Nucléotides
Les nucléotides sont des composés organiques qui servent de building blocks aux acides nucléiques, essentiels à la formation de l'ADN et de l'ARN. Chaque nucléotide est composé d'une base azotée, d'une molécule de sucre et d'un ou plusieurs groupes phosphate. Ces nucléotides s'assemblent pour former de longues chaînes, créant le matériel génétique qui porte et transmet l'information génétique dans tous les organismes vivants. Dans cette section, vous trouverez une large gamme de nucléotides essentiels pour la recherche en génétique, biologie moléculaire et biochimie. Ils sont fondamentaux pour étudier les processus génétiques, synthétiser des acides nucléiques et développer des outils diagnostiques et thérapeutiques. Chez CymitQuimica, nous proposons des nucléotides de haute qualité pour soutenir vos recherches scientifiques et applications, garantissant précision et fiabilité dans vos expériences.
Sous-catégories appartenant à la catégorie "Nucléotides"
2634 produits trouvés pour "Nucléotides"
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Adenosine 5'-monophosphate monohydrate
CAS :Adenosine 5'-monophosphate monohydrate (AMP) is a nucleotide that is released by cells in response to various stimuli. It is involved in the regulation of metabolic rate, cell death, and inflammatory responses. AMP may also act as a mediator of opioid-induced analgesia. AMP has been shown to inhibit the production of pro-inflammatory cytokines in activated macrophages and to reduce nociception at high doses. This drug also has an effect on blood pressure and may be used for the treatment of hypertension.Formule :C10H14N5O7P•H2ODegré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :365.24 g/molAllopurinol riboside
CAS :<p>Allopurinol riboside is a hydroxyl analog of allopurinol. Allopurinol riboside has minimal toxicity in tissue culture and exhibits no cytotoxicity in human serum. It is a potent inhibitor of microbial infection, including infections caused by Hepatitis C virus (HCV), Leishmania amazonensis, and Mycobacterium tuberculosis. Allopurinol riboside binds to adenine nucleotide and inhibits the synthesis of purines, which are necessary for DNA replication. This binding also inhibits the production of ATP, leading to cell death. In addition, allopurinol riboside inhibits the growth of human macrophages in vitro by inhibiting protein synthesis. Allopurinol riboside may be useful for treating HCV-induced liver disease or leishmaniasis.</p>Formule :C10H12N4O5Degré de pureté :Min. 97 Area-%Couleur et forme :White PowderMasse moléculaire :268.23 g/mol8-Aza-7-deaza-2'-deoxyadenosine
CAS :<p>8-Aza-7-deaza-2'-deoxyadenosine is a single-stranded DNA analogue that is used as a conjugate to deliver drugs to cells. It has been shown to be effective in the treatment of HIV by suppressing viral replication and the production of infectious virions. The drug is photolabile, which means it can be activated with light and then delivered to cells. 8-Aza-7-deaza-2'-deoxyadenosine has also been shown to inhibit the growth of human immunodeficiency virus (HIV) in vitro, but does not inhibit the growth of other viruses such as herpes simplex virus type 1 or adenovirus.</p>Formule :C10H13N5O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :251.24 g/mol2,2'-Anhydrothymidine
CAS :<p>2,2'-Anhydrothymidine is an anhydro version of thymidine. As 2,2'-Anhydrothymidine is a modified version of thymidine it can help researchers understand what happens when DNA is changed or damaged. Other possible uses as in research related to antiviral drug creation.</p>Formule :C10H12N2O5Degré de pureté :Min. 95%Couleur et forme :White Off-White PowderMasse moléculaire :240.21 g/mola-Adenosine
CAS :<p>a-Adenosine is a nucleoside that has been shown to have anti-cancer properties. It inhibits the proliferation of squamous carcinoma cells by irreversibly inhibiting adenosine deaminase, which converts adenosine to inosine, as well as other enzymes such as DNA polymerase and ribonucleotide reductase. The reaction mechanism for this inhibition is not yet fully understood, but it may be related to the inhibition of camp levels or receptor activity. a-Adenosine has also been shown to have anti-microbial properties against bacteria, fungi and yeast. It inhibits the growth of these microorganisms by binding to their cell walls and preventing protein synthesis. This drug is rapidly hydrolyzed in vivo and has an antimicrobial effect at physiological concentrations.<br>A more potent analog of a-adenosine (a-adenosinium) has been developed that can inhibit epidermal growth factor (EGF).</p>Formule :C10H13N5O4Degré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :267.24 g/mol2'-O-Allyluridine
