Nucléosides
Les nucléosides sont des building blocks fondamentaux des acides nucléiques, composés d'une base azotée attachée à une molécule de sucre. Dans cette section, vous trouverez une large gamme de nucléosides essentiels pour la recherche en biologie moléculaire, biochimie et pharmacologie. Ces composés jouent des rôles cruciaux dans la synthèse de l'ADN et de l'ARN, et sont également vitaux dans divers processus métaboliques. Les nucléosides sont utilisés pour étudier le matériel génétique, développer des thérapies antivirales et anticancéreuses, et comprendre les mécanismes cellulaires. Chez CymitQuimica, nous proposons des nucléosides de haute qualité pour soutenir vos besoins en recherche et développement, garantissant pureté et fiabilité pour vos applications expérimentales.
3569 produits trouvés pour "Nucléosides"
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8-Bromocyclic adenosine diphosphate ribose sodium
CAS :<p>8-Bromocyclic adenosine diphosphate ribose sodium salt (8BCAR) is a cytosolic cyclase inhibitor that inhibits the synthesis of cyclic adenosine monophosphate (cAMP). 8BCAR blocks the activation of protein kinase A, which is an enzyme involved in the phosphorylation of cAMP. 8BCAR has been shown to inhibit cardiac hypertrophy induced by growth factor-β1 and to increase mitochondrial membrane potential, as well as to suppress cardiomyocyte apoptosis. In addition, this drug can be used for the treatment of cancers such as leukemia and lymphoma.</p>Formule :C15H19BrN5NaO13P2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :642.19 g/mol2-Thiouridine-5'-monophosphate triethylammonium salt - Aqueous solution
CAS :<p>2-Thiouridine-5'-monophosphate triethylammonium salt is a synthetic nucleotide analog that inhibits the growth of cells by binding to the anticodon region, which blocks the entrance of amino acids into the ribosome. It also inhibits cell growth by preventing glycosidic bond formation and inhibiting purine metabolism. This drug has functional groups that allow it to be purified by chromatography and diffraction techniques. The drug is not active against bacteria that are resistant to glutamic acid, such as Mycobacterium tuberculosis or Mycobacterium avium complex. 2-Thiouridine-5'-monophosphate triethylammonium salt is a precursor for other drugs, such as cytidine 5'-triphosphate, which can be used in chemotherapy treatments.</p>Formule :C21H43N4O8PSDegré de pureté :Min. 95%Couleur et forme :Clear LiquidMasse moléculaire :542.63 g/mol2'-O-Methylcytidine-5'-triphosphate sodium salt - 100mM aqueous solution
CAS :<p>2'-O-Methylcytidine-5'-triphosphate sodium salt is a synthetic, modified nucleoside analog. It can be used as an antiviral agent and anticancer drug to inhibit viral replication and tumor growth. 2'-O-Methylcytidine-5'-triphosphate sodium salt has the ability to activate cellular DNA synthesis. This compound also inhibits RNA polymerase activity in cancer cells, which inhibits the production of proteins vital for cell division. 2'-O-Methylcytidine-5'-triphosphate sodium salt can be used as a phosphoramidite building block for the synthesis of oligonucleotides with novel structures.</p>Formule :C10H18N3O14P3·xNaDegré de pureté :Min. 95%Couleur et forme :Clear LiquidMasse moléculaire :497.18 g/mol2-Amino-9-(β-D-ribofuranosyl)purine
CAS :<p>2-Amino-9-(β-D-ribofuranosyl)purine is a purine nucleoside consisting of the base 2-aminopurine linked via an N9-glycosidic bond to β-D-ribofuranose. As an analog of adenosine, it retains structural compatibility with nucleic acids but exhibits distinct biochemical properties, most notably intrinsic fluorescence. This makes it a valuable probe in molecular biology for studying nucleic acid structure, base pairing, and conformational changes, as its fluorescence is sensitive to local stacking interactions and environmental conditions.</p>Formule :C10H13N5O4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :267.24 g/mol6-Chloro-7-deaza-9-(b-D-ribofuranosyl)purine
CAS :6-Chloro-7-deaza-9-(b-D-ribofuranosyl)purine is a novel nucleoside that has been shown to be an efficient activator of the transcription factor NFκB in vitro. 6-Chloro-7-deaza-9-(b-D-ribofuranosyl)purine is synthesized by phosphoramidite chemistry and purified by HPLC. It has been demonstrated to inhibit the replication of human immunodeficiency virus (HIV) in a dose dependent manner, which may be due to its ability to inhibit the synthesis of viral DNA and RNA. This product is highly pure and can be used for many purposes, including as a synthetic building block for DNA or as an antiviral drug.Formule :C11H12ClN3O4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :285.69 g/molN-Benzoyl-2'-deoxy-2'-fluoroadenosine, 3'-(hydrogen phosphonate)
