 373 (1977)<br></p>

<p>Applications 4-Nitrobiphenyl-2’,3’,4’,5’,6’-d5 (cas# 64421-02-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Hexadecanoic-13,13,14,14,15,15,16,16,16-d9 Acid (CAS# 1173022-49-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Succinic Acid (D6, 98%) (cas# 21668-90-6) is a useful research chemical.<br></p>

<p>Applications Clemastine N-Oxide-d5 is the isotope labelled analog of Clemastine N-Oxide (C568505); a metabolite of Clemastine Fumarate (C568500) which is a H1 histamine receptor antagonist and antihistaminic.<br>References Froehlich, L., et al.: Pharmazie, 51, 409 (1996); Weidmann, et al.: Boll. Chim. Farm., 106, 467 (1967); Gober, B., et al.: Pharmazie, 43, 539 (1988); Breccia, A., et al.: Curr. Ther. Res., 49, 622 (1991); Schran, H., et al.: J. Clin. Pharmacol., 36, 911 (1996)<br></p>

<p>Applications n-Dodecyltrimethylammonium-d34 Bromide (CAS# 2259752-12-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Homocitrulline-2,6,6-d3 is a labeled compound of L-Homocitrulline (H590900) which is an amino acid present in milk products.<br>References Evered, D. &amp; Vadgama, J.: Br. J. Nutr., 49, 35 (1983); Paik, W., et al.: Int. J. Biochem., 8, 317 (1977)<br></p>

<p>Applications Methylcyclohexane-D14 (D, 99.5%) (cas# 10120-28-2) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Benzyl Octyl Adipate-d17, is the labeled analogue of Benzyl Octyl Adipate (B285580), which is used as plasticizer. It can also be used for the synthesis of orally effective acid prodrugs of the β-Lactamase inhibitor Sulbactam (S699185).<br>References Sorokin, G. A., Plasticheskie Massy, 25 (1976); Kraus, A., Farbe + Lack,60, 185 (1954); English, A. R., et al.: J. Med. Chem., 33, 344 (1990);<br></p>

<p>Applications 1,3-Dichlorobenzene (D4, 98%) (cas# 2199-70-4) is a useful research chemical.<br></p>

<p>Applications N-1-Butyl-d9-1-demethylethyl Torsemide is labelled N-1-Butyl-1-demethylethyl Torsemide (B692375) which is an impurity of Torsemide (T548750), diuretic.<br>References Lesne, M., et al.: In. J. Clin. Pharmacol. Ther. Toxicol., 20, 382 (1982), Brater, D.C., et al.: Clin. Pharmacol. Ther., 42, 187 (1987),<br></p>

<p>Applications 2-Chloropropane-2-d1 (CAS# 53778-42-0) is a useful isotopically labeled research compound.<br></p>

<p>Stability Volatile<br>Applications N-Hexane (D14, 98%) (cas# 21666-38-6) is a useful research chemical.<br></p>

<p>Applications Labelled Methyl Methanethiosulfonate (M321500). Used for the rapid and selective modification of sulfhydryl groups of enzymes. Useful for mapping the pore-lining regions of the ryanodine receptor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stauffer, D.A., and Karlin, A.: Biochemistry, 33, 6840 (1994), Yang, N. et al.: Neuron, 16, 113 (1996), Kuner, T. et al.: Neuron, 17, 343 (1996), Ehrlich, B.E., et al.: J. Gen. Physiol., 109, 255 (1997), Dunten, R.L., et al.: Biochemistry, 32, 3139-3145 (1993)<br></p>

<p>Applications 3-Hydroxypropionic Acid-13C3 Sodium Salt is isotope labelled analogue of 3-Hydroxypropionic Acid Sodium Salt (H952480), which is beta hydroxy acid derived from plants and crops such as corn. 3-Hydroxypropionic Acid is used in the preparation of acrylates and biodegradable polymer polyester.<br>References Wang, Y. et al.: Biomacromol., 3, 828 (2002); Jiang, X. et al.: Appl. Microbiol. Biotech., 82, 995 (2009);<br></p>

<p>Applications 2,2'-Bipyridyl-d8 was a useful compound in the NMR study of soft porous nanocrystal and a bulk crystal.<br>References Hijikata, Y., et al.: Chem. Commun. (Cambridge, UK), 47, 7632 (2011)<br></p>

<p>Applications n-Dodecyl-d25-phosphocholine (CAS# 861924-55-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cyclopropylmethyl-d2 Alcohol (CAS# 90568-07-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-(Ethyl-d5)hexanoic Acid is an intermediate in the synthesis of Alexidine-d10 Dihydrochloride (A525002), which has antibacterial, antiplaque properties against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii.<br>References Coburn, R.A., et al.: J. Med. Chem., 21, 8, 829 (1978), Takayama, K., et al.: J. Biol. Chem., 269, 2241 (1994), Faure, P., et al.: Biochimie, 86, 411 (2004),<br></p>

<p>Applications Testosterone Octanoate-d15 is the isotope analog of Testosterone Octanoate. Testosterone Octanoate is a metabolite of tesosterone (T155000), which is used in biological studies to determine the hemolytic and lipophilic activity of this anabolic steroid.<br>References Biagi, G.L., et al.: J. Med. Chem., 13, 944 (1970); Biagi, G. L., et al.: J. Med. Chem., 18, 873 (1975)<br></p>

