Nucléosides

N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine-3'-lcaa-CPG is an antiviral agent that inhibits the RNA polymerase of the virus. It is a phosphoramidite, which is a nucleoside with a phosphate group at the 5' position. N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine has been shown to be cytotoxic against cancer cells, and have less side effects than other nucleosides. It has been shown to selectively bind to ribonucleosides and deoxyribonucleosides and inhibit their synthesis by binding to the enzyme DNA polymerase. This stops DNA replication and causes cell death.

<p>A cap analog that can incorporated into mRNA</p>

<p>2'-Deoxy-8-(9H-fluoren-2-ylamino)-guanosine (FdA) is a synthetic nucleoside that was designed for use as a dietary supplement to inhibit carcinogenesis. It is an analog of guanosine and is phosphorylated by cellular kinases to form 2'-deoxy-8-(9H-fluoren-2-ylamino)-inosine monophosphate. FdA inhibits the process of DNA replication in mammalian cells, which may be due to its ability to bind single stranded DNA. This drug has been shown to reduce the mutation frequency and increase the life span of mice with bladder cancer.</p>

6-(4-Iodobenzyl)-1-Methyl Pyrimidine-2,4-(1H,3H)-Dione is a nucleoside analog that has shown to be an activator of the ribonucleotide reductase enzyme. It has also been shown to have anticancer activity. 6-(4-Iodobenzyl)-1-Methyl Pyrimidine-2,4-(1H,3H)-Dione inhibits DNA synthesis by binding to the DNA molecule at the site of incorporation and preventing its duplication. This compound also inhibits RNA synthesis by binding to the RNA molecule at the site of incorporation and preventing its duplication. It has been shown to inhibit cancer cell growth in culture and can be used as a chemotherapeutic agent.

<p>4-Amino-3-benzyl-1H-pyrazolo[3,4-d]pyrimidine 1b-D-ribofuranose is a novel diphosphate activator that can modify the properties of deoxyribonucleosides and nucleosides. It has antiviral activity against human immunodeficiency virus type 1 (HIV) and herpes simplex virus type 2 (HSV). 4-Amino-3-benzyl-1H-pyrazolo[3,4-d]pyrimidine 1b -D--ribofuranose is also an anticancer agent that has been shown to have DNA binding ability, in addition to its ability to inhibit the proliferation of cancer cells.</p>

<p>Dihydrozeatin riboside-5'-monophosphate sodium salt is a cytokinin that belongs to the group of indole compounds. It has been shown to inhibit the biosynthesis of ethylene, which prevents fruit from ripening. Dihydrozeatin riboside-5'-monophosphate sodium salt is also able to inhibit the synthesis of adenosine, another plant hormone that inhibits growth and promotes dormancy in plants. The bioassay for this product has been done with amanita muscaria, an edible mushroom found in North America and Europe. This mushroom contains dihydrozeatin as well as other related compounds such as zeatin, which can be converted into dihydrozeatin by enzymes present in the intestines. The symptoms of poisoning by this mushroom include vomiting and diarrhea, owing to its effects on intestinal motility.</p>

3'-Azido-3'-deoxythymidine-methyl-D3-2,3,4-tri-O-acetyl-b-D-glucuronide methyl ester (AZT) is a novel nucleoside compound that is a phosphoramidite. AZT has antiviral activity against various DNA and RNA viruses, including HIV. It is also effective in the treatment of cancer. AZT inhibits viral replication by competitively inhibiting the incorporation of diphosphate into viral DNA or RNA. This process prevents the synthesis of new virus particles and the spread of infection to healthy cells. In addition, AZT may inhibit tumor growth by interfering with cell division and DNA synthesis.

1-(5'-Deoxy-5'-fluoro-a-D-arabinofuranosyl)-2-nitroimidazole is an anticancer drug that has been shown to inhibit tumor growth in vivo. This drug binds to the integrin receptor, which is expressed on the surface of cells and is involved in the process of cell adhesion. 1-(5'-Deoxy-5'-fluoro-a-D-arabinofuranosyl)-2-nitroimidazole inhibits tumor growth by inhibiting hypoxic tumor formation. Hypoxia is a condition where there is not enough oxygen for normal cell function. This drug has also been shown to reduce inflammation, which may be due to its ability to inhibit proinflammatory cytokines, such as IL-1β and TNFα, from binding to their receptors on cells. 1-(5'-Deoxy-5'-fluoro-a-D-arabinofuranosyl)-

<p>3'-Epi-GEMCITABINE is a nucleoside phosphoramidite that is used in the synthesis of DNA and RNA. It is an antiviral agent and also has anticancer activity. 3'-Epi-GEMCITABINE inhibits the growth of cells by inhibiting DNA synthesis, which leads to cell death. The chemical name for 3'-epigemcitabine is 2',3'-dideoxyinosine monophosphate. 3'-Epi-GEMCITABINE can be synthesized from 2',3'-dideoxyinosine monophosphate and 5-bromo-2'-deoxyuridine diphosphate.</p>

8-Oxoguanosine monophosphate (8-oxoGMP) is a synthetic nucleoside that is activated by the enzyme thioredoxin reductase and phosphorylated to form 8-oxoGTP. The anticancer activity of 8-oxoGMP is due to its ability to inhibit ribonucleotide reductase, which reduces the production of DNA and RNA in cells. This product has been shown to inhibit HIV replication in vitro and in vivo. It also inhibits viral replication by inhibiting the synthesis of viral nucleic acids such as DNA, RNA, and deoxyribonucleic acid (DNA).

