Toxicologie

Applications A metabolite of Bromethalin rodenticide found in the blood and liver of treated animals.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Van Lier, R.B.L., et at.: Fundamental Appl. Toxicol., 11, 664 (1988),

Stability Very Hygroscopic
Applications Labelled Metaproterenol (M225835). Bronchodilator.
References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),

Applications 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Labelled 5-FU, a potent antineoplastic agent in clinical use. Also an inhibitor of DNA synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 221 (1973), Miyashita, O., et al.: Chem. Pharm. Bull., 29, 3181 (1981), Hansen, R.M., et al.: Cancer Invest., 9, 637 (1991),

Stability Hygroscopic
Applications L-Penicillamine Hydrochloride is a salt form of L-Penicillamine (P2230005). L-Penicillamine is a metabolite of penicillin. L-Penicillamine is used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.
References Marti-Prats, L., et al.: Neurosci. Lett., 483, 143 (2010), Singh, A., et al.: J. Pharm. Sci., 99, 3931 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010),

Impurity Abacavir EP Impurity A
Applications ent-Abacavir (Abacavir EP Impurity A) is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Applications 2,2,4-Trimethyl-6(2H)-quinolinone 1-Oxide is a derivative of 2,6-Dihydro-2,2,4-trimethyl-6-quinolone (D449900) which is a metabolite of Ethoxyquin (E892800), an oxidation product of the antidegradant.
References Kahl, R., et al.: Toxicology, 28, 229 (1983), Burka, L., et al.: Xenobiotica, 26, 597 (1996), Bammler, T., et al.: Toxicol. Sci., 54, 30 (2000), Hayes, J., et al.: Cancer, 174, 103 (2001),

Applications Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral.
References Palella, F.J. Jr., et al.: N. Engl. J. Med., 338(13), 853 (1998), Nolan, D., et al.: Drugs, 63(23), 2555 (2003), Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),

Applications Labelled Curcumin (C838500). A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007),

Applications Third generation synthetic pyrethroid. Insecticide, acaricide. Useful in cannabis testing kits as a component in pesticide mixes (P698230).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),

Stability Hygroscopic
Applications Labelled Fenoterol (F248850). An β2-adrenergic agonist. Bronchodilator; tocolytic.
References Schuster, B., et al. Arzneim.-Forsch., 19, 1905 (1969), Gerris, J., et al.: Eur. J. Clin. Pharmacol., 18, 443 (1980), Heel, R.C., et al.: Drugs, 15, 3 (1978),

Applications 3-Methyl-4-(methylthio)phenol is a metabolite of Fenamiphos (F245700), a Systemic broad spectrum nematocide with anticholinesterase activity. Nematocide.
References Simon, L., et. al.: J. Agr. Food Chem., 40, 312 (1992); Brown, M.J., et al.: J. Agric. Food Chem., 29, 1129 (1981); Read, D.C., et al.: J. Econ. Entomol., 69, 429 (1976)

Applications Skeletal muscle relaxant.
References White, R.L., et al.: J. Med. Chem., 30, 263 (1987)

Applications Labelled Diltiazem (D460620). A calcium channel blocker with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).
References Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971), Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998), Hansson, L., et al.: Lancet, 356, 359 (2000),

Stability Hygroscopic
Applications A metabolite of 1-Naphthol.
References Redegeld, F., et al.: J. Pharmacol. Exp. Ther., 244, 263 (1988), Lohr, J., et al.: Pharmacol. Rev., 50, 107 (1998), Yokota, H., et al.: Biochem. J., 340, 405 (1999), Daidoji, T., et al.: Drug Metab. Dispos., 31, 993 (2003),

Applications Mydriatic.
References Bhargava, K., et al.: Br. J. Pharmcol., 24, 641 (1965), Bolton, T., et al.: J. Physiol., 570, 5 (2006),

Applications 3-Oxo-4,6-choladien-24-oic Acid is an intermediate in the synthesis of various bile acids.
References Iqbal, M.N., et al.: Steroids., 53, 413 (1989);

Stability Hygroscopic
Applications Carmoterol is a highly potent β2-selective adrenoceptor agonist having a long-lasting bronchodilating effect.
References Abagyan, R., et al.: J. Mol. Biol., 235, 983 (1994), Matsukawa, M., et al.: J. Pharm. Biomed. Anal., 17, 245 (1998), Cole, P., et al.: Nat. Chem. Biol., 4, 590 (2008),

Applications (-)-Carbovir, is a nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) caused mitochondrial toxicity in human hepatoma carcinoma cell.
References Suo, Z., et al.: J. Biol. Chem., 273, 27250 (1998), Ray, A., et al.: Antimicrob. Agents Chemother., 48, 1089 (2004), Lynx, M., et al.: Biochem. Pharmacol., 71, 1342 (2006),

