Toxicologie

Applications The active labelled carboxylic acid metabolite of Ebastine.
References Hashizume, T., et al.: Drug Metab. Dispos., 29, 798 (2001), Hashizume, T., et al.: J. Pharmacol. Exp. Ther., 300, 298 (2002), Matsumoto, S., et al.: Xenobiotica, 33, 615 (2003), Chaikin, P., et al.: Br. J. Clin. Pharmacol., 59, 346 (2005),

Applications 4,4'-Dichlorodiphenyldichloroethane - d8 is a synthetic organochlorine insecticide. 4,4'-Dichlorodiphenyldichloroethane- d8 is a metabolite of 4,4'-Dichlorodiphenyltrichloroethane - d8 (D434197). 4,4'-Dichlorodiphenyldichloroethane - d8 is a probable carcinogen (Group B2).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tao, S. et al.: Environ. Sci. Technol., 39, 2494 (2005); Zhou, Q. et al.: J. Chrom. A, 1216, 6680 (2009); Weiderpass, E. et al.: Cancer Epidemiol. Biomark. Prev,., 9, 487 (2000)

Impurity Azithromycin Related Compound O
Applications Azithromycin N-Ethyl is an analogue of Azithromycin (A927000), an semi-synthetic macrolide antibiotic that is related to Erythromycin (E649950).
References Bright, G.M., et al.: J. Antibio., 41, 1029 (1988);

Applications S-Benzyl di-sec-Butylthiocarbamate is an herbicide used in fruits and vegetables.
References Wang, Z. et al.: Anal. Meth., 7, 6358 (2015);

Applications A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant.
References Kelsey, J., et al.: J. Clin. Psychopharmacol., 16, 21 (1996), Long, C., et al.: J. Anal. Toxicol., 21, 166 (1997), Deecher, D., et al.: J. Pharmacol. Exp. Ther., 318, 657 (2006)

Applications Trimethadione is an anticonvulsant and antiepileptic agent used in the treatment of pregnant women. Prenatal exposure to anti-epileptic drugs (AEDs) has indicated increased risk of major or minor congenital malformation.
References Ahir, B. et al.: Toxicol. Vitro., 28, 948 (2014); Pastore, V. et al.: Bioorg. Med. Chem., 21, 841 (2013);

Applications Thiosultap Sodium Salt is used as an insecticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yan, X., et. al.: J. Plant Diseases Protection, 119, 152 (2012)

Applications N-Acetyl-S-(4-hydroxy-2-methyl-2-trans-buten-1-yl)-L-cysteine is a metabolite of Isoprene.
References Pecivova, P. et al.: J. Sci. Food Agric., 90, 1681 (2010); Hui, N. et al.: Meat Sci. Appl., 74 (2001); Kiviharju, K. et al.: J. Biotechnol., 117, 299 (2005);

Stability Hygroscopic
Applications Mefruside is a diuretic used for the treatment of edema and hypertension.
References Johansen, A., et al.: Euro. J. Epidemiol., 27, 63 (2012); Hasegawa, Y., et al.: Blood. Press. Supple., 1, 10 (2010);

Applications Cefcapene Pivoxil (C242550) derivative. Δ2-Cephalosporins are potentially related compounds in cephalosporin antibacterial compounds.
References Chavette, R.R., J. Med. Chem., 9, 741 (1966), Miyouchi, M., et al.: J. Chem. Pharm. Bull., 38, 1906 (1990), Sugioka, T., et al.: Chem. Pharm. Bull., 38, 1998 (1990),

Applications Labelled Tiludronic Acid (T441250). A biphosphonate bone resorption inhibitor.
References Fraser, W.D., et al.: Postgrad. Med. J., 73, 496 (1997),

Applications JNJ 42041935 is a selective hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) enzyme inhibitor. It can potentially be used for the treatment of inflammation-induced anemia.
References Barrett, T., et al.: Mol. Pharmacol., 79, 910 (2011); Thirstrup, K., et al.: Pharmacol. Res., 64, 268 (2011);

