Nucléotides
Les nucléotides sont des composés organiques qui servent de building blocks aux acides nucléiques, essentiels à la formation de l'ADN et de l'ARN. Chaque nucléotide est composé d'une base azotée, d'une molécule de sucre et d'un ou plusieurs groupes phosphate. Ces nucléotides s'assemblent pour former de longues chaînes, créant le matériel génétique qui porte et transmet l'information génétique dans tous les organismes vivants. Dans cette section, vous trouverez une large gamme de nucléotides essentiels pour la recherche en génétique, biologie moléculaire et biochimie. Ils sont fondamentaux pour étudier les processus génétiques, synthétiser des acides nucléiques et développer des outils diagnostiques et thérapeutiques. Chez CymitQuimica, nous proposons des nucléotides de haute qualité pour soutenir vos recherches scientifiques et applications, garantissant précision et fiabilité dans vos expériences.
Sous-catégories appartenant à la catégorie "Nucléotides"
2637 produits trouvés pour "Nucléotides"
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N6-Methyladenosine-5'-monophosphate sodium
CAS :N6-Methyladenosine-5'-monophosphate sodium is a synthetic nucleoside that has antiviral and anticancer activity. It is an activator of DNA polymerase α, which is involved in the synthesis of DNA. N6-Methyladenosine-5'-monophosphate sodium has been shown to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) in cultured cells and to induce apoptosis in cancer cells. This drug also inhibits the growth of certain bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) or Mycobacterium tuberculosis. N6-Methyladenosine-5'-monophosphate sodium may be used for the treatment of HIV/AIDS or cancer.Formule :C11H16N5O7P·2NaDegré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :407.23 g/mol2'-Deoxy-6-O-methyl-guanosine
CAS :2'-Deoxy-6-O-methyl-guanosine is a methylated nucleoside that has been shown to inhibit protein synthesis in cancer cells. It does so by inhibiting the synthesis of DNA, which is required for the production of proteins. This compound also inhibits monoclonal antibody production, which may be due to its ability to methylate DNA and prevent dna duplexes from being repaired. 2'-Deoxy-6-O-methyl-guanosine is used as a probe in the detection of human proteins by fluorescence spectroscopy. The sensitivity of this probe has been shown to be greater than 10 ng/mL, making it ideal for use in clinical settings where small quantities of proteins are present.
Formule :C11H15N5O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :281.27 g/mol2'-O-Methylcytidine-5'-monophosphate triethylammonium salt
CAS :2'-O-Methylcytidine-5'-monophosphate triethylammonium salt is a synthetic nucleoside that has been shown to be a substrate for DNA polymerase and an inhibitor of RNA synthesis. It has been used in the laboratory as a primer and as a biochemical tool to study viruses. 2'-O-Methylcytidine-5'-monophosphate triethylammonium salt is active against murine leukemia virus, but not against ciliated protozoan parasites such as Tetrahymena pyriformis. This compound has also been shown to inhibit the enzyme form of HIV reverse transcriptase and to be cytotoxic at high concentrations.Formule :C10H16N3O8P•C6H15NDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :438.41 g/mol3'-O-Acetyl-2'-deoxycytidine
CAS :3'-O-acetyl-2'-deoxycytidine is an activator that can be used in the synthesis of deoxyribonucleosides and nucleosides. It is a novel, modified, and high purity chemical entity that has shown anticancer and antiviral properties. 3'-O-acetyl-2'-deoxycytidine is a monophosphate nucleotide, which can be used in the synthesis of various pharmaceuticals. This product has been synthesized using high quality reagents in order to provide the best possible product for research purposes.Formule :C11H15N3O5Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :269.25 g/mol2'-Amino-2'-deoxyuridine
CAS :2'-Amino-2'-deoxyuridine is a modified nucleoside based on uridine. The 2'-hydroxyl group on the sugar is replaced by an amino group. This compound can be used for research purposes
Formule :C9H13N3O5Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :243.22 g/mol5'-Deoxyadenosine