CAS :2'-O-Allyluridine is a nucleoside analogue that contains a 2'-hydroxyl group and an allyl group. It is synthesized from the nucleoside uridine by the process of allylation. The regiospecificity of the allylation reaction has been analysed and it has been found that the amino function on the uridine reacts with an allylic hydrogen bond to form 2'-O-allyluridine. The synthesis of 2'-O-allyluridine was successful in laboratory conditions, but not under physiological conditions. Research into this compound is still ongoing as it may have potential applications in the treatment of various diseases, such as cancer.Formule :C12H16N2O6Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :284.27 g/mol2,2'-Anhydro-L-uridine
CAS :<p>2,2'-Anhydro-L-uridine is a nucleoside used in for research purposes. It is of particular interest due to it being an L-isomer which is different from the D-form sugars used by the human body. It is useful to study these kinds of molecules for their use in medicine, especially as antivirals</p>Formule :C9H10N2O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :226.19 g/mol2'-Deoxyguanosine monohydrate
CAS :<p>2'-Deoxyguanosine monohydrate is a nucleoside that has been shown to inhibit the synthesis of DNA in human cells. It has also been shown to have a role in the regulation of energy metabolism and mitochondrial functions. 2'-Deoxyguanosine monohydrate binds to the enzyme polymerase chain reaction, which prevents the reverse transcription process from occurring. This nucleoside is involved in the biological studies of cytokine production, such as IL-2 receptor binding and calcium pantothenate-dependent activation of nuclear DNA replication.</p>Formule :C10H13N5O4·H2ODegré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :285.26 g/mol8-azido-ATP sodium salt - 10mM aqueous solution
CAS :<p>8-Azidoadenosine 3',5'-cyclic monophosphosphate is used for nucleotide labelling via a click reaction involving the azide moiety and a terminal alkyne conjugated to a label. The reaction generates a stable nucleotide labelled adduct containing a triazole link.</p>Formule :C10H12N8O13P3·Na3Degré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :614.14 g/mol3'-Amino-2',3'-dideoxyadenosine
CAS :<p>3'-Amino-2',3'-dideoxyadenosine's lack of a 3'-hydroxyl group makes it a chain terminator for DNA polymerase, a key application in Sanger sequencing. Additionally, the 3'-amino group serves as a functional handle for modifying the 3' end of oligonucleotides with various labels or conjugates, expanding their utility in research and diagnostics.</p>Formule :C10H14N6O2Degré de pureté :Min. 98.0 Area-%Couleur et forme :White PowderMasse moléculaire :250.26 g/mol3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine
CAS :3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine is a deoxyribonucleoside that is chemically modified to be resistant to nucleases. It is used as an antiviral agent and activates the immune system by inducing cytokines, chemokines, and interferons. 3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine has been shown to have antidepressant effects in mice and rats. This drug also has been shown to inhibit the production of HIV viral particles in vitro.Formule :C41H51N5O8SiDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :769.96 g/mol2'-Deoxy-8-oxoguanosine
CAS :<p>2'-Deoxy-8-oxoguanosine (8-OHdG) is a product of oxidative DNA damage. The presence of 8-OHdG in urine has been used to detect and measure the degree of oxidative DNA damage in humans and animals, which may be linked to cancer and aging. When 8-OHdG is excreted into urine, it can react with other molecules such as protein or inorganic phosphorus, causing more oxidative DNA damage. 2'-Deoxy-8-oxoguanosine has also been shown to cause cell toxicity by damaging the cell's squamous epithelium, leading to cancer.For the 15N5 labelled version please check ND09970.</p>Formule :C10H13N5O5Degré de pureté :Min. 95 Area-%Couleur et forme :White PowderMasse moléculaire :283.25 g/mol1-(2’-Deoxy-2’-fluoro-arabinofuranosyl)-5-hydroxymethyluracil
