Toxicologie

<p>Applications Carbamate fungicide used in the agriculture industry<br>References Judelson, H., et al.: Mol. Plant Pathol., 7, 17 (2005), Grunwald, N., et al.: Phytopathol., 96, 1397 (2006), Celik, L., et al.: Chem. Res. Toxicol., 21, 2195 (2008),<br></p>

<p>Applications Its application as nitrification inhibitor of nitrogen fertilizers.<br>References Williams, B., et al.: J. Soil Sci., 34, 113 (1983), Leinweber, P., et al.: Biol. Fertil. Soils, 20, 17 (1995),<br></p>

<p>Stability Hygroscopic<br>Applications EPTC is a pesticide, S-Ethyl-N,N-dipropylthiocarbamate<br></p>

<p>Applications An isotopically labelled version of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>

<p>Applications The S-enantiomer of Clobenzorex (C583000), an anorexic.<br>References Thomasset, M., et al.: Experienta, 26, 692 (1970), Glasson, B., et al.: Arzneim.-Forsch., 21, 1985 (1971),<br></p>

<p>Applications Pre-emergence herbicide used for grass control in crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goldenthal, et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Robens, J.F., et al.: Vet. Hum. Toxicol., 22, 328 (1980),<br></p>

<p>Stability Hygroscopic<br>Applications Cefixime EP Impurity B Acetic Acid Salt is an impurity of the third generation cephalosporin antibiotic, Cefixime (C242800).<br>References Bian, L. et al.: Yao. Fen. Zaz., 30, 872 (2010);<br></p>

<p>Applications Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. Potent B-Raf inhibitor<br>References Halaban, R. et al.: Pigm. Cell. Melonoma Res., 23, 190 (2010); Yang, H. et al.: Cancer Res., 70, 5518 (2010); Comin-Anduix, B. et al.: Clin. Cancer Res., 16, 6040 (2010);<br></p>

<p>Applications 26-Deoxymonensin A Sodium Salt is a metabolite of Monensin (M515600, Na salt); a polyether antibiotic and coccidiostat.<br>References Pospisil, S., et al.: Appl. Environ. Microb., 60, 1561 (1994); Ashworth, D.M., et al.: J. Antibiot., 42, 1088 (1989);<br></p>

<p>Stability Air Sensitive<br>Applications Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.<br>References Sitar, D.S., et al.: J. Pharmacol. Exp. Ther., 184, 432 (1973), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 8, 351 (1979), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984), Atterwill, C.K., et al.: Food Chem. Toxicol., 29, 355 (1991),<br></p>

<p>Applications (5Z)-rel-Cloprostenol Sodium Salt is the d-enantiomer of Cloprostenol (C587300), an aryl-oxymethyl analog of prostaglandin F2α.<br>References Gumen, A., et al.: J. Animal. Sci., 56, 279 (2011); Leterlier, C.A., et al.: Reproduct. Domestic. Animals., 46, 481 (2011); Martins, J.P.N., et al.: J. Diary. Sci., 94, 2815 (2011);<br></p>

<p>Applications Ethoxysulfuron<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications (±)-Oxychlordane is a persistent organic pollutant that has been found on plants and animals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bachman, M.J., et. al.: Sci. Total Envir., 488, 115 (2014); Keller, J.M., et. al.: Environ. Sci. Tech., 48, 7807 (2014); Polder, A., et. al.: Sci. Total Environ., 488, 252 (2014)<br></p>

<p>Applications 5β-Dihydrocortisol, is a derivative of Cortisol (H714615), which is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland.<br>References Vigore, L., et al.: Cancer Ther., 6, 699 (2008), Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009), Lemos, D., et al.: J. Endocrinol., 201, 275 (2009), Chen, S., et al.: Am. J. Physiol., 296 (2009),<br></p>

<p>Applications Labelled Chlorotoluron (C421600(P)), which is a herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nelieu, S., et al.: Environ. Toxicol. Chem., 29, 2644 (2010), Aguilera-Luiz, M., et al.: Anal. Bioanal. Chem., 399, 2863 (2011),<br></p>

