Nucléotides
Les nucléotides sont des composés organiques qui servent de building blocks aux acides nucléiques, essentiels à la formation de l'ADN et de l'ARN. Chaque nucléotide est composé d'une base azotée, d'une molécule de sucre et d'un ou plusieurs groupes phosphate. Ces nucléotides s'assemblent pour former de longues chaînes, créant le matériel génétique qui porte et transmet l'information génétique dans tous les organismes vivants. Dans cette section, vous trouverez une large gamme de nucléotides essentiels pour la recherche en génétique, biologie moléculaire et biochimie. Ils sont fondamentaux pour étudier les processus génétiques, synthétiser des acides nucléiques et développer des outils diagnostiques et thérapeutiques. Chez CymitQuimica, nous proposons des nucléotides de haute qualité pour soutenir vos recherches scientifiques et applications, garantissant précision et fiabilité dans vos expériences.
Sous-catégories appartenant à la catégorie "Nucléotides"
2634 produits trouvés pour "Nucléotides"
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5-Carboxyhydroxymethyluridine
CAS :<p>5-Carboxyhydroxymethyluridine is a hydroxylated nucleoside that is used to study DNA repair. It is a nucleotide analogue that has been modified at the hydroxyl group by methylation. 5-Carboxyhydroxymethyluridine can be converted back to uridine by escherichia coli hydroxylases, but this conversion does not occur in vivo. 5-Carboxyhydroxymethyluridine can be used as a substrate for methyltransferase enzymes, which are involved in DNA repair. The enzyme 5'-methylthioadenosine phosphorylase converts 5-carboxyhydroxymethyluridine into S-adenosylhomocysteine and adenine. This conversion can be reversed by the enzyme methionine synthase. Some homologues of 5-carboxyhydroxymethyluridine have been found in nature and other modifications have been made on the</p>Formule :C11H14N2O9Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :318.24 g/mol5'-O-DMT-2'-O-methylcytidine
CAS :<p>5'-O-DMT-2'-O-methylcytidine is a monophosphate nucleoside of cytidine. It is used as an antiviral agent and has been shown to have anticancer effects in vitro. 5'-O-DMT-2'-O-methylcytidine is synthesized by modification of the natural deoxyribonucleosides, which are then phosphoramidited to form a 5'-O-DMT-2'-O-methylcytidine monophosphate. The synthesis process also produces diphosphate and triphosphate forms of the nucleoside, which can be used for other purposes.</p>Formule :C31H33N3O7Degré de pureté :Min. 95%Masse moléculaire :559.61 g/molGlycinamide ribonucleotide
CAS :<p>Glycinamide ribonucleotide (GAR) is a reactive metabolite that is formed from glycinamide, which is an intermediate in the synthesis of purines. GAR has been shown to bind to intracellular targets and inhibit their enzyme activities. GAR has been shown to inhibit the activity of enzymes that are involved in the synthesis of purines, such as ribonucleotides and nucleoside phosphates. These enzymes have been found in human tissues. GAR also inhibits the polymerase chain reaction (PCR) by binding to DNA and inhibiting its replication. This drug has also been shown to be effective against bowel disease by binding to bacterial dna gyrase, dna topoisomerase, and rna synthesis.</p>Formule :C7H15N2O8PDegré de pureté :Min. 80 Area-%Couleur et forme :PowderMasse moléculaire :286.18 g/molN1-Methyladenosine
CAS :<p>N1-Methyladenosine is a nucleoside that has been shown to inhibit the synthesis of proteins in the ribosome, which are essential for all cellular functions. N1-Methyladenosine has been shown to be effective against HIV infection, and has also been used as a chemotherapeutic agent in cancer cells. The optimum concentration of this drug is unknown, but it is known that at high concentrations, it can cause cellular death. N1-Methyladenosine has also been shown to be effective in treating metabolic disorders and autoimmune diseases.</p>Formule :C11H15N5O4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :281.27 g/molC2-Methyladenosine
CAS :<p>C2-Methyladenosine is a x-ray crystal structure of the mutant strain of Mycobacterium tuberculosis that has an efficient method for binding to the substrate. The uptake of C2-methyladenosine by the wild type strain was found to be at least four times higher than that of adenosine. The analog was also shown to have pharmacokinetic properties in fat cells, which leads to a decrease in ATP levels.</p>Formule :C11H15N5O4Degré de pureté :Min. 96 Area-%Couleur et forme :White PowderMasse moléculaire :281.27 g/molN3-Methylcytidine methosulfate