Applications A glucuronide metabolite of Chlorpyrifos (C425300).
References Barron, M.G., et al.: Environ. Toxicol. Chem., 12, 1469 (1993), Tang, J., et al.: Drug Metab. Dispos., 29, 1201 (2001),

Applications A nitrosourea alkylating agent approved in Japan for the treatment of chronic myelogenous leukemia and polycythemia vera. It can be used in biological study of synthesis of anti-EGFR antibody-drug conjugates. It can also be used in therapeutic use and biological study of BCMA (B-Cell Maturation Antigen) antigen binding proteins.
References Choi, H., et al.: PCT Int. Appl., WO 2017051254 A1 20170330 (2017);

Stability Light Sensitive, Temperature Sensitive
Applications A metabolite of all-trans Retinoic acid (R250200).
References Idres, N., et al.: Cancer Res., 61, 700 (2001), Taimi, M., et al.: J. Biol. Chem., 279, 77 (2004), Vermot, J., et al.: Science, 308, 563 (2005),

Applications 1-Ethyldihydro-6-imino-2,4,5(3H)-pyrimidinetrione 5-(O-Methyloxime) is a byproduct in the synthesis of 3-Ethyl-4-(methoxyamino)-2,5-dioxo-4-imidazolidinecarboxamide (E817920), which is a Cymoxanil (C988995), degradation product, used as a fungicide applied as a seed treatment or as a foliar application to the plants to control late blight.
References Dhingani, J. C., et al.: J. Pure. App. Microbiol., 6, 1683 (2012); Bakirici, G.T., et al.: Food. Chem., 135, 1901 (2012);

Applications Agricultural fungicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lu, X., et al.: Phytopathol., 100, 1162 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),

Applications Metaldehyde
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 6-O-Des(6-Amino-α-D-gluocopyranosyl) Amikacin Sulfate is a derivative of Amikacin (A578500), semisynthetic aminoglycoside antibiotic derived from Kanamycin A. Antibacterial.
References Cabana, T., et al.: Antimicrob. Agents Chemother., 3, 478 (1973), Cappelletti, L.M., et al.: J. Antibiot., 36, 328 (1983), Monteleone, P.M., et al.: Anal. Profiles Drug Subs., 12, 37 (1983),

Applications Labelled Bilirubin (B385300), a principal pigment of bile and constituent of many biliary calculi.
References Stenhagen, R., et al.: Biochem. J., 33, 1591 (1939), Gray, et al.: J. Chem. Soc., 2264, 2268 (1961),

Applications Fenobuccarb is a carbamate insecticide used as an agricultural insecticide on rice and cotton.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Strempel, S., et al.: Envrion. Toxicol. Chem., 32, 1187 (2013); Xu, X.M., et al.: Food. Chem., 135, 161 (2012);

Applications Atorvastatin impurity. Atorvastatin Methyl Ester
References Graul, A., et al.: Drugs Future, 22, 956 (1997),

Applications A metabolite of Desoxymetasone (D296970).
References Schriks, M., et al.: Environ. Sci. Technol., 44, 4766 (2010), Baeck, M., et al.: Eur. J. Dermatol., 20, 102 (2010), Lee, P., et al.: Bioorg. Med. Chem. Lett., 20, 69 (2010),

Applications Cetrimonium Chloride, is a topical antiseptic. It is also used in hair conditioners and shampoos, as a conditioning agent
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zahang, M. et al.: Zoazhi Huaxueoin, 24, 13 (2012);

Stability Material darkens in storage with no loss in purity
Applications 3-Chlorobenzenamine is used in the synthesis of pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT2C receptor ligands for the treatment of obesity. Also used in the synthesis of novel COX-2 inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yang, H. et al.: Eur. J. Med. Chem., 63, 558 (2013); Penning, T. et al.: J. Med. Chem., 40, 1347 (1997);

Applications Tebutam is used as herbicide and pesticide.