<p>Applications Octhilinone-d17 is a fungicide and an antimicrobial agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications An inhibitor of 5-lipoxygenase, the initial enzyme in the biosynthesis of leukotrienes from Arachidonic Acid. Used as an antiasthmatic.<br>References Carter, G.W., et al.: J. Pharmacol. Exp. Ther., 256, 929 (1991), Weinblatt, M.E., et al.: J. Rheumatol., 19, 1537 (1992), McGill, K and Busse, W.W.: Lancet, 348, 519 (1996)<br></p>

<p>Applications Palbociclib-d4 is an isotope labelled compound of Palbociclib (P139900). Palbociclib (P139900) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>

<p>Applications An optical isomer of the local anesthetic Mepivacaine (M225060) that is slightly more active than its (+)-isomer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Luduena, F.P. et al.: Arch. Int. Pharmacodyn. Ther., 200, 359 (1972); Jeske, A.H. et al.: Meth. Find. Exp. Clin. Pharmacol., 3, 33 (1981);<br></p>

<p>Applications Zeatin, purified from Zea mays, is a member of the cytokinin group of plant growth factors, the activity of which is attributed to its more stable trans form. Trans-Zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts. Trans-Zeatin is a potential agent for the management of skin photoaging.<br>References Murashige, T., et al.: Physiol. Plant, 15, 473 (1962), Brenneisen, P., et al.: J. Biol. Chem., 273, 5279 (1998), Choi, M., et al.: J. Dermatol. Sci., 46, 127 (2007), Bae, J., et al.: Food Chem. Toxicol., 46, 1298 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Atropine. Mydriatic; antispasmodic; used in preanesthetic medication.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brown, R.V., et al.: Br. J. Pharmacol., 15, 170 (1960), Shutt, L.E., et al.: Anaesthesia, 34, 476 (1979), Hinderling, P.H., et al.: J. Pharm. Sci., 74, 703 (1985),<br></p>

<p>Stability Air Sensitive<br>Applications 4,5-Dichloro-2-octyl-3(2H)-isothiazolone (cas# 64359-81-5) is a useful research chemical.<br></p>

<p>Stability Air sensitive, Material darkens in storage with no loss in purity<br>Applications Aniline is used in the manufacture of dyes, medicinals, resins, varnishes, perfumes, as a vulcanizing rubber or even as a solvent (1,2). Hazardous and noxious substance which affects the early life stages of marine animals (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Dyes and metabolites, Environmental Testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Barkov, A. et al.: Russ. Chem. Bull. 2012. Aug:61(8) pp1564-92. Zhang, X. et al.: Synthesis. 2013 45(10): 1357-13633. Cunha, I. et. al.: Environ. Sci. Pollut. Res. Int. 2017 Mar 10.<br></p>

<p>Applications An antitumor agent which also acts as a chemosterilant for male houseflies and other insects. Antineoplastic.<br>References Chang, S.C., et al.: Science, 144, 57 (1964), Ames, M.M., et al.: Cancer Res., 39, 5016 (1979), D’Incalci, M., et al.: Br. J. Cancer, 41, 630 (1980),<br></p>

<p>Applications Iprovalicarb-d8 is the deuterated form of Iprovalicarb (I747500), which is a systematic fungicide. Iprovalicarb is used for the control of pathogenic fungi from the oomycetes class in grapes, potatoes, tomatoes and other crops.<br>References Stubler, D., et al.: Pflanzensch.-Nach. Bay., 52, 33 (1999); Stenzel, K., et al.: Bright. Crop Prot. Conf. Pests Dis., 2, 367 (1998);<br></p>

<p>Applications Sulfobromophthalein (BSP) is an organic dye used a for liver diagnostics in vitro. Reagent for the quantitative determination of proteins.<br>References 1. McGuire, J., et al. 1977. Anal. Biochem. 83: 75-81. PMID: 920954<br></p>

<p>Applications (4R,6S)-rel-5,6-Dihydro-4-hydroxy-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-Dioxide is used as a reactant in the preparation of Dorzolamide Hydrochloride (D535100), which is a carbonic anhydrase inhibitor; antiglaucoma agent.<br>References Lippa, E.A., et al.: Ophthalmology, 98, 308 (1991); Wang, R.-F., et al.: Arch. Ophthalmol., 109, 1297 (1991); Whikehart, D., et al.: J. Ocul. Pharmacol., 7, 195 (1991); Sjoquist, B., et al.: Drug Metab. Dispos., 26, 745 (1998);<br></p>