CAS :5'-Deoxyadenosine is a nucleoside that is produced by the enzymatic reaction of glycolaldehyde and ATP. It is found in both DNA and RNA, where it plays an important role in the catalytic subunit of ribonucleotide reductase. 5'-Deoxyadenosine has been shown to be involved in hydrogen bonding with other molecules, such as ethanolamine. It also has a kinetic effect on the enzyme activity of ribonucleotide reductase by forming intramolecular hydrogen bonds with other adenine nucleotides. The analogs of 5'-deoxyadenosine have been shown to inhibit viral replication in cell culture studies using typhimurium virus.Formule :C10H13N5O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :251.25 g/mol2'-Deoxyguanosine-5'-monophosphate disodium salt
CAS :2'-Deoxyguanosine-5'-monophosphate disodium salt is an inorganic compound that has a furanose ring. It is used as a monofunctional building block for the synthesis of nucleotide derivatives. The conformations of 2'-deoxyguanosine-5'-monophosphate disodium salt are experimentally determined by x-ray data, which shows that the molecule adopts a twisted conformation with two possible orientations: one where the 2'OH group is oriented toward the phosphate group, and another where it is oriented away from it. The nature of these conformers can be confirmed by analyzing their x-ray diffraction patterns.Formule :C10H12N5Na2O7PDegré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :391.19 g/molUridine 5'-triphosphate disodium
CAS :Uridine 5'-triphosphate disodium salt is a supramolecular complex that binds to gold nanoparticles. The binding of uridine 5'-triphosphate disodium salt to gold nanoparticles can be used for the detection of metal ions through the photometric method. Uridine 5'-triphosphate disodium salt has been shown to inhibit the glutathione-dependent reduction of vitamin B12, which is a key step in methionine synthesis and folate metabolism. This inhibition may lead to a decrease in protein synthesis, ATP production, and cell division.Formule :C9H15N2O15P3•Na2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :530.12 g/mol2'-Deoxycytidine-5'-monophosphate disodium
CAS :2'-Deoxycytidine-5'-monophosphate disodium (2DdCMP) is a competitive inhibitor of receptor protein tyrosine kinases. It has been shown to inhibit the growth of various human cancer cell lines in vitro and to reduce tumor size in mice bearing transplanted human tumor xenografts. 2DdCMP inhibits the proliferation of cancer cells by interfering with the expression of growth factors that are involved in mitogenesis. This drug also inhibits the growth of new blood vessels, which is essential for tumor formation and progression. 2DdCMP binds to an allosteric site on receptor molecules, thereby blocking the binding site of other proteins such as growth factors and kinases that may be involved in tumorigenesis.Formule :C9H12N3O7PNa2Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :351.16 g/mol1-(5'-O-Benzoyl-2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)thymine
CAS :1-(5'-O-Benzoyl-2'-deoxy-2'-fluoro-β-L-arabinofuranosyl)thymine is a modified nucleoside analog with structural modifications that enhance its biological properties, stability, and pharmaceutical potential. The compound features thymine (5-methyluracil) as the nucleobase, a pyrimidine derivative. The sugar component is 2'-deoxy-2'-fluoro-β-L-arabinofuranose, which includes the L-arabinose configuration, a departure from the natural D-ribose or D-deoxyribose configuration typically found in DNA and RNA, influencing how the molecule is recognized by biological systems. The 2'-fluoro substitution at the sugar position improves the compound's stability and resistance to enzymatic degradation, while also potentially enhancing its antiviral activity. A 5'-O-benzoyl group serves as a protecting group, safeguarding the 5'-hydroxyl group during synthesis.Formule :C17H17FN2O6Degré de pureté :Min. 95%Masse moléculaire :364.33 g/mol2',3'-Dideoxyuridine-5'-triphosphate lithium - 100mM aqueous solution
CAS :2',3'-Dideoxyuridine-5'-triphosphate can be used with uracil DNA glycosylase to minimize PCR carryover contamination and enables the kinetics of deoxyuridine 5′-triphosphate nucleotidohydrolases to be investiagated.Formule :C9H15N2O13P3•LixDegré de pureté :Min. 95%Couleur et forme :Clear LiquidMasse moléculaire :452.14 g/mol6-Thio-9-(β-D-arabinofuranosyl)purine