Applications A novel bile acid, an analogue of Cholic acid (C432600).
References Yamaga, N., et al.: J. Biochem., 116, 1123 (1994),

Applications A new Sildenafil (S435000) analogue.
References Balayssac, S., et al.: J. Pharm. Biomed. Anal., 50, 602 (2009),

Applications Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
References Jones, P., et al.: J. Med. Chem., 52, 7170 (2009); Giannini, G., et al.: Bioorg. Med. Chem. Lett., 24, 462 (2014)

Applications Ivosidenib is a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers.
References Popovici-Muller, J., et al.: ACS Medicinal Chemistry Letters, 9, 300 (2018);

References Zeun, R., et al.: Pest Manag. Sci., 69, 527 (2013); Oostendorp, M., et al.: Phytopathology, 101, S133 (2011); Olaya, G., et al.: Phytopathology, 101, S132 (2011)

Applications Oxymatrine is a an anti-tumor agent triggering apoptosis in human leukemia cells.
References Liu, J. et al.: Tumor Biol., 35, 5409 (2014); Wang, C. et al.: Am. J. Chinese Med., 42, 543 (2014);

Applications Used as an antiparkinsonian agent and as an anticholinergic.
References Duperray, B., et al.: Eur. J. Drug Metab. Pharmacokinet., 2, 121 (1977),

Applications A toxic metabolite of Fenamiphos, a pesticide in fruits and vegetables.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Schenck, F., et al.: Bull. Environ. Contam. Toxicol., 73, 24 (2004), Okihashi, M., et al.: J. Pestic. Sci., 30, 368 (2005), Lopez, M., et al.: J. Agric. Food Chem., 56, 1553 (2008),

Applications Gibberellic Acid is a pentacyclic diterpene acid. Gibberellic Acid is a hormone that is found in plants which promotes the growth and elongation of cells. Gibberellic acid acts as a plant growth regulator on account of its physiological and morphological effects in extremely low concentrations. Generally Gibberellic acid affects only the plant parts above the soil surface.
References Bayle, J. et al.: Chem. Biol., 13, 99 (2006); Ihara, S. et al.: J. Cell Sci., 119, 500 (2006); Suh, B. et al.: Science, 314, 1454 (2006); Rinaudo, K. et al.: Nat. Biotechnol., 25, 795 (2007);

Impurity Fluticasone EP Impurity D
Applications Ticabesone Propionate is an impurity of Fluticasone, an antiallergic, anti-asthmatic and anti-inflammatory agent.
References Marrero-Ponce, Y., et al.: Europ. J. Med. Chem., 46, 5736 (2011); Dalvi, P., et al.: J. Chem., 20, 187 (2008);

Impurity Rosuvastatin EP Impurity G
Stability Hygroscopic
Applications ent-Rosuvastatin is an enantiomer of Rosuvastatin (R700500), an impurity which acts as a selective, competitive HMG-CoA reductase inhibitor (1). Antilipemic (2,3).
References 1. Watanabe, M. et al.: Bioorg. Med. Chem. 1997 Feb;5(2):437-44.2. Lee, E. et al.: Clin. Pharmacol. Ther. 2005 Oct;78(4):330-41.3. Ferdinand, C. et al.: Am. J. Cardiol. 2006 Jan 15;97(2):229-35.

Impurity Clobetasol Propionate EP Impurity G / Betamethasone EP Impurity B
Applications Clobetasol (Clobetasol Propionate EP Impurity G) is a topical corticosteroid. Glucocorticoid; anti-inflammatory.
References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, 246 (1986),

Applications Diafenthiuron is an insecticide.
References Delbeke, F., et al.: Entomophaga, 42, 349 (1997); Mezcua, M., et al.: Anal. Chem., 81, 913 (2009);

Applications Defluoro Linezolid is a defluorinated impurity of Linezolid (L466500).
References Kugelmann, E. et al.: J. Pharmac. Biomed. Anal., 54. 1047 (2011);

Impurity Pilocarpine Hydrochloride EP Impurity B
Stability Hygroscopic
Applications Pilocarpic Acid Sodium Salt is an imidazole derivative used in the preparation of novel sequentially labile pilocarpine prodrugs for improved ocular delivery.
References Bungaard, H. et al.: J. Med. Chem., 28, 978 (1985); Jarvinen, T.e t al.: Int. J. Pharmac., 79, 233 (1992);

Stability Hygroscopic
Applications Cefotaxime is an antibiotic with broad spectrum activity against Gram positive and Gram negative bacteria.