<p>Applications A potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>

<p>Stability Hygroscopic<br>Applications Metabolite of Flurbiprofen (F598700).<br>References Van Breemen, R., et al.: Drug Metab. Disposition, 14, 197 (1986), Spraul, M., et al.: J. Pharm. Biomed. Anal., 11, 1009 (1993),<br></p>

<p>Applications A labelled diuretic and antihypertensive.<br>References Wagieh, N., et al.: Drug Test. Anal., 2, 113 (2010), Prado-Prado, F., et al.: Bioorg. Med. Chem., 18, 2225 (2010), Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010),<br></p>

<p>Applications 2-Methylsulfonyl-4-trifluoromethylbenzoic acid is a Benzoic acid (B203900) derivative and is also a metabolite of Isoxaflutole (I918140), a herbicide used for the control of broadleaf and grass weeds in corn and sugarcane crops.<br>References Beltran, E., et al.: J. Agr. Food Chem., 51, 146 (2003); Lin, C., et al.: J. Agr. Food Chem., 51, 8011 (2003); Pallett, K., et al.: Pest. Biochem. Phys., 62, 113 (1998)<br></p>

<p>Stability Hygroscopic<br>Applications L-Glutaryl Carnitine Chloride is a metabolite of L-Carnitine (C184110).<br>References Millington, D., et al.: J. Inherit. Metab. Dis., 13, 321 (1990), Chace, D., et al.: Clin. Chem., 49, 1797 (2003),<br></p>

<p>Applications Probucol is an antilipemic.<br>References Shakir, D., et al.: J. Clin. Med. Res., 1, 8 (2009), Kubo, Y., et al.: Biol. Pharm. Bull., 32, 1880 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Applications Dichlorophene is an anthelmintic (Cestodes). Dichlorophene is used as agricultural fungicide; antimicrobial; germicide in soaps, shampoos.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Fundam. Appl. Toxicol., 7, 299 (1986), Sohoni, P., et al.: J. Endocrinol., 158, 327 (1998), Hotchkiss, A., et al.: Toxicol. Sci., 105, 235 (2008), Thomas, K., et al.: Environ. Sci. Technol., 43, 8066 (2009),<br></p>

<p> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Herbicide; plant regulator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wilson, V., et al.: Toxicol. Sci., 66, 69 (2002), Laville, N., et al.: Toxicology, 228, 98 (2006),<br></p>

<p>Applications Sulfentrazone is an herbicide used for controlling sedges in turfgrass.<br>References Shaner, D.L., et al.: Weed. Technol., 26, 633 (2012); Menezes, C.W.G. et al.: Weed. Res., 52, 520 (2012); Graber, E.R., et al.: Plant. Soil. 353, 95 (2012);<br></p>

<p>Applications Triamcinolone Hexacetonide is the Intra-articular glucocorticoid treatment for rheumatoid arthritis.<br>References Abd-El-Barr, M.M., et al.: J. Ocul. Pharmacol. Ther., 24, 197 (2007); Eberhard, B.A., et al.: J. Rheumatol., 31, 2507 (2004);<br></p>

<p>Applications 1,7-Dioxaspiro[5.5]undecane can be used as analyte in analytical study of selective extraction of Bactrocera oleae sexual pheromone from olive oil by dispersive magnetic microsolid phase extraction using a molecularly imprinted nanocomposite.<br>References Alcudia-Leon, M., et al.: J Chromatogr, 1455, 57 (2016);<br></p>

<p>Applications cis-5-Dodecenoyl Carnitine Inner Salt is an L-carnitine metobolite which are often used to diagnose specific inherited metabolic diseases especially glucose related ones.<br>References Yang, S. et l.: J. Chrom. B., Anal. Tech. Biomed. Life Sci., 857, 251 (2007);<br></p>