CAS :6-Thio-9-(b-D-arabinofuranosyl)purine is a purine analog that inhibits the enzyme uridine phosphorylase, which is involved in the metabolism of uridine. It has been shown to inhibit the growth of L1210 cells and also to be effective against subcutaneous tumors in mice. 6-Thio-9-(b-D-arabinofuranosyl)purine is active against schistosomiasis in mice, with an LD50 of 1 mg/kg. This drug has also been shown to have potential antitumor activity and was able to inhibit the growth of human lymphocytes and leukocytes.Formule :C10H12N4O4SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :284.29 g/mol9-(b-D-Arabinofuranosyl)guanine - Bio-X ™
CAS :9-(b-D-Arabinofuranosyl) guanine is a purine nucleoside in which guanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. 9-(b-D-Arabinofuranosyl) guanine binds to the phosphate groups in DNA and inhibits the synthesis of DNA causing cell death. It also has antineoplastic properties.Formule :C10H13N5O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :283.24 g/molInosine 5'-diphosphate trisodium
CAS :Inosine 5'-diphosphate trisodium salt is an antiviral compound that is used to inhibit the replication of many viruses, including herpes, influenza, and HIV. It has been shown to be effective against cancer cells in vitro. Inosine 5'-diphosphate trisodium salt is a modified nucleotide that is used as a phosphoramidite for DNA synthesis. This compound can also be used as an activator for deoxyribonucleoside triphosphates. It has been shown to have anticancer activity in vivo and in vitro and also inhibits viral DNA synthesis by preventing the formation of ribonucleotide triphosphates from ribonucleotides. The molecular weight of this compound is 390.4 g/mol and its CAS number is 81012-88-6.Formule :C10H11N4O11P2•Na3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :494.13 g/mol2'-Azido-2'-deoxyuridine
CAS :2'-Azido-2'-deoxyuridine is a synthetic nucleoside analog of uridine in which the 2'-hydroxyl group on the ribose sugar is replaced with an azido group (–N₃), and the base is unmodified uracil. This modification alters the sugar's conformation and chemical reactivity, enabling the use of this analog in bioorthogonal labeling strategies, particularly through azide-alkyne "click" chemistry. Its incorporation into nucleic acids can influence polymerase recognition and chain elongation, making it a useful probe in studies of RNA synthesis, structure, and function.Formule :C9H11N5O5Degré de pureté :Min. 98 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :269.21 g/molAcetyl hypoxanthine
CAS :Acetyl hypoxanthine is an inorganic compound that has a cyclophosphate group. It can be synthesized from the reaction of acetic acid and 6-chloropurine, which is activated with trifluoroacetic acid and irradiated with ultraviolet light. Acetyl hypoxanthine can then be synthesized by ammonolysis of chloroacetone using ammonia or by chlorinating acetylene with chlorine. The advantages of this compound are its high yield and low cost.Formule :C7H6N4O2Degré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :178.15 g/molCladribine
CAS :Deoxyadenosine analog resistant to adenosine deaminase
Formule :C10H12ClN5O3Degré de pureté :Min. 97 Area-%Couleur et forme :PowderMasse moléculaire :285.69 g/molGemcitabine base
CAS :Gemcitabine is a prodrug that is converted to 5-fluorouracil (5FU) in the body. It has been shown to inhibit the growth of bladder and pancreatic cancer cells by interfering with the synthesis of DNA. Gemcitabine inhibits DNA replication by binding to the epidermal growth factor receptor, which leads to cell death. Gemcitabine also acts as a competitive inhibitor of deoxycytidine kinase, which prevents the formation of deoxycytidine monophosphate from deoxyuridine monophosphate, preventing DNA replication. In addition, gemcitabine can activate apoptosis in some tumor cells by increasing levels of intracellular free calcium, which leads to activation of enzymes such as phospholipases and proteases that degrade proteins, lipids, and nucleic acids.Formule :C9H11F2N3O4Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :263.2 g/mol2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium
2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium is a fluorinated nucleotide analog used in biochemical and medicinal researchFormule :C9H12FN2O8P•C6H15NDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :427.36 g/molDihydrozeatin riboside
CAS :Dihydrozeatin riboside is a cytokinin, a group of plant hormones that regulate various aspects of plant growth and development. It is found in the form of an ester, dihydrozeatin riboside, which is produced by the action of trifluoroacetic acid on zeatin. The natural function of this hormone is to stimulate cell division in plants, but it has also been shown to have antibacterial effects against bacterial strains such as Bacillus subtilis and Escherichia coli. Dihydrozeatin riboside inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reductionFormule :C15H23N5O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :353.37 g/molN4-Benzoylcytidine
CAS :N4-Benzoylcytidine is a nucleoside that is used as part of the synthesis of the antiviral drug acyclovir. It is synthesized by reacting uridine with benzoyl chloride in a solid-phase synthesis. N4-Benzoylcytidine has shown to inhibit the growth of virus type-1 and other viruses, including those that cause herpes simplex and varicella zoster. This nucleoside also inhibits epidermal growth factor (EGF) and is a hybridization probe for human immunodeficiency virus (HIV). The benzoate group on this compound reacts with hydroxyl groups on proteins, which may be why it has been shown to stimulate epidermal growth in mammalian cells.Formule :C16H17N3O6Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :347.32 g/mol5'-Ethylcarboxamidoadenosine
CAS :5'-Ethylcarboxamidoadenosine (5-ECA) is an adenosine receptor antagonist that is used as a radioligand to study the binding of adenosine and other nucleotides to their receptors. 5-ECA binds to the A3 receptor, which is a member of the G protein-coupled receptor family. This compound also inhibits platelet aggregation and has been shown to have anti-inflammatory effects in mice with colon cancer. 5-ECA was found to inhibit tumor growth in a mouse model system by suppressing IL-2 production and reducing levels of PGE2, an effect that may be due to inhibition of cyclase activity. 5-ECA can be used in vitro for studies on pluripotent cells because it does not affect their ability to differentiate.Formule :C12H16N6O4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :308.29 g/mol5-Iodo-2'-O-methyluridine
CAS :5-Iodo-2'-O-methyluridine is a novel antiviral drug that inhibits replication of DNA and RNA viruses. It is chemically synthesized from 2' deoxyuridine monophosphate, which is modified to create the 5-iodo derivative. The modification at the 5th position of the uracil ring prevents the incorporation of methylation into DNA and RNA, which can lead to cancerous growths. This compound has been shown to be an excellent activator for DNA synthesis in vitro. It has also been shown to have anticancer properties in vitro and in vivo.Formule :C10H13IN2O6Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :384.12 g/molAcetyl coenzyme A trilithium
CAS :Acetyl coenzyme A trilithium salt (ACAT) is a prodrug that is metabolized in vivo to the active form, acetyl coenzyme A. Acetyl coenzyme A has been shown to inhibit the growth of human carcinoma cells and some typhimurium strains. It binds to cytochrome P450, which is involved in the oxidation of acetate and other organic substrates. ACAT has also been shown to be effective against squamous cell carcinoma by inhibiting the production of reactive oxygen species (ROS) in these cells. The anticancer activity of ACAT may be due to its ability to inhibit the conversion of amines into heterocyclic amines, which are known carcinogens.Formule :C23H35Li3N7O17P3SDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :827.37 g/mol5'-Deoxy-5'-(methylthio)adenosine
CAS :5'-Deoxy-5'-(methylthio)adenosine is a nucleoside that has been shown to inhibit the growth of bowel cancer cells. 5'-Deoxy-5'-(methylthio)adenosine blocks the synthesis of DNA and RNA by inhibiting the action of enzymes involved in DNA metabolism. It also inhibits methionine synthase and phosphorylase, which are involved in protein synthesis. This compound has been shown to be effective in treating cancer tissues due to its ability to inhibit polymerase chain reactions and prevent the formation of cancerous cells.Formule :C11H15N5O3SDegré de pureté :(Hplc-Ms) Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :297.34 g/mol2-Iodoadenosine
