Toxicologie

<p>Applications Labelled quinoline methanol antimalarial agent.<br>References Carroll, F.I., et al.: J. Med. Chem., 17, 210 (1974), Davidson, M.W., et al.: J. Med. Chem., 20, 1117 (1977), Brown, R.E., et al.: Life Sci., et al.: 25, 1857 (1979), Lim, P., et al.: Anal. Profiles Drug Subs., 14, 157 (1985),<br></p>

<p>Applications An labelled epilepsy drug. It has been used as co-therapy for treatment of epilepsy. It inhibits the enzymes responsible for metabolism of other anti-convulsant agents.<br>References Laurie, D., et al.: J. Neurosci., 12, 4151 (1992), Smith, A., et al.: J. Pharmacol. Exp. Therap., 311, 601 (2004), Trojnar, M., et al.: Pharm. Rep., 57, 154 (2005), Drafts, B., et al.: J. Pharm. Exp. Ther., 318, 1094 (2006), Picton, A., et al.: Brain Res., 1165, 40 (2007),<br></p>

<p>Stability Hygroscopic, Unstable in DMSO<br>Applications Post-emergence sulfonylurea herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gubbiga, N.G., et al.: Weed Technol., 9, 574 (1995), Ukrainczyk, L., et al.: J. Agric. Food Chem., 43, 855 (1995)<br></p>

<p>Stability Light Sensitive<br>Applications Labelled Rifabutin (R505000). Semisynthetic derivative of Rifamycin S that inhibits nucleic acid synthesis. An antibacterial (tuberculostatic).<br>References O’Brien, R.J., et al.: Infect. Dis., 9, 519 (1987), Anand, R., et al.: Antimicrob. AG. Chemother., 32 (684 (1988), Skinner, M.H., et al.: Antimicrob. Agent Chemother., 33, 1237 (1989),<br></p>

<p>Applications Piribedil is an antiparkisonian agent that acts as a dopamine agonist. Piribedil also displays α2-adrenergic antagonist properties. Piribedil has also been shown to counteract age-related memory impairment by improving memory and attention as well as increasing the velocity of psychomotor reactions and lability of nervous processes.<br>References Millan, M.J. et al.: J. Pharmacol. Exp. Therap., 297, 876 (2001); Gobert, A. et al.: J. Pharmacol. Exp. Therap., 305, 338 (2003); Bochkarev, V.K. et al.: Zh. Nevrol. Psikhiatr. Im. S.S. Korsakova, 105, 46 (2005);<br></p>

<p>Applications Docetaxel is an antimitotic Taxol analog antibiotic.<br></p>

<p>Applications Labelled Ferulic acid (4-hydroxy-3-methoxycinnamic acid or, in IUPAC nomenclature, 3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoic acid) which is a highly abundant phenolic phytochemical which is present in plant cell walls. It may have significant health benefits through its antioxidant and anti-cancer activity, and may also serve as a precursor in the manufacturing of useful aromatic compounds. Used as an antioxidant.<br>References Smart, M.G., et al.: Aust. J. Plant Physiol., 6, 485 (1979), Chen, C., et al.: J. Food Lipids, 2, 35,1995, Benzie, I., et al.: Anal. Biochem. 239, 70 (1996), Nardini, M., et al.: Food Chem., 79, 119 (2002), Lee, J., et al.: J. Agric. Food Chem., 52, 2647 (2004),<br></p>

<p>Applications Mevinphos is a pesticide used in the protection of crops. Insecticide. Useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rajski, L. et al.: Analyst, 138, 921 (2013); Lozano, A. et al.: J. Chrom. A., 1268, (2012);<br></p>

<p>Applications Solriamfetol is a selective dopamine and norepinephrine reuptake inhibitor used in the treatment of sleep apnea and narcolepsy.<br>References Baladi, Michelle G., et al.: J. of Pharmaco. and Exper. Therap., 366(2), 367-376 (2018);Abad, Vivien C., et al.: Expert Rev. of Resp. Med., 12(12), 1007-1019 (2018);Takahashi, Tatsunori, et al.: Exp. Opin. on Orphan Drugs, 6(10), 597-610 (2018)<br></p>

<p>Applications A spasmolytic agent related structurally to Tolperisone (T535475). Muscle relaxant (skeletal).<br>References Catterall, W., et al.: J. Biol. Chem., 256, 892 (1981), Farkas, S., et al.: Br. J. Pharmacol., 114, 1193 (1995), Xing, J., et al: Brain Res., 901, 128 (2001), Sakaue, A., et al.: J. Pharmacol. Sci., 95, 181 (2004),<br></p>

<p>Applications Oxythiamine Diphosphate is an inhibitor of pyruvate dehydrogenase complex.<br>References Zabrodskaya, S. V., et al.: Doklady Akademii Nauk BSSR, 31, 468 (1987), Chiger, M. B., et al.: Vestsi Akademii Navuk Belarusi, Seryya Biyalagichnykh Navuk, 2, 58 (1996), Strumilo, S., et al.: J. Enzyme Inhib., 10, 65 (1995)<br></p>