<p>Applications Carbamate herbicide; folic acid biosynthesis inhibitor.<br>References Cottrell, H.J., et al.: 207, 655 (1965), Smith, A.E., et al.: Pestic. Sci., 8, 449 (1977), Hossain, M.A., et al.: J. Weed Sci. Tech., 43, 10 (1998),<br></p>

<p>Applications Isotope labelled analogue of (R)-Amphetamine (A634240), a central nervous system stimulant and an anorexic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 85, 119 (1945), Behrendt, W.A, et al.: Arzneim.-Forsch., 13, 711 (1963), Seiden, L.S., Annu. Rev. Pharmacol. Toxicol., 32, 639 (1993),<br></p>

<p>Applications 3H-4,7a-Methanocyclohept[3,3a]indeno[5,4-b]oxete Benzenepropanoic Acid derivative is an analogue of Paclitaxel (P132500) and has weak antimitotic activity.<br>References Chen, S.H., et. al.: Tetrahedron Lett., 33, 7679 (1992)<br></p>

<p>Applications Desmethyl Bromethalin-13C is the labeled form of Desmethyl Bromethalin(D291200), is a metabolite of Bromethalin rodenticide found in the blood and liver of treated animals.<br>References Van Lier, R.B.L., et at.: Fundamental Appl. Toxicol., 11, 664 (1988),<br></p>

<p>Applications Olanzapine is a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic. Neuroprotective product.<br>References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)<br></p>

<p>Stability Moisture Sensitive<br>Applications Sulfometuron methyl is a substituted pyrimide compound for proteomics research. A sulfonylurea herbicides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Azcarate, M. P., et al.: J. Environ. Sci. Health, Part B: 50, 229 (2015); Tatum, V. L., et al.: Environ. Toxicol., 27, 671 (2012)<br></p>

<p>Applications Floxuridine is an antiviral; antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harris, M., et al.: Biophys. J., 4, 203 (1964),<br></p>

<p>Applications Labelled Tazarotenic Acid (T010060). Tazarotenic acid is the major active metabolite of Tazarotene (T010050).<br>References Nagpal, S., et al.: J. Biol. Chem., 270, 923 (1995), Madhu, C., et al.: J. Pharm. Sci., 86, 972 (1997), Attar, M., et al.: Drug Metab. Dispos., 31, 476 (2003),<br></p>

<p>Applications 5-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide is a metabolite of Temozolomide (T017775); an imidazotetrazine alkylating agent and antineoplastic.<br>References Newlands, E.S., et al.: Cancer Treat. Rev., 23, 35 (1997); Kim, C., et al.: J. Biol. Chem., 274, 1233 (1999); Hait, W., et al.: Cancer Res., 69, 1263 (2009); Wang, Y., et al.: J. Org. Chem., 62, 7288 (1997)<br></p>

<p>Applications RPA 202248-d3 is the isotope labelled derivative of isoxaflutole (I918140), a herbicide used for weed control.<br>References Menezes, C, W.G., et al.: Weed. Res., 52, 520 (2012); Gangwal, S., et al.: Sci. Total. Envrion., 435 (2012); Gomez-Perez, M.L., et al.: J. Chromatograph. A., 1248, 130 (2012);<br></p>

<p>Applications The active labelled carboxylic acid metabolite of Ebastine.<br>References Hashizume, T., et al.: Drug Metab. Dispos., 29, 798 (2001), Hashizume, T., et al.: J. Pharmacol. Exp. Ther., 300, 298 (2002), Matsumoto, S., et al.: Xenobiotica, 33, 615 (2003), Chaikin, P., et al.: Br. J. Clin. Pharmacol., 59, 346 (2005),<br></p>

<p>Stability Not Stable in hot solution<br>Applications Muscarinic receptor antagonist. Bronchodilator.<br>References Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994), Donohue, J. F., et al.: Chest, 122, 47 (2002), Profita, M., et al.: Allergy, 60, 1361 (2005), Dusser, D., et al.: Eur. Respir. J., 27, 547 (2006),<br></p>

<p>Stability Moisture Sensitive<br>Applications Fensulfothion Oxon is a metabolite of the insecticide fensulfonthion (F265490), an inhibitor of cholinesterase activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rainsford, K.D., et al.: Pest. Biochem. Physiol., 8, 302 (1978); Iverson, F., et al.: Can. J. Biochem., 54, 918 (1976);<br></p>