Stability Light Sensitive
Applications An intermediate in the preparation of Omeprazole metabolites.
References Hoffmann, K., et al.: Drug Metab. Disposition, 14, 341 (1986), Andersson, T., et al.: Brit. J. Clin. Pharmacol., 36, 521 (1993),

Stability Too Hygroscopic
Applications Erdosteine Thioacid Diammonium Salt is the active metabolite of Erdosteine (E596050), a mucolytic. Erdosteine was developed for the treatment of chronic obstructive bronchitis.
References Dechant, K., et al.: Drugs, 52, 875 (1996); Braga, P., et al.: Arzneim.-Forsch., 49, 344 (1999); Braga, P., et al.: Antimicrob. Agents Chemother., 43, 1013 (1999); Kuvandik, G., et al.: Toxicol. Pathol., 36, 714 (2008); Koyu, A., et al.: Mol. Cell. Biochem., 331, 43 (2009); Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010)

Applications (+)-Costunolide is an inhibitor of osteoclast differentiation, acting as an anti-inflammatory and anti-oxidant agent. It is a sesquiterpene lactone which mediates apoptosis.
References Cheon, Y. et al.: Phytother. Res., 28, 586 (2014); Butturini, E. et al.: Eur. J. Pharm., 730, 107 (2014);

Applications Sulforaphene is an extract from the seeds of Raphanus sativus and displays anti-inflammatory and anti-cancer activity.
References Kim, K. et al.: J. Ethnopharmacol., 151, 503 (2014);

Applications 2-Methyl-4-isothiazolin-3-one Hydrochloride is an isothiazolinone based biocide and preservative used in personal care products. It is also implicated as an allergen. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-containing solution.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Collier, P.J., et al.: J. App. Bacteriol., 69, 578 (1990); Smaoui, S., et al.: Biocontrol. Sci., 17, 135 (2012); Lodders, N., et al.: System. App. Microbiol., 35, 246 (2012); Felix, J.S., et al.: Anal. Bioanal. Chem., 403, 2869 (2012); Chem. and Eng. News, p.22 Dec. 15, 2014

Impurity Entecavir EP Impurity A
Applications An epimeric impurity of the antiviral drug Entecavir (E558900).

Applications Pyroxasulfone is an inhibitor of the biosynthesis of very-long-chain fatty acids. Pyroxasulfone is also used to control grass weed species in pre-emergence in major field crops.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Busi, R., et al.: Pest. Manag. Sci., 72, 1665 (2016)

Stability Hygroscopic, Light Sensitive
Applications A mixture of 2 labelled metabolites of Bbutadiene. The isomeric ratio has been determine to be approximately 1:1 based on proton nmr integration.
References Barnsley, E.A., et al.: Biochem. J., 100, 362 (1966),

Stability Hygroscopic
Applications An impurity in the synthesis of Erythromycin (E649950). An antibacterial.
References Zhang, L. et al.: J. Antibio., 64, 243 (2011); Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979),

Stability Hygroscopic
Applications Labelled Promazine (P756300). Antipsychotic. Tranquilizer.
References Banci, L., et al.: Biochemistry, 38, 3205 (1999), Lawal, O., et al.: Food Chemi., 87, 205 (2004), Shleev, S., et al.: Bioorg. Chem., 35, 35 (2007),

Applications 2,2,2-Trichloro-acetic Acid is an acetic acid analogue used for the precipitation of macromolecules including proteins, DNA and RNA as well as for cosmetic treatments.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wiley D. et al.: Clin. Infect. Dis., 35m S210 (2002);