Applications Desmedipham is a carbanilate based herbicide used in the weed control programs in sugar beet.
References Kittlaus, S., et al.: J. Chromatograph. A., 1283, 98 (2013); Wujek, B., et al.: J. Food. Agri. Environ., 10, 606 (2012);

Applications Gabapentin Lactam-d6, is the labeled analogue of Gabapentin Lactam (G117275), that reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.
References Zucker, B.,et al.: Naunyn Schmiedebergs Arch. Pharmacol., 370, 131 (2004)

Applications Teflubenzuron is an benzoylphenylurea chitin synthesis inhibitor used to control a wide range of insect pests and mites in fruit, vegetable, cereal and seed crops. Teflubenzuron is used in cannabis testing kits as a component of pesticide mixes (P698240).
References Carro, A.M., et al.: J. Separat. Sci., 35, 2866 (2012); Brock, T.C.M., et al.: Environ. Sci. Pollu. Res., 19, 3610 (2012);

Applications Epitizide is a diuretic agent.
References Pilsbury, V., et al.: J. Pharm. Pharmacol., 18, 713 (1966), Tisdall, P., et al.: Clin. Chem., 26, 702 (1980),

Stability Too Hygroscopic
Applications Erdosteine Thioacid Diammonium Salt is the active metabolite of Erdosteine (E596050), a mucolytic. Erdosteine was developed for the treatment of chronic obstructive bronchitis.
References Dechant, K., et al.: Drugs, 52, 875 (1996); Braga, P., et al.: Arzneim.-Forsch., 49, 344 (1999); Braga, P., et al.: Antimicrob. Agents Chemother., 43, 1013 (1999); Kuvandik, G., et al.: Toxicol. Pathol., 36, 714 (2008); Koyu, A., et al.: Mol. Cell. Biochem., 331, 43 (2009); Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010)

Applications Imazamethabenz-methyl is used in combined herbicides formulations, screening pesticides in foods using gas chromatography and mass spectrometry.
References Hansen, P., et al.: Den., Util. Model Appl. (2010), DK 201000204 U1 20101112.; Yi, X., et al.: Sepu, 34, 1097 (2016)

Applications N-Nitrosodiisopropylamine ia a nitrosoamine compound that shows carcinogenic effect.
References Scanlan, R., et al.: Cancer Res., 43, 2435 (1983), Spiegelhalder, B., et al.: Carcinogenesis, 4, 1147 (1983), Lijinsky, W., et al.: Mutat. Res., 443, 129 (1999), Robichova, S., et al.: Chem. Biol. Interact., 148, 163 (2004)

Applications Ketorolac-d5 is a labeled analogue of Ketorolac, a Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.
References Rooks, W.H., et al.: Agents Actions, 12, 684 (1982); Guzman, A., et al.: J. Med. Chem., 29, 589 (1986); McQuary, H.J., et al.: Clin. Pharmacol. Ther., 39, 89 (1986)

Applications A labelled analog of Lorazepam (L469850). Sedative, hypnotic.Controlled substance (depressant).
References Nudelman, A., et al.: J. Pharma. Sci., 63, 1886 (1974), Humpel, M., et al.: Eur. J. Drug Metab. Pharmacokinet., 4, 237 (1979), Girkin, R., et al.: Xenobiotica, 10, 401 (1980),

Stability Hygroscopic
Applications Dipotassium Glycyrrhizinate is used in improving the dissolution property of amphotericin B (AMB) and the bioavailability of the drug incorporated in suppositories.
References Tanaka, M., et. al.: Chem. Pharm. Bull., 40, 1559 (1992);

Stability Hygroscopic
Applications Single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex produced by Streptomyces tenebrarius. Antibacterial.A representative lot contains d4, d5, d6, d7, d8, and d9.
References Koch, K.F., et al.: Antimicrob. Agents Chemother., 309 (1970), Welles, J.S., et al.: Toxicol. Appl. Pharmacol., 22, 332 (1972), Dash, A.K., et al.: Anal. Profiles Drug Subs. Excip., 24, 579 (1996),

Applications Technical Chlorophenothane is derived from 2,4'-Dichlorodiphenyltrichloroethane (D434205), which is a chlorinated organic pesticide having estrogenic activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Iwata, H., et al.: Environ. Sci. Technol., 27, 1080 (1993), Beyer, A., et al.: Environ. Toxicol. Chem., 21, 941 (2002), Cunningham, S., et al.: Science, 317, 935 (2007)