CAS :<p>N3-Methylcytidine methosulfate is a novel antiviral agent that inhibits the synthesis of DNA and RNA. It has been shown to be effective against hepatitis B virus, herpes simplex virus, varicella-zoster virus, human immunodeficiency virus, and cytomegalovirus. N3-Methylcytidine methosulfate was found to be active in a variety of animal models including mice and rats. This drug has anticancer properties in the treatment of leukemia, lymphoma, and breast cancer. The phosphoramidite derivative of N3-methylcytidine methosulfate is used as an activator for oligonucleotide synthesis.</p>Formule :C10H15N3O5·CH4SO4Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :369.35 g/molN6-Ethenoadenosine
CAS :<p>N6-Ethenoadenosine is a fluorescent derivative that is used in biology to study the binding of receptor molecules to DNA. N6-Ethenoadenosine binds to the dinucleotide phosphate, which is an important component for many metabolic processes. It also has been shown to be an effective inhibitor of DNA duplexes and ATPase activity. N6-Ethenoadenosine has a glycosidic bond with p-nitrophenyl phosphate, which is a substrate of creatine kinase and can be used as an indicator of its activity. This product is also used as a marker for damaged DNA.</p>Formule :C12H13N5O4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :291.26 g/molGuanosine 3',5'-cyclic monophosphate
CAS :Guanosine 3',5'-cyclic monophosphate (cGMP) is a nucleotide that functions as a second messenger in the cell. It is involved in many cellular processes, including mitochondrial functions and energy metabolism. cGMP is synthesized from guanosine triphosphate (GTP) by the enzyme guanine nucleotide-binding protein, which hydrolyzes the phosphate group from GTP to form cGMP. cGMP has been shown to be involved in neuronal death, axonal growth, and glucose uptake in cells. Optimum concentrations of cGMP have been found to be between 1-10 μM. It has also been shown to be an important mediator of cyclic axonal growth and bowel disease. Guanosine 3',5'-cyclic monophosphate can also act as a polymerase chain reaction primer for DNA amplification in vitro.Formule :C10H12N5O7PDegré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :345.21 g/mol2-Chloroisonicotinic acid
CAS :<p>2-Chloroisonicotinic acid is a halogenated derivative of isonicotinic acid where a chlorine atom is substituted at the 2-position of the pyridine ring (next to the carboxylic acid group).</p>Formule :C6H4ClNO2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :157.55 g/mol2'-Deoxy-2',2'-difluorocytidine 5'-triphosphate triethylammonium salt - Aqueous solution
CAS :<p>2'-Deoxy-2',2'-difluorocytidine 5'-triphosphate triethylammonium salt - Aqueous solution is a nucleoside analog for research purposes</p>Formule :C9H14F2N3O13P3·C24H60N4Couleur et forme :Colorless PowderMasse moléculaire :907.9 g/mol2'-Deoxy-2'-fluoro-5-methylcytidine
CAS :<p>2'-Deoxy-2'-fluoro-5-methylcytidine is a nucleoside analog that is a modified version of cytidine, where the sugar (deoxyribose) has a fluoro modification at the 2' carbon and a methyl group is attached at the 5' position of the cytosine base. This modification confers unique properties that can be useful in research and drug development.</p>Formule :C10H14FN3O4Degré de pureté :Min. 95%Couleur et forme :Off-White PowderMasse moléculaire :259.23 g/molN4-Ethenocytidine
CAS :<p>N4-Ethenocytidine is a nucleoside analogue that has been synthesized and shown to be an effective inhibitor of the hepatitis C virus. N4-Ethenocytidine prevents the synthesis of viral RNA by attacking the 3'-hydroxyl group of uridine, which is involved in the formation of ribonucleotides. This compound can also inhibit rat liver microsomes through a hydrated attack on carbonyl groups. The reaction products are trifluoroacetic acid and chloride ions. N4-Ethenocytidine's fluorescence properties have been used to identify its reaction intermediates, which include uridylic acid and 4-etheno-N6-isopentenyladenosine.</p>Formule :C11H13N3O5Degré de pureté :Min. 95%Couleur et forme :White Off-White PowderMasse moléculaire :267.24 g/mol5'-O-DMT-2'-O-methyluridine
CAS :<p>5'-O-DMT-2'-O-methyluridine (5'-OMeT) is a phosphoramidite building block of a modified nucleoside that is used in biological research. The stability of 5'-OMeT has been studied by thermal denaturation studies and found to be more stable than other analogues such as 6-azacytidine, 6-azauridine, and 6-azathymidine. This may be due to its increased resistance to endonucleolytic cleavage. 5'-OMeT has not shown any significant biological activity in vivo or in vitro.</p>Formule :C31H32N2O8Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :560.61 g/mol8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate monosodium salt