CAS :2-Iodoadenosine is a chemical compound that is produced from the oxidation of uridine. It is used in the synthesis of peptides, which are important for biological processes like signal transduction and cell growth. 2-Iodoadenosine can be made by coupling other molecules to an adenosine molecule. This process involves a cross-coupling reaction with palladium catalysts or hydroxylation reactions with sodium borohydride. The resulting product has been shown to have anticancer and anti-microbial activities against protozoan parasites and cyclic peptide structures.Formule :C10H12IN5O4Degré de pureté :Min. 97 Area-%Couleur et forme :PowderMasse moléculaire :393.14 g/mol3'-Amino-3'-deoxycytidine
CAS :It is an antiviral agent that inhibits the replication of RNA viruses by acting as a chain terminator during RNA synthesis. It is also a valuable research tool for studying viral replication mechanisms and is being explored for potential anticancer properties.Formule :C9H14N4O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :242.23 g/mol3'-O-Acetylthymidine
CAS :3'-O-Acetylthymidine is a dinucleoside analogue of thymidine. It has been used as a model for human immunodeficiency virus (HIV) and has been shown to be resistant to HIV infection in vitro. 3'-O-Acetylthymidine inhibits the synthesis of protein by binding to the ribosomal RNA of the host cell, preventing the formation of an aminoacyl-tRNA synthetase complex with tRNA. This prevents the incorporation of amino acids into proteins, leading to inhibition of protein synthesis and cell death. 3'-O-Acetylthymidine also inhibits HIV replication by competing with deoxycytidine triphosphate for incorporation into DNA, preventing the synthesis of viral DNA. 3'-O-Acetylthymidine is hydrolyzed by esterases or glucuronidases, oxidized by cytochrome P450 enzymes, reduced by glutathione reductaseFormule :C12H16N2O6Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :284.27 g/molN4-Methyl-2'-O-methyl-cytidine
CAS :N4-Methyl-2'-O-methyl-cytidine is a nucleoside analog that is used as an antibiotic. The ribosomal RNA in prokaryotes has been found to be sensitive to this drug, which inhibits protein synthesis by reversibly binding to the 50S subunit of the ribosome and inhibiting translocation. N4-Methyl-2'-O-methyl-cytidine also binds to the ribonucleoprotein in eukaryotic cells, blocking translation of mRNA into proteins. N4-Methyl-2'-O-methyl-cytidine is effective against Gram positive bacteria, such as Staphylococcus aureus and Clostridium perfringens, while being inactive against Gram negative bacteria. This drug has a molecular weight of 197 and can be broken down into low molecular weight fragments or high molecular weight fragments.Formule :C11H17N3O5Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :271.27 g/mol3'-Azido-3'-deoxycytidine
CAS :3'-Azido-3'-deoxycytidine is a nucleoside analogue that is used in research. It is an analog of cytosine, with an azido group at the 3' position. 3'-Azido-3'-deoxycytidine has been shown to be effective against HIV-1 and HIV-2, although it has not been approved for use in humans. Research into the effects of this drug has demonstrated that it inhibits both DNA and RNA synthesis by interacting with nucleic acid polymerases. This leads to cell death by inhibiting the production of proteins vital for cell division.Formule :C9H12N6O4Degré de pureté :Min. 95%Masse moléculaire :268.23 g/mol6-Azauridine-5'-monophosphate
CAS :6-Azauridine-5'-monophosphate (6-AU) is a compound that is synthesized by the enzyme Azoarcus sp. 6-AU synthetase and is a precursor to azauridine, an intermediate in the biosynthesis of purines. It has been shown to inhibit bacterial growth in tissue culture and depression in mice. The kinetic data were obtained using a titration calorimetry assay at 25 degrees Celsius using subtilis. This drug also has convulsant effects on animals and can cause orotic aciduria when administered orally in high doses. 6-AU has been shown to be effective against cancer cells as well as infectious diseases such as tuberculosis and malaria.