CAS :<p>1-(2’-Deoxy-2’-fluoro-arabinofuranosyl)-5-hydroxymethyluracil (also abbreviated as FMAU-OH) is a modified nucleoside analog. It consists of a fluorinated sugar moiety (2’-deoxy-2’-fluoro-arabinofuranose) attached to a uracil base with a hydroxymethyl (-CH₂OH) group at the 5-position. The 2’-fluoro substitution and arabinose sugar configuration can enhance its stability and affect its incorporation into DNA or RNA. It has the potential to be used as an inhibitor of viral polymerases and can be used in research.</p>Formule :C10H13FN2O6Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :276.22 g/mol5'-O-Acetyl-2'-deoxy-2',2'-difluorocytidine
<p>5'-O-Acetyl-2'-deoxy-2',2'-difluorocytidine is a novel nucleoside that can be used as an antiviral and anticancer agent. It has shown to be more potent than other nucleosides in inhibiting the synthesis of viral DNA and RNA, which makes it a potential candidate for treating HIV infection and cancer. This drug can also act as an activator by stimulating the production of deoxyribonucleotides and ribonucleotides. 5'-O-Acetyl-2'-deoxy-2',2'-difluorocytidine has been shown to have high purity and quality, making it a good candidate for use in various fields of research.</p>Formule :C11H13F2N3O5Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :305.23 g/molIsoguanosine hydrate
CAS :<p>An isomer of guanosine, used as a synthesis intermediate.</p>Formule :C10H13N5O5·xH2ODegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :283.24 g/mol2'-Deoxyadenosine-5'-monophosphate free acid
CAS :2'-Deoxyadenosine-5'-monophosphate free acid (2DAMP) is a nucleoside analogue that can be used as a fluorescent probe for detecting water vapor. 2DAMP has been shown to have cytotoxic activity against solid tumours in vitro, and may act by hydrogen bonding interactions with the active site of the enzyme form. 2DAMP is also an important cofactor in the polymerase chain reaction, and can inhibit cellular proliferation by inhibiting nuclear DNA synthesis. This drug has been used as an active antiretroviral therapy, where it inhibits HIV-1 reverse transcriptase. 2DAMP's mechanism of action involves the inhibition of p-nitrophenyl phosphate reductase (PNPPR), which is responsible for converting p-nitrophenyl phosphate into p-nitrophenol.Formule :C10H14N5O6PDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :331.23 g/molN6-Isopentenyladenosine-5'-monophosphate disodium
CAS :<p>N6-Isopentenyladenosine-5'-monophosphate sodium salt is an adenosine conjugate acid. It is a monomer of polyribonucleotide chain, which is necessary for the formation of ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). N6-Isopentenyladenosine-5'-monophosphate sodium salt is a conjugate base that has the ability to bind to DNA. This binding prevents the formation of a complex with RNA polymerase, thereby inhibiting transcription and replication.</p>Formule :C15H22N5O7P•Na2Degré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :461.32 g/molAdenosine 3',5'-cyclic monophosphate
CAS :<p>Second messenger in intracellular signal transduction</p>Formule :C10H12N5O6PDegré de pureté :(%) Min. 95%Couleur et forme :White PowderMasse moléculaire :329.21 g/molClevudine
CAS :<p>Clevudine is a synthetic pyrimidine analogue effective against the hepatitis B virus (HBV). Once inside the cell, it is converted into its active forms, clevudine monophosphate and clevudine triphosphate. The triphosphate form competes with thymidine to be incorporated into viral DNA, leading to DNA chain termination and inhibition of the HBV DNA polymerase (reverse transcriptase). Due to its long half-life, clevudine significantly reduces covalently closed circular DNA (cccDNA), making relapse less likely after treatment ends.</p>Formule :C10H13FN2O5Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :260.22 g/mol9-(b-D-Arabinofuranosyl)hypoxanthine
CAS :<p>9-(b-D-Arabinofuranosyl)hypoxanthine is a glycosylated analogue of the incretin hormone glucagon-like peptide-1 (GLP-1). It has been shown to inhibit Streptococcus pyogenes and other bacteria. 9-(b-D-Arabinofuranosyl)hypoxanthine has also been shown to have inhibitory properties against zirconium oxide, pulmonary vasodilation, squamous cell carcinoma, and rate constant. This drug has not been studied in clinical trials for antiviral prophylaxis or arabinoside. The only known side effects are drug interactions with cyclin D2 and nitrate reductase.</p>Formule :C10H12N4O5Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :268.23 g/mol