<p>Applications (2-Nitrophenyl)phosphoric triamide is used in the preparation of N-phenylphosphoric acid triamides derivatives as agents for regulating or inhibiting enzymatic urea hydrolysis.<br>References Benini, S., et al.: Eur. J. Biochem., 239, 61 (1996), Witte, C., et al.: Plant Physiol., 128, 1129 (2002), Krajewska, B., rt al.: Bioorg. Chem. 35, 355 (2007),<br></p>

<p>Applications It is a major metabolite of Nicotine in humans. Carcinogen.<br>References Byrd, G., et al.: Drug Metab. Dispos., 20, 192 (1992), Benowitz, N., et al.: Br. J. Clin. Pharmacol., 51, 53 (2001), Hanioka, N., et al.: Xenobiotica, 31, 687 (2001), Ethell, B., et al.: Biochem. Pharmacol., 65, 1441 (2003), Yamanaka, H., et al.: Eur. J. Pharm. Sci., 22, 419 (2004),<br></p>

<p>Applications Cholinesterase inhibitor. Use as systemic insecticide, acaricide, nematocide. Used in Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dorough, W.H., et al.: J. Agric. Food Chem., 16, 319 (1968),<br></p>

<p>Applications Metaldehyde<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications (1R-cis)-Cyhalothric Acid is an intermediate in the synthesis of Bifenthrin (B383000), a third generation synthetic pyrethroid.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Faming Zhuanli Shenqing (2012), CN 102827004 A 20121219. Wei, W. J., et al.: Chirality., 22, 604 (2010);<br></p>

<p>Applications HIV protease inhibitor; water soluble prodrug of amprenavir.<br>References Falcoz, C., et al.: J. Clin. Pharmacol., 42, 887 92002), Chapman, T.M., et al.: Drugs, 64, 2101 (2004)<br></p>

<p>Applications 2-[3-(Trifluoromethyl)phenoxy]nicotinic Acid (cas# 36701-89-0) is a useful reagent for the preparation of difluoroalkylarenes via photocatalytic alkylation of trifluoromethylarenes with alkenes.<br>References Vogt, D. B., et al.: J. Am. Chem. Soc., 141, 13203 (2019)<br></p>

<p>Applications Epichlorohydrin is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smyth, H.F., et al.: J. Ind. Hyg. Toxicol., 30, 63 (1948),<br></p>

<p>Stability Volatile<br>Applications Enflurane is an anaesthetic compound used in the treatment of hyperthermia and hypertension as well as other instances requiring a controlled physiological environment.<br>References Kotani, N, Brain Res. Bull., 93, 69 (2013); Sigmond, N. Brit. J. Anaesth., 111, 197 (2013); Visoiu, M. et al.: Anesth. Anal., 118, 388 (2014);<br></p>

<p>Applications Labelled Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>

<p>Applications ω-Hydroxy-DEET is a metabolite of DEET (D228500), an insect repellant commonly used to prevent contact with mosquitoes.<br>References Constantino, L. &amp; Iley, J.: Xenobiotica, 29, 409 (1999); Syed, Z. &amp; Leal, W.: P. Natl. Acad. Sci. USA, 105, 13598 (2008)<br></p>

<p>Applications Analgesic.<br>References Haddad, P., et al.: Drugs, 62, 1649 (2002), Chiu, P., et al.: J. Pharmacol. Sci., 95, 311 (2004), Dubin, A., et al.: J. Biomol. Screen, 10, 168 (2005),<br></p>

<p>Applications Veratramine is useful as signal transduction inhibitor for treating tumors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Imamura, L., et al.: J. Trad. Med., 12, 129 (1995), Ingolfsdottir, K., et al.: Antimicrob. Agents. Chemother., 1997, 41, 215 (1997), Tezuka, Y., et al.: J. Nat. Prod., 61, 1397 (1988)<br></p>

<p>Applications Amino acid substitute tumor growth.<br>References Villiers, C.L., et al.: Eur. J. Biochem., 140, 421 (1984);<br></p>

