Toxicologie

<p>Applications 5-Amino-1-N-methylindole (CAS# 102308-97-4) is an indole derivative and building block, used in the copper-catalyzed synthesis of sulfonamides.<br>References Chen, Y.; et al.: J. Am. Chem. Soc., 140, 8781 (2018);<br></p>

<p>Applications 2-methoxy-3-pyridinesulfonyl chloride is patented as a reactant used to prepare erythromycin macrolide antibiotics as antibacterial and antiprotozoal agents.<br></p>

<p>Applications 1-Isocyanato-4-nitrobenzene is a useful synthetic intermediate. It can be used as a reactant in the synthesis of potent human NK1 tachykinin receptor antagonist. It can also be used to prepare N-{2-[(7-chloroquinolin-4-yl)amino]ethyl}ureas with antiprotozoal and antimycobacterial activities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Walpole, C., et al.: J. Med. Chem., 41, 3159 (1998); Nava-Zuazo, C., et al.: Bioorg. Med. Chem., 18, 6398 (2010)<br></p>

<p>Applications Erythromycin Glucoheptonate is a derivative of Erythromycin (E649950), an antibiotic.<br>References Delaforge, M. et al.: Biochem. Pharm., 32, 2309 (1983); Niederau, W. et al.: Chemother., 26, 121 (1980);<br></p>

<p>Applications 4-Amino-1-(10-phthalimidodecyl)quinaldinium Iodide is an intermediate for the synthesis of 4-Amino-1-[10-[(2-methyl-4-quinolyl)amino]decyl]quinaldinium Iodide Hydriodide (M493250), which is an impurity of Dequalinium (D288335); the active ingredient in various medications including antiseptic and anti-malarial agents.<br>References Kunisada, Y., et al.: J. Biomolec. Screen., 17, 140 (2012); Zeder-Lutz., G., et al.: Anal. Biochem., 421, 417 (2012)<br></p>

<p>Applications Methyl 2-((((Benzyloxy)carbonyl)amino)methyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate is an intermediate used in the synthesis of N-((5-Hydroxy-6-oxo-4-((2,4,6-trifluorobenzyl)carbamoyl)-1,6-dihydropyrimidin-2-yl)methyl)-1,3,4-oxadiazole-2-carboxamide (H950690), which is a derivative of Raltegravir (R100305), a potent integrase (IN) inhibitor for WT and S217Q PFV IN.<br>References Hare, S., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 20057 (2010); Hicks, C., et al.: Clin. Infect. Dis., 48, 931 (2009); Moss, D., et al.: Antimicrob. Agents Chemother., 56, 3020 (2012); Hare, S., et al.: Mol. Pharmacol., 80, 565 (2011)<br></p>

<p>Applications 1-(2,2-Dihydroxyethyl)-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic Acid is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.<br>References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;<br></p>

<p>Applications Zinc salicylate trihydrate (CAS# 16283-36-6) is a useful research chemical compound.<br></p>

<p>Applications (E)-1,1'-[2-(2,4-Difluorophenyl)-1-propene-1,3-diyl]bis-1H-1,2,4-triazole is an impurity of Fluconazole (F421000), an antifungal.<br>References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985),<br></p>

<p>Applications (Z)-2'-Deschloro Luliconazole is a Luliconazole (L473770) impurity. Luliconazole is an azole antifungal drug.<br>References Uhida, K., et al.: J. Infect. Chemother., 10, 216 (2004); Niwano, ., et al.: Antimicro. Agents Chemother., 42, 967 (1998)<br></p>

<p>Applications 5-Chloro-2-furancarbonyl Fluticasone Furoate is a Fluticasone Furoate(F599510) raw material impurity which is a synthetic corticosteroid derived from fluticasone for treatment of seasonal allergic rhinitis.<br>References DeWester, J., et al.: Allergy Asthma Proc., 24, 331 (2003), Hughes, S., et al.: Drug Metab. Dispos., 36, 2337 (2008), Meltzer, E., et al.: Clin. Drug Investig., 29, 79 (2009),<br></p>

<p>Applications Texas Red 4’-Propargyl Sulfonamide 2’-Sulfate is an intermediate in the synthesis of Texas Red-5-dUTP (T320100), a fluorescence-labelled nucleotide analog. Texas Red-5-dUTP is used diagnostically for detection of rearranged SS18 in formalin-fixed, paraffin-embedded synovial sarcoma.<br></p>

<p>Applications Ethyl 3-(4-bromo-2-chlorophenyl)-3-oxopropionate (CAS# 131994-22-4) is a useful research chemical compound.<br></p>

<p>Applications (3aR,4S,6aS)-4-Methoxytetrahydrofuro[3,4-b]furan-2(3H)-one is an isomer of an impurity of Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral.<br>References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005); Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005)<br></p>

<p>Applications Trimethoprim-13C3 (T795616) derivative. Antibacterial properties.<br></p>

<p>Applications p-Chloroaniline-d4 Deuterium Chloride is an intermediate in synthesizing N1-(4-chlorophenyl)-3,12-diimino-N14-2-chlorophenyl-2,4,11,13-Tetraazatetradecanediimidamide-d4 (C377537), an isotope labelled analog of N1-(4-chlorophenyl)-3,12-diimino-N14-2-chlorophenyl-2,4,11,13-Tetraazatetradecanediimidamide. N1-(4-chlorophenyl)-3,12-diimino-N14-2-chlorophenyl-2,4,11,13-Tetraazatetradecanediimidamide is an impurity of Chlorhexidine Digluconate (C292770). Chlorhexidine gluconate is an antimicrobial irrigant that is used as an antiseptic for the skin in the healthcare industry. It is used in hospitals to prevent infection of patients during surgeries and can also be found in mouth rinses.<br>References Addy, M. &amp; Wright, R.: J. Clin. Periodont., 5, 198 (1978); Kuruvilla, J. &amp; Kamath, M.: J. Endododont., 24, 472 (1998); Maki, D., et al.: Lancet, 338, 339 (1991); Popovich, K., et al.: Inf. Cont. Hosp. Epidem., 30, 959 (2009); Rosenberg, A., et al.: Surg. Gyn. Obst., 143, 789 (1976)<br></p>

<p>Applications 7,13-Bisside chainpacltaxel is a derivative of Paclitaxel (P132500) which has anticancer properties.<br>References Zhong, T., et al.: Bioconjugate Chem., 29, 437-444 (2018)<br></p>

<p>Applications Ethylmorphine 6-(Tri-O-acetylglucuronide Methyl Ester) is an protected metabolite of Ethyl Morphine (E925155), an analgesic and antitussive agent.<br>References Bugge, A., et al.: Acta, Chem. Scandinavica., 49, 380 (1995);<br></p>

<p>Applications Pyrethrin 1-d6(E/Z mixture) is the labeled analogue of Pyrethrin 1 (P991245), a pesticide residue that has been found in baby food.<br>References Luz Gomez-Perez, M., et. al.: Talanta, 131, 1 (2015)<br></p>