CAS :<p>N-Benzoyl-2'-deoxy-2'-fluoroadenosine, 3'-(hydrogen phosphonate) is a novel nucleoside that inhibits the replication of virus by binding to viral RNA. It is synthesized by reacting 2'-deoxy-2'-fluoroadenosine with pentafluorophenyl phosphate in the presence of an activator such as dicyclohexylcarbodiimide or N-hydroxysuccinimide. The synthesis of N-benzoyl-2'-deoxy-2'-fluoroadenosine, 3'-(hydrogen phosphonate) can be accomplished using commercially available nucleosides and phosphoramidites.</p>Degré de pureté :Min. 95%N6-Benzoyl-5'-O-DMT-2'-O-propynyladenosine 3'-CE phosphoramidite
CAS :<p>N6-Benzoyl-5'-O-DMT-2'-O-propynyladenosine 3'-CE phosphoramidite is a modified nucleoside, which is an important building block for DNA and RNA synthesis. It is synthesized by the condensation of 6-benzoyladenosine with 2'-O-propynyladenosin. The stability of this compound has been demonstrated by its resistance to hydrolysis and oxidation, while it can also be activated with a variety of activators, including NaBH4 or NaCNBH3. This novel nucleotide has shown anticancer activity in vivo and antiviral activity against HIV.</p>Formule :C50H54N7O8PDegré de pureté :Min. 95%Masse moléculaire :911.98 g/mol6-Amino-1-(2'-deoxy-b-D-ribofuranosyl)-4-hydrazino-1H-pyrazolo[3,4-d]pyrimidine
<p>6-Amino-1-(2'-deoxy-b-D-ribofuranosyl)-4-hydrazino-1H-pyrazolo[3,4-d]pyrimidine (6ADRP) is a synthetic nucleoside that is used as an activator of ribonucleosides and diphosphates in DNA synthesis. 6ADRP has antiviral activity against HIV and herpes simplex virus type 1. It binds to the viral DNA polymerase and prevents the addition of nucleotides to the growing DNA strand. 6ADRP is phosphorylated by T7 kinase to form the active metabolite, 6-amino-1-(2'-deoxy-[alpha]-D-ribofuranosyl)-5'-triphosphate (6ATP), which inhibits viral replication by preventing the formation of RNA primers.</p>Degré de pureté :Min. 95%Cyclopentenyl cytosine 5'-triphosphate sodium salt
<p>Cyclopentenyl cytosine 5'-triphosphate sodium salt is a synthetic, activator diphosphate. It is used as a phosphoramidite in the synthesis of DNA and RNA. Cyclopentenyl cytosine 5'-triphosphate sodium salt has been shown to have anticancer and antiviral properties.</p>Degré de pureté :Min. 95%5-Methoxycarbonylmethyluridine
CAS :<p>5-Methoxycarbonylmethyluridine is a nucleoside that is a precursor in the synthesis of other nucleotides. It has been shown to have potential as a biomarker for various diseases, such as metabolic disorders and hepatic steatosis. 5-Methoxycarbonylmethyluridine also inhibits the activity of methyltransferases, which are enzymes that catalyze the transfer of methyl groups from S-adenosylmethionine to substrates. It is also used as a model system for polymerase chain reaction in cancer research, because it has been shown to inhibit DNA replication by blocking the incorporation of uracil into DNA.<br>5-Methoxycarbonylmethyluridine has been found at high levels in fetal bovine serum and eukaryotic cells, but not in prokaryotes or cancerous tissues.</p>Formule :C12H16N2O8Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :316.26 g/mol2'-Azido-2'-deoxy-5'-O-DMT-uridine
CAS :<p>2'-Azido-2'-deoxy-5'-O-DMT-uridine is a nucleoside that has been modified with an azido group at the 2' position. The azido group is used to modify DNA and RNA nucleosides, which are monophosphate, ribonucleosides, and deoxyribonucleosides. This drug may be used as an activator of DNA synthesis or as a antiviral agent. It has been shown to inhibit HIV replication in vitro.</p>Degré de pureté :Min. 95%5’(R)-C-Methyladenosine
CAS :<p>5’(R)-C-Methyladenosine is a nucleoside that is used as an antiviral and anticancer agent. It has been shown to inhibit the replication of the human immunodeficiency virus type 1 (HIV-1) in a dose-dependent manner, with an IC50 value of about 0.4 μM for HIV-1 reverse transcriptase activity. In addition, 5’(R)-C-Methyladenosine has been shown to inhibit DNA synthesis and promote apoptosis in cancer cells by inhibiting transcription and translation. The compound also inhibits the growth of tumor cells in mice without affecting normal tissue growth.</p>Degré de pureté :Min. 95%3'-O-Methylguanosine 5'-triphosphate lithium
CAS :<p>3'-O-Methylguanosine 5'-triphosphate lithium is a nucleotide that has been synthesized and characterized. It is a biochemical regulatory molecule that is involved in the synthesis of DNA, RNA, and proteins. 3'-O-Methylguanosine 5'-triphosphate lithium binds to the guanine nucleotide binding protein G, which acts as an allosteric activator of the enzyme ribonucleotide reductase. The reconstituted enzyme system containing 3'-O-methylguanosine 5'-triphosphate lithium has demonstrated a high level of fidelity in the replication of dna templates.</p>Formule :C11H18N5O14P3•Li4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :564.97 g/mol8-Hydroxyadenosine