<p>Applications Labelled 2-(3,4-Dimethoxyphenyl)-N-methylethylamine (D470710, free amine) which is a methylated metabolite of Dopamine (D533780); a potent inhibitor of brain mitochondrial respiration used in Parkinson’s disease studies.<br>References Gluck, M.R. et al.: J. Neurochem., 91, 788 (2004); Charlton, C.G. et al.: Life Sci., 66, 2159 (2000);<br></p>

<p>Applications Octanoic-2,2-d2 Acid (CAS# 64118-36-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-(2-Butylamino)ethanol-d4 is labelled 2-(2-Butylamino)ethanol (B693945) which is an intermediate used to prepare 2-arylimino-1,3-thiazolidines as progesterone receptor binding ligands.<br>References Dixon, B., et al.: U.S., US 6353006 B1 20020305 (2002)<br></p>

<p>Applications cis-3-Hexen-1-ol-D2 is a labelled analogue of cis-3-Hexen-1-ol (H295005). cis-3-Hexen-1-ol is a naturally occuring compound that has the smell of freshly cut grass and is used to obtain a “green” taste/smell in certain flavours and fragrances.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dahill Jr., R.: J. Chem. Eng. Data, 17, 399 (1972); Serra, S., et al.: Trends Biotechnol., 23, 193 (2005)<br></p>

<p>Applications Phenol is purified here for molecular genetics applications. It is naturally found in tea leaves and plants, and has uses in the synthesis of antioxidant compounds due to the antioxidant activity caused by the phenol moiety. This structure also allows it to be used for syntheses of anti-bacterial &amp; anti-carcinogenic compounds. This is the labelled analog.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nam, S. et al.: J. Agri. Chem., 60, 9097 (2012); Xia, J. et al.: J. Agri. Chem., 57, 99 (2009); Khanal, P. et al.: Carcinogenesis, 32, 545 (2011);<br></p>

<p>Applications Isotope labelled Ethyl 3-Hydroxybutyrate is a useful synthetic intermediate. It is a reagent used to synthesize α-azido carboxylic acids. It is also used in Palladium mediated spiroketal synthesis.<br>References Evans, D., et al.: J. Am. Chem. Soc., 112, 4011 (1990); Conway, J., et al.: Tetrahedron, 61, 11910 (2005)<br></p>

<p>Applications 3-Chloro-6-(chloromethyl)benzene-1,2,4,5-d4 is an isotope-labeled analog of 4-Chlorobenzyl Chloride (C364730), which is a benzylchloride derivative used in the preparation of various biologically active compounds such as bronchodilators and antibacterial agents.<br>References Adams, M. et al.: Synth. Comm., 29, 2419 (1999); Foroumadi, A. et al.: Arch. Pharm. Res., 30, 138 (2007);<br></p>

<p>Applications n-Nonyl-6,6,7,7-d4 Alcohol (CAS# 33975-46-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Fluorobenzyl-alpha,alpha-d2 Chloride (CAS# 1219804-18-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tetrahydro-4H-pyran-4-ol-3,3,4,5,5-d5 (CAS# 1219795-46-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications N,N-Bis(2-chloroethyl)benzenesulfonamide-d5 is the isotope labelled analog of N,N-Bis(2-chloroethyl)benzenesulfonamide (B418910); a novel intermediate in the synthesis of Cetirizine (C281100).<br></p>

<p>Applications Carbon 13 Labelled analogue of Adenosine (A280400), a purine nucleoside that plays an important role in various biochemical processes.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010)<br></p>

<p>Applications Tuberculostearic Acid Methyl-d3 Ester is labelled Tuberculostearic Acid Methyl Ester (T897100), the methyl ester of Tuberculostearic Acid (T897090) which is a saturated fatty acid produced by Actinomycetales bacteria.<br>References Frencha, G., et al.: The Lancet, 330, 117 (1987)<br></p>

<p>Applications 5-Formylfuran-2-carboxylic Acid-13C6 is an isotope labelled form of 5-Formylfuran-2-carboxylic Acid(F700500).<br>References Nocito, F., et al.: ACS Omega, 3, 18724 (2018); Chen, G., et al.: Ind. Eng. Chem. Res., 57, 16172 (2018)<br></p>

<p>Applications 1-Chloro-2-(α-chlorophenylmethyl)benzene-d5 is the isotope labelled analog of 1-Chloro-2-(α-chlorophenylmethyl)benzene (C427570); a reagent in the synthesis of bifonazole analogs which have antibacterial and antifungal activities. It is also used in the preparation of diphenylpiperazine N-type calcium channel inhibitors.<br>References El Hage, S., et al.: Arch. Pharm., 344, 402 (2011); Pajouhesh, H., et al.: Bioorg. Med. Chem. Lett., 20, 1378 (2010)<br></p>

<p>Applications 1-Bromotetradecane-1,1,2,2-d4 (CAS# 1219798-81-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-p-Toluenesulfonate 1-Phenyl-d5-1,2-ethanediol is an intermediate in the synthesis of rac Mirabegron-d5 (M364902), which is a potent bladder relaxant and reagent for diabetes remedy.<br></p>

<p>Applications tert-Butyl-d9 Methyl Ether (CAS# 1219795-06-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Propane-2,2-d2-diamine 2HCl (CAS# 352438-79-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,4-Dichlorobenzoic-d3 Acid (CAS# 1398065-99-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromo-2,3,5-trichlorobenzene-d2 (CAS# 1219803-86-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-Methionine-2-d1 (CAS# 67866-74-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled photodegradation product of Chlorothalonil and Dichlofluanid.<br>References Al-Ekabi, H., et al.: J. Phys. Chem., 92, 5726 (1988), Pramauro, E., et al.: Environ. Sci. Technol., 27, 1790 (1993),<br></p>