Applications Iodosulfuron Methyl Ester Sodium is used as a pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Klein, J., et al.: J. AOAC Intrnational, 86, 1015 (2003); Pang, G., et al.: J. Chromat. A, 1125, 1 (2006)

Applications Labelled fluorinated quinolone antibacterial.
References Monk, J.P., et al.: Drugs, 33, 346 (1987), Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990)

Stability Hygroscopic, Light Sensitive
Applications Rifabutin N-Oxide is a metabolite of Rifabutin (R505000) and like its parent compound it exhibits antibacterial activity.
References Medeiros, M., et al.: PCT Int. Appl., 44, (2004); Anand, R., et al.: Antimicrob. AG. Chemother., 32 (684 (1988), Skinner, M.H., et al.: Antimicrob. Agent Chemother., 33, 1237 (1989),

Stability Hygroscopic
Applications Ethanolamine-13C2 Hydrochloride is the labeled analogue of Ethanolamine (E676500), which is used in the preparation of various pharmaceutical compounds and inhibitors. Ethanolamine-13C2, is also a 13C-labeled lipid precursor, used for the detection of phospholipid metabolism and the synthesis of phosphatidylethanolamine in T47D human breast cancer cells.
References Ronen, S. M., et al.: Magnetic Resonance Med., 25, 384 (1992); Lombardo, L. et al.: J. Med. Chem., 47, 6658 (2004); Egan, T.: J. Med. Chem., 43, 283 (2000);

Applications Labelled Thiamine (T344185). Essential nutrient required for carbohydrate metabolism; also involved in nerve function. Biosynthesized by microorganisms and plants. Dietary sources include whole grains, meat products, vegetables, milk, legumes and fruit. Also present in rice husks and yeast. Converted in vivo to Thiamine diphosphate, a coenzyme in the decarboxylation of α-keto acids. Chronic deficiency may lead to neurological impairment, bariberi, Wernicke-Korsakoff syndrome.
References Kawaski, T., et al.: Methods Enzymol., 122, 15 (1986), Mascher, H., et al.: J. Pharm. Sci., 82, 56 (1993),

Applications Thiamine is a essential nutrient required for carbohydrate metabolism; also involved in nerve function. Biosynthesized by microorganisms and plants. Dietary sources include whole grains, meat products, vegetables, milk, legumes and fruit. Also present in rice husks and yeast. Converted in vivo to Thiamine diphosphate, a coenzyme in the decarboxylation of α-keto acids. Chronic deficiency may lead to neurological impairment, bariberi, Wernicke-Korsakoff syndrome.
References Kawaski, T., et al.: Methods Enzymol., 122, 15 (1986), Mascher, H., et al.: J. Pharm. Sci., 82, 56 (1993),

Impurity USP Cefdinir Related Compound A Sodium Salt
Stability Hygroscopic
Applications (2(R)-2-[(Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-2-[(2RS,5RS)-5-methyl-7-oxo-2,4,5,7-tetrahydro-1H-furo[3,4-d][1,3]thiazin-2-yl]acetic Acid is an impurity in the synthesis of Cefdinir (C242670), a Cephalosporin antibiotic structurally similar to Cefixime (C242800).
References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984),Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985), Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986),

Applications Glecaprevir is an antiviral drug used in the treatment of patients with hepatitis C virus (HCV) genotype 1-6, of special interest for the treatment of patients with chronic kidney disease also suffering from HCV.
References Kwo, P., et. al.: J. Hepatol, 67, 263 (2017)Gane, E., et. al.: N. Engl. J. Med, 377, 1448 (2017)

Applications A labelled form of Hexythiazox (H298500), which is a mite growth regulator and a thiazolidine based acaricide that has long-lasting effects against many kinds of mites and is applied at any stage of the plant growth from budding to fruiting. Useful in cannabis testing kits as a component of pesticide mixes (P698240).
References Martini,X., et al.: Pest. Manage. Sci., 68, 1471 (2012); Gilbert-Lopez, B., et al.: Food. Control., 26, 341 (2012);