Formule :C8H12N3O9PDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :325.17 g/molUridine
CAS :Glycosylated pyrimidine analog; RNA componentFormule :C9H12N2O6Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :244.2 g/mol3'-O-(t-Butyldimethylsilyl)-2'-O-(2-methoxyethyl)-5-methyluridine
CAS :3'-O-(t-Butyldimethylsilyl)-2'-O-(2-methoxyethyl)-5-methyluridine is a novel, modified monophosphate nucleoside that can be activated to the corresponding diphosphate by adenosine kinase. The antiviral activity of 3'-O-(t-Butyldimethylsilyl)-2'-O-(2-methoxyethyl)-5-methyluridine has been demonstrated in vitro and in vivo against various viruses including HIV. In addition, this nucleoside phosphoramidite is used for synthesizing DNA and RNA. This product is CAS No. 1221967-92-5, Phosphoramidites, High purity and has a high quality.Formule :C19H34N2O7SiDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :430.57 g/molTenofovir disoproxil
CAS :Anti-viral; reverse transcriptase inhibitor
Formule :C19H30N5O10PDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :519.44 g/molN6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine
CAS :N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine is a sulfur containing compound that is an antibiotic. It has been shown to inhibit the growth of bacteria by binding to their ribosomes, which prevents protein synthesis and cell division. N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine also inhibits chemotaxis in roseobacters, which is the movement of cells or organisms in response to certain factors. This antibiotic may be useful for preventing symbiosis between marine bacteria and other organisms, as it inhibits the motility of these bacteria and their cycling. N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine also has a genetic determinant that regulates enteric bacteria and clades of ocean bacteria.Formule :C38H34FN5O6Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :675.72 g/mol2'-Amino-2'-deoxyinosine
CAS :2'-Amino-2'-deoxyinosine is a modified nucleoside, based on inosine. This compound has a 2'-amino substitution instead of a 2'-hydroxyl group, which has the potential to make the nucleoside more resistant to enzymatic degradation and enhance or alter base-pairing properties.Formule :C10H13N5O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :267.24 g/molN4-Benzoyl-2'-deoxy-5'-O-DMT-a-cytidine
CAS :N4-Benzoyl-2'-deoxy-5'-O-DMT-a-cytidine is a modified nucleoside that is synthesized by the reaction of the 2'-deoxyribonucleoside with 4-benzoylchloroformate and dimethoxytrityl. It has antiviral activity against a variety of DNA viruses, including herpes simplex virus type 1 (HSV), herpes simplex virus type 2 (HSV), varicella zoster virus, human cytomegalovirus, Epstein Barr virus, and human immunodeficiency virus. N4-Benzoyl-2'-deoxy-5'-O-DMT-a-cytidine also has anticancer properties and may be used for the treatment of melanoma. This compound shows good results in animal models and clinical trials.Formule :C37H35N3O7Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :633.71 g/molCytidine 3'(2’)-monophosphate