CAS :<p>8-Hydroxyadenosine (8-OHdG) is a purine nucleoside that is formed as a result of oxidative DNA damage. It is not an essential metabolite because it can be synthesized de novo. 8-OHdG has been shown to have potent anti-tumor activity in vitro and in vivo, which may be due to its ability to inhibit DNA replication. The biological effects of 8-OHdG are attributed to its ability to form hydrogen bonds with guanine residues in the double helix, and electrochemical detectors have been developed for its detection.</p>Formule :C10H13N5O5Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :283.25 g/mol3'-O-Aminoacetoxy-2'-deoxyadenosine
<p>amino functionalised nucleoside</p>Formule :C13H22N6O3Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :310.36 g/mol3'-O-Methyladenosine
CAS :<p>3'-O-Methyladenosine (3'OMeA) is a monomethylated adenosine that belongs to the group of nucleosides. It has been found to inhibit the activity of adenosine receptors, which are important for the regulation of blood pressure and central nervous system function. 3'OMeA also inhibits virus replication in human lymphocytes. 3'OMeA is synthesized by reaction with methylamine and purification by column chromatography. The molecule is a potential therapeutic target for HIV/AIDS, as it can be used as a specific agonist in order to block viral entry into cells.</p>Formule :C11H15N5O4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :281.27 g/mol1-(4’-Azido-3’,5’-di-O-benzoyl-2’-deoxy-2’-fluoro-b-D-arabinofuranosyl)uracil
CAS :<p>1-(4’-Azido-3’,5’-di-O-benzoyl-2’-deoxy-2’-fluoro-b-D-arabinofuranosyl)uracil is a synthetic antiviral agent that inhibits the activity of DNA and RNA polymerases. It also has anticancer properties. The compound is an analogue of 2'-deoxycytidine monophosphate (dCMP). This compound binds to the phosphate group of nucleoside triphosphates and prevents their incorporation into DNA or RNA. 1-(4’-Azido-3’,5’-di-O-benzoyl-2’-deoxy) -2′ fluoro -b D arabinofuranosyl) uracil has been shown to inhibit the growth of cancer cells in vitro.</p>Degré de pureté :Min. 95%Zebularine 3'-CE phosphoramidite
CAS :<p>Zebularine 3'CE phosphoramidite is a novel, high quality activator for modified DNA monophosphate. It is used as an anticancer drug and antiviral agent. Zebularine 3'CE phosphoramidite is a synthetic, diphosphate with high purity and high reactivity. It has been shown to activate deoxyribonucleosides to ribonucleosides in DNA synthesis, as well as being able to inhibit viral RNA synthesis by inhibiting viral polymerase.</p>Formule :C45H61N4O8PSiDegré de pureté :Min. 95%Couleur et forme :Off-white solid.Masse moléculaire :845.04 g/mol2'-Deoxy-N6-DMF-5'-O-MMT-adenosine 3'-CE phosphoramidite
CAS :<p>2'-Deoxy-N6-DMF-5'-O-MMT-adenosine 3'-CE phosphoramidite is a high purity, diphosphate nucleotide analog. It is an anticancer drug that inhibits DNA synthesis and can be used to treat cancer. The 2'-deoxy-N6-DMF moiety has been shown to inhibit the activity of DNA polymerase and other enzymes involved in DNA replication. This compound also has a novel mechanism of action that is not present in any other known anticancer drugs. CAS No. 195375-66-7.br>br>2'-Deoxy-N6-DMF 5'-O-MMT adenosine 3'-cephosphoramidite is often used as a building block for oligonucleotide synthesis because it is resistant to the removal of phosphate groups by alkaline phosphatases. The lack of phosphate groups makes this compound more stable than standard nucleotides</p>Formule :C42H51N8O5PDegré de pureté :Min. 95%Masse moléculaire :778.9 g/mol3'-Amino-N6-benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-3'-deoxyadenosine
<p>3'-Amino-N6-benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-3'-deoxyadenosine is a nucleoside that is synthesized by the modification of deoxyadenosine. It has antiviral and anticancer properties, as well as other novel applications. The synthesis of this compound can be achieved in two steps: first, the amino group is attached to the 3' carbon atom of the sugar ring by reacting with N6-(benzoyl)adenine. In the second step, a silyl group is attached to the 5' carbon atom of the sugar ring by reacting with tert-butyldimethylchlorosilane and DMT (dimethoxytrityl).</p>Formule :C44H50N6O6SiDegré de pureté :Min. 95%Masse moléculaire :786.99 g/mol
![6-Amino-1-(2'-deoxy-b-D-ribofuranosyl)-4-hydrazino-1H-pyrazolo[3,4-d]pyrimidine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FNA162940.webp&w=3840&q=75)