Impurity Ofloxacin EP Impurity E
Applications Desmethyl Ofloxacin (Ofloxacin EP Impurity E) is a metabolite of Ofoxacin (O245750), a fluorinated quinolone antibacterial.
References Leysen, D., et al.: Antimicrob. Agents Chemother., 33, 1 (1989); Polk, R., et al.: J. Antimicrob. Chemother., 27, 17 (1991); Todo, Y., et al.: Chem. Pharm. Bull., 42, 2049 (1994); Furuhata, K., et al.: Biol. Pharm. Bull., 21, 456 (1998); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990)

Applications Linezolid N-oxide is a derivative of Linezolid (L466500), an oxazolidinone antimicrobial that is used to treat infections against gram-positive bacteria, especially those that are drug-resistant (such as Vancomycin [HCl: V096500] resistant enterococci). Linezolid works by inhibiting bacterial protein synthesis.
References Dennis, L., et al.: Clin. Infect. Dis., 34, 1481 (2002); Clemett, D. & Markham, A.: Drugs, 59, 815 (2000); Gonzales, R., et al.: Lancet, 357, 1179 (2001); Tsiodras, S., et al.: Lancet, 358, 207 (2001)

Applications Labelled Carbocisteine (C178760). Carbocisteine is a mucolytic agent used in the treatment of respiratory disorders ranging from the influenza virus infection to chronic obstructive pulmonary disease (COPD).
References Stevenson, G.B. et al.: Eur. Resp. J., 27, 865 (2006); Suer, E. et al.: J. Infect. Chemother., 14, 333 (2008); Yamaya, M. et al.: Am. J. Physiol., 299, L160 (2010);

Applications Fluocortolone is a glucocorticoid used in the treatment of several conditions, including hemorrhoids. Fluocortolone is similar to Fluocortin, but with one less keto group.
References Breuer, et al.: Arzneim.-Forsch., 15, 50 (1965), Domenico, et al.: Arzneim.-Forsch., 15, 46 (1965), Gerhards, et al.: Acta Endocrinol., 68, 98 (1971),

Applications Cyprodinil is a broad-spectrum fungicide of the class of pyrimidinamines. It is commonly used for protection of cereal crops and fruits against fungal infections. Useful in cannabis testing kits as a component of pesticide mixes (P698235).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Heye, U.J. et al.: Bright. Crop Prot. Conf., Pests Dis., 2, 501 (1994); Boric, B. et al.: Pesticidi, 12, 277 (1997); Knauf-Beiter, G. et al.: Plant Dis., 79, 1098 (1995);

Stability Hygroscopic
Applications A nucleoside analog phosphates for topical use in the treatment of herpes virus infections. A topical treatment that seems to bypass a key mechanism responsible for resistance to Acyclovir.
References Furman, P., et al.: J. Virol., 32, 72 (1979), Darby, G., et al.: J. Gen. Virol., 48, 451 (1980),Prisbe, E., et al.: J. Med. Chem., 29, 671 (1986), Ellis, M., et al.: Antimicrob. Agents Chemother., 33, 304 (1989),

Applications Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters. Has little effect on the dopamine transporter.
References Wood, M.D., et al.: Neuropharmacology, 26, 1081 (1987), Casis, O., et al.: J. Cardiovasc. Pharmacol., 32, 521 (1998), Linner, L., et al.: Biol. Psychiatry, 46, 766 (1999), Teschemacher, et al.: Br. J. Pharmacol., 128, 479 (1999),

Applications 4-Methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-amine can be used as reactant/reagent in preparation of N-phenylsulfony-N'-pyrimidinylureas as herbicides.
References Hamprecht, G., et al.: Ger. Offen., DE 4322726 A1 19950112 (1995)

Applications (R)-Baclofen is the R-Enantiomer of Baclofen, a specific GABA-B receptor agonist and a muscle relaxant (1,2).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References (1) Brogden, R.N., et al.: Drugs, 8,1 (1974) (2) Song, Y., et al.: Endocrinology. en.2016-1776 (2017)