<p>Stability Very Hygroscopic<br>Applications Labelled Metaproterenol (M225835). Bronchodilator.<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),<br></p>

<p>Applications 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Third generation synthetic pyrethroid. Insecticide, acaricide. Useful in cannabis testing kits as a component in pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Fenoterol (F248850). An β2-adrenergic agonist. Bronchodilator; tocolytic.<br>References Schuster, B., et al. Arzneim.-Forsch., 19, 1905 (1969), Gerris, J., et al.: Eur. J. Clin. Pharmacol., 18, 443 (1980), Heel, R.C., et al.: Drugs, 15, 3 (1978),<br></p>

<p>Applications Skeletal muscle relaxant.<br>References White, R.L., et al.: J. Med. Chem., 30, 263 (1987)<br></p>

<p>Stability Hygroscopic<br>Applications 5-Aminoimidazole-4-carboxamide Lactose Adduct is a lactose adduct of 5-Aminoimidazole-4-carboxamide (A611690), a metabolite of Temozolomide (T017775).<br>References Jaeken, J., et al.: Lancet, 2, 1058 (1984), Baggott, J., et al.: Biochem. J., 236, 193 (1986), Baggott, J., et al.: Arch. Dermatol., 135, 813 (1999)<br></p>

<p>Applications A metabolite of polycyclic aromatic hydrocarbons in humans.<br>References Jacob, J., et al.: Xenobiotica, 12, 45 (1982), Becher, G., et al.: Cancer Lett., 17, 301 (1983), Hoffmann, D., et al.: Cancer Treat. Res., 72, 1 (1995), Einolf, H., et al.: Chem. Res. Toxicol., 10, 609 (1997),<br></p>

<p>Applications Bone metabolism modulator; inhibits bone resorption while maintaining bone formation. Antiosteoporotic.<br>References Buehler, J., et al.: Bone, 29, 176 (2001), Henrotin, Y., et al.: J. Bone Miner. Res.,16, 299 (2001), Meunier, P.J., et al.: N. Engl. J. Med., 350, 459 (2004),<br></p>

<p>Applications cetohydrazide-D3 is a labelled analogue of Acetohydrazide (A163770). Acetohydrazide is a metabolite of Isoniazid (I821450) an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Metushi, I.G., et al.: Chem. Res. Toxciol., 25, 2567 (2012); Fukino, K., et al.: J. Toxicol. Sci., 33, 667 (2008)<br></p>

<p>Applications Methyprylon is a sedative/hypnotic drug used for treating insomnia.<br>References Reinke, L. A., et al.: Res. Commun. Chem. Path., 11, 45 (1975); Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976)<br></p>

<p>Applications 4-Chlorophenylacetic Acid is a chlorinated phenyl acetic acid that is an antitumor differentiation inducer and may be an effective therapeutic agent in neuroblastoma therapy. 4-Chlorophenylacetic Acid shows plant growth-regulating activity.<br>References Chamberlain, V.K. et al.: Ann. Appl. Biol., 69, 65 (1971); Cai, G. et al.: Sheng. Wu. Xue., 15, 661 (1999); Pineau, T. et al.: Biochem. Pharmacol., 52, 659 (1996); Sidell, N. et al.: Br. J. Cancer, 412 (2003);<br></p>

<p>Impurity Oxytetracycline Hydrochloride EP Impurity B<br>Applications Tetracycline is a compound that has been shown to induce apoptosis in various cells. Tetracycline was a useful compound to study drug resistance of pathogens of infections in patients with severe liver disease.<br>References Yao, L., et al.: Zhongguo Linchuang Yanjiu, 29, 1510 (2016)<br></p>

<p>Applications (-)-Quinic Acid γ-Lactone is an intermediate in the synthesis of 4-O-(E)-Feruloylquinic Acid (F308985). 4-O-(E)-Feruloylquinic Acid is a phenolic acid with potential antioxidant and antifungal activities. Secondary metabolite in the coffee brewing process.<br>References Matei, M. et al.: J. Agri. Food Chem., 60, 12105 (2012); Dokli, I. et al.: Tetrahedron Asymm., 24, 785 (2013)<br></p>