Applications Didecyl Dimethyl Ammonium Chloride is a compound that exhibits some fungacidal and antimirobial functions.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kanazawa, A. et al.: Antimicrob. Agents Chemother., 38, 945 (1994)l; Schultz, T.P. et al.: Phytochem., 54, 47 (2000);

Stability Light Sensitive
Applications Anxiolytic. Controlled substance (depressant).
References Merlo, L., et al.: Arzneim.-Forsch., 24, 1759 (1974), Carrara, S., et al.: Eur. J. Clin. Pharmacol., 13, 335 (1978), Marcucci, F., et al.: J. Pharm. Sci., 67, 1470 (1978),

Applications A metabolite of Testosterone (T155000).CONTROLLED SUBSTANCE
References Brandon, E., et al.: Toxicol. Appl. Pharmacol., 189, 233 (2003), Froehlich, A., et al.: Drug Metab. Dispos., 33, 1532 (2005), Schmelzer, E., et al.: Xenobiotica, 6, 693 (2006), Jasmund, I., et al.: Biomol. Eng., 24, 59 (2007),

Applications Mebutizide is a thiazide diuretic.
References Madrid A.J. et al.: Rev. Clin. Esp., 114, 143 (1969);

Applications Acetohexamide is a sulfonylurea derivative. Acetohexamide is a hyopglycemic agent with moderate uricosuric activity. Acetohexamide is a first generation medication used in the treatment of diabetes metilus type 2.
References Yu, T-F. et al.: Metab. Clin. Exp., 17, 309 (1968); Harrower, A.D.B. et al.: Clin. Pharmacokin., 31, 111 (1996); Hirota, Y. et al.: Diab. Med., 26, 948 (2009);

Applications A metabolite of Mycophenolic acid (phase 1 metabolite).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nowak, I., et al.: Ther. Drug Monit., 19, 358 (1997), Bullingham, R., et al.: Clin. Pharmacokinet., 34, 429 (1998), Van Gelder, T., et al.: Ther. Drug Monit., 23, 119 (2001), Wen, X., et al.: Drug Metab. Dispos., 30, 631 (2002), Shipkova, M., et al.: Ther. Drug Monit., 25, 1,(2003),

Stability Hygroscopic
Applications Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).
References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),

Stability Hygroscopic
Applications 3-Hydroxyhexadecanoylcarnitine Inner Salt is a derivative of Carnitine, essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado. Also 3-Hydroxyhexadecanoylcarnitine works similar to the endogenous non-toxic molecule L-Carnitine (C184110) whose bioavailablity is improved due to the transport systems in place for Carnitine.
References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978), Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001), Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002), Karlic, H., et al.: Nutrition, 20, 709 (2004), O. Piermatti. et al.: Bioorg. Med. Chem., 16, 1444 (2008);

Applications Labelled Mecoprop (M203052). Herbicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gagne, F., et al.: Environ. Res., 103, 238 (2007), LaChapelle, A., et al.: Reprod. Toxicol., 23, 20 (2007),

Applications Thifluzamide is a fungicide found in cereals, vegetables and fruits; A succinate dehydrogenase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cui, C., et al.: Sepu, 35, 487-494 (2017); Sun, H., et al.: Pest Manag. Sci., 73, 896-903 (2017)

Applications Labelled Rasagiline. A selective irreversible MAO-B inhibitor. Rasagiline is an Antiparkinsonian agent.
References Rabey, J.M., et al.: Clin. Neuropharmacol., 23, 324 (2000), Glezer, S., et al.: Eur. J. Pharmacol., 472, 173 (2003), Youdim, M.B.H., et al.: Biochem. Pharmacol., 66, 1635 (2003), Chen, J.J., et al.: J. Clin. Pharmacol., 45, 878 (2005),

Applications Febuxostat-d7, is the labeled analogue of Febuxostat-d7 (F229000), a Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.
References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),

Applications Dimethyldimyristylammonium bromide is a cationic surfactant used in the study of lipid raft domains in membranes.
References Uyama, M.; et al.: J. Oleo Sci., 67, 67 (2018).

Applications Amphotericin B Methyl Ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B Methyl Esterin is a cholesterol binding compound that showed inhibiton of human immunodeficiency virus type 1 (HIV-1).
References Waheed, A.A. et al.: J. Biol. Chem., 281, 28699 (2006); Waheed, A. et al.: J. Virol., 82, 9776 (2008); Waheed, A., et al.: J. Biol. Chem., 281, 28699 (2006)

Applications Benzylmorphine is an opioid alkaloid that is a derivative of Morphine (M652285).
References Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 17, 259 (1988);