CAS :Cytidine 3’(2’)-monophosphate (CMP) is a biochemical substance that is found in the nucleic acids of cells. It is an equilibrative nucleoside and a precursor to the biosynthesis of uridine and cytidine. CMP is also an intermediate in the synthesis of the coenzyme tetrahydrofolate, which has been shown to inhibit the growth of antibiotic-resistant strains such as Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, and Enterobacter cloacae. Cytidine 3’(2’)-monophosphate can be converted into cytidine by phosphorylation with ATP or by methylation with S-adenosylmethionine. Cytidine 3’(2’)-monophosphate has been shown to have polymerase chain reaction activityFormule :C9H14N3O8PDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :323.2 g/mol2'-C-Methylguanosine
CAS :2'-C-Methylguanosine is a synthetic nucleoside analog of guanosine, modified at the 2'-carbon of the ribose sugar with a methyl group. This modification changes the molecule's biological behavior, making it potential useful in antiviral research and biochemical studies, especially those involving RNA synthesis.Formule :C11H15N5O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :297.27 g/mol5'-O-Benzoyl-2'-deoxy-N2-isobutyrylguanosine
CAS :5'-O-Benzoyl-2'-deoxy-N2-isobutyrylguanosine is a novel nucleoside that is synthesized by the modification of 5'-O-benzoyl-2'-deoxyguanosine with 2',3' -diisobutyrylaminopropylidene. It has shown anticancer, antiviral, and antiretroviral properties in vitro. In addition, this compound has been shown to inhibit the growth of human leukemia cells in vivo in a dose dependent manner. The structure of 5'-O-benzoyl-2'-deoxy-N2-isobutyrylguanosine is similar to that of the natural nucleosides adenosine and guanosine.Formule :C21H23N5O6Degré de pureté :Min. 97 Area-%Couleur et forme :Off-White PowderMasse moléculaire :441.45 g/mol5-Chloro-2'-deoxycytidine
CAS :5-Chloro-2'-deoxycytidine (5-Cl-dC) is a nucleoside analog that inhibits DNA synthesis by blocking the action of thymidylate synthase. It can be used in animal models to study bowel diseases, such as ulcerative colitis and Crohn's disease. 5-Cl-dC has been shown to be effective in treating the effects of radiation and chemical toxicity in HL60 cells, a type of human leukemia cell line. 5-Cl-dC has also been shown to enhance the cytotoxicity of eosinophil peroxidase, which is an enzyme that may be involved in the pathogenesis of asthma. This drug is currently being evaluated for its safety and efficacy in clinical trials involving patients with myelodysplastic syndrome or acute myeloid leukemia who are at risk for developing leukemia.
Formule :C9H12CIN3O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :261.67 g/mol5-Aminoallyl 2'-deoxyuridine 5'-triphosphate lithium salt - 100mM aqueous solution
CAS :5-Aminoallyl 2'-deoxyuridine 5'-triphosphate lithium salt - 100mM aqueous solution is a novel nucleoside analog with antiviral and anticancer activity. It has been shown to inhibit the replication of HIV-1 in human peripheral blood mononuclear cells and to inhibit tumor growth in mice. This drug also inhibits DNA synthesis, which may be due to its ability to inhibit ribonucleotide reductase and deoxynucleotide reductase, enzymes that are necessary for DNA synthesis.Formule :C12H20N3O14P3·xLiDegré de pureté :Min. 95%Couleur et forme :Colorless PowderMasse moléculaire :523.22 g/molN4-Acetyl-2'-deoxy-5-methylcytidine
N4-Acetyl-2'-deoxy-5-methylcytidine is a novel nucleoside analog of cytidine. It has been shown to be an activator of the immune system, and has antiviral and anticancer properties. This synthetic nucleoside is phosphorylated by kinases in cells to form N4-acetyl-2'-deoxy-5'-methyluridine monophosphate. The phosphate group can be removed by phosphatases in cells to yield N4-acetyl-2'-deoxycytidine, which is a precursor for DNA synthesis.