CAS :8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate monosodium salt (8-CPT-cAMP) is a cytosolic second messenger that regulates physiological processes. It interacts with the G protein coupled receptor 2-adrenergic receptor, and activates adenylyl cyclase to produce cAMP. 8-CPT-cAMP also induces mitochondrial membrane potential depolarization and Ca2+ release from the endoplasmic reticulum, which leads to cell death. The pro-apoptotic protein Bax is upregulated by 8-CPT-cAMP in cells and contributes to cell death.Formule :C16H14ClN5NaO6PSDegré de pureté :Min. 97 Area-%Couleur et forme :PowderMasse moléculaire :493.79 g/mol2',3'-Di-O-acetyladenoside
CAS :2',3'-Di-O-acetyladenoside is a nucleoside for use in research applicationsFormule :C14H17N5O6Degré de pureté :Min. 97 Area-%Couleur et forme :White PowderMasse moléculaire :351.31 g/mol2'-O-Methylguanosine
CAS :2'-O-Methylguanosine is a nucleoside that contains a 2'-O-methyl group at the 2' position of the ribose. It is a component of many nucleic acids and is usually found as a minor component in RNA. 2'-O-Methylguanosine has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase, which may be due to its ability to form hydrogen bonds with the phosphate backbone. This compound has also been shown to act as a competitive inhibitor for both wild-type and mutant bacterial strains, suggesting that it can inhibit DNA synthesis in bacteria by binding to the enzyme's active site. 2'-O-Methylguanosine is present in relatively high concentrations in tissues, such as liver and muscle, where it is involved in metabolism or energy production. The optimum concentration for detection by analytical methods varies depending on the type of detector used.Formule :C11H15N5O5Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :297.27 g/mol3'-O-Methylguanosine
CAS :<p>3'-O-Methylguanosine is a nucleoside that is found in the guanine molecule and has been shown to have inhibitory properties against malignant brain tumors. 3'-O-Methylguanosine blocks the synthesis of DNA, RNA, and peptide hormones. It also inhibits the growth of erythromycin-resistant strains of bacteria. The kinetic data for 3'-O-Methylguanosine was obtained from experiments with leukemic mice and carcinoma cell lines. The enzyme glut1 regulates the rate of metabolism of 3'-O-Methylguanosine. It is metabolized by dehydroascorbic acid reductase to 3'-deoxyadenosine monophosphate (dAMP) and then to adenosine monophosphate (AMP). The optimum pH for this reaction is 7.3 at 37 degrees Celsius.</p>Formule :C11H15N5O5Degré de pureté :Min. 98 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :297.27 g/mol5-Hydroxycytidine
CAS :<p>5-Hydroxycytidine is a pyrimidine nucleoside that is found in DNA and RNA. It can be produced by the conversion of cytidine 5-monophosphate to cytidine 5'-diphosphate, which is then hydrolyzed to produce 5-hydroxycytidine. This conversion requires the enzyme cytidylate kinase. The structure of 5-hydroxycytidine differs from other pyrimidine nucleosides as its hydroxyl group does not have an acidic proton present. Biological functions that have been attributed to 5-hydroxydihydrocytidylic acid include its ability to inhibit translation and induce cell death in lung cells. This compound has also been shown to modify DNA duplexes and form bioconjugates with proteins or small molecules, such as fluorescein and digoxigenin. These modifications are used in analytical methods such as phase chromatography, nuclear magnetic resonance spectroscopy</p>Formule :C9H13N3O6Degré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :259.22 g/mol8-Bromoguanosine hydrate
CAS :<p>8-Bromoguanosine hydrate is a brominated form of guanosine. It is used as a marker for colorectal cancer in urine samples. 8-Bromoguanosine hydrate can be used to calibrate the results of chromatographic analyses and to identify metabolic disorders, such as fatty acid oxidation defects. The compound is also an endogenous ligand that interacts with adenosine receptors and may have pro-apoptotic effects on cancer cells by triggering their death. 8-Bromoguanosine hydrate has been shown to be more effective than other brominated nucleosides in inducing apoptosis in malignant cells, including colorectal carcinoma cells.</p>Formule :C10H12BrN5O5·xH2ODegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :362.14 g/mol2'-Deoxy-5-hydroxymethylcytidine
CAS :2'-Deoxy-5-hydroxymethylcytidine is a nucleoside analog that inhibits the enzyme thymidylate synthase. The inhibition of this enzyme leads to a deficiency in the production of thymine, which is essential for DNA synthesis. 2'-Deoxy-5-hydroxymethylcytidine has been shown to be an effective anti-cancer agent in vitro and in vivo. It can also be used as a potential biomarker for cancer and can be used as a polymerase chain reaction (PCR) primer for detection of cancer tissue. This drug binds to the polymerase enzyme, preventing it from performing its function to replicate DNA, thereby halting cell division and causing cell death.Formule :C10H15N3O5Degré de pureté :Min. 95%Couleur et forme :White Yellow PowderMasse moléculaire :257.24 g/mol