<p>Applications Labelled Amitrole (A633380). Herbicide; plant regulator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wilson, V., et al.: Toxicol. Sci., 66, 69 (2002), Laville, N., et al.: Toxicology, 228, 98 (2006),<br></p>

<p>Applications A nonsedating type histamine H1-receptor antagonist. Antihistaminic.<br>References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Inomata, N., et al.: J. Dermatol., 36, 224 (2009), Carvajal, A., et al.: Clin. Pharmacol. Ther., 85, 481 (2009), Yamashita, S., et al.: Mol. Pharm., 6, 48 (2009),<br></p>

<p>Applications N-Isopropyl quaternary salt of Atropine. Nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.<br>References Groeben, H., et al.: Anesthesiology, 85, 867 (1996), Haddad, et al.: Br. J. Pharmacol., 127, 413 (1999), Barnes, P. J., et al.: Chest, 117, 63S (2000),<br></p>

<p>Applications Labelled Febuxostat (F229000). Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>

<p>Applications Penoxsulam is an acetolactate synthase inhibitor herbicide developed for controlling grasses, sedges, and broadleaf weeds in rice culture.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jabusch, T., and Tjeerdema, R.: J. Agric. Food Chem. 53, 18, 7179-183 (2005); Bamcjero, M., et al.: Sci. Total Environ. 807, 1, 160793 (2021)<br></p>

<p>Applications Ioxaglic Acid is used as a contrast medium during coronary angiograpy.<br>References Tragardh, B. et al.: Acta. Radiol. Diag., 24, 43 (1983); Sendo, T., et al.: Invest. Radiology, 35, 472 (2000),<br></p>

<p>Applications Insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Devine, G., et al.: Pestic. Sci., 55, 405 (1999), Ahmad, M., et al.: Pest Manag. Sci., 58, 203 (2002), El Kady, H., et al.: Pest Manag. Sci., 59, 865 (2003).<br></p>

<p>Applications N-Desmethyl Imatinib Mesylate is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.<br>References Schindler, T., et al.: Science, 289, 1938 (2000), Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),<br></p>

<p>Applications Tebufenozide is a synthetic nonsteroidal ecdysone agonist used in pesticide formulations (1) that causes premature molting; novel insect growth regulator (2,3,4) specific to lepidopteran species. Drinking water Contaminant Candidate List 3 (CCL3) as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Jordan T, et al.: Anal Bioanal Chem. 2009 Aug;394(8):2257-66 2. Vianna U. Et al.: Ecotoxicology. 2009 Feb;18(2):180-6. 3. Rose, G. et al. Food. Chem. 2009 Dec;117(4) pp634-6404. Wang, J. et al.: J. Agric. Food Chem. 2009 Mar 25;57(6):2162-73.<br></p>

<p>Applications Labelled 1,3-Phenylenediamine (P319835). 1,3-Phenylenediamine is used in the foaming-type hair dye composition.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kano, K., et al.: Biochim. Biophys Acta, 509, 289 (1978), Yu, Z., et al.: Mol. Membr. Biol., 15, 59 (1998),<br></p>

<p>Applications Dimethachlor-d6 is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt-d6 (D460284), which is the deuterium labelled form of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite and pollutant found in groundwater, surface water, and wastewater.<br>References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);<br></p>

<p>Applications Hecogenin, is a sapogenin present in the leaves of species from the Agave genus, possessing wide spectrum of pharmacology activities, such as having antinociceptive properties.<br>References Gama, K. B., et al.: J. Natural Prod., 76, 559 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications m-(Trifluoromethyl)acetophenone Oxime is a reactant in the synthesis of Trifloxystrobin (T778900) which is a broad-spectrum foliar fungicide used in plant protection.<br>References Chen, W., et al.: Huaxue Yanjiu, 25, 16 (2014); Margot, P. et al.: Bright. Crop Prot. Conf. Pest Dis., 2, 375 (1998); Karadimos, D.A. et al.: Crop Prot., 24, 23 (2005); Prom, L.K. et al.: Plant Dis., 87, 252 (2003);<br></p>

<p>Applications Anxiolytic; muscle relaxant (skeletal); anticonvulsant; ligand for the GABAA receptor benzodiazepine modulatory site. Controlled substance (depressant).<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Sisenwine, et al.: Arzneim. Forsch., 22, 682 (1972), Shearer, C.M., et al.: Anal. Profiles Drug Subs., 3, 441 (1974), Greenblatt, D.J., et al.: Clin. Pharmacokinet., 6, 89 (1981),<br></p>

<p>Stability Light Sensitive<br>Applications N-tert-Butyl-3-(2-hydroxypropan-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide is a metabolite of Amicarbazone (A605040); a triazolinone herbicide with a broad spectrum of weed control.<br>References Dayan, F., et al.: Weed Science, 57, 579 (2009); Elmore, M., et al.: Weed Technol., 27, 596 (2013); Dong, M., et al.: J. Sep. Sci., 38, 2245 (2015)<br></p>