Formule :C12H17N3O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :283.28 g/mol5-Aminouridine hydrochloride
CAS :5-Aminouridine hydrochloride is a novel nucleoside that is an inhibitor of RNA polymerase. It has been shown to be active against cancer cells, and is also effective in the treatment of viral infections such as HIV and hepatitis B. 5-Aminouridine hydrochloride is synthesized by reacting uracil with ammonia and hydrogen chloride. The product can be used as a building block for monophosphate or diphosphate analogs, which are important components in the synthesis of DNA and RNA. This product is available at high purity with low impurity levels.Formule :C9H14ClN3O6Degré de pureté :(%) Min. 95%Couleur et forme :PowderMasse moléculaire :295.68 g/mol2'-O-tert-Butyldimethylsilyl-5'-O-DMT-1-methylguanosine 3'-CE phosphoramidite
CAS :2'-O-tert-Butyldimethylsilyl-5'-O-DMT-1-methylguanosine 3'-CE phosphoramidite is a synthetic, antiviral monophosphate nucleoside. It is an activator that increases the activity of other nucleosides and can be used in DNA synthesis by incorporation into DNA molecules. 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-1-methylguanosine 3'-CE phosphoramidite has been shown to be effective against Hepatitis C virus, Human Immunodeficiency Virus 1 (HIV), and Herpes Simplex Virus 1.Formule :C47H64N7O8PSiDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :914.11 g/mol5'-Amino-5'-deoxyguanosine
CAS :5'-Amino-5'-deoxyguanosine (5-ADG) is an intermediate in the de novo synthesis of guanine nucleotides. It can be synthesized from 5-aminoimidazole ribonucleotide and guanosine monophosphate (GMP). 5-ADG is a substrate for the enzyme GTP cyclohydrolase, which converts it to GMP. This intermediate can also be formed by the action of phosphoryl chloride on 5-aminoimidazole ribonucleotide. The reaction of 5-ADG with malonic acid leads to the formation of inosinic acid, which has been postulated to be a precursor of purines. This conversion is catalyzed by adenylosuccinate synthetase and the enzyme adenylosuccinase.Formule :C10H14N6O4Degré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :282.26 g/molN6,2'-O-Dibutyryladenosine-3',5'-cyclic monophosphate sodium
CAS :N6,2'-O-Dibutyryladenosine-3',5'-cyclic monophosphate sodium (DB-cAMP) is a cyclic nucleoside that has been shown to promote dopaminergic neuron differentiation. It is commonly used in research studies involving the differentiation of induced pluripotent stem cell (iPSC)-derived neurons. This compound acts by activating intracellular signaling pathways that are involved in neuronal development and function. Its ability to enhance dopaminergic neuron differentiation makes it a valuable tool for researchers studying neurodegenerative diseases and exploring potential treatments.Formule :C18H23N5O8PNaDegré de pureté :Min. 95 Area-%Couleur et forme :Off-White PowderMasse moléculaire :491.38 g/mol2'-Deoxy-5'-O-DMT-2'-fluoro-N2-isobutyrylguanosine
CAS :2'-Deoxy-5'-O-DMT-2'-fluoro-N2-isobutyrylguanosine is a synthetic nucleoside. It is an activator for DNA synthesis and has anticancer, antiviral and antifungal properties. This product can be used as a reagent in the synthesis of DNA or RNA. This compound also has high purity and high quality.Formule :C35H36FN5O7Degré de pureté :Min. 95%Couleur et forme :Off-White PowderMasse moléculaire :657.7 g/molZidovudine
CAS :Inhibitor of reverse transcriptaseFormule :C10H13N5O4Degré de pureté :Min. 95%Couleur et forme :Off-White PowderMasse moléculaire :267.24 g/mol8-Aminoadenosine
CAS :8-Aminoadenosine can be used to study the mitochondrial membrane potential, a critical cellular function in which ATP levels are maintained by oxidative phosphorylation. 8-Aminoadenosine is one of the few drugs that have been shown to increase ATP levels in cells. It does this by increasing the permeability of mitochondria membranes and the rate of electron transport from complex I to complex II. The reaction mechanism is thought to involve an intramolecular hydrogen transfer from NADH to 8-aminoadenosine, forming an unstable intermediate that undergoes a conformational change that enables it to react with oxygen. 8-Aminoadenosine has been shown as an effective treatment for certain autoimmune diseases and resistant breast cancer. It also has anti-inflammatory effects, as well as receptor activity against HIV infection and Toll-like receptors.Formule :C10H14N6O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :282.26 g/mol