3',5'-Di-O-p-chlorobenzoyl-2'-deoxy-5-fluorouridine is a nucleoside derivative that has antiviral activity. It is synthesized by the condensation of 2,3,5-trihydroxybenzoic acid with 3'-chloro-5'-fluoroacetophenone in the presence of pyridine and triethylamine. The nucleoside has been shown to be an effective inhibitor of HIV replication in vitro. 3',5'-Di-O-p-chlorobenzoyl-2'-deoxy-5-fluorouridine also inhibits DNA synthesis in human lymphocytes at concentrations of 5 μM or less. This compound can be used as an activator for DNA polymerases and phosphoramidites for DNA synthesis.

<p>2'-Deoxy-3'-O-DMT-N2-iBu-guanosine--succinyl-CPG 1000 Å is a modified nucleoside that is synthesized from 2'-deoxyribonucleosides and succinic anhydride. It has antiviral, anticancer, and antimalarial activities. It can also be used to modify DNA sequences. This product is a novel phosphoramidite monomer with high purity.</p>

<p>Guanosine 5'-triphosphate trisodium hydrate is a novel antiviral agent that was discovered in the course of a research program to find new antiviral agents. It is an activator of guanylyl cyclase and it has been shown to have high quality and high purity. Guanosine 5'-triphosphate trisodium hydrate binds to ribonucleosides and deoxyribonucleosides, preventing their incorporation into viral DNA or RNA. This compound also has anticancer activity.</p>

3',5'-Di-O-acetyl-N2-acetyl-O6-diphenylcarbamoyl-2'-deoxy-D-guanosine is a synthetic nucleoside that has been modified with an acetyl group at the 3' and 5' positions of the sugar. It has antiviral, anticancer, and antiretroviral activities against HIV. This nucleoside has also been shown to inhibit human leukemia cells in vitro by binding to DNA, inhibiting its synthesis. The drug is currently undergoing clinical trials for the treatment of AIDS patients.

<p>Troxacitabine is a nucleoside analog that inhibits DNA synthesis by selectively blocking the function of DNA polymerase. It has been shown to have potent antitumor activity in mouse tumor models and in a human breast cancer xenograft model. Troxacitabine has also been shown to inhibit the proliferation of renal cell cancer cells and induce apoptosis in these cells, as well as reduce the viability of cancer cells from other tumor types. Troxacitabine has also been shown to have an effect on body mass index and hematologic response, although it is not currently approved for use in humans.</p>

2',3'-Anhydroinosine is an analog of the purine nucleoside inosine, which has been synthesized by catalytic dehalogenation of 2-fluoro-adenosine. The synthesis of this compound is based on a chemical reaction between 2-fluoro-adenosine and sodium hydroxide. This reaction produces 2',3'-anhydroinosine as a byproduct. 2',3'-Anhydroinosine inhibits the enzyme purine nucleoside phosphorylase, which prevents the conversion of inosine to hypoxanthine. This prevents purines from being used for protein synthesis, leading to cell death.

3'-Amino-2',3'-dideoxy-2-fluoroadenosine is a novel compound that inhibits the enzyme ribonucleotide reductase, which is involved in the synthesis of DNA. It also has antiviral and anticancer activities. 3'-Amino-2',3'-dideoxy-2-fluoroadenosine has high purity and high quality and can be used as an activator for phosphoramidite synthesis.

<p>8-(4-Chlorophenylthio)guanosine 3',5'-cyclic monophosphothioate Sp-isomer sodium salt (8-chloro-GTP) is a modified nucleoside that inhibits the synthesis of DNA by preventing the addition of nucleotides to the 3' end of DNA. It is an antiviral and anticancer agent, and can be used as a phosphoramidite in the synthesis of DNA. 8-chloro-GTP has shown high purity and high quality in synthesized DNA. Research on this compound is still ongoing, but it has been shown to be novel and modified compared to other nucleosides.</p>

<p>1-(b-D-Arabinofuranosyl)-5-iodouracil is a synthetic nucleoside that has antiviral and anticancer properties. It is a monophosphate nucleotide that inhibits viral RNA synthesis by inhibiting the enzyme ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. This inhibitor also blocks DNA synthesis by preventing the incorporation of b-D-arabinofuranosyl monophosphate into DNA. 1-(b-D-Arabinofuranosyl)-5-iodouracil has been shown to be effective in treating various types of cancer, including breast, lung, and prostate cancers. It also exhibits antitumor activity against certain human leukemia cells.</p>

Cytidine-5'-phosphate-3'-(6-aminohexyl)phosphate-biotin triethylammonium salt - 1 mM aqueous solution (10 mM Tris-HCl) is a nucleoside phosphate activator with antiviral effects. It has been successfully synthesized and shown to be an effective anticancer agent. Cytidine-5'-phosphate-3'-(6-aminohexyl)phosphate-biotin triethylammonium salt - 1 mM aqueous solution (10 mM Tris-HCl) is modified from cytidine, which contains the amino acid L-alanine in place of D-alanine. This modification increases the stability and bioavailability of this molecule. Cytidine, or cytidylate, is a nucleoside phosphate that is widely used in biochemistry as an activator for other nucleosides or as a substrate for enzymes