<p>Applications Paromomycin Deuterated Acetic Acid Salt is the isotope labelled analog of Paromomycin Sulfate. Paromomycin Sulfate is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis.<br>References Rehg, J.E. et al.: J. Infect. Dis., 170, 934 (1994); Fong, D. et al.: Am. J. Trop. Med. Hyg., 51, 758 (1994); Hafez, H.M. et al.: Arch. Anim. Nut., 64, 77 (2010);<br></p>

<p>Applications Furanylfentanyl is an opiod analgesic agent used which is an analog of Fentanyl (F275000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zernig, G., et al.: Life Sci., 57, 2113 (1995), Bot, G., et al.: J. Pharmacol. Exper. Therap., 285, 1207 (1998),<br></p>

<p>Applications A benzyl halide as postemergence herbicides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Singer, G.M., et al.: J. Med. Chem., 26, 309 (1983),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Tramadol.<br>References Raffa, R., et al.: J. Pharmacol. Exp. Ther., 267, 331 (1993), Pospisilova, M., et al.: J. Pharm. Biomed. Anal., 18, 777 (1998), Scott, L., et al.: Drugs, 60, 139 (2000), Wu, W., et al.: Xenobiotica, 32, 411 (2002),<br></p>

<p>Stability Light Sensitive<br>Applications α-Chlordane is an organochlorine pesticide/insecticide used in the protection of crops from pests.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shoeib, M., et al.: Env. Toxicol. Chem., 21, 984 (2002); Parlar, H. et al.: J. Agric. Food. Chem., 27, 278 (1979);<br></p>

<p>Applications 2-(Trifluoromethyl)benzoyl Chloride is used in the preparation of perfluorinated alkyl carboxanilides as soil insecticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gajewski, R.P., et. al.: J. Agr. Food Chem., 36, 174 (1988)<br></p>

<p>Applications Labelled Cefazolin (C242500). Semi-synthetic antibiotic derived from 7-amino-cephalosporanic acid. An antibacterial.<br>References Kozatani, et al.: Chem. Pharm. Bull., 20, 1105 (1972), Birkhead, H.A., et al.: J. Infect. Dis., 128, 379 (1973), Zappala, A.E., et al.: Anal. Profiles Drug Subs., 4, 1 (1975),<br></p>

<p>Applications Irbesartan-d4 is the labeled analogue of Irbesartan (I751000), an angiotensin II type 1 (AII1)-receptor antagonist.<br>References Gillis, J.C. and Markham, A.: Drugs, 54, 885 (1997); Chando, T.J., et al.: Drug. Metabol. Dispos., 26, 408 (1998); Massie, B., et al.: New Eng. J. Med., 359, 2456 (2008); Ren, X., et al.: Pharmacol., 83, 80 (2009)Aromatics, Heterocycles, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates &amp; Fine Chemicals<br></p>

<p>Stability Hygroscopic<br>Applications Dexon<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-[(4-chlorophenyl)methyl]cyclopentanamine is a useful reagent for the preparation of γ-​lactams.<br>References Fujii, T., et al.: Tetrahedron Letters, 61, 152276 (2020)<br></p>

<p>Applications Pirimicarb-desmethyl is a metabolite of Pirimicarb, which is a carbamate pesticide.<br>References Climent, M., Miranda, M.: J. Chromatogr. A, 738, 225 (1996); Pirisi, F., et al.: J. Agric. Food Chem., 44, 2417 (1996); Blasco, C., et al.: Electrophoresis, 30, 1698 (2009);<br></p>

<p>Stability Volatile<br>Applications PERILLEN (cas# 539-52-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications Haloxyfop-R-methyl-d3 is a labeled analogue of (R)-Haloxyfop Methyl Ester (H104020), which is a herbicide. It is used in the study of reduced rates of the acetyl-co enzyme A carboxylase (ACCase)-inhibiting herbicide.<br>References Neve, P., et al.: Theoretical and Applied Genetics, 110, 1154 (2005); Delye, C., et al.: Pest Management Sci., 58, 474 (2002)<br></p>

<p>Applications Labelled analog of a triazinetrione anticoccidial. Coccidiostat.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eberts, T., et al.: Clin. Chem., 25, 1440 (1979), Goodwin, M., et al.: Avian Dis., 29, 630 (1985), Sorensen, S., et al.: Clin. Chim. Acta, 264, 103 (1997), Conway, D., et al.: Poult. Sci., 280, 426 (2001),<br></p>

<p>Applications 4-[(1-Ethylpropyl)amino]-2-methyl-3,5-dinitro-benzoic Acid is a metabolite of Pendimethalin (P221900), an herbicide used to control the spread of weedgrass.<br>References Haith, D., et al.: Environ. Sci. Technol., 44, 6496 (2010); Jabran, K., et al.: Int. J. Agric. Biol., 12, 335 (2010); Rahaman, S., et al.: Environ. Ecol., 28, 1 (2010); Zulalian, J., et al.: J. Agric. Food Chem., 38, 1743-54 (1990);<br></p>